Cited by 113Silk-based biomaterials and applicationsBone Tissue Engineering MaterialsOsteoarthritis Treatment and Mechanisms

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Marginal sealing around integral bilayer scaffolds for repairing osteochondral defects based on photocurable silk hydrogels

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Wu, Xiaolin, Zhou, Mingliang, Jiang, Fei, Yin, Shi, Lin, Sihan, Yang, Guangzheng, Lu, Yuezhi, Zhang, Wenjie, Jiang, Xinquan·2021·Bioactive Materials

DOI 10.1016/j.bioactmat.2021.04.005PMC PMC8081879

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Abstract

Osteochondral repair remains a major challenge in current clinical practice despite significant advances in tissue engineering. In particular, the lateral integration of neocartilage into surrounding native cartilage is a difficult and inadequately addressed problem that determines the success of tissue repair. Here, a novel design of an integral bilayer scaffold combined with a photocurable silk sealant for osteochondral repair is reported. First, we fabricated a bilayer silk scaffold with a cartilage layer resembling native cartilage in surface morphology and mechanical strength and a BMP-2-loaded porous subchondral bone layer that facilitated the osteogenic differentiation of BMSCs. Second, a TGF-β3-loaded methacrylated silk fibroin sealant (Sil-MA) exhibiting biocompatibility and good adhesive properties was developed and confirmed to promote chondrocyte migration and differentiation. Importantly, this TGF-β3-loaded Sil-MA hydrogel provided a bridge between the cartilage layer of the scaffold and the surrounding cartilage and then guided new cartilage to grow towards and replace the degraded cartilage layer from the surrounding native cartilage in the early stage of knee repair. Thus, osteochondral regeneration and superior lateral integration were achieved in vivo by using this composite. These results demonstrate that the new approach of marginal sealing around the cartilage layer of bilayer scaffolds with Sil-MA hydrogel has tremendous potential for clinical use in osteochondral regeneration.

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Authors: Wu, X., Zhou, M., Jiang, F., Yin, S., Lin, S., Yang, G., Lu, Y., Zhang, W., & Jiang, X.
Affiliations: Shanghai Jiao Tong University (CN)
Corresponding author: Jiang, Fei
Zhang, Wenjie
Jiang, Xinquan
ORCID: Wu, Xiaolin
Jiang, Fei
Yang, Guangzheng
Zhang, Wenjie
Jiang, Xinquan
Venue: Bioactive Materials
Publisher: Elsevier BV
Published: 2021-11
Volume: 6
Issue: 11
Pages: 3976-3986
ISSN: 2097-1192 (ISSN-L)
2452-199X
DOI: 10.1016/j.bioactmat.2021.04.005
PMC: PMC8081879
OpenAlex: W3158673470
Cited by: 113
References: 52
Citations by year: 2026: 10 · 2025: 26 · 2024: 20 · 2023: 24 · 2022: 30 · 2021: 3
FWCI: 5.03
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Bioactive Materials (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (31700848, 81620108006, 81921002, 81991505)
National Key Research and Development Program of China (2016YFC1102900)
Topics: Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
Keywords: osteochondral regeneration, marginal sealing, bilayer scaffold, silk fibroin hydrogel, TGF-beta3, BMP-2, mesenchymal stem cells, chondrogenic differentiation, cartilage integration, knee cartilage repair, subchondral bone regeneration

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Marginal sealing around integral bilayer scaffolds for repairing osteochondral defects based on photocurable silk hydrogels

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