Antioxidants: Molecules, medicines, and myths

Free radicals in biology and medicine

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[1] Role of free radicals and catalytic metal ions in human disease: An overview

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A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics

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Reactive Species and Antioxidants. Redox Biology Is a Fundamental Theme of Aerobic Life

Halliwell, B. B. (2006) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.077073 · Cited by 2,402 · see citing works

Antioxidants prevent health-promoting effects of physical exercise in humans

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Free radicals in biology and medicine

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LIPID PEROXIDATION, OXYGEN RADICALS, CELL DAMAGE, AND ANTIOXIDANT THERAPY

Halliwell, B. B., & Gutteridge, J. C. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91886-5 · Cited by 796 · see citing works

Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?

Halliwell, B. B. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.01.028 · Cited by 767 · see citing works

Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not?

Halliwell, B., Rafter, J., & Jenner, A. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.268s · Cited by 711 · see citing works

Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis

Bjelaković, G., Nikolova, D., Simonetti, R. G., & Gluud, C. N. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17138-9 · Cited by 612 · see citing works

The biology of senescence

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Hormesis in aging

Rattan, S. I. S. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.03.002 · Cited by 498 · see citing works

The wanderings of a free radical

Halliwell, B. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.11.008 · Cited by 467 · see citing works

Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise

Childs, A. C., Jacobs, C. A., Kaminski, T. W., Halliwell, B. B., & Leeuwenburgh, C. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00640-2 · Cited by 335 · see citing works

Coordination of multiple dual oxidase–regulatory pathways in responses to commensal and infectious microbes in drosophila gut

Ha, E.-M., Lee, K.-A., Seo, Y. Y., Kim, S.-H., Lim, J.-H., Oh, B., Kim, J., & Lee, W. (2009) · Nature Immunology · doi:10.1038/ni.1765 · Cited by 331 · see citing works

Total antioxidant capacity

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The protective role of ROS in autoimmune disease

Hultqvist, M. H., Olsson, L. M., Gelderman, K. A., & Holmdahl, R. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.03.004 · Cited by 224 · see citing works

Phagocyte-derived reactive species: salvation or suicide?

Halliwell, B. B. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.07.005 · Cited by 192 · see citing works

Antioxidant Supplementation Increases the Risk of Skin Cancers in Women but Not in Men

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The mitochondrial free radical theory of ageing - Where do we stand?

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A New Arthritis Therapy with Oxidative Burst Inducers

Hultqvist, M. H., Olofsson, P., Gelderman, K. A., Holmberg, J., & Holmdahl, R. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030348 · Cited by 145 · see citing works

Free Radicals and Iron: Chemistry, Biology, and Medicine

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Deceptively simple but simply deceptive – Caenorhabditis elegans lifespan studies: Considerations for aging and antioxidant effects

Gruber, J., Ng, L. F., Poovathingal, S. K., & Halliwell, B. B. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.09.051 · Cited by 111 · see citing works

Systematic review: primary and secondary prevention of gastrointestinal cancers with antioxidant supplements

Bjelaković, G., Nikolova, D., Simonetti, R. G., & Gluud, C. N. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03785.x · Cited by 103 · see citing works

Antiinflammatory Effects of Hydrogen Peroxide in Neutrophil Activation and Acute Lung Injury

Zmijewski, J. W., Lorne, E., Zhao, X., Tsuruta, Y., Sha, Y., Liu, G., & Abraham, E. H. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200806-851oc · Cited by 95 · see citing works

Improved resistance to wear and fatigue fracture in high pressure crystallized vitamin E-containing ultra-high molecular weight polyethylene

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Maintaining immune homeostasis in fly gut

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Cautions in the use of biomarkers of oxidative damage; the vascular and antioxidant effects of dark soy sauce in humans

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Free radical theory of aging: Beneficial effect of adding antioxidants to the maternal mouse diet on life span of offspring; possible explanation of the sex difference in longevity

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On the Road to Bacterial Cell Death

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Lack of effect of acute oral ingestion of vitamin C on oxidative stress, arterial stiffness or blood pressure in healthy subjects

Kelly, R. P., Yeo, K. P., Isaac, H. B., Lee, J. C., Huang, S. H., Teng, L., Halliwell, B. B., & Wise, S. D. (2008) · Free Radical Research · doi:10.1080/10715760802087431 · Cited by 42 · see citing works

Phagomimetic Action of Antimicrobial Agents

Gutteridge, J. M. C., Quinlan, G. J., & Kovacic, P. (1998) · Free Radical Research · doi:10.3109/10715769809097871 · Cited by 40 · see citing works

Ncf1-Associated Reduced Oxidative Burst Promotes IL-33R+ T Cell-Mediated Adjuvant-Free Arthritis in Mice

Hagenow, K., Gelderman, K. A., Hultqvist, M. H., Merky, P., Bäcklund, J., Frey, O., Kamradt, T., & Holmdahl, R. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900966 · Cited by 31 · see citing works

Does redox regulation of cell function explain why antioxidants perform so poorly as therapeutic agents?

Gutteridge, J. M. C. (1999) · Redox Report · doi:10.1179/135100099101534819 · Cited by 21 · see citing works

AUTOXIDATION AND ANTIOXIDANTS: HISTORICAL PERSPECTIVE

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Notopterygium forbesii Boiss Extract and Its Active Constituent Phenethyl Ferulate Attenuate Pro-Inflammatory Responses to Lipopolysaccharide in RAW 264.7 Macrophages. A “Protective” Role for Oxidative Stress?

Tang, S. Y., Cheah, I. K.-M., Wang, H., & Halliwell, B. B. (2009) · Chemical Research in Toxicology · doi:10.1021/tx900163h · Cited by 17 · see citing works

Redox cell biology and genetics

Sen, C. K., & Packer, L. (2002) · Cited by 12 · see citing works

The antioxidant myth

Melton, L. (2006) · The New Scientist · Cited by 9 · see citing works

The emerging role of reactive oxygen and nitrogen species in redox biology and some implications for plasma applications to medicine and biology

Graves, D. B. (2012) · Journal of Physics D Applied Physics · doi:10.1088/0022-3727/45/26/263001 · Cited by 1,512 · see citing works

13 reasons why the brain is susceptible to oxidative stress

Cobley, J. N., Fiorello, M. L., & Bailey, D. M. (2018) · Redox Biology · doi:10.1016/j.redox.2018.01.008 · Cited by 1,215 · see citing works

Free radicals and antioxidants: updating a personal view

Halliwell, B. B. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00476.x · Cited by 918 · see citing works

Unraveling the biological roles of reactive oxygen species

Murphy, M. P., Holmgren, A., Larsson, N.-G., Halliwell, B., Chang, C. J., Kalyanaraman, B., Rhee, S. G., Thornalley, P. J., Partridge, L., Gems, D., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.010 · Cited by 836 · see citing works

Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease

Ruiz, S., Pérgola, P. E., Zager, R. A., & Vaziri, N. D. (2013) · Kidney International · doi:10.1038/ki.2012.439 · Cited by 722 · see citing works

Understanding mechanisms of antioxidant action in health and disease

Halliwell, B. B. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00645-4 · Cited by 673 · see citing works

Functions of ROS in Macrophages and Antimicrobial Immunity

Herb, M., & Schramm, M. (2021) · Antioxidants · doi:10.3390/antiox10020313 · Cited by 633 · see citing works

Taking a good look at free radicals in the aging process

Hekimi, S., Lapointe, J., & Wen, Y. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.06.008 · Cited by 606 · see citing works

Biomarkers of Oxidative Stress and Antioxidant Defense

Çekiç, S. D., Özkan, G., Avan, A. N., Uzunboy, S., Çapanoğlu, E., & Apak, R. (2021) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2021.114477 · Cited by 601 · see citing works

Strategies to increase nitric oxide signalling in cardiovascular disease

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Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation

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Male Oxidative Stress Infertility (MOSI): Proposed Terminology and Clinical Practice Guidelines for Management of Idiopathic Male Infertility

Agarwal, A. K., Parekh, N. V., Selvam, M. K. P., Henkel, R., Shah, R. S., Homa, S. T., Ramasamy, R., Ko, E., Tremellen, K. P., Esteves, S. C., et al. (2019) · The World Journal of Men s Health · doi:10.5534/wjmh.190055 · Cited by 479 · see citing works

Antioxidant Therapy: Current Status and Future Prospects

Firuzi, O., Miri, R., Tavakkoli, M., & Saso, L. (2011) · Current Medicinal Chemistry · doi:10.2174/092986711803414368 · Cited by 470 · see citing works

Chronic pancreatitis

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Advantages and limitations of common testing methods for antioxidants

Amorati, R., & Valgimigli, L. (2014) · Free Radical Research · doi:10.3109/10715762.2014.996146 · Cited by 458 · see citing works

A synopsis on aging—Theories, mechanisms and future prospects

da Costa, J. P., Vitorino, R. M. P., Silva, G. M., Vogel, C., Duarte, A. C., & Rocha‐Santos, T. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.06.005 · Cited by 486 · see citing works

Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

Calabrese, V., Cornelius, C., Dinkova‐Kostova, A. T., Iavicoli, I., Paola, R. D., Koverech, A., Cuzzocrea, S., Rizzarelli, E., & Calabrese, E. J. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.11.002 · Cited by 420 · see citing works

Oxidative stress in apoptosis and cancer: an update

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The antioxidant paradox: less paradoxical now?

Halliwell, B. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04272.x · Cited by 318 · see citing works

Ergothioneine – a diet‐derived antioxidant with therapeutic potential

Halliwell, B., Cheah, I. K., & Tang, R. M. Y. (2018) · FEBS Letters · doi:10.1002/1873-3468.13123 · Cited by 305 · see citing works

Natural Antioxidants: Fascinating or Mythical Biomolecules?

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Poor Oral Health as a Determinant of Malnutrition and Sarcopenia

Azzolino, D., Passarelli, P. C., Angelis, P. D., Piccirillo, G. B., D’Addona, A., & Cesari, M. (2019) · Nutrients · doi:10.3390/nu11122898 · Cited by 292 · see citing works

Are Flavonoids Effective Antioxidants in Plants? Twenty Years of Our Investigation

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Systems Biology of Free Radicals and Antioxidants

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Exercise-Induced Skeletal Muscle Remodeling and Metabolic Adaptation: Redox Signaling and Role of Autophagy

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Clinical trials of antioxidants as cancer prevention agents: Past, present, and future

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Antioxidant Activity and Protecting Health Effects of Common Medicinal Plants

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Mini-Review: Oxidative stress, redox stress or redox success?

Gutteridge, J. M. C., & Halliwell, B. B. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.05.045 · Cited by 229 · see citing works

Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity

Calabrese, V., Cornelius, C., Cuzzocrea, S., Iavicoli, I., Rizzarelli, E., & Calabrese, E. J. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.007 · Cited by 225 · see citing works

Resveratrol content and antioxidant properties of underutilized fruits

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Polyphenols and health: Moving beyond antioxidants

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Meta-regression analyses, meta-analyses, and trial sequential analyses of the effects of supplementation with beta-carotene, vitamin A, and vitamin E singly or in different combinations on all-cause mortality: do we have evidence for lack of harm?

Bjelakovic, G., Nikolova, D., & Gluud, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074558 · Cited by 183 · see citing works

Optimisation of antioxidant extraction from Solanum tuberosum potato peel waste by surface response methodology

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Mitonuclear match: Optimizing fitness and fertility over generations drives ageing within generations

Lane, N. J. (2011) · BioEssays · doi:10.1002/bies.201100051 · Cited by 177 · see citing works

Deleterious Effects of Reactive Metabolites

Attia, S. M. (2010) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.4.13246 · Cited by 175 · see citing works

CURRENT NUTRITIONAL RECOMMENDATIONS AND NOVEL DIETARY STRATEGIES TO MANAGE SARCOPENIA

Calvani, R., Miccheli, A., Landi, F., Bossola, M., Cesari, M., Leeuwenburgh, C., Sieber, C. C., Bernabei, R., & Marzetti, E. (2013) · The Journal of Frailty & Aging · doi:10.14283/jfa.2013.7 · Cited by 163 · see citing works

Evaluation ofp-cymene, a natural antioxidant

de Oliveira, T. M., de Carvalho, R. B. F., da Costa, I. H. F., de Oliveira, G. A. L., de Souza, A. A., de Lima, S. G., & de Freitas, R. M. (2014) · Pharmaceutical Biology · doi:10.3109/13880209.2014.923003 · Cited by 153 · see citing works

Redox biology of exercise: an integrative and comparative consideration of some overlooked issues

Nikolaidis, M. G., Kyparos, A., Spanou, C., Paschalis, V., Theodorou, A. A., & Vrabas, I. S. (2012) · Journal of Experimental Biology · doi:10.1242/jeb.067470 · Cited by 152 · see citing works

Antioxidant-Induced Stress

Villanueva, C., & Kross, R. D. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13022091 · Cited by 149 · see citing works

Antioxidants as therapies: can we improve on nature?

Murphy, M. P. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.010 · Cited by 148 · see citing works

Dietary oxidative stress and antioxidant defense with an emphasis on plant extract administration

Veskoukis, A. S., Tsatsakis, A. M., & Kouretas, D. (2011) · Cell Stress and Chaperones · doi:10.1007/s12192-011-0293-3 · Cited by 139 · see citing works

Do antioxidants impair signaling by reactive oxygen species and lipid oxidation products?

Niki, E. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.09.025 · Cited by 138 · see citing works

Polyphenols activate Nrf2 in astrocytes via H2O2, semiquinones, and quinones

Erlank, H., Elmann, A., Kohen, R., & Kanner, J. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.033 · Cited by 137 · see citing works

Real time monitoring and quantification of reactive oxygen species in breast cancer cell line MCF-7 by 2′,7′–dichlorofluorescin diacetate (DCFDA) assay

Figueroa, D., Asaduzzaman, M., & Young, F. M. (2018) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2018.03.007 · Cited by 137 · see citing works

Aging is not a disease: implications for intervention

Rattan, S. I. S. (2014) · Aging and Disease · doi:10.14336/ad.2014.0500196 · Cited by 135 · see citing works

Resveratrol Protects C6 Astrocyte Cell Line against Hydrogen Peroxide-Induced Oxidative Stress through Heme Oxygenase 1

Quincozes‐Santos, A., Bobermin, L. D., Latini, A., Wajner, M., Souza, D. O., Gonçalves, C., & Gottfried, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064372 · Cited by 132 · see citing works

Antioxidants in Sport Nutrition

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Cisplatin-induced ototoxicity: Updates on molecular mechanisms and otoprotective strategies

Tang, Q., Wang, X., Jin, H., Mi, Y., Liu, L., Dong, M., Chen, Y., & Zou, Z. (2021) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2021.03.008 · Cited by 132 · see citing works

Neuroprotective Properties of the Marine Carotenoid Astaxanthin and Omega-3 Fatty Acids, and Perspectives for the Natural Combination of Both in Krill Oil

Barros, M. P., Poppe, S. C., & Bondan, E. F. (2014) · Nutrients · doi:10.3390/nu6031293 · Cited by 134 · see citing works

Influence of vitamin C and vitamin E on redox signaling: implications for exercise adaptations

Cobley, J. N., McHardy, H., Morton, J. P., Nikolaidis, M. G., & Close, G. L. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.018 · Cited by 118 · see citing works

An Update on Oxidative Damage to Spermatozoa and Oocytes

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Oxidative stability of O/W and W/O/W emulsions: Effect of lipid composition and antioxidant polarity

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Oxidative stress in the trabecular meshwork (Review)

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Human Vitamin K 2,3-Epoxide Reductase Complex Subunit 1-like 1 (VKORC1L1) Mediates Vitamin K-dependent Intracellular Antioxidant Function

Westhofen, P., Watzka, M., Marinova, M., Hass, M. D. S., Kirfel, G., Müller, J., Bevans, C. G., Müller, C. R., & Oldenburg, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.210971 · Cited by 114 · see citing works

Hyperhomocysteinemia as a risk factor for the neuronal system disorders.

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Pomegranate juice consumption increases GSH levels and reduces lipid and protein oxidation in human blood

Matthaiou, C., Goutzourelas, N., Stagos, D., Σαράφογλου, Ε., Jamurtas, A. Z., Koulocheri, S. D., Haroutounian, S. A., Tsatsakis, A. M., & Kouretas, D. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.07.027 · Cited by 107 · see citing works

Reductive stress impairs myoblasts mitochondrial function and triggers mitochondrial hormesis

Singh, F., Charles, A., Schlagowski, A.-I., Bouitbir, J., Bonifacio, A., Piquard, F., Krähenbühl, S., Gény, B., & Zoll, J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.03.006 · Cited by 104 · see citing works

Dual Role of ROS as Signal and Stress Agents: Iron Tips the Balance in favor of Toxic Effects

Gammella, E., Recalcati, S., & Cairo, G. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8629024 · Cited by 106 · see citing works

Nutritional Countermeasures Targeting Reactive Oxygen Species in Cancer: From Mechanisms to Biomarkers and Clinical Evidence

Samoylenko, A., Hossain, J. A., Mennerich, D., Kellokumpu, S., Hiltunen, J. K., & Kietzmann, T. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4662 · Cited by 100 · see citing works

Medicinally Important Aromatic Plants With Radioprotective Activity

Samarth, R. M., Samarth, M., & Matsumoto, Y. (2017) · Future Science OA · doi:10.4155/fsoa-2017-0061 · Cited by 99 · see citing works

Structural characterization and protective effect of gallic acid grafted O-carboxymethyl chitosan against hydrogen peroxide-induced oxidative damage

Bai, R., Yong, H., Zhang, X., Liu, J., & Liu, J. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.12.037 · Cited by 99 · see citing works

Diet-Derived Antioxidants: The Special Case of Ergothioneine

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Analysis and Antioxidant Capacity of Anthocyanin Pigments. Part I: General Considerations Concerning Polyphenols and Flavonoids

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Number of manic episodes is associated with elevated DNA oxidation in bipolar I disorder

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Exercise redox biochemistry: Conceptual, methodological and technical recommendations

Cobley, J. N., Close, G. L., Bailey, D. M., & Davison, G. W. (2017) · Redox Biology · doi:10.1016/j.redox.2017.03.022 · Cited by 96 · see citing works

Reactive oxygen species (ROS), oxygen radicals and antioxidants: Where are we now, where is the field going and where should we go?

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Antioxidant Molecules from Marine Fungi: Methodologies and Perspectives

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Understanding Iron: Promoting Its Safe Use in Patients With Chronic Kidney Failure Treated by Hemodialysis

Vaziri, N. D. (2013) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2012.10.027 · Cited by 82 · see citing works

Protective role of chrysin on thioacetamide-induced hepatic encephalopathy in rats

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Nutritional compositions and antioxidative capacity of the silk obtained from immature and mature corn

Rahman, N. A., & Ishak, W. R. W. (2013) · Journal of King Saud University - Science · doi:10.1016/j.jksus.2013.11.002 · Cited by 86 · see citing works

Citrinin-Generated Reactive Oxygen Species Cause Cell Cycle Arrest Leading to Apoptosis via the Intrinsic Mitochondrial Pathway in Mouse Skin

Kumar, R., Dwivedi, P. D., Dhawan, A., Das, M., & Ansari, K. M. (2011) · Toxicological Sciences · doi:10.1093/toxsci/kfr143 · Cited by 80 · see citing works

Mechanisms of cisplatin ototoxicity: theoretical review

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Effect of Low-Power Laser (LPL) and Light-Emitting Diode (LED) on Inflammatory Response in Burn Wound Healing

Silveira, P. C. L., Ferreira, K. B., da Rocha, F. R., Pieri, B. L. D. S., Pedroso, G. S., de Souza, C. T., Nesi, R. T., & Pinho, R. A. (2016) · Inflammation · doi:10.1007/s10753-016-0371-x · Cited by 78 · see citing works

Oxidative Stress in Oocytes and Embryo Development: Implications for In Vitro Systems

Lin, J., & Wang, L. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8209 · Cited by 79 · see citing works

Determinação da capacidade antioxidante de produtos naturais in vitro pelo método do DPPH•: estudo de revisão

Oliveira, G. L. D. S. (2015) · Revista Brasileira de Plantas Medicinais · doi:10.1590/1983-084x/12_165 · Cited by 77 · see citing works

Reflections of an aging free radical

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Resveratrol Prevents Ammonia Toxicity in Astroglial Cells

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Metabolismo mitocondrial, radicais livres e envelhecimento

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In vivo neuroprotective effect of L-carnitine against oxidative stress in maple syrup urine disease

Mescka, C. P., Moraes, T. B., Rosa, A. P., Mazzola, P. N., Piccoli, B. L., Jacques, C. E. D., Dalazen, G. R., Coelho, J. G., Cortes, M. X., Terra, M., et al. (2011) · Metabolic Brain Disease · doi:10.1007/s11011-011-9238-x · Cited by 70 · see citing works

Anti-inflammatory and wound healing potential of cashew apple juice ( Anacardium occidentale L.) in mice

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Exercise improves mitochondrial and redox-regulated stress responses in the elderly: better late than never!

Cobley, J. N., Moult, P. R., Burniston, J. G., Morton, J. P., & Close, G. L. (2014) · Biogerontology · doi:10.1007/s10522-014-9546-8 · Cited by 69 · see citing works

Anti-Oxidative and Cholinesterase Inhibitory Effects of Leaf Extracts and Their Isolated Compounds from Two Closely Related Croton Species

Ndhlala, A. R., Aderogba, M. A., Ncube, B., & Staden, J. V. (2013) · Molecules · doi:10.3390/molecules18021916 · Cited by 70 · see citing works

Overexpression of copper/zinc superoxide dismutase from mangrove Kandelia candel in tobacco enhances salinity tolerance by the reduction of reactive oxygen species in chloroplast

Jing, X., Hou, P., Lu, Y., Deng, S., Li, N.-Y., Zhao, R., Sun, J., Wang, Y., Han, Y., Lang, T., et al. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00023 · Cited by 70 · see citing works

Role of exercise-induced reactive oxygen species in the modulation of heat shock protein response

Fittipaldi, S., Dimauro, I., Mercatelli, N., & Caporossi, D. (2013) · Free Radical Research · doi:10.3109/10715762.2013.835047 · Cited by 70 · see citing works

Polyphenolic allelochemical pyrogallic acid induces caspase-3(like)-dependent programmed cell death in the cyanobacterium Microcystis aeruginosa

Lu, Z., Sha, J., Tian, Y., Zhang, X., Liu, B., & Wu, Z. (2016) · Algal Research · doi:10.1016/j.algal.2016.11.007 · Cited by 69 · see citing works

Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning

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Ammonia-induced oxidative damage in neurons is prevented by resveratrol and lipoic acid with participation of heme oxygenase 1

Bobermin, L. D., Wartchow, K. M., Flores, M. P., Leite, M. C., Quincozes‐Santos, A., & Gonçalves, C. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2015.05.005 · Cited by 66 · see citing works

Efficacy of Nutritional Interventions as Stand-Alone or Synergistic Treatments with Exercise for the Management of Sarcopenia

Damanti, S., Azzolino, D., Roncaglione, C., Arosio, B., Rossi, P., & Cesari, M. (2019) · Nutrients · doi:10.3390/nu11091991 · Cited by 62 · see citing works

Translational research involving oxidative stress and diseases of aging

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Antioxidant and antipyretic studies on Pothos scandens L

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Oxidative stress and inflammation: liver responses and adaptations to acute and regular exercise

Barcelos, R. P., Royes, L. F. F., González‐Gallego, J., & Bresciani, G. (2017) · Free Radical Research · doi:10.1080/10715762.2017.1291942 · Cited by 65 · see citing works

Evaluation of the antioxidant, antibacterial, and antibiofilm activity of the sesquiterpene nerolidol

de Moura, D. F., Rocha, T. A., Barros, D. D. M., da Silva, M. M., Santana, M. D. S., Neta, B. M., Cavalcanti, I. M. F., Martins, R. D., & da Silva, M. V. (2021) · Archives of Microbiology · doi:10.1007/s00203-021-02377-5 · Cited by 64 · see citing works

What is the Proximal Cause of Aging?

Zimniak, P. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00189 · Cited by 61 · see citing works

Homocysteine in Neurology: A Possible Contributing Factor to Small Vessel Disease

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Effects of blackcurrant-based juice on atherosclerosis-related biomarkers in cultured macrophages and in human subjects after consumption of a high-energy meal

Huebbe, P., Giller, K., de Pascual‐Teresa, S., Arkenau, A., Adolphi, B., Portius, S., Arkenau, C., & Rimbach, G. H. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511005642 · Cited by 60 · see citing works

Effects of pyrogallic acid on Microcystis aeruginosa: oxidative stress related toxicity

Lu, Z., Zhang, Y., Gao, Y., Liu, B., Sun, X., He, F., Zhou, Q., & Wu, Z. (2016) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2016.06.039 · Cited by 60 · see citing works

Cyanate Induces Oxidative Stress Injury and Abnormal Lipid Metabolism in Liver through Nrf2/HO-1

Hu, L., Tian, K., Zhang, T., Fan, C., Zhou, P., Zeng, D., Zhao, S., Li, L., Smith, H. S., Li, J., et al. (2019) · Molecules · doi:10.3390/molecules24183231 · Cited by 60 · see citing works

Antioxidant Activity of Glyceollins Derived from Soybean Elicited with Aspergillus sojae

Kim, H. J., Suh, H., Kim, J. H., Park, S., Joo, Y. C., & Kim, J. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf102829z · Cited by 58 · see citing works

Protein Adducts and Protein Oxidation as Molecular Mechanisms of Flavonoid Bioactivity

Joyner, P. M. (2021) · Molecules · doi:10.3390/molecules26165102 · Cited by 56 · see citing works

Cytotoxic effects of Mn(III)N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate

Ye, X., Fels, D. R., Tovmasyan, A. G., Aird, K. M., Dedeugd, C., Allensworth, J. L., Kos, I., Park, W., Spasojević, I., Devi, G. R., et al. (2011) · Free Radical Research · doi:10.3109/10715762.2011.616199 · Cited by 56 · see citing works

1Chapter 8 Myths and Misconceptions about Antioxidants and Health

Prasad, K. N. (2016) · CRC Press eBooks · doi:10.1201/ebk1439821060-23

Ten misconceptions about antioxidants

Bast, A., & Haenen, G. R. M. M. (2013) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2013.05.010 · Cited by 157 · see citing works

Antioxidant Supplements

Lightsey, D. M. (2019) · Routledge eBooks · doi:10.4324/9780429331336-8 · Cited by 1 · see citing works

Understanding the Antioxidant Controversy

Milbury, P. E., & Richer, A. C. (2007) · Praeger eBooks · doi:10.5040/9798216029823 · Cited by 5 · see citing works

Antioxidant Medications: Facts, Myths and Prospects

El‐Mowafy, A. M. (2013) · Biochemistry & Analytical Biochemistry · doi:10.4172/2161-1009.1000e137 · Cited by 3 · see citing works