The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
The gut microbiome in psoriasis and psoriatic arthritis
Abstract
This review summarizes existing research on the gut microbiome composition and function in psoriasis and psoriatic arthritis, exploring potential roles in disease pathogenesis, progression, and management. A strong relationship between skin, joint, and gastrointestinal inflammation exists, as demonstrated by an increased prevalence of psoriasis, psoriatic arthritis, and inflammatory bowel disease co-occurring together; however, the link between them has not been fully elucidated. Studies analyzing the gut microbiome in psoriasis and psoriatic arthritis reveal a unique pattern of dysbiosis. With regard to the gut microbiome's role in psoriasis and psoriatic arthritis pathogenesis, we discuss several theories including intestinal permeability, altered immune homeostasis, and imbalance of short- and medium-chain fatty acid-producing bacteria. We also discuss how the gut microbiome affects patient risk of psoriatic arthritis and other serious comorbidities, and how fecal microbes could be used clinically as therapeutic targets or markers of disease.
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“the abundance of Actinobacteria in the gut of patients with psoriasis was less than that of healthy controls.”
From Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity (2021) · cites this paper as [101]
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Der Einfluss von Adipositas auf die Krankheitsaktivität bei entzündlich rheumatischen Erkrankungen
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Long Covid, the Gut, and Autoimmune Skin Diseases: A Novel Therapeutic ApproachPreprint
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Clinical and Functional State of the Intestine in Patients with Psoriatic Arthritis
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Gut microbiota dysbiosis and joint diseases: advances in the gut-joint axis
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Elevated fecal calprotectin levels in psoriasis: association with disease severity
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Metadata
- Authors
- Myers, B., Brownstone, N., Reddy, V., Chan, S., Thibodeaux, Q., Truong, A., Bhutani, T., Chang, H.-W., & Liao, W.
- Affiliations
- University of California, San Francisco (US)
- University of California, Berkeley (US)
- Corresponding author
- Liao, Wilson
- ORCID
- Venue
- Best Practice & Research Clinical Rheumatology
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 33
- Issue
- 6
- Pages
- 101494
- ISSN
- 1521-6942 (ISSN-L)
- OpenAlex
- W3023269883
- Cited by
- 127
- References
- 98
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 31 · 2023: 26 · 2022: 23 · 2021: 24 · 2020: 2
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Best Practice & Research Clinical Rheumatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- gut microbiota, psoriasis, psoriatic arthritis, dysbiosis, intestinal permeability, immune homeostasis, short-chain fatty acids, medium-chain fatty acids, inflammatory bowel disease, comorbidities, pathogenesis, fecal microbiota transplantation, biomarkers, therapeutic target
- MeSH terms
- Gastrointestinal Microbiome, Humans, Psoriasis, Arthritis, Psoriatic, Microbiota, Dysbiosis
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