Testing an App-Assisted Treatment for Suicide Prevention in a Randomized Controlled Trial: Effects on Suicide Risk and Depression
Open accessAbstract
Suicide is a global public health problem and effective psychological interventions are needed. The objective of the present study was to evaluate the effect of an app-assisted suicide prevention treatment on suicide risk and depression. One hundred twenty-nine participants were randomized to treatment as usual (TAU), consisting of psychotherapy adhering to the framework of Collaborative Assessment and Management of Suicidality (CAMS), with (TAU+APP, N = 60) or without (TAU, N = 69) access to a mobile application (i.e., LifeApp'tite). Suicide risk and symptoms of depression were assessed pre- and posttherapy, and at 4-month follow-up. The TAU+APP group showed a smaller decrease on self-reported suicide risk at the end of treatment, corresponding to a medium between-group effect size (p = .008, d = 0.46). At the 4-month follow-up this was the case only at the trend level, where the effect size was also of a smaller magnitude (p = .057, d = 0.30). No differences between the treatment groups were observed on self-reported depressive symptoms, either immediately following treatment (p = .732, d = 0.05) or at follow-up (p = .467, d = 0.11). The unexpected negative effect concerning suicide risk points to crucial consideration of issues pertaining to timing, dosing, and content when adding new technology to existing treatments both in this and other populations.
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Internet-based interventions have not been shown to prevent suicidal behavior, and only 3 of 10 studies reported benefit for suicidal ideation.
“Internet-based interventions have not been shown to prevent suicidal behavior (Table S5) but are highly scalable. Only 3/10 studies reported benefit for suicidal ideation(117–123) (Table S5).”
From Improving Suicide Prevention Through Evidence-Based Strategies: A Systematic Review (2021) · cites this paper as [118]
The introduction (manuscript p. 5) reports that a game-like app significantly reduced suicidal behaviors, although the effect was not maintained at one month. That contradicts the categorical claim that internet-based interventions have not been shown to prevent suicidal behavior. The paper does not report a tally of benefits in 3 of 10 studies of suicidal ideation. (LLM, conf=0.84)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredAlternative metrics such as number of clicks were reported in only 1 of the reviewed studies [36].
“but this was only the case in 1 of the reviewed studies [36].”
From Digital Mental Health Interventions for Depression: Scoping Review of User Engagement (2022) · cites this paper as [36]
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BackgroundA special type of homicide-suicide: A retrospective study of the characteristics of extended suicide
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Jha, S., Chan, G., Jewer, S., Agyapong, V. I. O., & Orji, R. (2025) · International Journal of Human-Computer Interaction · doi:10.1080/10447318.2025.2453608 · Cited by 5 · see citing works
“Another study on 129 psychiatric patients at a Danish hospital evaluated a psycho-therapy-based app, LifeApp’tite, with and without clinical treatment (O’Toole et al., 2019).”
The Role of Digital Technology in Youth Suicide Prevention
Kenny, B., Robinson, J., & Núñez, D. E. (2025) · Depression and personality · doi:10.1007/978-3-031-96037-6_8 · Cited by 2 · see citing works
Großmann, T., Hörger, J., Bayer, N., Bückle, S., Buschek, D., Fegert, J. M., Laurenz, P., Lühr, M., Marek, F., Rassenhofer, M., et al. (2025) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph22111607 · Cited by 2 · see citing works
“Some focus exclusively on safety planning, differing in functionality and availability (cf. [30]), while others integrate additional features, such as a digital HopeBox, a diary, or psychoeducation [15,23,26,27,31].”
Codesign of Digital Health Tools for Suicide Prevention: A Scoping Review
Wepa, D., Neal, M., Abo-Gazala, W., Cusworth, S., Hargan, J., Mistry, M., Vaughan, J., Giles, S., & Khan, M. (2023) · British journal of healthcare and medical research · doi:10.14738/bjhmr.105.15365 · Cited by 1 · see citing works
Suicide: Epidemiology, Prevention, Assessment, Treatment, and Outcomes
Menon, V., Subramanian, K., & Balasubramanian, I. (2024) · Advances in mental health and addiction · doi:10.1007/978-3-031-56192-4_5 · Cited by 4 · see citing works
A Digital Mental Health Approach for Supporting Suicide Prevention: A Qualitative Study
Castillo-Sánchez, G., Toribio-Guzmán, J. M., Celada-Bernal, S., Hernández, M. A., Díez, I. D. L. T., & Franco, M. (2024) · International Journal of Mental Health and Addiction · doi:10.1007/s11469-024-01347-4 · Cited by 2 · see citing works
“Including technologies in existing treatments can be somewhat problematic with the timing, dosage, and content in applied research in this field (O’Toole et al., 2019).”
Cardoso, N. D. O., Salvador, E. Z., Tagliapietra, K. D. R., Sanseverino, M. A., Vissoci, J. R. N., & Machado, W. D. L. (2023) · Estudos de Psicologia (Campinas) · doi:10.1590/1982-0275202340e210035 · Cited by 2 · see citing works
Kearns, J. C., Polizzi, C. P., Naganuma-Carreras, J., Bourassa, K. J., Halverson, T. F., Perskaudas, R., Kimbrel, N. A., Interian, A., Bossarte, R. M., DeBeer, B. B., et al. (2025) · Clinical Psychology Review · doi:10.1016/j.cpr.2025.102614 · Cited by 3 · see citing works
Jeong, H., Kim, H., Jeon, Y., & Kim, H. (2025) · International Journal of Mental Health Nursing · doi:10.1111/inm.70001 · Cited by 4 · see citing works
“Most studies also qualitatively evaluated usability and feasibility (Bruen et al. 2020; Dubov et al. 2021; Grist, Porter, and Stallard 2018; Morgiève et al. 2020; Nuij et al. 2022; O'Grady et al. 2020; O'Toole, Arendt, and Pedersen 2019; Pauwels et al. 2017).”
McNeil, M. J., Gryglewicz, K., Hines, S., Duffy, T. L., Seigman, M. D., Nalla, S., Taliaferro, L. A., & Wiśniewski, P. (2022) · doi:10.2196/preprints.36944
Lipschitz, J. M., Boxtel, R. V., Torous, J. B., Firth, J., Lebovitz, J. G., Burdick, K. E., & Hogan, T. P. (2022) · doi:10.2196/preprints.39204
Shin, H. D., Durocher, K., Sequeira, L., Zaheer, J., Torous, J. B., & Strudwick, G. (2022) · Research Square · doi:10.21203/rs.3.rs-1910437/v1
Intoxicação por medicamentos no Brasil: período pré-pandêmico e pandemia da Covid -19
Santana, M. O. D., Araújo, A. S., Costa, P. R. D. S. M., Ramos, N. R. D. S., Souza, K. A. C., & Chaves, A. C. T. A. (2023) · Brazilian Journal of Health Review · doi:10.34119/bjhrv6n6-477
Jeong, H., Kim, H., Jeon, Y., & Kim, H. (2024) · doi:10.2196/preprints.57170
A Systematic Analysis on the Effectiveness of Mobile Applications for Suicide Prevention
Büyükbayram, A., & Erfidan, S. C. (2024) · İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi · doi:10.61399/ikcusbfd.1544262
“Bring them back to life”: LifeLink Application for Caregivers Dealing with Suicidality
Jha, S., Chan, G., Jewer, S., Agyapong, V. I. O., & Orji, R. (2025) · CHI Conference on Human Factors in Computing Systems · doi:10.1145/3706598.3713699
“…have been utilized to encourage behavior change across various domains, such as increasing physical activity [55, 67], promoting healthy eating [60, 62], quitting smoking, managing diseases [65], supporting mental health [4, 5], discouraging substance use, improving time management [3] and…”
Jha, S., Chan, G., & Orji, R. (2025) · Lecture notes in computer science · doi:10.1007/978-3-031-94959-3_10
Luo, M., Yue, Y., Du, N., Xiao, Y., Chen, C., & Huan, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26661233
Luo, M., Yue, Y., Du, N., Xiao, Y., Chen, C., & Huan, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26661239
Luo, M., Yue, Y., Du, N., Xiao, Y., Chen, C., & Huan, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26661236
Luo, M., Yue, Y., Du, N., Xiao, Y., Chen, C., & Huan, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26661230
Luo, M., Yue, Y., Du, N., Xiao, Y., Chen, C., & Huan, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26661227
Luo, M., Yue, Y., Du, N., Xiao, Y., Chen, C., & Huan, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26661242
Park, C., Zhu, J., Man, R. H. C., Rosenblat, J. D., Iacobucci, M., Gill, H., Mansur, R. B., & McIntyre, R. S. (2019) · Annals of Clinical Psychiatry · doi:10.1177/154733251903100409
- Authors
- O'Toole, M. S., Arendt, M. B., & Pedersen, C. M.
- Affiliations
- Aarhus University Hospital (DK)
- Venue
- Behavior Therapy
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 50
- Issue
- 2
- Pages
- 421-429
- ISSN
- 0005-7894 (ISSN-L)
- OpenAlex
- W2885214120
- Cited by
- 71
- References
- 38
- Citations by year
- 2025: 10 · 2024: 21 · 2023: 12 · 2022: 9 · 2021: 8 · 2020: 7 · 2019: 4
- FWCI
- 5.99
- Type
- journal article
- Language
- en
- Open access
- green
- pure.au.dk
- Licence
- Locations
- Behavior Therapy (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Keywords
- suicide prevention, mobile health apps, digital mental health interventions, suicide risk, depressive symptoms, Collaborative Assessment and Management of Suicidality, psychotherapy, treatment effects
- MeSH terms
- Suicide Prevention, Adolescent, Adult, Depression, Female, Humans, Male, Psychotherapy, Risk Factors, Suicide, Self-Injurious Behavior, Treatment Outcome, Mobile Applications
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