CoChat
Sign Up
Cited by 41Polymer Surface Interaction StudiesSurgical Sutures and AdhesivesTissue Engineering and Regenerative Medicine

Recent Development and Applications of Polydopamine in Tissue Repair and Regeneration Biomaterials

Open access
Guo, Kai, Wang, Yong, Feng, Zi-Xuan, Lin, Xiao-Ying, Wu, Zhang-Rui, Zhong, Xin-Cao, Zhuang, Ze-Ming, Zhang, Tao +2 more·2024·International Journal of Nanomedicine
DOI 10.2147/ijn.s437854PMC PMC10824616
Open this paper in CoChat — free accountOpen PDF

Abstract

The various tissue damages are a severe problem to human health. The limited human tissue regenerate ability requires suitable biomaterials to help damage tissue repair and regeneration. Therefore, many researchers devoted themselves to exploring biomaterials suitable for tissue repair and regeneration. Polydopamine (PDA) as a natural and multifunctional material which is inspired by mussel has been widely applied in different biomaterials. The excellent properties of PDA, such as strong adhesion, photothermal and high drug-loaded capacity, seem to be born for tissue repair and regeneration. Furthermore, PDA combined with different materials can exert unexpected effects. Thus, to inspire researchers, this review summarizes the recent and representative development of PDA biomaterials in tissue repair and regeneration. This article focuses on why apply PDA in these biomaterials and what PDA can do in different tissue injuries.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.2147/ijn.s437854

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The in vivo degradation of PDA exhibits a characteristic two-stage process, described as 'surface etching followed by interlayer delamination.'

    “The in vivo degradation of PDA exhibits a characteristic two-stage process, described as “surface etching followed by interlayer delamination.””

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [21]

    The “pH-Responsive Bacteria Reactive Biomaterials with PDA” section (page unavailable) says that PDA’s outer layer degrades in an acidic biofilm microenvironment. It does not describe in vivo degradation as a characteristic two-stage process, or report surface etching followed by interlayer delamination. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • In vitro degradation studies have shown that under oxidative conditions (0.1 mmol L−1 H2O2, pH 7.4, 37 °C), PDA film thickness decreases by approximately 42% within 30 days.

    “In vitro degradation studies have shown that under oxidative conditions (0.1 mmol L−1 H2O2, pH 7.4, 37 °C), PDA film thickness decreases by approximately 42% within 30 days.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [21]

    The pH-Responsive Bacteria Reactive Biomaterials with PDA section describes degradation of a PDA film’s outer layer in acidic biofilms (pH below 6.0), not film thinning under the stated oxidative conditions. Searches for H2O2, 42%, and film thickness over 30 days found no passage reporting the claimed measurement; page numbers are unavailable in our copy. (LLM, conf=0.74)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 169

  1. [1]Deng X, Gould M, Ali MA. A review of current advancements for wound healing: biomaterial applications and medical devices. J Biomed Mater Res B Appl Biomater. 2022; 110(11): 2542– 2573. doi: 10.1002/jbm.b.35086 35579269 PMC9544096 · DOI
  2. [2]Babilotte J, Guduric V, Le Nihouannen D, Naveau A, Fricain JC, Catros S. 3D printed polymer-mineral composite biomaterials for bone tissue engineering: fabrication and characterization. J Biomed Mater Res B Appl Biomater. 2019; 107(8): 2579– 2595. doi: 10.1002/jbm.b.34348 30848068 · DOI
  3. [3]Jiang BG, Han N, Rao F, Wang YL, Kou YH, Zhang PX. Advance of peripheral nerve injury repair and reconstruction. Chin Med J. 2017; 130(24): 2996– 2998. doi: 10.4103/0366-6999.220299 29237933 PMC5742928 · DOI
  4. [4]Zhang Q, Liu Y, Li J, Wang J, Liu C. Recapitulation of growth factor-enriched microenvironment via BMP receptor activating hydrogel. Bioact Mater. 2023; 20: 638– 650. doi: 10.1016/j.bioactmat.2022.06.012 35846838 PMC9270210 · DOI
  5. [5]Zhang W, Yu M, Cao Y, et al. An anti-bacterial porous shape memory self-adaptive stiffened polymer for alveolar bone regeneration after tooth extraction. Bioact Mater. 2023; 21: 450– 463. doi: 10.1016/j.bioactmat.2022.08.030 36185742 PMC9486049 · DOI
  6. [6]Chen Q, Nan Y, Yang Y, et al. Nanodrugs alleviate acute kidney injury: manipulate RONS at kidney. Bioact Mater. 2023; 22: 141– 167. doi: 10.1016/j.bioactmat.2022.09.021 36203963 PMC9526023 · DOI
  7. [7]Jin J, Liu Y, Jiang C, et al. Arbutin-modified microspheres prevent osteoarthritis progression by mobilizing local anti-inflammatory and antioxidant responses. Mater Today Bio. 2022; 16: 100370. doi: 10.1016/j.mtbio.2022.100370 PMC9352975 35937573 · DOI
  8. [8]Liu Z, Tang Q, Liu RT, et al. Laponite intercalated biomimetic multilayer coating prevents glucocorticoids induced orthopedic implant failure. Bioact Mater. 2023; 22: 60– 73. doi: 10.1016/j.bioactmat.2022.09.013 36203962 PMC9519439 · DOI
  9. [9]Taghizadeh A, Taghizadeh M, Yazdi MK, et al. Mussel-inspired biomaterials: from chemistry to clinic. Bioeng Transl Med. 2022; 7(3): e10385. doi: 10.1002/btm2.10385 36176595 PMC9472010 · DOI
  10. [10]Cavallini C, Vitiello G, Adinolfi B, et al. Melanin and melanin-like hybrid materials in regenerative medicine. Nanomaterials. 2020; 10(8): 1518. doi: 10.3390/nano10081518 32756369 PMC7466405 · DOI
  11. [11]Miller DR, Spahn JE, Waite JH. The staying power of adhesion-associated antioxidant activity in mytilus californianus. J R Soc Interface. 2015; 12(111): 20150614. doi: 10.1098/rsif.2015.0614 26468070 PMC4614499 · DOI
  12. [12]Kord Forooshani P, Lee BP. Recent approaches in designing bioadhesive materials inspired by mussel adhesive protein. J Polym Sci a Polym Chem. 2017; 55(1): 9– 33. doi: 10.1002/pola.28368 27917020 PMC5132118 · DOI · Paper page
  13. [14]Haining RL, Achat-Mendes C. Neuromelanin, one of the most overlooked molecules in modern medicine, is not a spectator. Neural Regen Res. 2017; 12(3): 372– 375. doi: 10.4103/1673-5374.202928 28469642 PMC5399705 · DOI
  14. [15]d’Ischia M, Wakamatsu K, Cicoira F, et al. Melanins and melanogenesis: from pigment cells to human health and technological applications. Pigm Cell Melanoma Res. 2015; 28(5): 520– 544. doi: 10.1111/pcmr.12393 26176788 · DOI
  15. [16]Danner EW, Kan Y, Hammer MU, Israelachvili JN, Waite JH. Adhesion of mussel foot protein Mefp-5 to mica: an underwater superglue. Biochemistry. 2012; 51(33): 6511– 6518. doi: 10.1021/bi3002538 22873939 PMC3428132 · DOI
  16. [17]Kalia S, Zhao J, Zeng H, McLean D, Kollias N, Lui H. Melanin quantification by in vitro and in vivo analysis of near-infrared fluorescence. Pigm Cell Melanoma Res. 2018; 31(1): 31– 38. doi: 10.1111/pcmr.12624 28805346 · DOI
  17. [18]Ou-Yang H, Stamatas G, Kollias N. Spectral responses of melanin to ultraviolet A irradiation. J Invest Dermatol. 2004; 122(2): 492– 496. doi: 10.1046/j.0022-202X.2004.22247.x 15009735 · DOI
  18. [19]Liu Y, Ai K, Ji X, et al. Comprehensive insights into the multi-antioxidative mechanisms of melanin nanoparticles and their application to protect brain from injury in ischemic stroke. J Am Chem Soc. 2017; 139(2): 856– 862. doi: 10.1021/jacs.6b11013 27997170 PMC5752099 · DOI
  19. [22]Hong S, Zhang QL, Zheng DW, et al. Enzyme mimicking based on the natural melanin particles from human hair. iScience. 2020; 23(1): 100778. doi: 10.1016/j.isci.2019.100778 31901818 PMC6948237 · DOI
  20. [23]Roy S, Rhim J-W. Agar-based antioxidant composite films incorporated with melanin nanoparticles. Food Hydrocoll. 2019; 94: 391– 398. doi: 10.1016/j.foodhyd.2019.03.038 · DOI
  21. [24]Ma H, Zhou Q, Chang J, Wu C. Grape seed-inspired smart hydrogel scaffolds for melanoma therapy and wound healing. ACS Nano. 2019; 13(4): 4302– 4311. doi: 10.1021/acsnano.8b09496 30925040 · DOI
  22. [25]Lee H, Dellatore SM, Miller WM, Messersmith PB. Mussel-inspired surface chemistry for multifunctional coatings. Science. 2007; 318(5849): 426– 430. doi: 10.1126/science.1147241 17947576 PMC2601629 · DOI · Paper page
  23. [26]Pennisi P, Salehinejad MA, Corso AM, Merlo EM, Avenanti A, Vicario CM. Delay discounting in parkinson’s disease: a systematic review and meta-analysis. Behav Brain Res. 2023; 436: 114101. doi: 10.1016/j.bbr.2022.114101 36087861 · DOI
  24. [27]Wang Y, Chen L, Ren DY, et al. Mussel-inspired collagen-hyaluronic acid composite scaffold with excellent antioxidant properties and sustained release of a growth factor for enhancing diabetic wound healing. Mater Today Bio. 2022; 15: 100320. doi: 10.1016/j.mtbio.2022.100320 PMC9218585 35757026 · DOI
  25. [28]Yuan Z, Lin C, Dai L, et al. Near-infrared light-activatable dual-action nanoparticle combats the established biofilms of methicillin-resistant Staphylococcus aureus and its accompanying inflammation. Small. 2021; 17(13): e2007522. doi: 10.1002/smll.202007522 33690998 · DOI
  26. [29]Ma K, Dong P, Liang M, Yu S, Chen Y, Wang F. Facile assembly of multifunctional antibacterial nanoplatform leveraging synergistic sensitization between silver nanostructure and vancomycin. ACS Appl Mater Interfaces. 2020; 12(6): 6955– 6965. doi: 10.1021/acsami.9b22043 31977179 · DOI
  27. [30]Zeng WN, Wang D, Yu QP, et al. Near-infrared light-controllable multifunction mesoporous polydopamine nanocomposites for promoting infected wound healing. ACS Appl Mater Interfaces. 2022; 14(2): 2534– 2550. doi: 10.1021/acsami.1c19209 34985258 · DOI
  28. [31]Yazdi MK, Zare M, Khodadadi A, et al. Polydopamine biomaterials for skin regeneration. ACS Biomater Sci Eng. 2022; 8(6): 2196– 2219. doi: 10.1021/acsbiomaterials.1c01436 35649119 · DOI
  29. [32]Tolabi H, Bakhtiary N, Sayadi S, et al. A critical review on polydopamine surface-modified scaffolds in musculoskeletal regeneration. Front Bioeng Biotechnol. 2022; 10: 1008360. doi: 10.3389/fbioe.2022.1008360 36466324 PMC9715616 · DOI
  30. [33]Zheng D, Huang C, Zhu X, Huang H, Xu C. Performance of polydopamine complex and mechanisms in wound healing. Int J Mol Sci. 2021; 22(19). doi: 10.3390/ijms221910563 PMC8508909 34638906 · DOI
  31. [34]Chen CT, Martin-Martinez FJ, Jung GS, Buehler MJ. Polydopamine and eumelanin molecular structures investigated with ab initio calculations. Chem Sci. 2017; 8(2): 1631– 1641. doi: 10.1039/c6sc04692d 28451292 PMC5364519 · DOI
  32. [35]Saiz-Poseu J, Mancebo-Aracil J, Nador F, Busque F, Ruiz-Molina D. The chemistry behind catechol-based adhesion. Angew Chem Int Ed Engl. 2019; 58(3): 696– 714. doi: 10.1002/anie.201801063 29573319 · DOI · Paper page
  33. [36]Wheat JC, Wolf JS Jr. Advances in bioadhesives, tissue sealants, and hemostatic agents. Urol Clin North Am. 2009; 36(2): 265– 75, x. doi: 10.1016/j.ucl.2009.02.002 19406326 · DOI
  34. [37]Radosevich M, Goubran HI, Burnouf T. Fibrin sealant: scientific rationale, production methods, properties, and current clinical use. Vox Sang. 1997; 72(3): 133– 143. doi: 10.1046/j.1423-0410.1997.7230133.x 9145483 · DOI
  35. [38]Joch C. The safety of fibrin sealants. Cardiovasc Surg. 2003; 11: 23– 28. doi: 10.1016/S0967-2109(03)00068-1 12869985 · DOI
  36. [39]Ennker J, Ennker IC, Schoon D, et al. The impact of gelatin-resorcinol glue on aortic tissue - a histomorphologic evaluation. J Vasc Surg. 1994; 20(1): 34– 43. doi: 10.1016/0741-5214(94)90173-2 8028087 · DOI
  37. [40]Furst W, Banerjee A. Release of glutaraldehyde from an albumin-glutaraldehyde tissue adhesive causes significant in vitro and in vivo toxicity. Ann Thorac Surg. 2005; 79(5): 1522– 1529. doi: 10.1016/j.athoracsur.2004.11.054 15854927 · DOI
  38. [41]Fan C, Fu J, Zhu W, Wang DA. A mussel-inspired double-crosslinked tissue adhesive intended for internal medical use. Acta Biomater. 2016; 33: 51– 63. doi: 10.1016/j.actbio.2016.02.003 26850148 · DOI
  39. [42]Chen W, Wang R, Xu TT, et al. A mussel-inspired poly(gamma-glutamic acid) tissue adhesive with high wet strength for wound closure. J Mater Chem B. 2017; 5(28): 5668– 5678. doi: 10.1039/c7tb00813a · DOI
  40. [43]Pandey N, Soto-Garcia L, Yaman S, et al. Polydopamine nanoparticles and hyaluronic acid hydrogels for mussel-inspired tissue adhesive nanocomposites. Biomater Adv. 2022; 134: 112589. doi: 10.1016/j.msec.2021.112589 35525749 PMC9753139 · DOI
  41. [44]Leng F, Chen F, Jiang X. Modified porous carboxymethyl chitin microspheres by an organic solvent-free process for rapid hemostasis. Carbohydr Polym. 2021; 270: 118348. doi: 10.1016/j.carbpol.2021.118348 34364597 · DOI
  42. [45]Zhang X, Sun GH, Tian MP, et al. Mussel-inspired antibacterial polydopamine/chitosan/temperature-responsive hydrogels for rapid hemostasis. Int J Biol Macromol. 2019; 138: 321– 333. doi: 10.1016/j.ijbiomac.2019.07.052 31295499 · DOI
  43. [46]Liu C, Yao W, Tian M, Wei J, Song Q, Qiao W. Mussel-inspired degradable antibacterial polydopamine/silica nanoparticle for rapid hemostasis. Biomaterials. 2018; 179: 83– 95. doi: 10.1016/j.biomaterials.2018.06.037 29980077 · DOI
  44. [47]Li G, Liang Y, Xu C, et al. Polydopamine reinforced hemostasis of a graphene oxide sponge via enhanced platelet stimulation. Colloids Surf B Biointerfaces. 2019; 174: 35– 41. doi: 10.1016/j.colsurfb.2018.10.074 30419476 · DOI
  45. [48]Shin M, Park S-G, Oh B-C, et al. Complete prevention of blood loss with self-sealing haemostatic needles. Nat Mater. 2017; 16(1): 147– 152. doi: 10.1038/nmat4758 27698353 · DOI
  46. [49]Liu C, Liu X, Liu C, et al. A highly efficient, in situ wet-adhesive dextran derivative sponge for rapid hemostasis. Biomaterials. 2019; 205: 23– 37. doi: 10.1016/j.biomaterials.2019.03.016 30901635 · DOI
  47. [50]Sigal A, Martin A, Ong A. Availability and use of hemostatic agents in prehospital trauma patients in pennsylvania translation from the military to the civilian setting. Open Access Emerg Med. 2017; 9: 47– 52. doi: 10.2147/OAEM.S134657 28740438 PMC5505603 · DOI
  48. [51]Liang Y, Xu C, Liu F, Du S, Li G, Wang X. Eliminating heat injury of zeolite in hemostasis via thermal conductivity of graphene sponge. ACS Appl Mater Interfaces. 2019; 11(27): 23848– 23857. doi: 10.1021/acsami.9b04956 31245992 · DOI
  49. [52]Zhang H, Fan T, Chen W, Li Y, Wang B. Recent advances of two-dimensional materials in smart drug delivery nano-systems. Bioact Mater. 2020; 5(4): 1071– 1086. doi: 10.1016/j.bioactmat.2020.06.012 32695937 PMC7363990 · DOI
  50. [53]Gong M, Liu C, Liu C, et al. Biomimetic hydroxyapate/polydopamine composites with good biocompatibility and efficiency for uncontrolled bleeding. J Biomed Mater Res B Appl Biomater. 2021; 109(11): 1876– 1892. doi: 10.1002/jbm.b.34849 33847453 · DOI
  51. [54]Kozen BG, Kircher SJ, Henao J, Godinez FS, Johnson AS. An alternative hemostatic dressing: comparison of CELOX, HemCon, and QuikClot. Acad Emerg Med. 2008; 15(1): 74– 81. doi: 10.1111/j.1553-2712.2007.00009.x 18211317 · DOI
  52. [55]Cao S, Yang Y, Zhang S, Liu K, Chen J. Multifunctional dopamine modification of green antibacterial hemostatic sponge. Mater Sci Eng C Mater Biol Appl. 2021; 127: 112227. doi: 10.1016/j.msec.2021.112227 34225872 · DOI
  53. [56]Li M, Zhang Z, Liang Y, He J, Guo B. Multifunctional tissue-adhesive cryogel wound dressing for rapid nonpressing surface hemorrhage and wound repair. ACS Appl Mater Interfaces. 2020; 12(32): 35856– 35872. doi: 10.1021/acsami.0c08285 32805786 · DOI
  54. [57]Hu J, Ding Y, Tao B, et al. Surface modification of titanium substrate via combining photothermal therapy and quorum-sensing-inhibition strategy for improving osseointegration and treating biofilm-associated bacterial infection. Bioact Mater. 2022; 18: 228– 241. doi: 10.1016/j.bioactmat.2022.03.011 35387171 PMC8961458 · DOI
  55. [58]Dong Q, Liang X, Chen F, et al. Injectable shape memory hydroxyethyl cellulose/soy protein isolate based composite sponge with antibacterial property for rapid noncompressible hemorrhage and prevention of wound infection. Int J Biol Macromol. 2022; 217: 367– 380. doi: 10.1016/j.ijbiomac.2022.07.051 35839954 · DOI · Paper page
  56. [59]Guo Z, Zhang Z, Zhang N, et al. A Mg(2+)/polydopamine composite hydrogel for the acceleration of infected wound healing. Bioact Mater. 2022; 15: 203– 213. doi: 10.1016/j.bioactmat.2021.11.036 35386343 PMC8940763 · DOI
  57. [60]Deng Y, Shi J, Chan YK, et al. Heterostructured metal-organic frameworks/polydopamine coating endows polyetheretherketone implants with multimodal osteogenicity and photoswitchable disinfection. Adv Healthc Mater. 2022; 11(14): e2200641. doi: 10.1002/adhm.202200641 35521819 · DOI
  58. [61]Li X, Li B, Liu R, Dong Y, Zhao Y, Wu Y. Development of pH-responsive nanocomposites with remarkably synergistic antibiofilm activities based on ultrasmall silver nanoparticles in combination with aminoglycoside antibiotics. Colloids Surf B Biointerfaces. 2021; 208: 112112. doi: 10.1016/j.colsurfb.2021.112112 34600361 · DOI
  59. [62]Sun H, Dong J, Wang YYF, et al. Polydopamine-Coated Poly(L-lactide) nanofibers with controlled release of VEGF and BMP-2 as a regenerative periosteum. Acs Biomater Sci Eng. 2021; 7(10): 4883– 4897. doi: 10.1021/acsbiomaterials.1c00246 34472855 · DOI
  60. [63]Chen J, Wu J, Mu J, et al. An antioxidative sophora exosome-encapsulated hydrogel promotes spinal cord repair by regulating oxidative stress microenvironment. Nanomedicine. 2023; 47: 102625. doi: 10.1016/j.nano.2022.102625 36334896 · DOI
  61. [64]Eawsakul K, Tancharoen S, Nasongkla N. Combination of dip coating of BMP-2 and spray coating of PLGA on dental implants for osseointegration. J Drug Deliv Sci Tec. 2021; 61. doi: 10.1016/j.jddst.2020.102296 · DOI
  62. [65]Hettiaratchi MH, O’Meara MJ, Teal CJ, Payne SL, Pickering AJ, Shoichet MS. Local delivery of stabilized chondroitinase ABC degrades chondroitin sulfate proteoglycans in stroke-injured rat brains. J Control Release. 2019; 297: 14– 25. doi: 10.1016/j.jconrel.2019.01.033 30690102 · DOI
  63. [66]Shadish JA, Benuska GM, DeForest CA. Bioactive site-specifically modified proteins for 4D patterning of gel biomaterials. Nat Mater. 2019; 18(9): 1005– 1014. doi: 10.1038/s41563-019-0367-7 31110347 PMC6706293 · DOI
  64. [67]Pearson HB, Mason DE, Kegelman CD, et al. Effects of bone morphogenetic protein-2 on neovascularization during large bone defect regeneration. Tissue Eng Part A. 2019; 25(23–24): 1623– 1634. doi: 10.1089/ten.TEA.2018.0326 30973074 PMC6919258 · DOI
  65. [68]Agarwal R, Garcia AJ. Biomaterial strategies for engineering implants for enhanced osseointegration and bone repair. Adv Drug Deliv Rev. 2015; 94: 53– 62. doi: 10.1016/j.addr.2015.03.013 25861724 PMC4598264 · DOI
  66. [69]Kim S, Kim J, Gajendiran M, et al. Enhanced skull bone regeneration by sustained release of BMP-2 in interpenetrating composite hydrogels. Biomacromolecules. 2018; 19(11): 4239– 4249. doi: 10.1021/acs.biomac.8b01013 30231204 · DOI
  67. [70]Schoonraad SA, Trombold ML, Bryant SJ. The effects of stably tethered BMP-2 on MC3T3-E1 preosteoblasts encapsulated in a PEG hydrogel. Biomacromolecules. 2021; 22(3): 1065– 1079. doi: 10.1021/acs.biomac.0c01085 33555180 PMC8479702 · DOI
  68. [71]Wu Y, Li X, Sun Y, et al. Multiscale design of stiffening and ROS scavenging hydrogels for the augmentation of mandibular bone regeneration. Bioact Mater. 2023; 20: 111– 125. doi: 10.1016/j.bioactmat.2022.05.021 35663335 PMC9133584 · DOI
  69. [72]Pike DB, Cai S, Pomraning KR, et al. Heparin-regulated release of growth factors in vitro and angiogenic response in vivo to implanted hyaluronan hydrogels containing VEGF and bFGF. Biomaterials. 2006; 27(30): 5242– 5251. doi: 10.1016/j.biomaterials.2006.05.018 16806456 · DOI
  70. [73]Pellegrini L, Burke DF, von Delft F, Mulloy B, Blundell TL. Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. Nature. 2000; 407(6807): 1029– 1034. doi: 10.1038/35039551 11069186 · DOI
  71. [74]Lund J, Sondergaard MT, Conover CA, Overgaard MT. Heparin-binding mechanism of the IGF2/IGF-binding protein 2 complex. J Mol Endocrinol. 2014; 52(3): 345– 355. doi: 10.1530/JME-13-0184 24604839 · DOI
  72. [75]Kim S, Cui ZK, Kim PJ, Jung LY, Lee M. Design of hydrogels to stabilize and enhance bone morphogenetic protein activity by heparin mimetics. Acta Biomater. 2018; 72: 45– 54. doi: 10.1016/j.actbio.2018.03.034 29597024 PMC5938156 · DOI
  73. [76]Hettiaratchi MH, Krishnan L, Rouse T, Chou C, McDevitt TC, Guldberg RE. Heparin-mediated delivery of bone morphogenetic protein-2 improves spatial localization of bone regeneration. Sci Adv. 2020; 6(1): eaay1240. doi: 10.1126/sciadv.aay1240 31922007 PMC6941907 · DOI
  74. [77]Zhang X, Li J, Chen J, et al. Enhanced bone regeneration via PHA scaffolds coated with polydopamine-captured BMP2. J Mater Chem B. 2022; 10(32): 6214– 6227. doi: 10.1039/d2tb01122k 35920210 · DOI
  75. [78]Gao YK, Yuan ZY, Yuan XJ, et al. Bioinspired porous microspheres for sustained hypoxic exosomes release and vascularized bone regeneration. Bioact Mater. 2022; 14: 377– 388. doi: 10.1016/j.bioactmat.2022.01.041 35386817 PMC8964815 · DOI
  76. [79]Zhu H, Ji X, Guan H, et al. Tantalum nanoparticles reinforced polyetheretherketone shows enhanced bone formation. Mater Sci Eng C Mater Biol Appl. 2019; 101: 232– 242. doi: 10.1016/j.msec.2019.03.091 31029316 · DOI
  77. [80]Hu W, Lu S, Ma Y, et al. Poly(dopamine)-inspired surface functionalization of polypropylene tissue mesh for prevention of intra-peritoneal adhesion formation. J Mater Chem B. 2017; 5(3): 575– 585. doi: 10.1039/c6tb02667b 32263673 · DOI
  78. [81]Wardani AK, Ariono D, Subagjo Wenten IG, et al. Hydrophilic modification of polypropylene ultrafiltration membrane by air-assisted polydopamine coating. Polym Adv Technol. 2019; 30(4): 1148– 1155. doi: 10.1002/pat.4549 · DOI
  79. [82]Jia L, Han F, Wang H, et al. Polydopamine-assisted surface modification for orthopaedic implants. J Orthop Translat. 2019; 17: 82– 95. doi: 10.1016/j.jot.2019.04.001 31194087 PMC6551362 · DOI · Paper page
  80. [83]Gao C, Wang Y, Han F, et al. Antibacterial activity and osseointegration of silver-coated poly(ether ether ketone) prepared using the polydopamine-assisted deposition technique. J Mater Chem B. 2017; 5(47): 9326– 9336. doi: 10.1039/c7tb02436c 32264535 · DOI
  81. [84]Deng Z, Shang B, Peng B. Polydopamine based colloidal materials: synthesis and applications. Chem Rec. 2018; 18(4): 410– 432. doi: 10.1002/tcr.201700051 29124869 · DOI
  82. [85]Ford Versypt AN, Pack DW, Braatz RD. Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres--A review. J Control Release. 2013; 165(1): 29– 37. doi: 10.1016/j.jconrel.2012.10.015 23103455 PMC3518665 · DOI
  83. [86]Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020; 367(6478). doi: 10.1126/science.aau6977 PMC7717626 32029601 · DOI · Paper page
  84. [87]Silva AKA, Perretta S, Perrod G, et al. Thermoresponsive gel embedded with adipose stem-cell-derived extracellular vesicles promotes esophageal fistula healing in a thermo-actuated delivery strategy. ACS Nano. 2018; 12(10): 9800– 9814. doi: 10.1021/acsnano.8b00117 30231208 · DOI
  85. [88]Bei HP, Hung PM, Yeung HL, Wang S, Zhao X. Bone-a-petite: engineering exosomes towards bone, osteochondral, and cartilage repair. Small. 2021; 17(50): e2101741. doi: 10.1002/smll.202101741 34288410 · DOI
  86. [89]Fan J, Lee CS, Kim S, Chen C, Aghaloo T, Lee M. Generation of small RNA-modulated exosome mimetics for bone regeneration. ACS Nano. 2020; 14(9): 11973– 11984. doi: 10.1021/acsnano.0c05122 32897692 PMC7530137 · DOI
  87. [90]Li LM, Zhang Y, Mu JF, et al. Transplantation of human mesenchymal stem-cell-derived exosomes immobilized in an adhesive hydrogel for effective treatment of spinal cord injury. Nano Lett. 2020; 20(6): 4298– 4305. doi: 10.1021/acs.nanolett.0c00929 32379461 · DOI
  88. [91]Mol EA, Lei ZY, Roefs MT, et al. Injectable supramolecular ureidopyrimidinone hydrogels provide sustained release of extracellular vesicle therapeutics. Adv Healthc Mater. 2019; 8(20). doi: 10.1002/adhm.201900847 31559704 · DOI
  89. [92]Swanson WB, Gong T, Zhang Z, et al. Controlled release of odontogenic exosomes from a biodegradable vehicle mediates dentinogenesis as a novel biomimetic pulp capping therapy. J Control Release. 2020; 324: 679– 694. doi: 10.1016/j.jconrel.2020.06.006 32534011 PMC7429296 · DOI
  90. [93]Hu ZA, Ma C, Rong X, Zou SJ, Liu XH. Immunomodulatory ECM-like microspheres for accelerated bone regeneration in diabetes mellitus. Acs Appl Mater Inter. 2018; 10(3): 2377– 2390. doi: 10.1021/acsami.7b18458 PMC6437671 29280610 · DOI
  91. [94]Lee CS, Kim S, Fan JB, Hwang HS, Aghaloo T, Lee M. Smoothened agonist sterosome immobilized hybrid scaffold for bone regeneration. Sci Adv. 2020; 6(17). doi: 10.1126/sciadv.aaz7822 PMC7176430 32494652 · DOI
  92. [95]Su N, Hao YY, Wang F, Hou WD, Chen HF, Luo Y. Mesenchymal stromal exosome-functionalized scaffolds induce innate and adaptive immunomodulatory responses toward tissue repair. Sci Adv. 2021; 7(20). doi: 10.1126/sciadv.abf7207 PMC8115917 33980490 · DOI
  93. [96]Fan L, Guan PF, Xiao CR, et al. Exosome-functionalized polyetheretherketone-based implant with immunomodulatory property for enhancing osseointegration. Bioact Mater. 2021; 6(9): 2754– 2766. doi: 10.1016/j.bioactmat.2021.02.005 33665507 PMC7897935 · DOI · Paper page
  94. [97]Sun YH, Qin HS, Yan ZQ, Zhao CQ, Ren JS, Qu XG. Combating biofilm associated infection in vivo: integration of quorum sensing inhibition and photodynamic treatment based on multidrug delivered hollow carbon nitride sphere (vol 29, 1808222, 2019). Adv Funct Mater. 2020; 30(9). doi: 10.1002/adfm.201909740 · DOI
  95. [98]Farhood B, Mortezaee K, Goradel NH, et al. Curcumin as an anti-inflammatory agent: implications to radiotherapy and chemotherapy. J Cell Physiol. 2019; 234(5): 5728– 5740. doi: 10.1002/jcp.27442 30317564 · DOI
  96. [99]Chen T, Zhuang B, Huang Y, et al. Inhaled curcumin mesoporous polydopamine nanoparticles against radiation pneumonitis. Acta Pharm Sin B. 2022; 12(5): 2522– 2532. doi: 10.1016/j.apsb.2021.10.027 35646537 PMC9136532 · DOI
  97. [100]Li B, Webster TJ. Bacteria antibiotic resistance: new challenges and opportunities for implant-associated orthopedic infections. J Orthop Res. 2018; 36(1): 22– 32. doi: 10.1002/jor.23656 28722231 PMC5775060 · DOI
  98. [101]Sun X, Li L, Zhang H, et al. Near-infrared light-regulated drug-food homologous bioactive molecules and photothermal collaborative precise antibacterial therapy nanoplatform with controlled release property. Adv Healthc Mater. 2021; 10(16): e2100546. doi: 10.1002/adhm.202100546 34081401 · DOI
  99. [102]Chiang WL, Lin TT, Sureshbabu R, et al. A rapid drug release system with a NIR light-activated molecular switch for dual-modality photothermal/antibiotic treatments of subcutaneous abscesses. J Control Release. 2015; 199: 53– 62. doi: 10.1016/j.jconrel.2014.12.011 25499553 · DOI
  100. [104]Fiorica C, Palumbo FS, Pitarresi G, et al. Ciprofloxacin releasing gellan gum/polydopamine based hydrogels with near infrared activated photothermal properties. Int J Pharm. 2021; 610: 121231. doi: 10.1016/j.ijpharm.2021.121231 34715261 · DOI
  101. [105]Che L, Wang Y, Sha D, et al. A biomimetic and bioactive scaffold with intelligently pulsatile teriparatide delivery for local and systemic osteoporosis regeneration. Bioact Mater. 2023; 19: 75– 87. doi: 10.1016/j.bioactmat.2022.03.023 35441117 PMC8990063 · DOI
  102. [106]Allen TM, Cullis PR. Liposomal drug delivery systems: from concept to clinical applications. Adv Drug Deliv Rev. 2013; 65(1): 36– 48. doi: 10.1016/j.addr.2012.09.037 23036225 · DOI · Paper page
  103. [107]Kong G, Braun RD, Dewhirst MW. Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature. Cancer Res. 2001; 61(7): 3027– 3032. 11306483
  104. [108]Wang Y, Shim MS, Levinson NS, Sung HW, Xia Y. Stimuli-responsive materials for controlled release of theranostic agents. Adv Funct Mater. 2014; 24(27): 4206– 4220. doi: 10.1002/adfm.201400279 25477774 PMC4249693 · DOI
  105. [109]Jung WK, Koo HC, Kim KW, Shin S, Kim SH, Park YH. Antibacterial activity and mechanism of action of the silver ion in Staphylococcus aureus and Escherichia coli. Appl Environ Microbiol. 2008; 74(7): 2171– 2178. doi: 10.1128/AEM.02001-07 18245232 PMC2292600 · DOI
  106. [110]Smetana AB, Klabunde KJ, Marchin GR, Sorensen CM. Biocidal activity of nanocrystalline silver powders and particles. Langmuir. 2008; 24(14): 7457– 7464. doi: 10.1021/la800091y 18543995 · DOI
  107. [111]Samavedi S, Whittington AR, Goldstein AS. Calcium phosphate ceramics in bone tissue engineering: a review of properties and their influence on cell behavior. Acta Biomater. 2013; 9(9): 8037– 8045. doi: 10.1016/j.actbio.2013.06.014 23791671 · DOI
  108. [112]Zhang Z, Zhang J, Zhang B, Tang J. Mussel-inspired functionalization of graphene for synthesizing Ag-polydopamine-graphene nanosheets as antibacterial materials. Nanoscale. 2013; 5(1): 118– 123. doi: 10.1039/c2nr32092d 23138501 · DOI
  109. [113]Xie X, Mao C, Liu X, et al. Tuning the bandgap of photo-sensitive polydopamine/Ag3PO4/graphene oxide coating for rapid, noninvasive disinfection of implants. ACS Cent Sci. 2018; 4(6): 724– 738. doi: 10.1021/acscentsci.8b00177 29974068 PMC6026779 · DOI
  110. [114]Yang Y, Zhou X, Chan YK, et al. Photo-activated nanofibrous membrane with self-rechargeable antibacterial function for stubborn infected cutaneous regeneration. Small. 2022; 18(12): e2105988. doi: 10.1002/smll.202105988 35088512 · DOI
  111. [115]Wang L, He S, Wu X, et al. Polyetheretherketone/nano-fluorohydroxyapatite composite with antimicrobial activity and osseointegration properties. Biomaterials. 2014; 35(25): 6758– 6775. doi: 10.1016/j.biomaterials.2014.04.085 24835045 · DOI
  112. [116]Yan J, Yang L, Lin MF, Ma J, Lu X, Lee PS. Polydopamine spheres as active templates for convenient synthesis of various nanostructures. Small. 2013; 9(4): 596– 603. doi: 10.1002/smll.201201064 23117928 · DOI
  113. [117]Zhang R, Jiang G, Gao Q, et al. Sprayed copper peroxide nanodots for accelerating wound healing in a multidrug-resistant bacteria infected diabetic ulcer. Nanoscale. 2021; 13(37): 15937– 15951. doi: 10.1039/d1nr04687j 34523658 · DOI · Paper page
  114. [118]Lin A, Liu Y, Zhu X, et al. Bacteria-responsive biomimetic selenium nanosystem for multidrug-resistant bacterial infection detection and inhibition. ACS Nano. 2019; 13(12): 13965– 13984. doi: 10.1021/acsnano.9b05766 31730327 · DOI
  115. [119]Lynge ME, van der Westen R, Postma A, Stadler B. Polydopamine--a nature-inspired polymer coating for biomedical science. Nanoscale. 2011; 3(12): 4916– 4928. doi: 10.1039/c1nr10969c 22024699 · DOI · Paper page
  116. [120]Pan H, Shen X, Tao W, Chen S, Ye X. Fabrication of polydopamine-based curcumin nanoparticles for chemical stability and pH-responsive delivery. J Agric Food Chem. 2020; 68(9): 2795– 2802. doi: 10.1021/acs.jafc.9b07697 32031786 · DOI
  117. [121]Liu Y, Ai K, Lu L. Polydopamine and its derivative materials: synthesis and promising applications in energy, environmental, and biomedical fields. Chem Rev. 2014; 114(9): 5057– 5115. doi: 10.1021/cr400407a 24517847 · DOI · Paper page
  118. [122]Ran P, Zheng H, Cao WX, et al. On-demand changeable theranostic hydrogels and visual imaging-guided antibacterial photodynamic therapy to promote wound healing. Acs Appl Mater Inter. 2022; 14(43): 49375– 49388. doi: 10.1021/acsami.2c15561 36270272 · DOI
  119. [123]Peng D, Liu G, He Y, et al. Fabrication of a pH-responsive core-shell nanosystem with a low-temperature photothermal therapy effect for treating bacterial biofilm infection. Biomater Sci. 2021; 9(22): 7483– 7491. doi: 10.1039/d1bm01329g 34635886 · DOI
  120. [124]Wang X, Wang CP, Wang XY, Wang YT, Zhang Q, Cheng YY. A polydopamine nanoparticle-knotted Poly(ethylene glycol) hydrogel for on-demand drug delivery and chemo-photothermal therapy. Chem Mater. 2017; 29(3): 1370– 1376. doi: 10.1021/acs.chemmater.6b05192 · DOI
  121. [125]Yin J, Zhong J, Wang J, et al. 3D-printed high-density polyethylene scaffolds with bioactive and antibacterial layer-by-layer modification for auricle reconstruction. Mater Today Bio. 2022; 16: 100361. doi: 10.1016/j.mtbio.2022.100361 PMC9352972 35937577 · DOI
  122. [126]Wu M, Chen F, Liu H, et al. Bioinspired sandwich-like hybrid surface functionalized scaffold capable of regulating osteogenesis, angiogenesis, and osteoclastogenesis for robust bone regeneration. Mater Today Bio. 2022; 17: 100458. doi: 10.1016/j.mtbio.2022.100458 PMC9583582 36278143 · DOI · Paper page
  123. [127]Yuan R, Yang N, Fan S, et al. Biomechanical motion-activated endogenous wound healing through LBL self-powered nanocomposite repairer with pH-responsive anti-inflammatory effect. Small. 2021; 17(50): e2103997. doi: 10.1002/smll.202103997 34713581 · DOI
  124. [128]Xiong F, Wei S, Sheng H, et al. Three-layer core-shell structure of polypyrrole/polydopamine/poly(l-lactide) nanofibers for wound healing application. Int J Biol Macromol. 2022; 222(Pt B): 1948– 1962. doi: 10.1016/j.ijbiomac.2022.09.284 36202331 · DOI
  125. [129]Zheng Z, Li M, Shi P, et al. Polydopamine-modified collagen sponge scaffold as a novel dermal regeneration template with sustained release of platelet-rich plasma to accelerate skin repair: a one-step strategy. Bioact Mater. 2021; 6(8): 2613– 2628. doi: 10.1016/j.bioactmat.2021.01.037 33615046 PMC7881170 · DOI
  126. [130]Zhu Z, Gao Q, Long Z, et al. Corrigendum to ”polydopamine/poly(sulfobetaine methacrylate) co-deposition coatings triggered by CuSO4/H2O2 on implants for improved surface hemocompatibility and antibacterial activity” [Bioactive materials 6 (2021) 2546–2556]. Bioact Mater. 2022; 17: 195– 196. doi: 10.1016/j.bioactmat.2022.01.037 35386459 PMC8965024 · DOI
  127. [131]Xu X, Li Y, Wang L, et al. Triple-functional polyetheretherketone surface with enhanced bacteriostasis and anti-inflammatory and osseointegrative properties for implant application. Biomaterials. 2019; 212: 98– 114. doi: 10.1016/j.biomaterials.2019.05.014 31112825 · DOI
  128. [132]Decher G. Fuzzy nanoassemblies: toward layered polymeric multicomposites. Science. 1997; 277(5330): 1232– 1237. doi: 10.1126/science.277.5330.1232 · DOI
  129. [133]de Villiers MM, Otto DP, Strydom SJ, Lvov YM. Introduction to nanocoatings produced by layer-by-layer (LbL) self-assembly. Adv Drug Deliv Rev. 2011; 63(9): 701– 715. doi: 10.1016/j.addr.2011.05.011 21699936 · DOI
  130. [134]Yang Z, Xi Y, Bai J, et al. Covalent grafting of hyperbranched poly-L-lysine on Ti-based implants achieves dual functions of antibacteria and promoted osteointegration in vivo. Biomaterials. 2021; 269: 120534. doi: 10.1016/j.biomaterials.2020.120534 33243425 · DOI
  131. [135]Wasilewska M, Adamczyk Z, Ocwieja M, Wojnar D, Zeliszewska P. Silver nanoparticle/fibrinogen bilayers - mechanism of formation and stability determined by in situ electrokinetic measurements. J Colloid Interface Sci. 2018; 513: 170– 179. doi: 10.1016/j.jcis.2017.11.019 29153710 · DOI
  132. [136]Tian L, Zhang Z, Tian B, Zhang X, Wang N. Study on antibacterial properties and cytocompatibility of EPL coated 3D printed PCL/HA composite scaffolds. RSC Adv. 2020; 10(8): 4805– 4816. doi: 10.1039/c9ra10275b 35495239 PMC9049012 · DOI · Paper page
  133. [137]Pajorova J, Bacakova M, Musilkova J, et al. Morphology of a fibrin nanocoating influences dermal fibroblast behavior. Int J Nanomed. 2018; 13: 3367– 3380. doi: 10.2147/IJN.S162644 PMC5997127 29922057 · DOI
  134. [138]Zhang Y, Wang F, Huang Q, et al. Layer-by-layer immobilizing of polydopamine-assisted epsilon-polylysine and gum Arabic on titanium: tailoring of antibacterial and osteogenic properties. Mater Sci Eng C Mater Biol Appl. 2020; 110: 110690. doi: 10.1016/j.msec.2020.110690 32204005 · DOI
  135. [139]Zhao Y, Bai L, Zhang Y, et al. Type I collagen decorated nanoporous network on titanium implant surface promotes osseointegration through mediating immunomodulation, angiogenesis, and osteogenesis. Biomaterials. 2022; 288: 121684. doi: 10.1016/j.biomaterials.2022.121684 35995624 · DOI
  136. [140]Zhao X, Zhou L, Li Q, Zou Q, Du C. Biomimetic mineralization of carboxymethyl chitosan nanofibers with improved osteogenic activity in vitro and in vivo. Carbohydr Polym. 2018; 195: 225– 234. doi: 10.1016/j.carbpol.2018.04.090 29804972 · DOI
  137. [141]Feng L, Shi W, Chen Q, et al. Smart asymmetric hydrogel with integrated multi-functions of NIR-triggered tunable adhesion, self-deformation, and bacterial eradication. Adv Healthc Mater. 2021; 10(19): e2100784. doi: 10.1002/adhm.202100784 34050632 · DOI
  138. [142]Yang F, Murugan R, Ramakrishna S, Wang X, Ma YX, Wang S. Fabrication of nano-structured porous PLLA scaffold intended for nerve tissue engineering. Biomaterials. 2004; 25(10): 1891– 1900. doi: 10.1016/j.biomaterials.2003.08.062 14738853 · DOI
  139. [143]Shim IK, Jung MR, Kim KH, et al. Novel three-dimensional scaffolds of poly(L-lactic acid) microfibers using electrospinning and mechanical expansion: fabrication and bone regeneration. J Biomed Mater Res B Appl Biomater. 2010; 95(1): 150– 160. doi: 10.1002/jbm.b.31695 20725960 · DOI
  140. [144]Wu S, Peng H, Li X, Streubel PN, Liu Y, Duan B. Effect of scaffold morphology and cell co-culture on tenogenic differentiation of HADMSC on centrifugal melt electrospun poly (L‑lactic acid) fibrous meshes. Biofabrication. 2017; 9(4): 044106. doi: 10.1088/1758-5090/aa8fb8 29134948 PMC5849472 · DOI
  141. [145]Zhou Q, Xie J, Bao M, et al. Engineering aligned electrospun PLLA microfibers with nano-porous surface nanotopography for modulating the responses of vascular smooth muscle cells. J Mater Chem B. 2015; 3(21): 4439– 4450. doi: 10.1039/c5tb00051c 32262788 · DOI
  142. [146]Mao X, Cheng R, Zhang H, et al. Self-healing and injectable hydrogel for matching skin flap regeneration. Adv Sci. 2019; 6(3): 1801555. doi: 10.1002/advs.201801555 PMC6364594 30775235 · DOI
  143. [147]Li L, Yan B, Yang J, Huang W, Chen L, Zeng H. Injectable self-healing hydrogel with antimicrobial and antifouling properties. Acs Appl Mater Inter. 2017; 9(11): 9221– 9225. doi: 10.1021/acsami.6b16192 28266838 · DOI
  144. [148]Rao KM, Narayanan KB, Uthappa UT, Park PH, Choi I, Han SS. Tissue adhesive, self-healing, biocompatible, hemostasis, and antibacterial properties of fungal-derived carboxymethyl chitosan-polydopamine hydrogels. Pharmaceutics. 2022; 14(5): 1028. doi: 10.3390/pharmaceutics14051028 35631614 PMC9145872 · DOI
  145. [149]Yi J, Nguyen KT, Wang W, et al. Mussel-inspired adhesive double-network hydrogel for intraoral ultrasound imaging. ACS Appl Bio Mater. 2020; 3(12): 8943– 8952. doi: 10.1021/acsabm.0c01211 35019570 · DOI
  146. [150]Zhang G, Chen S, Peng Z, et al. Topologically enhanced dual-network hydrogels with rapid recovery for low-hysteresis, self-adhesive epidemic electronics. ACS Appl Mater Interfaces. 2021; 13(10): 12531– 12540. doi: 10.1021/acsami.1c00819 33685117 · DOI
  147. [151]Chen T, Chen Y, Rehman HU, et al. Ultratough, self-healing, and tissue-adhesive hydrogel for wound dressing. ACS Appl Mater Interfaces. 2018; 10(39): 33523– 33531. doi: 10.1021/acsami.8b10064 30204399 · DOI
  148. [152]Mourya VK, Inamdara N, Ashutosh Tiwari N. Carboxymethyl chitosan and its applications. Adv Mater Lett. 2010; 1(1): 11– 33. doi: 10.5185/amlett.2010.3108 · DOI
  149. [153]Dai S, Yue S, Ning Z, Jiang N, Gan Z. Polydopamine nanoparticle-reinforced near-infrared light-triggered shape memory polycaprolactone-polydopamine polyurethane for biomedical implant applications. ACS Appl Mater Interfaces. 2022; 14(12): 14668– 14676. doi: 10.1021/acsami.2c03172 35311259 · DOI
  150. [154]Gong T, Zhao K, Liu X, Lu L, Liu D, Zhou S. A dynamically tunable, bioinspired micropatterned surface regulates vascular endothelial and smooth muscle cells growth at vascularization. Small. 2016; 12(41): 5769– 5778. doi: 10.1002/smll.201601503 27595865 · DOI
  151. [155]Gogoi S, Karak N. Biobased biodegradable waterborne hyperbranched polyurethane as an ecofriendly sustainable material. ACS Sustain Chem Eng. 2014; 2(12): 2730– 2738. doi: 10.1021/sc5006022 · DOI
  152. [156]Daraghmeh DN, King C, Wiese MD. A review of liquid biopsy as a tool to assess epigenetic, cfDNA and miRNA variability as methotrexate response predictors in patients with rheumatoid arthritis. Pharmacol Res. 2021; 173: 105887. doi: 10.1016/j.phrs.2021.105887 34536550 · DOI
  153. [157]Mondelo-Macía P, Castro-Santos P, Castillo-García A, Muinelo-Romay L, Diaz-Peña R. Circulating free DNA and its emerging role in autoimmune diseases. J Pers Med. 2021; 11(2): 151. doi: 10.3390/jpm11020151 33672659 PMC7924199 · DOI
  154. [158]Liang H, Peng B, Dong C, et al. Cationic nanoparticle as an inhibitor of cell-free DNA-induced inflammation. Nat Commun. 2018; 9(1): 4291. doi: 10.1038/s41467-018-06603-5 30327464 PMC6191420 · DOI
  155. [159]Wang Y, Ma X, Ding C, Jia L. pH-responsive deoxyribonucleic acid capture/release by polydopamine functionalized magnetic nanoparticles. Anal Chim Acta. 2015; 862: 33– 40. doi: 10.1016/j.aca.2015.01.009 25682426 · DOI
  156. [160]Chen Y, Wang Y, Jiang X, et al. Dimethylamino group modified polydopamine nanoparticles with positive charges to scavenge cell-free DNA for rheumatoid arthritis therapy. Bioact Mater. 2022; 18: 409– 420. doi: 10.1016/j.bioactmat.2022.03.028 35415310 PMC8968194 · DOI
  157. [161]Zheng B, Deng G, Zheng J, et al. Self-polymerized polydopamine-based nanoparticles for acute kidney injury treatment through inhibiting oxidative damages and inflammatory. Int J Biochem Cell Biol. 2022; 143: 106141. doi: 10.1016/j.biocel.2021.106141 34954154 · DOI
  158. [162]Saita M, Kaneko J, Sato T, et al. Novel antioxidative nanotherapeutics in a rat periodontitis model: reactive oxygen species scavenging by redox injectable gel suppresses alveolar bone resorption. Biomaterials. 2016; 76: 292– 301. doi: 10.1016/j.biomaterials.2015.10.077 26559357 · DOI
  159. [163]Wei Y, Fu J, Wu W, et al. Quercetin prevents oxidative stress-induced injury of periodontal ligament cells and alveolar bone loss in periodontitis. Drug Des Devel Ther. 2021; 15: 3509– 3522. doi: 10.2147/DDDT.S315249 PMC8366957 34408403 · DOI
  160. [164]Bao X, Zhao J, Sun J, Hu M, Yang X. Polydopamine nanoparticles as efficient scavengers for reactive oxygen species in periodontal disease. ACS Nano. 2018; 12(9): 8882– 8892. doi: 10.1021/acsnano.8b04022 30028940 · DOI · Paper page
  161. [165]Fu Y, Zhang J, Wang Y, et al. Reduced polydopamine nanoparticles incorporated oxidized dextran/chitosan hybrid hydrogels with enhanced antioxidative and antibacterial properties for accelerated wound healing. Carbohydr Polym. 2021; 257: 117598. doi: 10.1016/j.carbpol.2020.117598 33541635 · DOI
  162. [166]Li Y, Yang L, Hou Y, et al. Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes. Bioact Mater. 2022; 18: 213– 227. doi: 10.1016/j.bioactmat.2022.03.021 35387166 PMC8961429 · DOI
  163. [167]Sohrabi Y, Lagache SMM, Schnack L, et al mTOR-dependent oxidative stress regulates oxLDL-induced trained innate immunity in human monocytes. Front Immunol. 2018; 9: 3155. doi: 10.3389/fimmu.2018.03155 30723479 PMC6350618 · DOI
  164. [168]Shi H, Jin L, Li J, et al. Mesoporous polydopamine nanoparticles for sustained release of rapamycin and reactive oxygen species scavenging to synergistically accelerate neurogenesis after spinal cord injury. J Mater Chem B. 2022; 10(33): 6351– 6359. doi: 10.1039/d2tb00841f 35942619 · DOI
  165. [169]Wei X, Zhou W, Tang Z, et al. Magnesium surface-activated 3D printed porous PEEK scaffolds for in vivo osseointegration by promoting angiogenesis and osteogenesis. Bioact Mater. 2023; 20: 16– 28. doi: 10.1016/j.bioactmat.2022.05.011 35633876 PMC9123089 · DOI
  166. [170]Wu HY, Lin YH, Lee AK, Kuo TY, Tsai CH, Shie MY. Combined effects of polydopamine-assisted copper immobilization on 3d-printed porous Ti6Al4V scaffold for angiogenic and osteogenic bone regeneration. Cells. 2022; 11(18): 1. PMC9497129 36139399
  167. [171]Liu G, Xiong Q, Xu Y, et al. Magnetically separable MXene@Fe3O4/Au/PDA nanosheets with photothermal-magnetolytic coupling antibacterial performance. Appl Surf Sci. 2022; 590: 153125. doi: 10.1016/j.apsusc.2022.153125 · DOI
  168. [172]Fang Q, Wang J, Wu S, Leung KC, Xu Y, Xuan S. NIR-induced improvement of catalytic activity and antibacterial performance over AuAg nanorods in Rambutan-like Fe(3)O(4)@AgAu@PDA magnetic nanospheres. J Hazard Mater. 2023; 445: 130616. doi: 10.1016/j.jhazmat.2022.130616 37056020 · DOI
  169. [173]Fang Q, Wang J, Xiong Q, et al. Anisotropic α-Fe2O3/AgAu/Polydopamine nanostructures for photothermally enhanced antibacterial applications. ACS Appl Nano Mater. 2023; 6(7): 6423– 6434. doi: 10.1021/acsanm.3c01068 · DOI

Cited by

Sorted by citations

Authors
Guo, K., Wang, Y., Feng, Z.-X., Lin, X.-Y., Wu, Z.-R., Zhong, X.-C., Zhuang, Z.-M., Zhang, T., Chen, J., & Tan, W.-Q.
Affiliations
  • Sir Run Run Shaw Hospital (CN)
  • Zhejiang University (CN)
Corresponding author
  • Chen, Jian
  • Tan, Wei-Qiang
ORCID
Venue
International Journal of Nanomedicine
Publisher
Informa UK Limited
Published
2024-01
Volume
Volume 19
Pages
859-881
ISSN
  • 1176-9114 (ISSN-L)
  • 1178-2013
DOI
10.2147/ijn.s437854
PMC
PMC10824616
OpenAlex
W4391232781
Cited by
41
References
3
Citations by year
2026: 24 · 2025: 14 · 2024: 3
FWCI
0.97
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Nanomedicine (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Funders
  • National Natural Science Foundation of China (82172206)
  • Zhejiang University
Topics
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
polydopamine, tissue repair, tissue regeneration, biomaterials, mussel-inspired materials, adhesion, photothermal properties, drug loading, tissue damage
MeSH terms
Biocompatible Materials, Humans, Indoles, Polymers, Regeneration, Wound Healing

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review