Interleukin-1–Receptor Antagonist in the Muckle–Wells Syndrome
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To the Editor: Studies of hereditary inflammatory disorders have identified novel genes and pathways that may be involved in inflammation and apoptosis generally. Mutations in one such gene, variou...
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Anakinra, an IL-1 receptor antagonist, is used effectively to treat autoinflammatory syndromes and gout in patients.
“Since Anakinra (IL-1ra) is efficiently used in the clinical treatment of autoinflammatory syndromes (26) as well as gout patients (27), the present study suggests a potential use of Anakinra in order to slow down progression of asbestosis, silicosis and possibly other inflammatory lung diseases.”
From Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica (2008) · cites this paper as [26]
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Gout-associated uric acid crystals activate the NALP3 inflammasome
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Self-citationCaspases in apoptosis and beyond
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- Authors
- Hawkins, P. N., Lachmann, H. J., & McDermott, M. F.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2003-06-19
- Volume
- 348
- Issue
- 25
- Pages
- 2583-2584
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W1996264333
- Cited by
- 654
- References
- 5
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 13 · 2020: 13 · 2019: 15 · 2018: 12 · 2017: 18 · 2016: 15 · 2015: 23 · 2014: 15 · 2013: 31 · 2012: 29
- FWCI
- 31.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- interleukin-1 receptor antagonist, Muckle-Wells syndrome, IL1R1, inflammation, apoptosis, genetic mutations
- MeSH terms
- Amyloidosis, Humans, Male, Nephrotic Syndrome, Recombinant Proteins, Sialoglycoproteins, Syndrome, Receptors, Interleukin-1, Interleukin 1 Receptor Antagonist Protein
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