The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Circadian disruption and metabolic disease: Findings from animal models
Open accessAbstract
Social opportunities and work demands have caused humans to become increasingly active during the late evening hours, leading to a shift from the predominantly diurnal lifestyle of our ancestors to a more nocturnal one. This voluntarily decision to stay awake long into the evening hours leads to circadian disruption at the system, tissue, and cellular levels. These derangements are in turn associated with clinical impairments in metabolic processes and physiology. The use of animal models for circadian disruption provides an important opportunity to determine mechanisms by which disorganization in the circadian system can lead to metabolic dysfunction in response to genetic, environmental, and behavioral perturbations. Here we review recent key animal studies involving circadian disruption and discuss the possible translational implications of these studies for human health and particularly for the development of metabolic disease.
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“A major finding to link chrono-disruption and metabolic homeostasis at the molecular level was the discovery of a specific 24-h circadian rhythmicity in adipose tissue genes in 2005 (49,50) .”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [50]
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Cites
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
Control of sleep and wakefulness
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Circadian clock control of endocrine factors
Gamble, K. L., Berry, R., Frank, S. J., & Young, M. E. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.78 · Cited by 539
Meta-analysis on shift work and risks of specific obesity types
Sun, M., Feng, W., Wang, F., Li, P., Li, Z., Li, M., Tse, G., Vlaanderen, J., Vermeulen, R., & Tse, L. A. (2018) · Obesity Reviews · doi:10.1111/obr.12621 · Cited by 391
Circadian disruption: what do we actually mean?
Vetter, C. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14255 · Cited by 333
Metadata
- Authors
- Arble, D. M., Ramsey, K. M., Bass, J., & Turek, F. W.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Turek, Fred W.
- Venue
- Best Practice & Research Clinical Endocrinology & Metabolism
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 24
- Issue
- 5
- Pages
- 785-800
- ISSN
- 1521-690X (ISSN-L)
- PMC
- PMC3011935
- OpenAlex
- W2043741320
- Cited by
- 192
- References
- 94
- Citations by year
- 2026: 5 · 2025: 17 · 2024: 12 · 2023: 11 · 2022: 8 · 2021: 13 · 2020: 12 · 2019: 12 · 2018: 12 · 2017: 16 · 2016: 12 · 2015: 14 · 2014: 8 · 2013: 14 · 2012: 18
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Best Practice & Research Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- e-Publications@Marquette (Marquette University) (submittedVersion)
- Funders
- National Institute on Aging (P01AG011412)
- National Heart, Lung, and Blood Institute (T32HL007909)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Physiology (medical) › Dietary Effects on Health
- Keywords
- circadian rhythm disruption, metabolic disorders, animal models, nocturnal activity, circadian system, metabolic dysfunction, translational research
- MeSH terms
- Animals, Biological Clocks, Brain, Circadian Rhythm, Disease Models, Animal, Humans, Metabolic Diseases, Models, Biological, Photoperiod, Sleep Disorders, Circadian Rhythm
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