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The DOI matches its Crossref record; 123 of the 123 references it cites were found in a registry or an index.

The development of collagen based composite scaffolds for bone regeneration

Open access
Zhang, Dawei, Wu, Xiaowei, Chen, Jingdi, Lin, Kaili·2018·Bioactive Materials

Abstract

Bone is consisted of bone matrix, cells and bioactive factors, and bone matrix is the combination of inorganic minerals and organic polymers. Type I collagen fibril made of five triple-helical collagen chains is the main organic polymer in bone matrix. It plays an important role in the bone formation and remodeling process. Moreover, collagen is one of the most commonly used scaffold materials for bone tissue engineering due to its excellent biocompatibility and biodegradability. However, the low mechanical strength and osteoinductivity of collagen limit its wider applications in bone regeneration field. By incorporating different biomaterials, the properties such as porosity, structural stability, osteoinductivity, osteogenicity of collagen matrixes can be largely improved. This review summarizes and categorizes different kinds of biomaterials including bioceramic, carbon and polymer materials used as components to fabricate collagen based composite scaffolds for bone regeneration. Moreover, the possible directions of future research and development in this field are also proposed.

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Crossref · 10.1016/j.bioactmat.2017.08.004

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Metadata

Authors
Zhang, D., Wu, X., Chen, J., & Lin, K.
Venue
Bioactive Materials
Publisher
Elsevier BV
Published
2018-03
Volume
3
Issue
1
Pages
129-138
ISSN
  • 2097-1192 (ISSN-L)
  • 2452-199X
OpenAlex
W2754505481
Cited by
435
References
123
FWCI
13.97
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: The development of collagen based composite scaffolds for bone regeneration. https://app.cochat.ai/papers/10.1016/j.bioactmat.2017.08.004
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Zhang, D., Wu, X., Chen, J., & Lin, K. (2018). The development of collagen based composite scaffolds for bone regeneration. Bioactive Materials. https://doi.org/10.1016/j.bioactmat.2017.08.004

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.