Cited by 71Genetics, Aging, and Longevity in Model OrganismsToxic Organic Pollutants ImpactMitochondrial Function and Pathology

The Aryl Hydrocarbon Receptor (AhR) in the Aging Process: Another Puzzling Role for This Highly Conserved Transcription Factor

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Brinkmann, Vanessa, Ale-Agha, Niloofar, Haendeler, Judith, Ventura, Natascia·2020·Frontiers in Physiology

Abstract

Aging is the most important risk factor for the development of major life-threatening diseases such as cardiovascular disorders, cancer, and neurodegenerative disorders. The aging process is characterized by the accumulation of damage to intracellular macromolecules and it is concurrently shaped by genetic, environmental and nutritional factors. These factors influence the functionality of mitochondria, which play a central role in the aging process. Mitochondrial dysfunction is one of the hallmarks of aging and is associated with increased fluxes of ROS leading to damage of mitochondrial components, impaired metabolism of fatty acids, dysregulated glucose metabolism, and damage of adjacent organelles. Interestingly, many of the environmental (e.g., pollutants and other toxicants) and nutritional (e.g., flavonoids, carotenoids) factors influencing aging and mitochondrial function also directly or indirectly affect the activity of a highly conserved transcription factor, the Aryl hydrocarbon Receptor (AhR). Therefore, it is not surprising that many studies have already indicated a role of this versatile transcription factor in the aging process. We also recently found that the AhR promotes aging phenotypes across species. In this manuscript, we systematically review the existing literature on the contradictory studies indicating either pro- or anti-aging effects of the AhR and try to reconcile the seemingly conflicting data considering a possible dependency on the animal model, tissue, as well as level of AhR expression and activation. Moreover, given the crucial role of mitochondria in the aging process, we summarize the growing body of evidence pointing toward the influence of AhR on mitochondria, which can be of potential relevance for aging.

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Authors
Brinkmann, V., Ale-Agha, N., Haendeler, J., & Ventura, N.
Affiliations
Leibniz Institute of Environmental Medicine (DE)
Corresponding author
  • Haendeler, Judith
  • Ventura, Natascia
Venue
Frontiers in Physiology
Published
2020-01-14
Volume
10
Pages
1561-1561
ISSN
1664-042X (ISSN-L)
OpenAlex
W2999281779
Cited by
71
References
110
Citations by year
2026: 5 · 2025: 6 · 2024: 12 · 2023: 14 · 2022: 16 · 2021: 12 · 2020: 6
FWCI
1.51
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Physiology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
aryl hydrocarbon receptor, aging, mitochondrial dysfunction, reactive oxygen species, transcription factors, flavonoids, carotenoids, environmental pollutants, cross-species comparison

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