Vitamin D Protects against Immobilization-Induced Muscle Atrophy Via Neural Crest-Derived Cells in Mice
Open accessAbstract
Vitamin D deficiency is a recognized risk factor for sarcopenia development, but mechanisms underlying this outcome are unclear. Here, we show that low vitamin D status worsens immobilization-induced muscle atrophy in mice. Mice globally lacking vitamin D receptor (VDR) exhibited more severe muscle atrophy following limb immobilization than controls. Moreover, immobilization-induced muscle atrophy was worse in neural crest-specific than in skeletal muscle-specific VDR-deficient mice. Tnfα expression was significantly higher in immobilized muscle of VDR-deficient relative to control mice, and was significantly elevated in neural crest-specific but not muscle-specific VDR-deficient mice. Furthermore, muscle atrophy induced by limb immobilization in low vitamin D mice was significantly inhibited in Tnfα-deficient mice. We conclude that vitamin D antagonizes immobilization-induced muscle atrophy via VDR expressed in neural crest-derived cells.
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Oral administration of vitamin D protects against immobilization-induced muscle atrophy in C57BL/6 mice via vitamin D receptor.
“Oral administration of vitamin D protects against immobilization-induced muscle atrophy in C57BL/6 mice via vitamin D receptor [60].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [60]
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- Authors
- Nakamura, S., Sato, Y., Kobayashi, T., Kaneko, Y., Ito, E., Soma, T., Okada, H., Miyamoto, K., Oya, A., Matsumoto, M., Nakamura, M., Kanaji, A., & Miyamoto, T.
- Affiliations
- Keio University (JP)
- The University of Tokyo (JP)
- Corresponding author
- Kanaji, Arihiko
- Miyamoto, Takeshi
- ORCID
- Venue
- Scientific Reports
- Published
- 2020-07-22
- Volume
- 10
- Issue
- 1
- Pages
- 12242-12242
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC7376070
- OpenAlex
- W3045158103
- Cited by
- 44
- References
- 69
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 7 · 2023: 9 · 2022: 4 · 2021: 10 · 2020: 1
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Grant-in-aid for Scientific Research in Japan
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- vitamin D, vitamin D receptor, muscle atrophy, immobilization, sarcopenia, neural crest-derived cells, TNF-α, skeletal muscle, vitamin D deficiency
- MeSH terms
- Animals, Female, Mice, Inbred C57BL, Muscular Atrophy, Neural Crest, Vitamin D, Vitamin D Deficiency, Receptors, Calcitriol, Mice, Knockout, Muscle, Skeletal, Mice, Sarcopenia
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