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Cited by 236Tissue Engineering and Regenerative Medicine3D Printing in Biomedical ResearchHydrogels: synthesis, properties, applications

Decellularized extracellular matrix biomaterials for regenerative therapies: Advances, challenges and clinical prospects

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Golebiowska, Aleksandra A., Intravaia, Jonathon T., Sathe, Vinayak M., Kumbar, Sangamesh G., Nukavarapu, Syam P.·2024·Bioactive Materials
DOI 10.1016/j.bioactmat.2023.09.017PMC PMC10622743
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Abstract

Tissue engineering and regenerative medicine have shown potential in the repair and regeneration of tissues and organs via the use of engineered biomaterials and scaffolds. However, current constructs face limitations in replicating the intricate native microenvironment and achieving optimal regenerative capacity and functional recovery. To address these challenges, the utilization of decellularized tissues and cell-derived extracellular matrix (ECM) has emerged as a promising approach. These biocompatible and bioactive biomaterials can be engineered into porous scaffolds and grafts that mimic the structural and compositional aspects of the native tissue or organ microenvironment, both in vitro and in vivo. Bioactive dECM materials provide a unique tissue-specific microenvironment that can regulate and guide cellular processes, thereby enhancing regenerative therapies. In this review, we explore the emerging frontiers of decellularized tissue-derived and cell-derived biomaterials and bio-inks in the field of tissue engineering and regenerative medicine. We discuss the need for further improvements in decellularization methods and techniques to retain structural, biological, and physicochemical characteristics of the dECM products in a way to mimic native tissues and organs. This article underscores the potential of dECM biomaterials to stimulate in situ tissue repair through chemotactic effects for the development of growth factor and cell-free tissue engineering strategies. The article also identifies the challenges and opportunities in developing sterilization and preservation methods applicable for decellularized biomaterials and grafts and their translation into clinical products.

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200 of 273 shown

Authors
Golebiowska, A. A., Intravaia, J. T., Sathe, V. M., Kumbar, S. G., & Nukavarapu, S. P.
Affiliations
  • University of Connecticut (US)
  • UConn Health (US)
Corresponding author
Nukavarapu, Syam P.
ORCID
Venue
Bioactive Materials
Publisher
Elsevier BV
Published
2024-02
Volume
32
Pages
98-123
ISSN
  • 2097-1192 (ISSN-L)
  • 2452-199X
DOI
10.1016/j.bioactmat.2023.09.017
PMC
PMC10622743
OpenAlex
W4387352646
Cited by
236
References
298
Citations by year
2026: 50 · 2025: 127 · 2024: 57 · 2023: 2
FWCI
15.27
Type
journal article
Language
en
Open access
Licence
Locations
  • Bioactive Materials (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Science Foundation
  • Sudbury Community Foundation
  • National Institute of Biomedical Imaging and Bioengineering
  • National Institutes of Health (01EB030060, 01EB020640)
Topics
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
decellularized extracellular matrix, decellularization methods, cell-derived extracellular matrix, biomaterials, scaffolds, bioinks, tissue engineering, regenerative medicine, growth factor delivery, cell-free tissue engineering, clinical translation, tissue microenvironment

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Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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