The Aryl Hydrocarbon Receptor (AhR) in the Aging Process: Another Puzzling Role for This Highly Conserved Transcription Factor
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Aging is the most important risk factor for the development of major life-threatening diseases such as cardiovascular disorders, cancer, and neurodegenerative disorders. The aging process is characterized by the accumulation of damage to intracellular macromolecules and it is concurrently shaped by genetic, environmental and nutritional factors. These factors influence the functionality of mitochondria, which play a central role in the aging process. Mitochondrial dysfunction is one of the hallmarks of aging and is associated with increased fluxes of ROS leading to damage of mitochondrial components, impaired metabolism of fatty acids, dysregulated glucose metabolism, and damage of adjacent organelles. Interestingly, many of the environmental (e.g., pollutants and other toxicants) and nutritional (e.g., flavonoids, carotenoids) factors influencing aging and mitochondrial function also directly or indirectly affect the activity of a highly conserved transcription factor, the Aryl hydrocarbon Receptor (AhR). Therefore, it is not surprising that many studies have already indicated a role of this versatile transcription factor in the aging process. We also recently found that the AhR promotes aging phenotypes across species. In this manuscript, we systematically review the existing literature on the contradictory studies indicating either pro- or anti-aging effects of the AhR and try to reconcile the seemingly conflicting data considering a possible dependency on the animal model, tissue, as well as level of AhR expression and activation. Moreover, given the crucial role of mitochondria in the aging process, we summarize the growing body of evidence pointing toward the influence of AhR on mitochondria, which can be of potential relevance for aging.
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When AhR is triggered, overall endogenous pineal melatonin production is suppressed.
“When AhR is triggered, overall endogenous pineal melatonin production is suppressed [32,55,56,57,58].”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [58]
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López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
Kenyon, C. J. (2010) · Nature · doi:10.1038/nature08980 · Cited by 2,739 · see citing works
Senolytics improve physical function and increase lifespan in old age
Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287 · see citing works
The moulding of senescence by natural selection
Hamilton, W. D. O. (1966) · Journal of Theoretical Biology · doi:10.1016/0022-5193(66)90184-6 · Cited by 2,273 · see citing works
Kirkwood, T. B. L. (1977) · Nature · doi:10.1038/270301a0 · Cited by 2,007 · see citing works
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
Opitz, C. A., Litzenburger, U. M., Sahm, F., Ott, M., Tritschler, I., Trump, S., Schumacher, T., Jestaedt, L., Schrenk, D., Weller, M., et al. (2011) · Nature · doi:10.1038/nature10491 · Cited by 1,898 · see citing works
Rothhammer, V., Mascanfroni, I. D., Bunse, L., Takenaka, M. C., Kenison, J. E., Mayo, L., Chao, C.-C., Patel, B., Yan, R., Blain, M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4106 · Cited by 1,559 · see citing works
Lim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., & Cole, G. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08370.2001 · Cited by 1,530 · see citing works
Poland, A., Glover, E., & Kende, A. S. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33205-2 · Cited by 1,370 · see citing works
Immune System Impairment and Hepatic Fibrosis in Mice Lacking the Dioxin-Binding Ah Receptor
Fernandez-Salguero, P., Pineau, T., Hilbert, D. M., McPhail, T., Lee, S. S. T., Kimura, S., Nebert, D. W., Rudikoff, S., Ward, J. M., & Gonzalez, F. J. (1995) · Science · doi:10.1126/science.7732381 · Cited by 1,075 · see citing works
Schmidt, J. V., Su, G. H., Reddy, J., Simon, M., & Bradfield, C. (1996) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.93.13.6731 · Cited by 932 · see citing works
Kirkwood, T. B. L. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00419-5 · Cited by 801 · see citing works
Ristow, M., & Zarse, K. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.014 · Cited by 789 · see citing works
Extending life span by increasing oxidative stress
Ristow, M., & Schmeisser, S. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.010 · Cited by 718 · see citing works
Benzo[ a ]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor
Shimizu, Y., Nakatsuru, Y., Ichinose, M., Takahashi, Y., Kume, H., Mimura, J., Fujii‐Kuriyama, Y., & Ishikawa, T. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.2.779 · Cited by 640 · see citing works
Mimura, J., Yamashita, K., Nakamura, K., Morita, M., Takagi, T. N., Nakao, K., Ema, M., Sogawa, K., Yasuda, M., Katsuki, M., et al. (1997) · Genes to Cells · doi:10.1046/j.1365-2443.1997.1490345.x · Cited by 626 · see citing works
Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology
Mandal, P. K. (2005) · Journal of Comparative Physiology B · doi:10.1007/s00360-005-0483-3 · Cited by 598 · see citing works
Modern Biological Theories of Aging
McDonald, R. B. (1989) · Journal of Nutrition · doi:10.1093/jn/119.6.952 · Cited by 465 · see citing works
Fritsche, E., Schäfer, C., Calles, C., Bernsmann, T., Bernshausen, T., Wurm, M., Hübenthal, U., Cline, J. E., Hajimiragha, H., Schroeder, P., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701764104 · Cited by 437 · see citing works
Ma, Q., & Whitlock, J. P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.14.8878 · Cited by 426 · see citing works
Rea, S. L., Ventura, N., & Johnson, T. E. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050259 · Cited by 383 · see citing works
Self-citationAmyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan
Alavez, S., Vantipalli, M. C., Zucker, D. J. S., Klang, I. M., & Lithgow, G. J. (2011) · Nature · doi:10.1038/nature09873 · Cited by 370 · see citing works
Rannug, A., Rannug, U., Rosenkranz, H. S., Winqvist, L., Westerholm, R. N., Agurell, E., & Grafström, A.-K. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47743-5 · Cited by 357 · see citing works
Lesions of Aryl-hydrocarbon Receptor–deficient Mice
Fernández‐Salguero, P. M., Ward, J. M., Sundberg, J. P., & Gonzalez, F. J. (1997) · Veterinary Pathology · doi:10.1177/030098589703400609 · Cited by 352 · see citing works
Jin, U.-H., Lee, S., Sridharan, G. V., Lee, K., Davidson, L. A., Jayaraman, A., Chapkin, R. S., Alaniz, R. C., & Safe, S. H. (2014) · Molecular Pharmacology · doi:10.1124/mol.113.091165 · Cited by 330 · see citing works
Caenorhabditis elegans pathways that surveil and defend mitochondria
Liu, Y., Samuel, B. S., Breen, P. C., & Ruvkun, G. (2014) · Nature · doi:10.1038/nature13204 · Cited by 309 · see citing works
An introduction to the molecular basics of aryl hydrocarbon receptor biology
Abel, J., & Haarmann‐Stemmann, T. (2010) · Biological Chemistry · doi:10.1515/bc.2010.128 · Cited by 297 · see citing works
Nuclear Localization and Export Signals of the Human Aryl Hydrocarbon Receptor
Ikuta, T., Eguchi, H., Tachibana, T., Yoneda, Y., & Kawajiri, K. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.5.2895 · Cited by 287 · see citing works
Sandoval-Acuña, C., Ferreira, J., & Speisky, H. (2014) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2014.05.017 · Cited by 285 · see citing works
Duncan, D. M., Burgess, E. A., & Duncan, I. (1998) · Genes & Development · doi:10.1101/gad.12.9.1290 · Cited by 278 · see citing works
The heterochromatin loss model of aging
Villeponteau, B. (1997) · Experimental Gerontology · doi:10.1016/s0531-5565(96)00155-6 · Cited by 261 · see citing works
New Trends in Aryl Hydrocarbon Receptor Biology
Mulero‐Navarro, S., & Fernández‐Salguero, P. M. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00045 · Cited by 254 · see citing works
The hallmarks of fibroblast ageing
Tigges, J., Krutmann, J., Fritsche, E., Haendeler, J., Schaal, H., Fischer, J. W., Kalfalah, F., Reinke, H., Reifenberger, G., Stühler, K., et al. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.03.004 · Cited by 250 · see citing works
Self-citationCiolino, H. P., Daschner, P. J., Wang, T. T. Y., & Yeh, G. C. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00143-9 · Cited by 241 · see citing works
Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin
Kampkötter, A., Timpel, C., Zurawski, R. F., Ruhl, S., Chovolou, Y., Proksch, P., & Wätjen, W. (2007) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2007.10.004 · Cited by 239 · see citing works
Meyer, B. K., & Perdew, G. H. (1999) · Biochemistry · doi:10.1021/bi982223w · Cited by 232 · see citing works
Indoles from commensal bacteria extend healthspan
Sonowal, R., Swimm, A., Sahoo, A., Luo, L., Matsunaga, Y., Wu, Z., Bhingarde, J. A., Ejzak, E. A., Ranawade, A., Qadota, H., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1706464114 · Cited by 197 · see citing works
Powell‐Coffman, J. A., Bradfield, C. A., & Wood, W. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2844 · Cited by 188 · see citing works
Wu, D., Nishimura, N., Kuo, V., Fiehn, O., Shahbaz, S., Winkle, L. S. V., Matsumura, F., & Vogel, C. F. A. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.220202 · Cited by 186 · see citing works
The Caenorhabditis elegans aryl hydrocarbon receptor, AHR-1, regulates neuronal development
Qin, H., & Powell‐Coffman, J. A. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.02.004 · Cited by 179 · see citing works
Yueh, M., Huang, Y.-H., Hiller, A., Chen, S., Nguyen, N. T., & Tukey, R. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300645200 · Cited by 177 · see citing works
Lahvis, G. P., Pyzalski, R. W., Glover, E., Pitot, H. C., McElwee, M. K., & Bradfield, C. A. (2005) · Molecular Pharmacology · doi:10.1124/mol.104.008888 · Cited by 168 · see citing works
Palermo, C. M., Westlake, C. A., & Gasiewicz, T. A. (2005) · Biochemistry · doi:10.1021/bi047433p · Cited by 167 · see citing works
Cristina, D., Cary, M., Lunceford, A., Clarke, C., & Kenyon, C. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000450 · Cited by 166 · see citing works
Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor
Schimizu, Y. (2000) · Medical Entomology and Zoology · Cited by 164 · see citing works
Pietsch, K., Saul, N., Menzel, R., Stürzenbaum, S. R., & Steinberg, C. E. W. (2008) · Biogerontology · doi:10.1007/s10522-008-9199-6 · Cited by 161 · see citing works
Marlowe, J. L., Knudsen, E. S., Schwemberger, S. J., & Puga, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404315200 · Cited by 159 · see citing works
Marinković, N., Pašalić, D., Ferenčak, G., Gršković, B., & Stavljenić-Rukavina, A. (2010) · Archives of Industrial Hygiene and Toxicology · doi:10.2478/10004-1254-61-2010-2024 · Cited by 158 · see citing works
Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor
Senft, A. P., Dalton, T. P., Nebert, D. W., Genter, M. B., Puga, A., Hutchinson, R. J., Kerzee, J. K., Uno, S., & Shertzer, H. G. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01014-6 · Cited by 157 · see citing works
Curcumin Promotes A-beta Fibrillation and Reduces Neurotoxicity in Transgenic Drosophila
Caesar, I., Jonson, M., Nilsson, K. P. R., Thor, S., & Hammarström, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031424 · Cited by 152 · see citing works
Huang, X., Powell‐Coffman, J. A., & Jin, Y. (2004) · Development · doi:10.1242/dev.00959 · Cited by 145 · see citing works
The genetics of human longevity: an intricacy of genes, environment, culture and microbiome
Dato, S., Rose, G., Crocco, P., Monti, D., Garagnani, P., Franceschi, C., & Passarino, G. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.03.011 · Cited by 134 · see citing works
Kaeberlein, M. R. (2013) · F1000Prime Reports · doi:10.12703/p5-5 · Cited by 132 · see citing works
Kim, M. D., Jan, L. Y., & Jan, Y. N. (2006) · Genes & Development · doi:10.1101/gad.1459706 · Cited by 130 · see citing works
Smith, C. J., O’Brien, T., Chatzigeorgiou, M., Spencer, W. C., Feingold-Link, E., Husson, S. J., Hori, S., Mitani, S., GOTTSCHALK, A. R., Schafer, W. R., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.05.009 · Cited by 122 · see citing works
Smirnova, A. V., Wincent, E., Bergander, L. V., Alsberg, T. E., Bergman, J., Rannug, A., & Rannug, U. (2015) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.5b00416 · Cited by 122 · see citing works
AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins
Yano, M., Terada, K., & Mori, M. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200305051 · Cited by 107 · see citing works
Curfs, D. M. J., Knaapen, A. M., Pachen, D. M. F. A., Gjbels, M. J. J., Lutgens, E., Smook, M., Kockx, M. M., Daemen, M. J. A. P., & van Schooten, F. (2005) · The FASEB Journal · doi:10.1096/fj.04-2269fje · Cited by 102 · see citing works
The Paradox of Mitochondrial Dysfunction and Extended Longevity
Munkácsy, E., & Rea, S. L. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.03.016 · Cited by 101 · see citing works
Structure-Dependent Modulation of Aryl Hydrocarbon Receptor-Mediated Activities by Flavonoids
Jin, U.-H., Park, H., Li, X., Davidson, L. A., Allred, C. D., Patil, B. S., Jayaprakasha, G. K., Orr, A. A., Mao, L., Chapkin, R. S., et al. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy075 · Cited by 101 · see citing works
Janssens, G. E., Lin, X.-X., Millán-Ariño, L., Kavšek, A., Sen, I., Seinstra, R. I., Stroustrup, N., Nollen, E. A. A., & Riedel, C. G. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.044 · Cited by 95 · see citing works
Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols
Ajami, M., Pazoki–Toroudi, H., Amani, H., Nabavi, S. F., Braidy, N., Vacca, R. A., Atanasov, A. G., MOCAN, A., & Nabavi, S. M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.11.022 · Cited by 91 · see citing works
de Souza, A. R., Zago, M., Pollock, S. J., Sime, P. J., Phipps, R. P., & Baglole, C. J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.258764 · Cited by 89 · see citing works
Hu, P., Herrmann, R., Bednar, A., Saloupis, P., Dwyer, M. A., Yang, P., Qi, X., Thomas, R. S., Jaffe, G. J., Boulton, M. E., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307574110 · Cited by 89 · see citing works
Kerley-Hamilton, J. S., Trask, H. W., Ridley, C. J. A., DuFour, E., Lesseur, C., Ringelberg, C. S., Moodie, K. L., Shipman, S. L., Korc, M., Gui, J., et al. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs002 · Cited by 89 · see citing works
The aryl hydrocarbon receptor promotes aging phenotypes across species
Eckers, A., Jakob, S., Heiß, C., Haarmann‐Stemmann, T., Goy, C., Brinkmann, V., Cortese-Krott, M. M., Sansone, R., Esser, C., Ale‐Agha, N., et al. (2016) · Scientific Reports · doi:10.1038/srep19618 · Cited by 86 · see citing works
Self-citationHwang, H. J., Dornbos, P., Steidemann, M., Dunivin, T. K., Rizzo, M., & LaPres, J. J. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.04.005 · Cited by 81 · see citing works
Gao, D., Wu, M.-F., Wang, C., Wang, Y., & Zuo, Z. (2015) · Aquatic Toxicology · doi:10.1016/j.aquatox.2015.08.013 · Cited by 77 · see citing works
Okey, A. B., Dubé, A. W., & Vella, L. M. (1984) · PubMed · Cited by 77 · see citing works
Koizumi, M., Tatebe, J., Watanabe, I., Yamazaki, J., Ikeda, T., & Morita, T. (2014) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.23663 · Cited by 76 · see citing works
Das, D. N., Naik, P. P., Mukhopadhyay, S., Panda, P. K., Sinha, N., Meher, B. R., & Bhutia, S. K. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.08.020 · Cited by 76 · see citing works
Schiavi, A., Torgovnick, A., Kell, A. M., Megalou, E. V., Castelein, N., Guccini, I., Marzocchella, L., Gelino, S., Hansen, M., Malisan, F., et al. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.12.002 · Cited by 75 · see citing works
Self-citationMechanisms and therapeutic prospects of polyphenols as modulators of the aryl hydrocarbon receptor
Xue, Z., Li, D., Yu, W., Zhang, Q., Hou, X., He, Y., & Kou, X. (2017) · Food & Function · doi:10.1039/c6fo01810f · Cited by 73 · see citing works
Amakura, Y., Tsutsumi, T., Sasaki, K., Yoshida, T., & Maitani, T. (2003) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.26.1754 · Cited by 71 · see citing works
Николаевна, П. Е., Lashmanova, E., Dobrovolskaya, E., Zemskaya, N. V., Kudryavtseva, A. V., Shaposhnikov, M. V., & Moskalev, A. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00505 · Cited by 71 · see citing works
Mao, K., Ji, F., Breen, P. C., Sewell, A. K., Han, M., Sadreyev, R. I., & Ruvkun, G. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.022 · Cited by 71 · see citing works
Hossain, A., Tsuchiya, S., Minegishi, M., Osada, M., Ikawa, S., Tezuka, F.-A., Kaji, M., Konno, T., Watanabe, M., & Kikuchi, H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.31.19853 · Cited by 70 · see citing works
Esser, C. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.10.002 · Cited by 69 · see citing works
Singh, K. P., Bennett, J. A., Casado, F. L., Walrath, J. L., Welle, S. L., & Gasiewicz, T. A. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0346 · Cited by 68 · see citing works
Sauzeau, V., Carvajal-González, J. M., Riolobos, A. S., Sevilla, M. A., Menacho-Márquez, M., Román, Á., Abad, A., Montero, M. J., Fernández‐Salguero, P. M., & Bustelo, X. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.187534 · Cited by 63 · see citing works
Ming, M., Zhao, B., Shea, C. R., Shah, P., Qiang, L., White, S. R., Sims, D. M., & He, Y. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.09.035 · Cited by 62 · see citing works
Curcumin suppresses the transformation of an aryl hydrocarbon receptor through its phosphorylation
Nishiumi, S., Yoshida, K., & Ashida, H. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.08.007 · Cited by 60 · see citing works
Tappenden, D. M., Lynn, S. G., Crawford, R. B., Lee, K., Vengellur, A., Kaminski, N. E., Thomas, R. S., & LaPres, J. J. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.05.004 · Cited by 60 · see citing works
Henry, E. C., & Gasiewicz, T. A. (1993) · Biochemical Journal · doi:10.1042/bj2940095 · Cited by 60 · see citing works
The interplay between mitochondria and autophagy and its role in the aging process
Schiavi, A., & Ventura, N. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.02.015 · Cited by 59 · see citing works
Self-citationWang, Q., Kurita, H., Carreira, V., Ko, C., Fan, Y., Zhang, X., Biesiada, J., Medvedovic, M., & Puga, A. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv246 · Cited by 59 · see citing works
Qin, H., Zhai, Z., & Powell‐Coffman, J. A. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.07.017 · Cited by 58 · see citing works
An Evolutionarily Conserved Role for the Aryl Hydrocarbon Receptor in the Regulation of Movement
Williams, E. G., Mouchiroud, L., Frochaux, M., Pandey, A., Andreux, P. A., Deplancke, B., & Auwerx, J. H. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004673 · Cited by 56 · see citing works
Huang, S., Shui, X., He, Y. Z., Xue, Y., Li, J., Li, G., Lei, W., & Chen, C. (2015) · Scientific Reports · doi:10.1038/srep08022 · Cited by 54 · see citing works
An update on the dietary ligands of the AhR
Ashida, H., Nishiumi, S., & Fukuda, I. (2008) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.4.11.1429 · Cited by 53 · see citing works
Kaeberlein, M. R. (2015) · Veterinary Pathology · doi:10.1177/0300985815591082 · Cited by 53 · see citing works
Qiao, Y., Li, Q., Du, H.-Y., Wang, Q.-W., Huang, Y., & Liu, W. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.04.160 · Cited by 53 · see citing works
Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis
Maglioni, S., Schiavi, A., Runci, A., Shaik, A., & Ventura, N. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.03.026 · Cited by 52 · see citing works
Self-citationCarreira, V., Fan, Y., Kurita, H., Wang, Q., Ko, C., Naticchioni, M., Jiang, M., Koch, S. E., Zhang, X., Biesiada, J., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142440 · Cited by 52 · see citing works
Baba, T., Shima, Y., Owaki, A., Mimura, J., Oshima, M., Fujii-Kuriyama, Y., & Morohashi, K. (2008) · Sexual Development · doi:10.1159/000117714 · Cited by 50 · see citing works
Ah Receptor Signaling Controls the Expression of Cardiac Development and Homeostasis Genes
Carreira, V., Fan, Y., Wang, Q., Zhang, X., Kurita, H., Ko, C., Naticchioni, M., Jiang, M., Koch, S. E., Medvedovic, M., et al. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv138 · Cited by 48 · see citing works
Fisher, M. T., Nagarkatti, M., & Nagarkatti, P. S. (2005) · Toxicology Letters · doi:10.1016/j.toxlet.2005.01.008 · Cited by 47 · see citing works
Lack of the aryl hydrocarbon receptor accelerates aging in mice
Bravo‐Ferrer, I., Cuartero, M. I., Medina, V., Quero, D. L. A., Peña‐Martínez, C., Pérez‐Ruíz, A., Fernández-Valle, M. E., Hernández‐Sánchez, C., Fernández‐Salguero, P. M., Lizasoaín, I., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201901333r · Cited by 47 · see citing works
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Sutter, T. R., Olesen, K. M., Bhuju, J., Guo, Z., & Sutter, T. R. (2018) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2018.10.019 · Cited by 45 · see citing works
Li, Z., Wang, K., Yang, X., Zhuang, Z., Wang, J., & Tong, X. (2014) · Europe PMC (PubMed Central) · Cited by 37 · see citing works
Moreno-Marín, N., Barrasa, E., Morales‐Hernández, A., Paniagua, B., Blanco‐Fernández, G., Merino, J. M., & Fernández‐Salguero, P. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-10984-w · Cited by 29 · see citing works
Direct control of antennal identity by the spineless-aristapedia gene of Drosophila
Burgess, E., & Duncan, I. (1990) · Molecular and General Genetics MGG · doi:10.1007/bf00259398 · Cited by 28 · see citing works
Aarnio, V., Storvik, M., Lehtonen, M., Asikainen, S., Reisner, K., Callaway, J. C., Rudgalvyte, M., Lakso, M., & Wong, G. (2010) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2009.12.006 · Cited by 26 · see citing works
Kudo, K., Takeuchi, T., Murakami, Y., Ebina, M., & Kikuchi, H. (2009) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.06.003 · Cited by 25 · see citing works
Lung regeneration after toxic injury is improved in absence of dioxin receptor
Morales‐Hernández, A., Nacarino-Palma, A., Moreno-Marín, N., Barrasa, E., Paniagua, B., Catalina‐Fernández, I., Alvarez, A. M., Bustelo, X. R., Merino, J. M., & Fernández‐Salguero, P. M. (2017) · Stem Cell Research · doi:10.1016/j.scr.2017.10.009 · Cited by 23 · see citing works
Uric acid stones in the urinary bladder of aryl hydrocarbon receptor (AhR) knockout mice
Butler, R., Inzunza, J., Suzuki, H., Fujii‐Kuriyama, Y., Warner, M. N., & Gustafsson, J.-Α. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120581109 · Cited by 22 · see citing works
Panchanathan, R., Liu, H., & Choubey, D. (2015) · International Journal of Toxicology · doi:10.1177/1091581815578013 · Cited by 11 · see citing works
The Caenorhabditis elegans aryl hydrocarbon receptor, AHR-1, regulates neuronal development
Qin, H. (2004) · Developmental Biology · doi:10.1016/s0012-1606(04)00119-8 · Cited by 9 · see citing works
Effects of Japanese Kelp (Kombu) on Life Span of Benzo [a] pyrene-Fed Mice
Sakakibara, H., Nakagawa, S., WAKAMEDA, H., NAKAGIRI, Y., KAMATA, K., DAS, S. K., Tsuji, T., & Kanazawa, K. (2005) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.51.369 · Cited by 8 · see citing works
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Salminen, A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101573 · Cited by 197 · see citing works
Minich, D. M., Henning, M., Darley, C., Fahoum, M., Schuler, C. B., & Frame, J. (2022) · Nutrients · doi:10.3390/nu14193934 · Cited by 176 · see citing works
Intestinal epithelial cell metabolism at the interface of microbial dysbiosis and tissue injury
Rath, E., & Haller, D. (2022) · Mucosal Immunology · doi:10.1038/s41385-022-00514-x · Cited by 149 · see citing works
Xenobiotic metabolism and transport in Caenorhabditis elegans
Hartman, J. H., Widmayer, S. J., Bergemann, C. M., King, D. E., Morton, K. S., Romersi, R. F., Jameson, L. E., Leung, M. C. K., Andersen, E. C., Taubert, S., et al. (2021) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937404.2021.1884921 · Cited by 124 · see citing works
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Larigot, L., Benoit, L., Koual, M., Tomkiewicz, C., Barouki, R., & Coumoul, X. (2021) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-052220-115707 · Cited by 108 · see citing works
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Tête, A., Brial, F., Benoit, L., Koual, M., Tomkiewicz, C., Kim, M. J., Blanc, É., Coumoul, X., & Bortoli, S. (2021) · Cells · doi:10.3390/cells11010110 · Cited by 96 · see citing works
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Yao, Y., Shang, W., Bao, L., Peng, Z., & Wu, C. (2024) · European Journal of Immunology · doi:10.1002/eji.202350631 · Cited by 77 · see citing works
Xie, L., Wu, Q., Li, K., Khan, M. A. S., Zhang, A., Sinha, B., Li, S., Chang, S. L., Brody, D. L., Grinstaff, M. W., et al. (2024) · Aging and Disease · doi:10.14336/ad.2024.0134 · Cited by 63 · see citing works
Salminen, A. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04520-x · Cited by 56 · see citing works
Xie, H., Yang, N., Lu, L., Sun, X.-A., Li, J., Wang, X., Guo, H., Zhou, L., Liu, J., Wu, H., et al. (2024) · Advanced Science · doi:10.1002/advs.202402066 · Cited by 52 · see citing works
Urbauer, E., Rath, E., & Haller, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.602814 · Cited by 52 · see citing works
Kiss, T., Nyúl‐Tóth, Á., Gulej, R., Tarantini, S., Csípő, T., Mukli, P., Ungvari, A., Balasubramanian, P., Yabluchanskiy, A., Benyó, Z., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00519-1 · Cited by 48 · see citing works
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Ren, R., Fang, Y., Sherchan, P., Lu, Q., Lenahan, C., Zhang, J. H., Zhang, J., & Tang, J. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0215 · Cited by 36 · see citing works
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Anderson, G., Almulla, A. F., Reiter, R. J., & Maes, M. H. J. (2023) · Cells · doi:10.3390/cells12091237 · Cited by 19 · see citing works
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Lim, H. J., Jang, W. B., Rethineswaran, V. K., Choi, J., Lee, E. J., Park, S., Jeong, Y., Ha, J. S., Yun, J., Choi, Y. J., et al. (2023) · Cells · doi:10.3390/cells12152005 · Cited by 17 · see citing works
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Whole Blood Expression Pattern of Inflammation and Redox Genes in Mild Alzheimer’s Disease
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Wang, Y., Xu, P., Chen, H., Guo, X., Gao, J., Wang, T., Yao, D., Li, X., Liu, B., & Yuan, J. (2025) · Toxicology · doi:10.1016/j.tox.2025.154219 · Cited by 10 · see citing works
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Zhang, J., Dong, X., Pang, Q., & Zhang, A. (2024) · Mediators of Inflammation · doi:10.1155/mi/2662362 · Cited by 6 · see citing works
Lavorato, M., Mathew, N. D., Shah, N., Nakamaru‐Ogiso, E., & Falk, M. J. (2021) · Journal of Visualized Experiments · doi:10.3791/62244 · Cited by 6 · see citing works
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Gao, X., Yu, J., Zhang, L., Shi, H., Yan, Y., Han, Y., Fang, M., Liu, Y., Wu, C., Fan, S., et al. (2024) · Journal of Applied Toxicology · doi:10.1002/jat.4578 · Cited by 3 · see citing works
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Hsu, J., Fang, H.-H., & Su, J.-G. J. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03901-4 · Cited by 1 · see citing works
Lin, L.-W., Jang, H. S., Song, Z., Ebrahimi, A., Yang, J., Nguyen, B. D., O’Donnell, E. F., Hendrix, D. A., Maier, C. S., & Kolluri, S. K. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116896 · Cited by 1 · see citing works
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Jing, Y., Xuying, Y. O. U., Feng, Y., Wu, S., Wang, K., Yuan, H., & Liu, J. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1801871 · Cited by 1 · see citing works
Choi, H. S., Kim, J. T., Lee, H. K., Park, W. H., Pak, Y. K., & Lee, S. W. (2021) · Endocrinology and Metabolism · doi:10.3803/enm.2021.1226 · Cited by 1 · see citing works
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Heidari, R., & Ommati, M. M. (2023) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815124484123010008 · Cited by 1 · see citing works
Aryl Hydrocarbon Receptor Blocks Aging-Induced Senescence in the Liver and Fibroblast CellsPreprint
Nacarino-Palma, A., Rico-Leo, E. M., Campisi, J., Ramanathan, A., Merino, J. M., & Fernández-Salguero, P. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.25.432074 · Cited by 1 · see citing works
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Gupta, P. L., Trivedi, U., Rajput, M., Oza, T., Chauhan, J., & Sanghvi, G. V. (2021) · Wiley eBooks · doi:10.1002/9781119717317.ch4 · Cited by 1 · see citing works
D’Amico, F., Fabbrini, M., Barone, M., Brigidi, P., & Turroni, S. (2023) · Endocrinology · doi:10.1007/978-3-031-08115-6_16-1
Yu, T., & Fan, H. D. (2026) · Postgraduate Medical Journal · doi:10.1093/postmj/qgag017
Daley-Bauer, L., Flantzer, L., Kyu, S., Godoy, A., Weinberg, J., Marconi, V. C., Jones, D. P., & Younes, S.-A. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1852583 · Cited by 2 · see citing works
Marín-Díaz, B., González-Rico, F. J., Ordóñez-Mata, L., Román, Á., Merino, J. M., & Fernández‐Salguero, P. M. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00596-0
- Authors
- Brinkmann, V., Ale-Agha, N., Haendeler, J., & Ventura, N.
- Affiliations
- Leibniz Institute of Environmental Medicine (DE)
- Corresponding author
- Haendeler, Judith
- Ventura, Natascia
- Venue
- Frontiers in Physiology
- Publisher
- Frontiers Media SA
- Published
- 2020-01-14
- Volume
- 10
- Pages
- 1561-1561
- ISSN
- 1664-042X (ISSN-L)
- PMC
- PMC6971224
- OpenAlex
- W2999281779
- Cited by
- 71
- References
- 110
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 12 · 2023: 14 · 2022: 16 · 2021: 12 · 2020: 6
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Physiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- aryl hydrocarbon receptor, aging, mitochondrial dysfunction, reactive oxygen species, transcription factors, flavonoids, carotenoids, environmental pollutants, cross-species comparison
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