Effects of Fucoxanthin on the Inhibition of Dexamethasone-Induced Skeletal Muscle Loss in Mice
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Fucoxanthin (Fx) has preventive effect against muscle atrophy and myotube loss in vitro, but it has not yet been examined in vivo. Therefore, we aimed to investigate the effect of Fx on dexamethasone (Dex)-induced muscle atrophy and fat mass in mice. ICR mice were fed with Fx diets from 2 weeks before Dex treatment to the end of the study. Muscle atrophy was induced in the mice by oral administration of Dex. Body weight was significantly lower by Dex treatment. Visceral fat mass in the Fx-treated group were significantly lower than those in the control group. The Dex-induced decrease in tibialis anterior muscle mass was ameliorated by Fx treatment. Fx treatment significantly attenuated muscle lipid peroxidation compared with the control and Dex-treated groups. The phosphorylation of AMPK was significantly higher in the Dex-treated group than in the control group. The expression of cytochrome c oxidase (COX) IV was significantly higher in the Fx-treated group than in the control group. These results suggest that Fx may be a beneficial material to prevent muscle atrophy in vivo, in addition to the effect of fat loss.
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Fucoxanthin increases tibialis anterior muscle and gastrocnemius muscle weight and protects against dexamethasone-induced muscle atrophy through reducing oxidative stress in tibialis anterior muscle in ICR mice.
“Fucoxanthin, a carotenoid produced by Undaria pinnatifida and Phaeodactylum tricornutum, increases tibialis anterior muscle and gastrocnemius muscle weight and protects against dexamethasone-induced muscle atrophy through reducing oxidative stress in tibialis anterior muscle in ICR mice [156].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [156]
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Vignaud, J., Loiseau, C., Hérault, J., Mayer, C., Côme, M., Martin, I., & Ulmann, L. (2023) · Antioxidants · doi:10.3390/antiox12051050 · Cited by 72 · see citing works
Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy
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- Authors
- Yoshikawa, M., Hosokawa, M., Miyashita, K., Nishino, H., & Hashimoto, T.
- Affiliations
- Ritsumeikan University (JP)
- Hokkaido University (JP)
- Kyoto Prefectural University of Medicine (JP)
- Corresponding author
- Hashimoto, Takeshi
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2021-03-26
- Volume
- 13
- Issue
- 4
- Pages
- 1079
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC8066636
- OpenAlex
- W3146471255
- Cited by
- 25
- References
- 38
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 7 · 2023: 3 · 2022: 2 · 2021: 2
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- the Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science, and Technology (18K19762, 26702029)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- fucoxanthin, dexamethasone, muscle atrophy, skeletal muscle atrophy, fat mass, lipid peroxidation, AMPK phosphorylation, tibialis anterior, glucocorticoid-induced muscle wasting, dietary supplementation
- MeSH terms
- Animals, Dexamethasone, Gene Expression Regulation, Male, Mice, Inbred ICR, Muscle Proteins, Muscular Atrophy, Muscle, Skeletal, Xanthophylls, Mice
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