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Glucocorticoid-induced skeletal muscle atrophy
Abstract
Many pathological states characterized by muscle atrophy (e.g., sepsis, cachexia, starvation, metabolic acidosis and severe insulinopenia) are associated with an increase in circulating glucocorticoids (GC) levels, suggesting that GC could trigger the muscle atrophy observed in these conditions. GC-induced muscle atrophy is characterized by fast-twitch, glycolytic muscles atrophy illustrated by decreased fiber cross-sectional area and reduced myofibrillar protein content. GC-induced muscle atrophy results from increased protein breakdown and decreased protein synthesis. Increased muscle proteolysis, in particular through the activation of the ubiquitin proteasome and the lysosomal systems, is considered to play a major role in the catabolic action of GC. The stimulation by GC of these two proteolytic systems is mediated through the increased expression of several Atrogenes ("genes involved in atrophy"), such as FOXO, Atrogin-1, and MuRF-1. The inhibitory effect of GC on muscle protein synthesis is thought to result mainly from the inhibition of the mTOR/S6 kinase 1 pathway. These changes in muscle protein turnover could be explained by changes in the muscle production of two growth factors, namely Insulin-like Growth Factor (IGF)-I, a muscle anabolic growth factor and Myostatin, a muscle catabolic growth factor. This review will discuss the recent progress made in the understanding of the mechanisms involved in GC-induced muscle atrophy and consider the implications of these advancements in the development of new therapeutic approaches for treating GC-induced myopathy. This article is part of a Directed Issue entitled: Molecular basis of muscle wasting.
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“Although the exact mechanism underlying glucocorticoid-induced skeletal muscle atrophy is unclear, it is considered to be multifactorial and is related to decreased protein synthesis, increased protein degradation, alterations in carbohydrate metabolism, oxidative stress, and/or decreased sarcolemmal excitability [16].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [16]
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Metadata
- Authors
- Schakman, O., Kalista, S., Barbé, C., Loumaye, A., & Thissen, J. P.
- Affiliations
- UCLouvain (BE)
- Corresponding author
- Thissen, J.P.
- Venue
- The International Journal of Biochemistry & Cell Biology
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 45
- Issue
- 10
- Pages
- 2163-2172
- ISSN
- 1357-2725 (ISSN-L)
- OpenAlex
- W2092885411
- Cited by
- 705
- References
- 157
- Citations by year
- 2026: 81 · 2025: 74 · 2024: 58 · 2023: 60 · 2022: 68 · 2021: 62 · 2020: 58 · 2019: 43 · 2018: 44 · 2017: 37 · 2016: 45 · 2015: 48 · 2014: 24 · 2013: 2
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The International Journal of Biochemistry & Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion)
- Funders
- Fund for Scientific Medical Research (Belgium)
- National Fund for Scientific Research (Belgium)
- Association Française contre les Myopathies (France)
- Association Belge contre les Maladies neuro-musculaires
- Fonds Spéciaux de Recherche (Université catholique de Louvain, Belgium)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Keywords
- glucocorticoid-induced muscle atrophy, skeletal muscle atrophy, muscle protein degradation, ubiquitin-proteasome system, lysosomal proteolysis, atrogenes, atrogin-1, MuRF1, FOXO, muscle protein synthesis, insulin-like growth factor I, myostatin, glucocorticoid-induced myopathy, cachexia, sepsis
- MeSH terms
- Animals, Glucocorticoids, Humans, Muscular Atrophy, Protein Biosynthesis, Signal Transduction
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