Free radicals and antioxidants – quo vadis?
Abstract
The field of free radicals and antioxidants, or 'redox biology', is fundamental to aerobic life. Aerobes constantly make reactive species, but modulate their actions by synthesizing antioxidants. This balance allows some reactive species to perform useful functions while minimizing oxidative damage. In general, dietary antioxidants are ineffective at modulating the 'redox balance' in humans. This helps to explain why, although oxidative damage contributes to the development and pathology of several human diseases, dietary 'antioxidant' supplements have limited efficacy in disease prevention. Cell culture as usually performed imposes oxidative stress upon cells, which can lead to artefactual data in studies of the roles of reactive species and the actions of added antioxidants in cultured cells. This brief commentary highlights in broad terms the current status of the redox biology field and the major challenges it faces in the next decade.
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The correlation between oxidative stress status and affective disorders development could arise from the vulnerability of the central nervous system to oxidative damage.
“In fact, the correlation between the oxidative stress status and affective disorders development could arise from the vulnerability of central nervous system (CNS) to oxidative damage.”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [28]
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- Authors
- Halliwell, B.
- Affiliations
- National University of Singapore (SG)
- Corresponding author
- Halliwell, Barry
- ORCID
- Halliwell, Barry
- Venue
- Trends in Pharmacological Sciences
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 32
- Issue
- 3
- Pages
- 125-130
- ISSN
- 0165-6147 (ISSN-L)
- OpenAlex
- W2025973101
- Cited by
- 706
- References
- 64
- Citations by year
- 2026: 16 · 2025: 26 · 2024: 43 · 2023: 48 · 2022: 50 · 2021: 63 · 2020: 55 · 2019: 48 · 2018: 36 · 2017: 43 · 2016: 53 · 2015: 46 · 2014: 55 · 2013: 48 · 2012: 52
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Keywords
- free radicals, antioxidants, redox biology, reactive oxygen species, oxidative stress, oxidative damage, dietary antioxidants, antioxidant supplements, disease prevention
- MeSH terms
- Animals, Antioxidants, Free Radicals, Humans, Oxidation-Reduction, Oxidative Stress, Cell Culture Techniques, Dietary Supplements
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