Clinical manifestations of testicular adrenal rest tumor in males with congenital adrenal hyperplasia

Yu, Min Kyung; Jung, Mo Kyung; Kim, Ki Eun; Kwon, Ah Reum; Chae, Hyun Wook; Kim, Duk Hee; Kim, Ho-Seong

doi:10.6065/apem.2015.20.3.155

Cited by 34Sexual Differentiation and DisordersAdrenal Hormones and DisordersTesticular diseases and treatments

Clinical manifestations of testicular adrenal rest tumor in males with congenital adrenal hyperplasia

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Yu, Min Kyung, Jung, Mo Kyung, Kim, Ki Eun, Kwon, Ah Reum, Chae, Hyun Wook, Kim, Duk Hee, Kim, Ho-Seong·2015·Annals of Pediatric Endocrinology & Metabolism

DOI 10.6065/apem.2015.20.3.155PMC PMC4623344

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Abstract

PURPOSE: In male patients with congenital adrenal hyperplasia (CAH), the presence of testicular adrenal rest tumors (TARTs) have been reported, however their prevalence and clinical manifestations are not well known. Untreated TARTs may lead to testicular structural damage and infertility. This study was conducted to investigate the prevalence of TARTs in male patients with CAH, and characterize the manifestations to identify contributing factors to TART. METHODS: Among 102 CAH patients aged 0-30 years, 24 male patients have been regularly followed up in our outpatient clinic at Severance Children's Hospital from January 2000 to December 2014. In order to reveiw the characteristics of TART patients, we calculated the mean levels of hormones during the 5 years before the time of investigation. Five patients underwent follow-up scrotal ultrasonography (US) after adjusting the dosage of glucocorticoids. RESULTS: TARTs were detected in 8 of the 13 patients (61.5%). The median age of TARTs diagnosis was 20.2 years with the youngest case being 15.5 years old. The mean serum level of adrenocorticotropic hormone (ACTH) was higher in the TARTs patient group compared to the non-TARTs group (P<0.05). The tumor size decreased in 3 cases, slightly increased in 1 case, and had no change in another case. CONCLUSION: The serum ACTH level might be associated with the growth promoting factor for TARTs, but the exact mechanism has not been clearly identified. Screening for TARTs using US is important in male patients with CAH for early-detection and prevention of ongoing complications, such as infertility.

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The prevalence of TART is between 21-33% of boys with classic 21OH.
“and 21-33% of boys 98,116 with classic 21OH”
From Congenital adrenal hyperplasia (2017) · cites this paper as [116]

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Authors: Yu, M. K., Jung, M. K., Kim, K. E., Kwon, A. R., Chae, H. W., Kim, D. H., & Kim, H.-S.
Affiliations: Yonsei University (KR)
Department of Pediatrics, Severance Children's Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Department of Pediatrics, Sohwa Children's Hospital, Seoul, Korea.
Corresponding author: Kim, Ho-Seong
ORCID: Jung, Mo Kyung
Kim, Ki Eun
Chae, Hyun Wook
Kim, Ho-Seong
Venue: Annals of Pediatric Endocrinology & Metabolism
Publisher: Korean Society of Pediatric Endocrinology
Published: 2015
Volume: 20
Issue: 3
Pages: 155
ISSN: 2287-1012 (ISSN-L)
2287-1292
DOI: 10.6065/apem.2015.20.3.155
PMC: PMC4623344
OpenAlex: W2155946002
Cited by: 34
References: 40
Citations by year: 2026: 2 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 2
FWCI: 1.59
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/3.0/ (tdm)
Locations: Annals of Pediatric Endocrinology & Metabolism (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Surgery › Testicular diseases and treatments
Keywords: testicular adrenal rest tumor, congenital adrenal hyperplasia, male patients, prevalence, clinical features, ACTH, testicular ultrasound, infertility, glucocorticoid therapy, tumor growth

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Clinical manifestations of testicular adrenal rest tumor in males with congenital adrenal hyperplasia

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