The dsRNA protein kinase PKR: Virus and cell control

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Mutations in the Nonstructural Protein 5a Gene and Response to Interferon in Patients with Chronic Hepatitis C Virus 1b Infection

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Downregulation of protein kinase PKR activation by porcine reproductive and respiratory syndrome virus at its early stage infection

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The Interplay Between Therapeutic Self-Amplifying RNA and the Innate Immune System: Balancing Efficiency and Reactogenicity

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Targeting the integrated stress response in ophthalmology

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Regulation of PKR activation and apoptosis during oxidative stress by TRBP phosphorylation

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Transcriptional Control of Metastasis by Integrated Stress Response Signaling

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Next Generation Therapeutic Strategy for Treatment and Prevention of Alzheimer’s Disease and Aging-Associated Cognitive Decline: Transient, Once-in-a-Lifetime-Only Depletion of Intraneuronal Aβ (iAβ) by Its Targeted Degradation via Augmentation of Intra-iAβ-Cleaving Activities of BACE1 and/or BACE2

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Recent developments in sustained-release and targeted drug delivery applications of solid lipid nanoparticles

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Elevated levels of IL-6 in IgA nephropathy patients are induced by an epigenetically driven mechanism modulated by viral and bacterial RNA

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Analysis of the Differential Host Cell Nuclear Proteome Induced by Attenuated and Virulent Hemorrhagic Arenavirus Infection

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A potential robust antiviral defense state in the common vampire bat: Expression, induction and molecular characterization of the three interferon-stimulated genes -OAS1, ADAR1 and PKR

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Testing automatic methods to predict free binding energy of host–guest complexes in SAMPL7 challenge

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Computational search of hybrid human/SARS-CoV-2 dsRNA reveals unique viral sequences that diverge from those of other coronavirus strains

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Gene expression profiles predicting the response to IFN-β and a combination of temozolomide and IFN-β in malignant gliomas

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Coronavirus S protein alters dsRNA accumulation and stress granule formation through regulation of ADAR1-p150 expression

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Mammalian orthoreovirus Infection is Enhanced in Cells Pre-Treated with Sodium Arsenite

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Murine Norovirus Infection Results in Anti-inflammatory Response Downstream of Amino Acid Depletion in Macrophages

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Luteolin protects DYT-PRKRA cells from apoptosis by suppressing PKR activation

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Grouper PKR activation inhibits red-spotted grouper nervous necrosis virus (RGNNV) replication in infected cells

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Ebola Virus VP35 Protein: Modeling of the Tetrameric Structure and an Analysis of Its Interaction with Human PKR

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Chapter 3 Virus Versus Host Cell Translation

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Dicer and PKR as Novel Regulators of Embryonic Stem Cell Fate and Antiviral Innate Immunity

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Viral Hemorrhagic Septicemia Virus Activates Integrated Stress Response Pathway and Induces Stress Granules to Regulate Virus Replication

Ramnani, B., Powell, S., Shetty, A. G., Manivannan, P., Hibbard, B. R., Leaman, D. W., & Malathi, K. (2023) · Viruses · doi:10.3390/v15020466 · Cited by 10

Principles of Design of Clinical Trials for Prevention and Treatment of Alzheimer’s Disease and Aging-Associated Cognitive Decline in the ACH2.0 Perspective: Potential Outcomes, Challenges, and Solutions

Volloch, V., & Rits‐Volloch, S. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-230037 · Cited by 11

Proteome analysis of vaccinia virus IHD-W-infected HEK 293 cells with 2-dimensional gel electrophoresis and MALDI-PSD-TOF MS of on solid phase support N-terminally sulfonated peptides

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Ctenopharyngodon idella IKK&bgr; interacts with PKR and I&kgr;B&agr;

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Grass carp ( Ctenopharyngodon idella ) STAT3 regulates the eIF2α phosphorylation through interaction with PKR

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Regulation of Protein Kinase R by Epstein-Barr Virus EBER1 RNA

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GCN2-Like Kinase Modulates Stress Granule Formation During Nutritional Stress in Trypanosoma cruzi

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Grass carp (Ctenopharyngodon idella) PACT induces cell apoptosis and activates NF-кB via PKR

Hu, Z., Du, H., Lin, G., Han, K. S., Cheng, X., Feng, Z., Mao, H., & Hu, C. (2020) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2020.05.036 · Cited by 10

Mammalian reovirus µ1 protein attenuates RIG-I and MDA5-mediated signaling transduction by blocking IRF3 phosphorylation and nuclear translocation

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RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer

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Porcine circovirus type 2 exploits cap to inhibit PKR activation through interaction with Hsp40

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Cytoplasmic proteotoxicity regulates HRI-dependent phosphorylation of eIF2α via the Hsp70-Bag3 module

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ATF4 Signaling in HIV-1 Infection: Viral Subversion of a Stress Response Transcription Factor

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Use of IFN-Based Biotherapeutics to Harness the Host Against Foot-And-Mouth Disease

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News from Mars: Two-Tier Paradox, Intracellular PCR, Chimeric Junction Shift, Dark Matter mRNA and Other Remarkable Features of Mammalian RNA-Dependent mRNA Amplification. Implications for Alzheimer’s Disease, RNA-Based Vaccines and mRNA Therapeutics

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Diverse aberrancies target yeast mRNAs to cytoplasmic mRNA surveillance pathways

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PKR plays a positive role in osteoblast differentiation by regulating GSK-3β activity through a β-catenin-independent pathway

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Evolution of eIF2α Kinases: Adapting Translational Control to Diverse Stresses

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Ebolavirus interferon antagonists—protein interaction perspectives to combat pathogenesis

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Ctenopharyngodon idella p53 mediates between NF-κB and PKR at the transcriptional level

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Omics Analyses Uncover Host Networks Defining Virus-Permissive and -Hostile Cellular States

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Novel Molecular Basis for Synapse Formation: Small Non-coding Vault RNA Functions as a Riboregulator of MEK1 to Modulate Synaptogenesis

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Longitudinal global transcriptomic profiling of preclinical systemic sclerosis reveals molecular changes associated with disease progression

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On the Inadequacy of the Current Transgenic Animal Models of Alzheimer’s Disease: The Path Forward

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Strategic deactivation of mRNA COVID‐19 vaccines: New applications for siRNA therapy and RIBOTACs

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Flaviviral Regulation of the Unfolded Protein Response: Can Stress be Beneficial?

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Species‐specific inhibition of capripoxvirus replication by host antiviral protein kinase R

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Proteolytic Activities of Enterovirus 2A Do Not Depend on Its Interaction with SETD3

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Susceptibility and Permissivity of Zebrafish (Danio rerio) Larvae to Cypriniviruses

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Inhibition of protein deacetylation augments herpes simplex virus type 1-activated transcription of host fucosyltransferase genes associated with virus-induced sLex expression

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The Regulatory and Kinase Domains but Not the Interdomain Linker Determine Human Double-stranded RNA-activated Kinase (PKR) Sensitivity to Inhibition by Viral Non-coding RNAs

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Accumulation of RNA-dependent protein kinase (PKR) in the nuclei of lung cancer cells mediates radiation resistance

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Rhabdoviruses, Antiviral Defense, and SUMO Pathway

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Structural study of novel vaccinia virus E3L and dsRNA-dependent protein kinase complex

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Genetic Signatures of Acute Asthma Exacerbation Related With Ineffective Response to Corticosteroid

Kang, M., Lee, H. S., Tantisira, K. G., & Park, H. (2020) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2020.12.4.626 · Cited by 7

Combining supervised machine learning with statistics reveals differential gene expression patterns related to energy metabolism in the jejuna of chickens divergently selected for antibody response to sheep red blood cells

Nolin, S. J., Taylor, R. L., Edens, F. W., Siegel, P. B., & Ashwell, C. M. (2023) · Poultry Science · doi:10.1016/j.psj.2023.102751 · Cited by 7

Sleep-wake behavior and responses to sleep deprivation and immune challenge of protein kinase RNA-activated knockout mice

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SIRT1 Suppresses Activating Transcription Factor 4 (ATF4) Expression in Response to Proteasome Inhibition

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Experimental evolution of an RNA virus in cells with innate immunity defects

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Molecular barcoding of viral vectors enables mapping and optimization of mRNAtrans-splicing

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Antisense transcription from lentiviral gene targeting linked to an integrated stress response in colorectal cancer cells

Ha, T., DiPrima, M., Kopardé, V. N., Jailwala, P., Ohnuki, H., Feng, J., Palangat, M., Larson, D. R., & Tosato, G. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.05.029 · Cited by 6

The Raf kinase inhibitors Dabrafenib and Regorafenib impair Zika virus replication via distinct mechanisms

Wilken, L., Rimmelzwaan, G. F., & Elbahesh, H. (2024) · Journal of Virology · doi:10.1128/jvi.00618-24 · Cited by 6

Mutation in Prkra results in cerebellar abnormality and reduced eIF2α phosphorylation in a model of DYT-PRKRA

Burnett, S. B., Culver, A. M., Simon, T. A., Rowson, T., Frederick, K., Palmer, K. J., Murray, S. A., Davis, S. W., & Patel, R. C. (2024) · Disease Models & Mechanisms · doi:10.1242/dmm.050929 · Cited by 6

PKR modulates sterile systemic inflammation-triggered neuroinflammation and brain glucose metabolism disturbances

Cheng, W., Lee, X.-Z., Lai, M. S., Ho, J. Y. S., & Chang, R. C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1469737 · Cited by 7

Alzheimer’s Disease is Driven by Beta-Amyloid Generated in the Amyloid Precursor Protein-Independent Pathway and Retained Intraneuronally: Research and Therapeutic Strategies in a New AD Paradigm

Volloch, V., & Rits‐Volloch, S. (2019) · Annals of Integrative Molecular Medicine · doi:10.33597/aimm.-v2-id1010 · Cited by 6

Prolonged Primary Rhinovirus Infection of Human Nasal Epithelial Cells Diminishes the Viral Load of Secondary Influenza H3N2 Infection via the Antiviral State Mediated by RIG-I and Interferon-Stimulated Genes

Ong, H. H., Liu, J., Oo, Y., Thong, M. K. T., Wang, D. Y., & Chow, V. T. K. (2023) · Cells · doi:10.3390/cells12081152 · Cited by 6

HSV-1 Triggers an Antiviral Transcriptional Response during Viral Replication That Is Completely Abrogated in PKR−/− Cells

Pennisi, R., & Sciortino, M. T. (2023) · Pathogens · doi:10.3390/pathogens12091126 · Cited by 6

Human Betacoronavirus OC43 Interferes with the Integrated Stress Response Pathway in Infected Cells

Dolliver, S. M., Galbraith, C., & Khaperskyy, D. A. (2024) · Viruses · doi:10.3390/v16020212 · Cited by 6

Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling

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Vanishing White Matter Disease

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Transcriptome analysis of host response to porcine epidemic diarrhea virus nsp15 in IPEC-J2 cells

Ouyang, T., Yang, Z., Wan, J., Zhang, Y., Wang, X., Kong, L., Wang, T., & Li, Y. (2021) · Microbial Pathogenesis · doi:10.1016/j.micpath.2021.105195 · Cited by 6

The protective mechanism of protein kinase R to inhibit neuronal ferroptosis in cerebral injury from subarachnoid hemorrhage

Lei, J., Song, S., Chen, Z., Shu, S., Liu, Q., & Hu, W. (2022) · Brain and Behavior · doi:10.1002/brb3.2722 · Cited by 6

Synthesis and in vitro assessment of chemically modified siRNAs targeting BCL2 that contain 2′-ribose and triazole-linked backbone modifications

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Monitoring integrated stress response in live DrosophilaPreprint

Lidsky, P. V., Yuan, J. T., Lashkevich, K. A., Dmitriev, S. E., & Andino, R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.13.548942 · Cited by 6

Triclosan administration to humanized UDP-glucuronosyltransferase 1 neonatal mice induces UGT1A1 through a dependence on PPARα and ATF4

Weber, A. A., Yang, X., Mennillo, E., Wong, S., Le, S., Teo, J. Y. A., Chang, M. W., Benner, C. W., Ding, J., Jain, M., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107340 · Cited by 5

Origin and function of anti-interferon type I viral proteins

Acchioni, M., Acchioni, C., Hiscott, J. B., & Sgarbanti, M. (2025) · Virology · doi:10.1016/j.virol.2025.110456 · Cited by 6

Deciphering the multifaceted role of double-stranded RNA sensor protein kinase R: pathophysiological function beyond the antiviral response

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PKR-driven ISR signaling controls synaptic translation and structural plasticity in an age-dependent manner

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Activation of PKR by a short-hairpin RNA

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Residues required for phosphorylation of translation initiation factor eIF2α under diverse stress conditions are divergent between yeast and human

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Vanishing white matter disease

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A Potential Role for c-MYC in the Regulation of Meibocyte Cell Stress

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The integrated stress response suppresses antiviral RNA interference by autophagy-mediated degradation of the RNA-induced silencing complex

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The role of gasdermin-mediated mitochondrial RNA release in amplifying secondary immune response during microbial infection

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Hypermethylation of nc886 in HPV-positive oropharyngeal cancer and its clinical implications: An epigenome-wide association study

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Crystal structures reveal a novel dimer of the RWD domain of human general control nonderepressible 2

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DYT-PRKRA Mutation P222L Enhances PACT’s Stimulatory Activity on Type I Interferon Induction

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Expression, purification, and in vitro characterization of kinase domain of NtGCN2 from tobacco

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Moderne Konzepte der Nanobiotechnologie für mRNA‐Abgabesysteme

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Stimulators of translation identified during a small molecule screening campaign

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DAF-16/Foxo suppresses the transgenerational sterility of prg-1 piRNA mutants via a systemic small RNA pathwayPreprint

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Nucleic acid nanomaterials: Mechanisms and strategies for regulating innate immune activation

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The dsRNA-dependent protein kinase, PKR and cell death

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Impact of Protein Kinase PKR in Cell Biology: from Antiviral to Antiproliferative Action

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