Enhanced osteogenic differentiation of stem cells by 3D printed PCL scaffolds coated with collagen and hydroxyapatite
Open accessAbstract
Bone tissue engineering uses various methods and materials to find suitable scaffolds that regenerate lost bone due to disease or injury. Poly(ε-caprolactone) (PCL) can be used in 3D printing for producing biodegradable scaffolds by fused deposition modeling (FDM). However, the hydrophobic surfaces of PCL and its non-osteogenic nature reduces adhesion and cell bioactivity at the time of implantation. This work aims to enhance bone formation, osteogenic differentiation, and in vitro biocompatibility via PCL scaffolds modification with Hydroxyapatite (HA) and Collagen type I (COL). This study evaluated the osteosupportive capacity, biological behavior, and physicochemical properties of 3D-printed PCL, PCL/HA, PCL/COL, and PCL/HA/COL scaffolds. Biocompatibility and cells proliferation were investigated by seeding human adipose tissue-derived mesenchymal stem cells (hADSCs) onto the scaffolds, which were analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, and 6-diamidino-2-phenylindole (DAPI) staining. In addition, the bone differentiation potential of the hADSCs was assessed using calcium deposition, alkaline phosphatase (ALP) activity, and bone-related protein and genes. Although all constructed scaffolds support hADSCs proliferation and differentiation, the results showed that scaffold coating with HA and COL can boost these capacities in a synergistic manner. According to the findings, the tricomponent 3D-printed scaffold can be considered as a promising choice for bone tissue regeneration and rebuilding.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
PCL scaffold coated with collagen and HA showed enhanced proliferation and differentiation of human adipose tissue-derived mesenchymal stem cells through a synergistic effect.
“PCL scaffold coated with collagen and HA showed enhanced proliferation and differentiation of human adipose tissue-derived mesenchymal stem cells through a synergistic effect.”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [95]
The Results (Biocompatibility of scaffolds; page unavailable) report increased proliferation of human adipose-derived stem cells on HA- and collagen-coated PCL scaffolds. The Results (Osteoinductivity of scaffolds; page unavailable) attribute higher ALP activity, a marker of osteogenic differentiation, to a synergistic effect of HA and collagen. The paper does not attribute the proliferation increase to that synergistic effect. (LLM, conf=0.84)
Experimental — accuracy not yet measuredCoating collagen and HA can improve the overall bioactivity of the scaffold.
“These results also substantiated that the coating of collagen and HA can improve the overall bioactivity of the scaffold.”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [95]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Polymers for 3D Printing and Customized Additive Manufacturing
Ligon, S. C., Liska, R., Stampfl, J., Gurr, M., & Mülhaupt, R. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00074 · Cited by 3,785 · see citing works
3D bioactive composite scaffolds for bone tissue engineering
Turnbull, G. S., Clarke, J., Picard, F., Riches, P. E., Jia, L., Han, F., Li, B., & Shu, W. (2017) · Bioactive Materials · doi:10.1016/j.bioactmat.2017.10.001 · Cited by 1,350 · see citing works
Designing Biomaterials for 3D Printing
Güvendiren, M., Molde, J., Soares, R. M. D., & Kohn, J. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00121 · Cited by 737 · see citing works
3D printing of bone tissue engineering scaffolds
Wang, C., Huang, W., Zhou, Y., He, L., He, Z., Chen, Z., He, X., Tian, S., Liao, J., Lu, B., et al. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.01.004 · Cited by 661 · see citing works
Kafle, A., Luis, E., Silwal, R., Pan, H. M., Shrestha, P. L., & Bastola, A. K. (2021) · Polymers · doi:10.3390/polym13183101 · Cited by 587 · see citing works
PCL-Based Composite Scaffold Matrices for Tissue Engineering Applications
Siddiqui, N., Asawa, S., Birru, B., Baadhe, R. R., & Rao, S. (2018) · Molecular Biotechnology · doi:10.1007/s12033-018-0084-5 · Cited by 461 · see citing works
The development of collagen based composite scaffolds for bone regeneration
Zhang, D., Wu, X., Chen, J., & Lin, K. (2017) · Bioactive Materials · doi:10.1016/j.bioactmat.2017.08.004 · Cited by 435 · see citing works
Characterization of printed PLA scaffolds for bone tissue engineering
Grémare, A., Gudurić, V., Bareille, R., Héroguez, V., Latour, S., L’Heureux, N., Fricain, J., Catros, S., & Nihouannen, D. L. (2017) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36289 · Cited by 363 · see citing works
Hassanajili, S., Karami-Pour, A., Oryan, A., & Talaei‐Khozani, T. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.109960 · Cited by 346 · see citing works
Strategies for Bone Regeneration: From Graft to Tissue Engineering
Battafarano, G., Rossi, M., Martino, V. D., Marampon, F., Borro, L., Secinaro, A., & Fattore, A. D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031128 · Cited by 299 · see citing works
Review of 3D printable hydrogels and constructs
Li, H., Tan, C., & Li, L. (2018) · Materials & Design · doi:10.1016/j.matdes.2018.08.023 · Cited by 253 · see citing works
Holländer, J., Genina, N., Jukarainen, H., Khajeheian, M., Rosling, A., Mäkilä, E. M., & Sandler, N. (2016) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2015.12.012 · Cited by 252 · see citing works
Chitosan and gelatin-based electrospun fibers for bone tissue engineering
Sruthi, R., Balagangadharan, K., & Selvamurugan, N. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.04.115 · Cited by 232 · see citing works
Gonçalves, E. M., Oliveira, F. J., Silva, R. F., Neto, M. A., Fernandes, M. H., Amaral, M., Vallet‐Regí, M., & Vila, M. (2015) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.33432 · Cited by 222 · see citing works
Klimek, K., & Ginalska, G. (2020) · Polymers · doi:10.3390/polym12040844 · Cited by 207 · see citing works
Mondal, S., Nguyen, T. P., Pham, V. H., Hoang, G., Manivasagan, P., Kim, M. H., Nam, S. Y., & Oh, J. (2019) · Ceramics International · doi:10.1016/j.ceramint.2019.10.057 · Cited by 204 · see citing works
(2015) · Johnson Matthey Technology Review · doi:10.1595/205651315x688406 · Cited by 193 · see citing works
3D printing of HA / PCL composite tissue engineering scaffolds
Jiao, Z., Luo, B., Xiang, S., Ma, H., Yu, Y., & Yang, W. (2019) · Advanced Industrial and Engineering Polymer Research · doi:10.1016/j.aiepr.2019.09.003 · Cited by 147 · see citing works
Rajzer, I., Menaszek, E., Kwiatkowski, R., Planell, J. A., & Castaño, Ó. (2014) · Materials Science and Engineering C · doi:10.1016/j.msec.2014.08.017 · Cited by 146 · see citing works
Trakoolwannachai, V., Kheolamai, P., & Ummartyotin, S. (2019) · Composites Part B Engineering · doi:10.1016/j.compositesb.2019.106974 · Cited by 142 · see citing works
Babilotte, J., Gudurić, V., Nihouannen, D. L., Naveau, A., Fricain, J., & Catros, S. (2019) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.34348 · Cited by 134 · see citing works
Bose, S., Sarkar, N., & Banerjee, D. (2018) · Materials Today Chemistry · doi:10.1016/j.mtchem.2018.03.005 · Cited by 132 · see citing works
Materials-Directed Differentiation of Mesenchymal Stem Cells for Tissue Engineering and Regeneration
Leach, J. K., & Whitehead, J. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00741 · Cited by 126 · see citing works
Zhang, W., Ullah, I., Shi, L., Zhang, Y., Ou, H., Zhou, J., Ullah, M. W., Zhang, X., & Li, W. (2019) · Materials & Design · doi:10.1016/j.matdes.2019.107946 · Cited by 126 · see citing works
Cestari, F., Petretta, M., Yang, Y., Motta, A., Grigolo, B., & Sglavo, V. M. (2021) · Sustainable materials and technologies · doi:10.1016/j.susmat.2021.e00318 · Cited by 103 · see citing works
Rashad, A., Mohamed‐Ahmed, S., Ojansivu, M., Berstad, K., Yassin, M. A., Kivijärvi, T., Heggset, E. B., Syverud, K., & Mustafa, K. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b01194 · Cited by 100 · see citing works
Alksnė, M., Kalvaitytė, M., Šimoliūnas, E., Rinkūnaitė, I., Gendvilienė, I., Ločs, J., Rutkūnas, V., & Bukelskienė, V. (2020) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2020.103641 · Cited by 98 · see citing works
Aidun, A., Firoozabady, A. S., Moharrami, M., Ahmadi, A., Haghighipour, N., Bonakdar, S., & Faghihi, S. (2019) · Artificial Organs · doi:10.1111/aor.13474 · Cited by 97 · see citing works
Mineralization of Biomaterials for Bone Tissue Engineering
Wu, X., Walsh, K., Hoff, B. L., & Camci‐Unal, G. (2020) · Bioengineering · doi:10.3390/bioengineering7040132 · Cited by 97 · see citing works
Zou, L., Zhang, Y., Liu, X., Chen, J., & Zhang, Q. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.03.004 · Cited by 96 · see citing works
Huang, B., Vyas, C., Byun, J. J., El-Newehy, M. H., Huang, Z., & Bártolo, P. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110374 · Cited by 96 · see citing works
Formation of porous HPCL/LPCL/HA scaffolds with supercritical CO2 gas foaming method
Moghadam, M., Hassanajili, S., Esmaeilzadeh, F., Ayatollahi, M., & Ahmadi, M. (2017) · Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials · doi:10.1016/j.jmbbm.2016.12.014 · Cited by 91 · see citing works
Hassan, M. I., & Sultana, N. (2017) · 3 Biotech · doi:10.1007/s13205-017-0889-0 · Cited by 90 · see citing works
3D Printing for the Clinic: Examining Contemporary Polymeric Biomaterials and Their Clinical Utility
Weems, A. C., Pérez‐Madrigal, M. M., Arno, M. C., & Dove, A. P. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.9b01539 · Cited by 88 · see citing works
Puyana, V. M. P., Wieringa, P. A., Yuste, Y., de la Portilla, F., Guererro, A., Romero, A., & Moroni, L. (2021) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37156 · Cited by 87 · see citing works
Enzymatic degradation of graphene/polycaprolactone materials for tissue engineering
Murray, E., Thompson, B. C., Sayyar, S., & Wallace, G. G. (2014) · Polymer Degradation and Stability · doi:10.1016/j.polymdegradstab.2014.10.010 · Cited by 86 · see citing works
New Materials for 3D-Printing Based on Polycaprolactone with Gum Rosin and Beeswax as Additives
Pavón, C., Aldás, M., López, J., & Bou, S. F. (2020) · Polymers · doi:10.3390/polym12020334 · Cited by 85 · see citing works
Kim, C. G., Han, K. S., Lee, S., Kim, M. C., Kim, S. Y., & Nah, J. (2021) · Applied Sciences · doi:10.3390/app11146351 · Cited by 82 · see citing works
Brugmans, M. C. P., Söntjens, S. H. M., Cox, M. A. J., Nandakumar, A., Bosman, A. W., Mes, T., Janssen, H. M., Bouten, C. V. C., Baaijens, F. F., & Driessen‐Mol, A. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.08.034 · Cited by 80 · see citing works
Li, Q., Lei, X., Wang, X., Cai, Z., Lyu, P., & Zhang, G. (2019) · Tissue Engineering Part A · doi:10.1089/ten.tea.2018.0201 · Cited by 74 · see citing works
Wang, Q., Ma, Z., Wang, Y., Zhong, L., & Xie, W. (2020) · Bio-Design and Manufacturing · doi:10.1007/s42242-020-00095-3 · Cited by 71 · see citing works
Yu, J., Xu, Y., Li, S. C., Seifert, G. V., & Becker, M. L. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b01222 · Cited by 67 · see citing works
Kim, Y., Lim, J. Y., Yang, G. H., Seo, J.-H., Ryu, H., & Kim, G. (2019) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2019.06.027 · Cited by 66 · see citing works
Patil, V. A., & Masters, K. S. B. (2020) · Bioengineering · doi:10.3390/bioengineering7040163 · Cited by 63 · see citing works
Raina, D. B., Larsson, D., Mrkonjic, F., Isaksson, H., Kumar, A., Lidgren, L., & Tägil, M. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.01.006 · Cited by 62 · see citing works
Kim, M. H., Yun, C., Chalisserry, E. P., Lee, Y. W., Kang, H. W., Park, S., Jung, W., Oh, J., & Nam, S. Y. (2018) · Materials Letters · doi:10.1016/j.matlet.2018.03.025 · Cited by 62 · see citing works
A 3D-Printed PLCL Scaffold Coated with Collagen Type I and Its Biocompatibility
He, Y., Liu, W. X., Guan, L., Chen, J., Duan, L., Jia, Z., Huang, J., Li, W., Liu, J., Xiong, J., et al. (2018) · BioMed Research International · doi:10.1155/2018/5147156 · Cited by 58 · see citing works
Goodarzi, H., Hashemi‐Najafabadi, S., Baheiraei, N., & Bagheri, F. (2019) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-019-00184-0 · Cited by 58 · see citing works
Boron Nitride Based Nanobiocomposites: Design by 3D Printing for Bone Tissue Engineering
Belaid, H., Nagarajan, S., Barou, C., Huon, V., Barés, J., Balme, S., Miele, P., Cornu, D., Cavaillès, V., Teyssier, C., et al. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b00965 · Cited by 53 · see citing works
Park, S., Kim, J. E., Han, J., Jeong, S. J., Lim, J. W., Lee, M. C., Son, H., Kim, H. B., Choung, Y., Seonwoo, H., et al. (2021) · Polymers · doi:10.3390/polym13020257 · Cited by 49 · see citing works
Lynch, C. R., Kondiah, P. P. D., & Choonara, Y. E. (2021) · Molecules · doi:10.3390/molecules26092518 · Cited by 49 · see citing works
Mystiridou, E., Patsidis, A. C., & Bouropoulos, N. (2021) · Applied Sciences · doi:10.3390/app11094253 · Cited by 47 · see citing works
Non-Cytotoxic Agarose/Hydroxyapatite Composite Scaffolds for Drug Release
Witzler, M., Ottensmeyer, P. F., Gericke, M., Heinze, T. J., Tobiasch, E., & Schulze, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143565 · Cited by 44 · see citing works
Karimi, Z., Seyedjafari, E., Mahdavi, F. S., Hashemi, S. M., Khojasteh, A., Kazemi, B., & Mohammadi‐Yeganeh, S. (2019) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36638 · Cited by 39 · see citing works
Self-citationMashhadikhan, M., Soleimani, M., Parivar, K., & Yaghmaei, P. (2015) · PubMed Central · Cited by 34 · see citing works
Arab‐Ahmadi, S., Irani, S., Bakhshi, H., Atyabi, F., & Ghalandari, B. (2020) · Polymers for Advanced Technologies · doi:10.1002/pat.5128 · Cited by 34 · see citing works
Self-citationYu, J., Lee, S., Choi, S., Kim, K. K., Ryu, B., Kim, C., Jung, C., Min, B., Xin, Y.-Z., Park, S. A., et al. (2020) · Polymers · doi:10.3390/polym12102203 · Cited by 29 · see citing works
Shapourzadeh, A., Atyabi, S.-M., Irani, S., & Bakhshi, H. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.02.036 · Cited by 28 · see citing works
Self-citationLee, C.-F., Hsu, Y., Lin, Y., Nguyen, T.-T., Chen, H.-W., Nabilla, S. C., Hou, S., Chang, F., & Chung, R. (2021) · Polymers · doi:10.3390/polym13183123 · Cited by 27 · see citing works
3D-printed poly-ε-caprolactone-CaCO3-biocomposite-scaffolds for hard tissue regeneration
Neumann, R., Neunzehn, J., Hinüber, C., Flath, T., Schulze, F. P., & Wiesmann, H.-P. (2018) · eXPRESS Polymer Letters · doi:10.3144/expresspolymlett.2019.2 · Cited by 22 · see citing works
Hashemi, S., Amirabad, L. M., Farzad‐Mohajeri, S., Rad, M. R., Fahimipour, F., Ardeshirylajimi, A., Dashtimoghadam, E., Salehi, M., Soleimani, M., Dehghan, M. M., et al. (2021) · Cell and Tissue Research · doi:10.1007/s00441-020-03374-8 · Cited by 22 · see citing works
Self-citationRosales‐Ibáñez, R., Cubo-Mateo, N., Rodríguez-Navarrete, A., González‐González, A. M., Villamar-Duque, T. E., Flores-Sánchez, L. O., & Rodríguez-Lorenzo, L. M. (2021) · Polymers · doi:10.3390/polym13071154 · Cited by 21 · see citing works
Coating of Laponite on PLA Nanofibrous for Bone Tissue Engineering Application
Orafa, Z., Irani, S., Zamanian, A., Bakhshi, H., Nikukar, H., & Ghalandari, B. (2021) · Macromolecular Research · doi:10.1007/s13233-021-9028-1 · Cited by 20 · see citing works
Self-citationLi, B., Ren, K., Wang, Y., Qi, Y., Chen, X., & Huang, Y. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b11287 · Cited by 19 · see citing works
Song, Y., Mou, R., Li, Y., & Yang, T. (2020) · Medical Science Monitor · doi:10.12659/msm.919309 · Cited by 17 · see citing works
Karimzadeh, L., Seyedjafari, E., Hossein, G., Nabiuni, M., Ara, M. H. M., & Salber, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910332 · Cited by 16 · see citing works
Self-citationModulating the chemo-mechanical response of structured DNA assemblies through binding molecules
Lee, C., Kim, Y., Kim, K. S., Lee, J. Y., & Kim, D. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab1119 · Cited by 15 · see citing works
Marouf, N., Nojehdehian, H., & Ghorbani, F. (2019) · Polymers and Polymer Composites · doi:10.1177/0967391119874972 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties
Feng, P., Zhao, R., Tang, W., Yang, F. Y., Tian, H., Peng, S., Pan, H., & Shuai, C. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202214726 · Cited by 246 · see citing works
Huang, H., Qiang, L., Fan, M., Liu, Y., Yang, A., Chang, D., Li, J., Sun, T. S., Wang, Y., Guo, R., et al. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.07.004 · Cited by 87 · see citing works
Collagen as a bio-ink for 3D printing: a critical review
Debnath, S., Agrawal, A., Jain, N., Chatterjee, K., & Player, D. J. (2025) · Journal of Materials Chemistry B · doi:10.1039/d4tb01060d · Cited by 63 · see citing works
Integrated and Bifunctional Bilayer 3D Printing Scaffold for Osteochondral Defect Repair
Li, C., Zhang, W., Nie, Y., Jiang, D., Jia, J., Zhang, W., Li, L., Yao, Z., Qin, L., & Lai, Y. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202214158 · Cited by 58 · see citing works
Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration.
Kavitha Sri, A., Arthi, C., Neya, N. R., & Hikku, G. S. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acc99e · Cited by 57 · see citing works
Furkó, M., Balázsi, K., & Balázsi, C. (2023) · Coatings · doi:10.3390/coatings13020360 · Cited by 48 · see citing works
Current advancements in bio-ink technology for cartilage and bone tissue engineering
Badhe, R. V., Chatterjee, A., Bijukumar, D. R., & Mathew, M. T. (2023) · Bone · doi:10.1016/j.bone.2023.116746 · Cited by 44 · see citing works
Omigbodun, F. T., Oladapo, B. I., & Osa-uwagboe, N. (2024) · Journal of Reinforced Plastics and Composites · doi:10.1177/07316844241278045 · Cited by 44 · see citing works
Zarei, M., Sayedain, S. S., Askarinya, A., Sabbaghi, M., & Alizadeh, R. (2023) · Scientific Reports · doi:10.1038/s41598-023-41226-x · Cited by 43 · see citing works
Stafin, K., Śliwa, P., & Piątkowski, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216180 · Cited by 38 · see citing works
Babaei, M., Ebrahim-Najafabadi, N., Mirzadeh, M., Abdali, H., Farnaghi, M., Gharavi, M. K., Kheradmandfard, M., Kharazi, A. Z., & Poursamar, S. A. (2024) · Biomaterials Advances · doi:10.1016/j.bioadv.2024.213900 · Cited by 32 · see citing works
Zhang, P., Chen, J., Sun, Y., Cao, Z., Zhang, Y., Mo, Q., Yao, Q., & Zhang, W. (2023) · Journal of Materials Chemistry B · doi:10.1039/d2tb02203f · Cited by 29 · see citing works
Li, L., Li, H., Wang, Q., Xue, Y., Dai, Y. Q., Dong, Y., Shao, M., & Lyu, F. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00574 · Cited by 28 · see citing works
Conductive nerve conduit with piezoelectric properties for enhanced PC12 differentiation
Javidi, H., A., A. R. S., Sadrnezhaad, S. K., & Najmoddin, N. (2023) · Scientific Reports · doi:10.1038/s41598-023-38456-4 · Cited by 28 · see citing works
Tommasino, C., Auriemma, G., Sardo, C., Alvarez‐Lorenzo, C., Garofalo, E., Morello, S., Falcone, G., & Aquino, R. P. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123093 · Cited by 27 · see citing works
Shah, S. R., Modi, C. D., Singh, S. K., Mori, D., Soniwala, M. M., & Prajapati, B. G. (2024) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-024-00351-3 · Cited by 26 · see citing works
Qian, J., Su, L., He, J., Ruan, R., Wang, J., Wang, Z., Xiao, P., Liu, C., Cao, Y., Li, W., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c06848 · Cited by 25 · see citing works
Rashidi, N., Najmoddin, N., Tavakoli, A. H., & Samanipour, R. (2024) · Surfaces and Interfaces · doi:10.1016/j.surfin.2024.104683 · Cited by 24 · see citing works
Zhu, S., Sun, H., Mu, T., & Richel, A. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c15719 · Cited by 23 · see citing works
Kiumarsi, N., & Najmoddin, N. (2023) · Surfaces and Interfaces · doi:10.1016/j.surfin.2023.102973 · Cited by 22 · see citing works
Three‐Dimensional Printing Applications for Bone Tissue Engineering: A Review
Jalise, S. Z., Mehrabi, A., Habibi, S., Milan, P. B., & Rezapour, A. (2025) · Polymers for Advanced Technologies · doi:10.1002/pat.70152 · Cited by 21 · see citing works
Barbosa, F., Garrudo, F. F. F., Marques, A. C., Cabral, J. M. S., Morgado, J., Ferreira, F. C., & Silva, J. C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713203 · Cited by 21 · see citing works
Hou, X., Sitthisang, S., Song, B., Xu, X., Jonhson, W., Tan, Y., Yodmuang, S., & He, C. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c14716 · Cited by 18 · see citing works
Dacrory, S. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.132297 · Cited by 17 · see citing works
Hatt, L. P., van der Heide, D., Armiento, A. R., & Stoddart, M. J. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1258161 · Cited by 16 · see citing works
Khan, S. B., Chen, S., & Sun, X. (2024) · Polymer Bulletin · doi:10.1007/s00289-024-05154-8 · Cited by 16 · see citing works
3D Printed Eggshell Microparticle-Laden Thermoplastic Scaffolds for Bone Tissue Engineering
Gezek, M., Altunbek, M., Gouveia, M. E. T., & Camci‐Unal, G. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c02800 · Cited by 16 · see citing works
Petousis, M., Michailidis, N., Korlos, A., Papadakis, V. M., David, C., Sagris, D., Mountakis, N., Argyros, A., Valsamos, J., & Vidakis, N. (2024) · Polymers · doi:10.3390/polym16172400 · Cited by 15 · see citing works
Abbas, L., Nazir, F., Gulzar, A., Maryam, L., Tayyeb, A., & Iqbal, M. (2022) · Journal of Polymers and the Environment · doi:10.1007/s10924-022-02717-6 · Cited by 14 · see citing works
Natural based hydrogels promote chondrogenic differentiation of human mesenchymal stem cells
Tehrani, T. Z., Irani, S., Ardeshirylajimi, A., & Seyedjafari, E. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1363241 · Cited by 14 · see citing works
Self-citationNanomaterial‐Integrated 3D Biofabricated Structures for Advanced Biomedical Applications
Rahman, M., Dip, T. M., Nur, M. G., Hossain, M. H., Snow, F., Hossain, N. B., Mirabedini, A., Quigley, A. F., Padhye, R., & Houshyar, S. (2025) · Macromolecular Materials and Engineering · doi:10.1002/mame.202500083 · Cited by 13 · see citing works
Jadbabaee, S., Far, F. M., Esmaeili, J., & Kolahdoozan, M. (2025) · Chemistry · doi:10.3390/chemistry7050137 · Cited by 12 · see citing works
Askey, J., van den Berg, A., Gomez, S. R., Donnelly, C., Grundler, D., & Ladak, S. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202516383 · Cited by 12 · see citing works
Mierzejewska, Ż. A., Veselinović, V., Trtić, N., Marin, S., Borys, J., & Antonowicz, B. (2026) · Journal of Functional Biomaterials · doi:10.3390/jfb17010044 · Cited by 14 · see citing works
Wang, Q., Zhou, F., Qiu, T., Liu, Y., Luo, W., Wang, Z., Li, H., Xiao, E., Wei, Q., & Wu, Y. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb00962b · Cited by 12 · see citing works
N’Gatta, K. M., Assanvo, E. F., El Hayek, J., Masquelez, N., Kamgang Syapnjeu, P., Deabate, S., Bonniol, V., Soussan, L., Zamora-Ledezma, C., Elango, J., et al. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c06504 · Cited by 12 · see citing works
Megha, M., Mohan, C. C., Joy, A., Unnikrishnan, G., Thomas, J. P., Haris, M., Bhatt, S. G., Kolanthai, E., & Senthilkumar, M. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124266 · Cited by 12 · see citing works
Janmohammadi, M., Nourbakhsh, M. S., & Bahraminasab, M. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141114 · Cited by 11 · see citing works
Tang, Y., Zhang, Y., Zou, L., Sun, C., Tang, W., Zou, Y., Zhou, A., Fu, W., Wang, F., Li, K., et al. (2025) · Biofabrication · doi:10.1088/1758-5090/adcbd7 · Cited by 11 · see citing works
Bottom-up Biomaterial strategies for creating tailored stem cells in regenerative medicine
Cruz-Gonzalez, B., Johandes, E., Gramm, D., & Hanjaya‐Putra, D. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1581292 · Cited by 11 · see citing works
Chen, K., Li, Y., Xuan, Y., Khan, M., Wang, X., Zhang, X., & Guo, F. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.102905 · Cited by 10 · see citing works
Farnaghi, M., Poursamar, S. A., Farzan, M., Farzan, M., Kouhi, M., & Rafienia, M. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.114505 · Cited by 11 · see citing works
Wu, X., Zhao, F., Wang, H., Schirhagl, R., & Włodarczyk-Biegun, M. K. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101593 · Cited by 10 · see citing works
SrCO3@PCL/PDA composite scaffold promote osteoporotic bone regeneration through immune regulation
Du, J., Bao, X., Jing, W., Tang, C., Wang, C., Shi, C., Yi, C., Xu, G., & Li, D. (2025) · Composites Part B Engineering · doi:10.1016/j.compositesb.2025.112406 · Cited by 10 · see citing works
Regenerative Engineering of a Biphasic Patient-Fitted Temporomandibular Joint Condylar Prosthesis
Nedrelow, D. S., Rassi, A., Ajeeb, B., Jones, C. P. E., Huebner, P., Ritto, F., Williams, W. R., Fung, K.-M. A., Gildon, B. W., Townsend, J. M., et al. (2023) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2023.0093 · Cited by 10 · see citing works
Wang, Y., Li, G., Zhu, H., Wan, Z., Zhang, X., Ma, Y., & Xie, L. (2024) · Macromolecules · doi:10.1021/acs.macromol.4c00133 · Cited by 9 · see citing works
Chen, L., Zhou, C., Xie, Q., Xia, L., Liu, L., Bao, W., Lin, H., Xiong, X., Zhang, H., Zheng, Z., et al. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s512994 · Cited by 9 · see citing works
Romero‐Araya, P., Cárdenas, V., Nenen, A., Martínez, G., Pavicic, F., Ehrenfeld, P., Sérandour, G., Covarrubias, C., Neira, M., Moreno‐Villoslada, I., et al. (2023) · Polymer · doi:10.1016/j.polymer.2023.126448 · Cited by 9 · see citing works
Joy, K., David, S. S., Shanmugavadivu, A., Selvamurugan, N., & Mani, P. (2024) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2024.2391218 · Cited by 9 · see citing works
Teng, Y., Wang, X., Song, L., Yang, J., Hou, S., Lv, Q., Jiang, L., Guan, Y., & Shi, J. (2025) · Biomedical Materials · doi:10.1088/1748-605x/adb2ce · Cited by 8 · see citing works
Mohammadpour, S., Mokhtarzade, A., Jafari-Ramiani, A., & Solati‐Hashjin, M. (2024) · Materials Today Communications · doi:10.1016/j.mtcomm.2024.109056 · Cited by 8 · see citing works
Kannan, P. R., Sangkert, S., Jiang, C., Li, Y., Zhao, R., Iqbal, M. Z., & Kong, X. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.143390 · Cited by 8 · see citing works
TGF-β1/BSA coating modulates multi-phasic scaffolds for osteochondral tissue regeneration
Ghorbani, F., Ghalandari, B., Detsch, R., Liu, C., & Boccaccini, A. R. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101879 · Cited by 8 · see citing works
Lopresti, F., Campora, S., Rigogliuso, S., Nicosia, A., Cicero, A. L., Marco, C. D., Tornabene, S., Ghersi, G., & Carrubba, V. L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052507 · Cited by 8 · see citing works
Kim, T., Oh, G., Heo, S., Heo, S., Kim, Y.-M., Lee, D., Kang, H. W., Kim, H., Lee, B., Choi, I., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.137480 · Cited by 8 · see citing works
Antibacterial Properties of PCL@45s5 Composite Biomaterial Scaffolds Based on Additive Manufacturing
Zhang, C., Ru, Y., You, J., Lin, R., Chen, S., Qi, Y., Li, D., Zhang, C., & Qiu, Z. (2024) · Polymers · doi:10.3390/polym16233379 · Cited by 8 · see citing works
Tajvar, S., Hadjizadeh, A., Samandari, S. S., & Mashayekhan, S. (2025) · Bioprinting · doi:10.1016/j.bprint.2025.e00389 · Cited by 7 · see citing works
Dedeloudi, A., Bertelli, P. M., Martinez-Marcos, L., Quinten, T., Lengyel, I., Andersen, S. K., & Lamprou, D. A. (2025) · Journal of Functional Biomaterials · doi:10.3390/jfb16100358 · Cited by 7 · see citing works
Overview of Antimicrobial Biodegradable Polyester-Based Formulations
Gherasim, O., Grumezescu, V., & Irimiciuc, Ș. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032945 · Cited by 7 · see citing works
Joy, A., Megha, M., Mohan, C. C., Thomas, J. P., Bhat, S. G., & Senthilkumar, M. (2024) · Materials Today Chemistry · doi:10.1016/j.mtchem.2024.102031 · Cited by 8 · see citing works
Soe, H. N., Khangkhamano, M., Meesane, J., Kokoo, R., Chukaew, S., & Maung, S. T. M. (2025) · Ceramics International · doi:10.1016/j.ceramint.2025.01.018 · Cited by 6 · see citing works
de Laorden, E. H., Rodilla, B. L., Arroyo‐Hernández, M., & Iglesias, M. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1590393 · Cited by 6 · see citing works
Nanoparticle-mediated bone regeneration: From molecular mechanisms to clinical translation
Wang, S., Zhai, S., Wang, B., Yan, Y., Gong, X., Liang, Z., Medina, G., Mak, D., Caron, J., & Mak, M. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114409 · Cited by 6 · see citing works
Shemshadsara, F. G., Ai, J., Bayat, M., Ebrahimi‐Barough, S., Shirian, S., Mohamadnia, A., Kouhestani, M., Javdani, M., Karimzadeh, M. H., & Bahrami, N. (2025) · Journal of Biological Engineering · doi:10.1186/s13036-025-00578-w · Cited by 6 · see citing works
Bahraminasab, M., Arabhalvaei, M., & Ghanbari, M. A. (2025) · BioMedical Engineering OnLine · doi:10.1186/s12938-025-01475-5 · Cited by 6 · see citing works
Rajapaksa, R., Wang, Y.-C., Chin, Y. C., Jang, K., Abdal‐hay, A., Ivanovski, S., & Feroz, S. (2026) · Biomimetics · doi:10.3390/biomimetics11020107 · Cited by 6 · see citing works
Musı́lková, J., Beran, M., Sedlář, A., Slepička, P., Bartoš, M., Kolská, Z., Havlíčková, Š., Luňáčková, J., Svobodová, L., Froněk, M., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26072974 · Cited by 6 · see citing works
Tolbert, J. W., French, T., Kitson, A., Okpara, C., Hammerstone, D. E., Lazarte, S., Babuska, T. F., Gonzalez‐Fernandez, T., Krick, B. A., & Chow, L. W. (2024) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37674 · Cited by 6 · see citing works
Hydroxyapatite and polycaprolactone composites as potential biomaterials in biomedical applications
Copur, O., Tezcaner, A., & Evis, Z. (2025) · International Journal of Polymeric Materials · doi:10.1080/00914037.2025.2512725 · Cited by 5 · see citing works
In situ printing of biodegradable implant for healing critical-sized bone defect
Jeon, I. Y., Jeon, Y. M., Choi, J. H., Lee, S., Kim, M., Kim, J. H., Lee, J. S., Hwang, J., Jeong, D., Carroll, G., et al. (2025) · Device · doi:10.1016/j.device.2025.100873 · Cited by 5 · see citing works
Moghaddaszadeh, A., Ghiasvand, M. E., Seddiqi, H., Ravasjani, S. A., & Klein‐Nulend, J. (2025) · Journal of Biomaterials Applications · doi:10.1177/08853282251392820 · Cited by 5 · see citing works
Designing osteogenic interfaces on 3D-Printed thermoplastic bone scaffolds
Negi, A., Goswami, K., Diwan, H., Agrawal, G., & Murab, S. (2025) · Materials Today Chemistry · doi:10.1016/j.mtchem.2025.102635 · Cited by 5 · see citing works
Maibohm, C., Saldana-Lopez, A., Silvestre, Ó. F., & Nieder, J. B. (2022) · Polymers · doi:10.3390/polym14194168 · Cited by 5 · see citing works
Advances and challenges in electrospun polycaprolactone nanofibers for wound healing applications
Verma, P., Tiwari, V., & Chauhan, P. S. (2026) · European Polymer Journal · doi:10.1016/j.eurpolymj.2026.114605 · Cited by 4 · see citing works
Lin, T., He, Z., Zhao, T., Fan, Q., Hu, R., Jiang, J., Dang, J., Zhang, M., & Sun, D. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.124790 · Cited by 4 · see citing works
Mimicking microbone tissue by 3-dimensional printing
Lee, S., & Lee, J. W. (2024) · Organoid · doi:10.51335/organoid.2024.4.e4 · Cited by 4 · see citing works
Taephatthanasagon, T., Purbantoro, S. D., Rodprasert, W., Pathanachai, K., Charoenlertkul, P., Mahanonda, R., Sa‐Ard‐Iam, N., Kuncorojakti, S., Soedarmanto, A., Jamilah, N. S., et al. (2024) · BMC Veterinary Research · doi:10.1186/s12917-024-04246-x · Cited by 4 · see citing works
Vadivelmurugan, A., & Tsai, S. (2022) · Coatings · doi:10.3390/coatings12121888 · Cited by 4 · see citing works
Shen, S., Li, Y., Chen, M., Guo, W., Gao, S., Zhang, Z., Zhuo, N., Liu, S., & Guo, Q. (2025) · Bioengineering & Translational Medicine · doi:10.1002/btm2.70022 · Cited by 3 · see citing works
Verde, T. F. C. L., Viana, M. R., Furtado, A. S. A., Brito, G. D. C., Cunha, M. H. D. S., Filgueiras, L. A., Mendes, A. N., Marciano, F. R., de Souza, C. M., Stocco, T. D., et al. (2025) · Journal of Functional Biomaterials · doi:10.3390/jfb16120441 · Cited by 3 · see citing works
Innovative Hydroxyapatite–Hydrogel Composites for Cartilage Regeneration
Vișan, A. I., Duta, L., & Neguț, I. (2026) · Gels · doi:10.3390/gels12080727 · Cited by 3 · see citing works
Amukarimi, S., Zadshakoyan, M., & Mobasherpour, I. (2024) · Applied Physics A · doi:10.1007/s00339-024-07878-w · Cited by 3 · see citing works
Gharacheh, H., Abaci, A., Alkhoury, K., Choudhury, E., Liaw, C., Chester, S. A., & Güvendiren, M. (2024) · Soft Matter · doi:10.1039/d4sm01197j · Cited by 3 · see citing works
A Tri‐Polymer‐Åkermanite Electrospun Scaffold for Enhanced Bone Regeneration
Rosales‐Ibáñez, R., González‐González, A. M., Rodríguez-Martínez, J. J., Carrillo-Escalante, H. J., Bretado, L. A., Salinas-Delgado, Y. D. L. Á., Cruz, R., Talamás‐Lara, D., Ludert, J. E., & Hernández‐Sánchez, F. (2025) · Journal of Applied Polymer Science · doi:10.1002/app.57378 · Cited by 3 · see citing works
Nandhini, P., Devakumaran, T. V., Murugan, M., Mickymaray, S., Alothaim, A. S., & Rajan, M. (2023) · Process Biochemistry · doi:10.1016/j.procbio.2023.10.018 · Cited by 3 · see citing works
Investigating the Promising P28 Peptide-Loaded Chitosan/Ceramic Bone Scaffolds for Bone Regeneration
Zhou, K., Simonassi-Paiva, B., Fehrenbach, G. W., Yan, G., Portela, A., Pogue, R. E., Cao, Z. Q., Fournet, M. B., & Devine, D. M. (2024) · Molecules · doi:10.3390/molecules29174208 · Cited by 3 · see citing works
Jamilludin, M. A., Supii, A. I., Partini, J., Kusindarta, D. L., & Yusuf, Y. (2025) · Materials Chemistry and Physics · doi:10.1016/j.matchemphys.2025.130798 · Cited by 2 · see citing works
Kim, H. B., Kwon, S., Kim, Y.-H., Eom, J. S., Shim, J., & Han, H. H. (2025) · Polymers · doi:10.3390/polym18010109 · Cited by 2 · see citing works
Ardeshiriansharifabadi, S., Asefnejad, A., & Azami, M. (2026) · Results in Engineering · doi:10.1016/j.rineng.2026.109540 · Cited by 2 · see citing works
Haryati, E., Lolo, J. A., Dinatha, I. K. H., Juliadmi, D., Kusumaatmaja, A., Partini, J., Ana, I. D., Syahruddin, M. H., Wihadmadyatami, H., Nuryanti, A., et al. (2026) · Next Materials · doi:10.1016/j.nxmate.2026.102833 · Cited by 2 · see citing works
Xuanhao, L., Jing, Z., Xu, B., Yang, X., Wang, Y., Zhi, H., Bin, L., & Song, F. (2026) · Biomaterials Advances · doi:10.1016/j.bioadv.2026.215079 · Cited by 2 · see citing works
Hydrogel Elastic Energy: A Stressor Triggering an Adaptive Stress‐Mediated Cell Response
Lipari, S., Sacco, P., Cok, M., Scognamiglio, F., Romano, M., Brun, F., Giulianini, P. G., Marsich, E., Aachmann, F. L., & Donati, I. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202402400 · Cited by 2 · see citing works
Megha, M., Joy, A., Mohan, C. C., Unnikrishnan, G., Thomas, J. P., Haris, M., Bhat, S. G., Kolanthai, E., & Senthilkumar, M. (2025) · Ceramics International · doi:10.1016/j.ceramint.2025.02.225 · Cited by 2 · see citing works
Enhancing the biomechanical response of 3D-printed polylactic acid scaffolds with heat treatment
Maheshwari, S., Singh, A. K., Chatterjee, K., Alam, Z., & Singh, S. S. (2025) · Emergent Materials · doi:10.1007/s42247-025-01155-z · Cited by 2 · see citing works
Caronna, F., Limem, S., Do, L. D. K., Ronan, W., & Dolan, E. B. (2025) · Biomedical Materials · doi:10.1088/1748-605x/ada85d · Cited by 1 · see citing works
Poly ε-Caprolactone Scaffolds: Advancements in Bone Regeneration and Grafting
Raoufinia, R., Hashemi, S., Arabi, K., Naghipoor, K., Fakoor, F., & Saburi, E. (2025) · OBM Transplantation · doi:10.21926/obm.transplant.2502245 · Cited by 2 · see citing works
On the Design and Development of a Conformal Sensor Using 3D Gel Printing of Polycaprolactone
Mehta, A., Singh, R., Kumar, J., & Kumar, R. (2025) · Journal of The Institution of Engineers (India) Series C · doi:10.1007/s40032-025-01230-8 · Cited by 1 · see citing works
Mun, J., Pack, S. P., & Lee, H. (2025) · RSC Advances · doi:10.1039/d5ra04406e · Cited by 1 · see citing works
Chatterjee, K., Singh, A. K., Maheshwari, S., Alam, Z., & Singh, S. S. (2025) · Journal of Polymer Science · doi:10.1002/pol.20250553 · Cited by 1 · see citing works
Shorouei, S., Karimzadeh, L., Kehtari, M., Vaziri, N., Taheriazam, A., Moradikhah, F., Jafari, A. M., Seyedjafari, E., & Salber, J. (2025) · Scientific Reports · doi:10.1038/s41598-025-25897-2 · Cited by 1 · see citing works
Self-citation
- Authors
- Ebrahimi, Z., Irani, S., Ardeshirylajimi, A., & Seyedjafari, E.
- Affiliations
- Islamic Azad University, Tehran (IR)
- Shahid Beheshti University (IR)
- University of Tehran (IR)
- Corresponding author
- Seyedjafari, Ehsan
- Venue
- Scientific Reports
- Published
- 2022-07-20
- Volume
- 12
- Issue
- 1
- Pages
- 12359-12359
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC9300684
- OpenAlex
- W4286504968
- Cited by
- 141
- References
- 68
- Citations by year
- 2026: 39 · 2025: 49 · 2024: 31 · 2023: 18 · 2022: 4
- FWCI
- 7.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- polycaprolactone, 3D-printed scaffolds, osteogenic differentiation, hydroxyapatite coating, human adipose-derived mesenchymal stem cells, bone tissue engineering, biocompatibility, cell proliferation, alkaline phosphatase activity, calcium deposition, fused deposition modeling
- MeSH terms
- Collagen, Humans, Osteogenesis, Polyesters, Stem Cells, Durapatite, Tissue Scaffolds, Printing, Three-Dimensional
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
