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Testicular adrenal rest tumours in congenital adrenal hyperplasia
Open accessAbstract
In adult patients with congenital adrenal hyperplasia (CAH) the presence of testicular adrenal rest tumours (TART) is an important cause of gonadal dysfunction and infertility. In the last decade several papers have focused on the origin and pathogenesis of these tumours. In this paper we review the embryological, histological, biochemical and clinical features of TART and discuss the treatment options. Furthermore, we propose a new five-stage classification of TART, based on sonographic, clinical and biochemical parameters, that may lead to a better follow up and treatment of patients with TART.
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“Adrenal rest is most commonly found in the rete testis (Figure 3C) and has been described in the ovaries and broad ligament.112,113”
From Congenital adrenal hyperplasia (2017) · cites this paper as [112]
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Metadata
- Authors
- Claahsen-van der Grinten, H. L., Otten, B. J., Stikkelbroeck, M. M. L., Sweep, F. C. G. J., & Hermus, A. R. M. M.
- Affiliations
- Radboud University Medical Center (NL)
- Venue
- Best Practice & Research Clinical Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 23
- Issue
- 2
- Pages
- 209-220
- ISSN
- 1521-690X (ISSN-L)
- OpenAlex
- W2095688197
- Cited by
- 187
- References
- 74
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 9 · 2023: 11 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 12 · 2018: 12 · 2017: 12 · 2016: 20 · 2015: 13 · 2014: 13 · 2013: 7 · 2012: 14
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- congenital adrenal hyperplasia, gonadal dysfunction, infertility, carcinogenesis, embryology, histology, biochemical properties, sonographic classification, treatment options, follow-up
- MeSH terms
- Adrenal Hyperplasia, Congenital, Adrenal Rest Tumor, Adult, Female, Humans, Male, Ovarian Neoplasms, Testicular Neoplasms
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