Cited by 706Redox biology and oxidative stressAntioxidant Activity and Oxidative StressFree Radicals and Antioxidants

Free radicals and antioxidants – quo vadis?

Halliwell, Barry·2011·Trends in Pharmacological Sciences

Abstract

The field of free radicals and antioxidants, or 'redox biology', is fundamental to aerobic life. Aerobes constantly make reactive species, but modulate their actions by synthesizing antioxidants. This balance allows some reactive species to perform useful functions while minimizing oxidative damage. In general, dietary antioxidants are ineffective at modulating the 'redox balance' in humans. This helps to explain why, although oxidative damage contributes to the development and pathology of several human diseases, dietary 'antioxidant' supplements have limited efficacy in disease prevention. Cell culture as usually performed imposes oxidative stress upon cells, which can lead to artefactual data in studies of the roles of reactive species and the actions of added antioxidants in cultured cells. This brief commentary highlights in broad terms the current status of the redox biology field and the major challenges it faces in the next decade.

Integrity signals

Registry

Crossref · 10.1016/j.tips.2010.12.002

Cites

64 of 64 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Halliwell, B.
Affiliations
National University of Singapore (SG)
Corresponding author
Halliwell, Barry
Venue
Trends in Pharmacological Sciences
Publisher
Elsevier BV
Published
2011-03
Volume
32
Issue
3
Pages
125-130
ISSN
0165-6147 (ISSN-L)
OpenAlex
W2025973101
Cited by
706
References
64
Citations by year
2026: 16 · 2025: 26 · 2024: 43 · 2023: 48 · 2022: 50 · 2021: 63 · 2020: 55 · 2019: 48 · 2018: 36 · 2017: 43 · 2016: 53 · 2015: 46 · 2014: 55 · 2013: 48 · 2012: 52
FWCI
5.20
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Pharmacological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
Keywords
free radicals, antioxidants, redox biology, reactive oxygen species, oxidative stress, oxidative damage, dietary antioxidants, antioxidant supplements, disease prevention
MeSH terms
Animals, Antioxidants, Free Radicals, Humans, Oxidation-Reduction, Oxidative Stress, Cell Culture Techniques, Dietary Supplements

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review