Cited by 87Redox biology and oxidative stressAntioxidant Activity and Oxidative StressFree Radicals and Antioxidants

Reactive oxygen species (ROS), oxygen radicals and antioxidants: Where are we now, where is the field going and where should we go?

Halliwell, Barry·2022·Biochemical and Biophysical Research Communications

Abstract

The field of oxygen free radicals, antioxidants and reactive oxygen species (ROS) has exploded in the past few decades, and BBRC has published several seminal papers. ROS can cause oxidative damage, but also play fundamental roles in living organisms, in such processes as signal transduction and defence against pathogens. ROS underpin every aspect of human biology. Indeed, an endless stream of published papers refers to the biological roles of "ROS". Sadly, much of this work is mechanistically meaningless. To make progress, the detailed molecular mechanisms of action of ROS must be elucidated and appropriate methodology must be used to measure them and the oxidative damage that they can cause, as emphasized in a recent review by Murphy et al. Attention must also switch from clinical studies involving administration of high-dose supplements of vitamins E, C and β-carotene for the treatment or prevention of human disease into other promising diet-derived cytoprotective agents. One of them may be ergothioneine.

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Crossref · 10.1016/j.bbrc.2022.08.098

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Authors
Halliwell, B.
Affiliations
National University of Singapore (SG)
Corresponding author
Halliwell, Barry
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
2022-12
Volume
633
Pages
17-19
ISSN
0006-291X (ISSN-L)
OpenAlex
W4308313960
Cited by
87
References
39
Citations by year
2026: 15 · 2025: 33 · 2024: 24 · 2023: 14 · 2022: 1
FWCI
1.88
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
Keywords
reactive oxygen species, oxygen free radicals, antioxidants, oxidative damage, signal transduction, pathogen defense, vitamin supplementation, ergothioneine
MeSH terms
Antioxidants, Free Radicals, Humans, Vitamin E, Reactive Oxygen Species, Oxidative Stress

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