Cited by 152Chemical Analysis and Environmental ImpactThyroid Disorders and TreatmentsWater Treatment and Disinfection

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Perchlorate, iodine and the thyroid

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Leung, Angela M., Pearce, Elizabeth N., Braverman, Lewis E.·2010·Best Practice & Research Clinical Endocrinology & Metabolism

DOI 10.1016/j.beem.2009.08.009PMC PMC4137763

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Abstract

In pharmacologic doses, perchlorate inhibits thyroidal iodine uptake and subsequently decreases thyroid hormone production. Although pharmacologic doses may be used in the treatment of hyperthyroidism, recent literature has focussed on the detection of low levels of perchlorate in the environment, groundwater and foodstuffs and their potential adverse effects on human thyroid function. This is of particular concern to the developing foetus and infant, whose normal neurodevelopment depends on adequate iodine intake for the production of thyroid hormones. Further research is needed to clarify the potential health effects of low-level chronic environmental perchlorate exposure. The health impact of environmental perchlorate may be dependent upon adequate iodine intake and should be interpreted in combination with other environmental exposures that are also potential thyroidal endocrine disruptors.

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Authors: Leung, A. M., Pearce, E. N., & Braverman, L. E.
Affiliations: Boston University (US)
Corresponding author: Pearce, Elizabeth N.
ORCID: Leung, Angela M.
Pearce, Elizabeth N.
Braverman, Lewis E.
Venue: Best Practice & Research Clinical Endocrinology & Metabolism
Publisher: Elsevier BV
Published: 2010-02
Volume: 24
Issue: 1
Pages: 133-141
ISSN: 1521-690X (ISSN-L)
DOI: 10.1016/j.beem.2009.08.009
PMC: PMC4137763
OpenAlex: W1965540535
Cited by: 152
References: 98
Citations by year: 2026: 9 · 2025: 9 · 2024: 10 · 2023: 11 · 2022: 13 · 2021: 13 · 2020: 5 · 2019: 10 · 2018: 7 · 2017: 10 · 2016: 11 · 2015: 10 · 2014: 9 · 2013: 6 · 2012: 8
FWCI: 0.79
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23HD068552)
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Chemical Analysis and Environmental Impact
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Water Treatment and Disinfection
Keywords: perchlorate, iodine, thyroid function, thyroid hormone synthesis, hyperthyroidism, groundwater contamination, food contamination, endocrine disruptors
MeSH terms: Sodium-Iodide Symporters, Environmental Exposure, Environmental Pollutants, Female, Humans, Iodine, Lactation, Perchlorates, Pregnancy, Antithyroid Agents, Thyroid Gland, Symporters

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Perchlorate, iodine and the thyroid

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