Cited by 163Nanoplatforms for cancer theranosticsUltrasound and Hyperthermia ApplicationsNanoparticle-Based Drug Delivery

Rational Design of Biomaterials to Potentiate Cancer Thermal Therapy

Zhu, Yujie, Li, Quguang, Wang, Chunjie, Hao, Yu, Yang, Nailin, Chen, Minjiang, Ji, Jiansong, Feng, Liangzhu +1 more·2023·Chemical Reviews

Abstract

Cancer thermal therapy, also known as hyperthermia therapy, has long been exploited to eradicate mass lesions that are now defined as cancer. With the development of corresponding technologies and equipment, local hyperthermia therapies such as radiofrequency ablation, microwave ablation, and high-intensity focused ultrasound, have has been validated to effectively ablate tumors in modern clinical practice. However, they still face many shortcomings, including nonspecific damages to adjacent normal tissues and incomplete ablation particularly for large tumors, restricting their wide clinical usage. Attributed to their versatile physiochemical properties, biomaterials have been specially designed to potentiate local hyperthermia treatments according to their unique working principles. Meanwhile, biomaterial-based delivery systems are able to bridge hyperthermia therapies with other types of treatment strategies such as chemotherapy, radiotherapy and immunotherapy. Therefore, in this review, we discuss recent progress in the development of functional biomaterials to reinforce local hyperthermia by functioning as thermal sensitizers to endow more efficient tumor-localized thermal ablation and/or as delivery vehicles to synergize with other therapeutic modalities for combined cancer treatments. Thereafter, we provide a critical perspective on the further development of biomaterial-assisted local hyperthermia toward clinical applications.

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Crossref · 10.1021/acs.chemrev.2c00822

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351 of 351 references verified0 citation errors · 0 not checkable

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  • Temperature-sensitive materials (thermosensitive liposomes or polymers) respond to hyperthermia, improving nanocarrier permeability and activating release of radiopharmaceuticals.

    “Temperature-sensitive materials, such as thermosensitive liposomes or polymers, respond to hyperthermia, improving nanocarrier permeability and activating the release of radiopharmaceuticals [27].”

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Authors
Zhu, Y., Li, Q., Wang, C., Hao, Y., Yang, N., Chen, M., Ji, J., Feng, L., & Liu, Z.
Affiliations
  • Soochow University (CN)
  • Wenzhou Medical University (CN)
Corresponding author
  • Ji, Jiansong
  • Feng, Liangzhu
  • Liu, Zhuang
Venue
Chemical Reviews
Published
2023-03-13
Volume
123
Issue
11
Pages
7326-7378
ISSN
  • 0009-2665 (ISSN-L)
  • 1520-6890
OpenAlex
W4324020235
Cited by
163
References
351
Citations by year
2026: 35 · 2025: 48 · 2024: 63 · 2023: 17
FWCI
3.66
Type
journal article
Language
en
Open access
closed
Locations
  • Chemical Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Collaborative Innovation Center of Suzhou Nano Science and Technology
  • Ministry of Science and Technology of the People's Republic of China (2021YFF0701800, 2022YFF0706500)
  • Natural Science Foundation of Jiangsu Province (BK20220110)
  • National Natural Science Foundation of China (22077093, 52032008)
  • Higher Education Discipline Innovation Project
  • Suzhou Key Laboratory of Nanotechnology and Biomedicine
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
cancer hyperthermia, thermal ablation, biomaterials, drug carriers, combination cancer therapy, radiofrequency ablation, microwave ablation, high-intensity focused ultrasound, tumor ablation, anticancer drug delivery
MeSH terms
Biocompatible Materials, Humans, Hyperthermia, Induced, Immunotherapy, Neoplasms

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