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Sterilization and disinfection methods for decellularized matrix materials: Review, consideration and proposal
Open accessAbstract
Sterilization is the process of killing all microorganisms, while disinfection is the process of killing or removing all kinds of pathogenic microorganisms except bacterial spores. Biomaterials involved in cell experiments, animal experiments, and clinical applications need to be in the aseptic state, but their physical and chemical properties as well as biological activities can be affected by sterilization or disinfection. Decellularized matrix (dECM) is the low immunogenicity material obtained by removing cells from tissues, which retains many inherent components in tissues such as proteins and proteoglycans. But there are few studies concerning the effects of sterilization or disinfection on dECM, and the systematic introduction of sterilization or disinfection for dECM is even less. Therefore, this review systematically introduces and analyzes the mechanism, advantages, disadvantages, and applications of various sterilization and disinfection methods, discusses the factors influencing the selection of sterilization and disinfection methods, summarizes the sterilization and disinfection methods for various common dECM, and finally proposes a graphical route for selecting an appropriate sterilization or disinfection method for dECM and a technical route for validating the selected method, so as to provide the reference and basis for choosing more appropriate sterilization or disinfection methods of various dECM.
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“Some sterilization methods may increase FBR incidence via crosslinking ECM components and interfering with subsequent degradation [219].”
From Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine (2023) · cites this paper as [219]
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Metadata
- Authors
- Tao, M., Ao, T., Mao, X., Yan, X., Javed, R., Hou, W., Wang, Y., Sun, C., Lin, S., Yu, T., & Ao, Q.
- Affiliations
- China Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Sichuan University (CN)
- Corresponding author
- Ao, Qiang
- Venue
- Bioactive Materials
- Publisher
- Elsevier BV
- Published
- 2021-09
- Volume
- 6
- Issue
- 9
- Pages
- 2927-2945
- ISSN
- 2097-1192 (ISSN-L)
- 2452-199X
- PMC
- PMC7930362
- OpenAlex
- W3134529887
- Cited by
- 119
- References
- 194
- Citations by year
- 2026: 5 · 2025: 21 · 2024: 29 · 2023: 33 · 2022: 25 · 2021: 6
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Bioactive Materials (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Sichuan Province Science and Technology Support Program (2020YFH0008)
- National Key Research and Development Program of China (2017YFA0105802)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Immunology and Microbiology › Microbiology › Medical Device Sterilization and Disinfection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Inactivation Methods
- Keywords
- decellularized extracellular matrix, sterilization, disinfection, aseptic processing, sterilization validation, biomaterials, immunogenicity, proteoglycans, tissue engineering scaffolds
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