Rational Design of Biomaterials to Potentiate Cancer Thermal Therapy
Abstract
Cancer thermal therapy, also known as hyperthermia therapy, has long been exploited to eradicate mass lesions that are now defined as cancer. With the development of corresponding technologies and equipment, local hyperthermia therapies such as radiofrequency ablation, microwave ablation, and high-intensity focused ultrasound, have has been validated to effectively ablate tumors in modern clinical practice. However, they still face many shortcomings, including nonspecific damages to adjacent normal tissues and incomplete ablation particularly for large tumors, restricting their wide clinical usage. Attributed to their versatile physiochemical properties, biomaterials have been specially designed to potentiate local hyperthermia treatments according to their unique working principles. Meanwhile, biomaterial-based delivery systems are able to bridge hyperthermia therapies with other types of treatment strategies such as chemotherapy, radiotherapy and immunotherapy. Therefore, in this review, we discuss recent progress in the development of functional biomaterials to reinforce local hyperthermia by functioning as thermal sensitizers to endow more efficient tumor-localized thermal ablation and/or as delivery vehicles to synergize with other therapeutic modalities for combined cancer treatments. Thereafter, we provide a critical perspective on the further development of biomaterial-assisted local hyperthermia toward clinical applications.
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Temperature-sensitive materials (thermosensitive liposomes or polymers) respond to hyperthermia, improving nanocarrier permeability and activating release of radiopharmaceuticals.
“Temperature-sensitive materials, such as thermosensitive liposomes or polymers, respond to hyperthermia, improving nanocarrier permeability and activating the release of radiopharmaceuticals [27].”
From Radiopharmaceuticals: navigating the frontier of precision medicine and therapeutic innovation (2024) · cites this paper as [27]
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Radiopharmaceuticals: navigating the frontier of precision medicine and therapeutic innovation
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“Temperature-sensitive materials, such as thermosensitive liposomes or polymers, respond to hyperthermia, improving nanocarrier permeability and activating the release of radiopharmaceuticals [27].”
BackgroundYang, N., Yang, X., Cheng, S., Gao, X., Sun, S., Huang, X., Ge, J., Han, Z., Huang, C., Wang, Y., et al. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.05.010 · Cited by 38 · see citing works
Self-citation
- Authors
- Zhu, Y., Li, Q., Wang, C., Hao, Y., Yang, N., Chen, M., Ji, J., Feng, L., & Liu, Z.
- Affiliations
- Soochow University (CN)
- Wenzhou Medical University (CN)
- Corresponding author
- Ji, Jiansong
- Feng, Liangzhu
- Liu, Zhuang
- ORCID
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2023-03-13
- Volume
- 123
- Issue
- 11
- Pages
- 7326-7378
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- OpenAlex
- W4324020235
- Cited by
- 163
- References
- 351
- Citations by year
- 2026: 35 · 2025: 48 · 2024: 63 · 2023: 17
- FWCI
- 3.66
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Chemical Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- Ministry of Science and Technology of the People's Republic of China (2021YFF0701800, 2022YFF0706500)
- Natural Science Foundation of Jiangsu Province (BK20220110)
- National Natural Science Foundation of China (22077093, 52032008)
- Higher Education Discipline Innovation Project
- Suzhou Key Laboratory of Nanotechnology and Biomedicine
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- cancer hyperthermia, thermal ablation, biomaterials, drug carriers, combination cancer therapy, radiofrequency ablation, microwave ablation, high-intensity focused ultrasound, tumor ablation, anticancer drug delivery
- MeSH terms
- Biocompatible Materials, Humans, Hyperthermia, Induced, Immunotherapy, Neoplasms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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