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Cited by 7Thyroid Disorders and TreatmentsEffects of Radiation ExposureRadioactive contamination and transfer

A systems biology approach to propose a new mechanism of regulation of repetitive prophylaxis of stable iodide on sodium/iodide symporter (NIS)

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Cohen, David P.A., Lebsir, Dalila, Benderitter, Marc, Souidi, Maâmar·2019·Biochimie
DOI 10.1016/j.biochi.2019.04.024
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Abstract

Our group showed that repetitive dose of potassium iodide (KI) for eight days offers an efficient protection for exposure to repeated radioactive emissions without adverse effects on adult rats. However, differential expression of genes implicated in Wolff-Chaikoff effect was observed. To understand the Wolff-Chaikoff regulation and its molecular constituents during repetitive administration of KI, a biochemical reaction network was constructed as a "geographical" map of the thyrocyte depicting iodide and thyroid hormone synthesis. Path analysis of the network has been performed to investigate the presence of a regulatory circuit of the node iodide to the node "nis transcription". NIS is responsible for the uptake of KI and plays an important role in the Wolff-Chaikoff effect. The map is a source for the most updated information about iodide and thyroid hormone metabolism. Based on this map, we propose a hypothesis that shows a putative mechanism behind NIS regulation and KI uptake.

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  • Cohen et al. used a bioinformatic approach to map out a regulatory network underpinning the Wolff-Chaikoff phenomena, with the goal of predicting the protective effect of repetitive dosing of iodide as a prophylactic measure.

    “More recently, Cohen et al. has used a bioinformatic approach to map out a regulatory network underpinning the Wolff-Chaikoff phenomena, with the goal of predicting the protective effect of repetitive dosing of iodide as a prophylactic measure (277).”

    From Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion (2022) · cites this paper as [277]

    The Abstract and Materials and methods describe a systems-biology network used to investigate Wolff–Chaikoff regulation during repetitive potassium iodide administration. But the paper states its aim was to explain observed gene-expression changes and propose a mechanism of NIS regulation, not to predict the protective effect of repeated prophylactic dosing. Page numbers are unavailable in our copy. (LLM, conf=0.87)

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Cited by

Sorted by citations

Authors
Cohen, D. P. A., Lebsir, D., Benderitter, M., & Souidi, M.
Affiliations
Institut de Radioprotection et de Sûreté Nucléaire (FR)
Corresponding author
Souidi, Maâmar
ORCID
Venue
Biochimie
Publisher
Elsevier BV
Published
2019-07
Volume
162
Pages
208-215
ISSN
  • 0037-9042 (ISSN-L)
  • 0300-9084
DOI
10.1016/j.biochi.2019.04.024
OpenAlex
W2944032530
Cited by
7
References
1
Citations by year
2024: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2018: 1
FWCI
0.66
Type
journal article
Language
en
Open access
Licence
Locations
  • Biochimie (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by-nc)
Funders
ANR-RSNR (ANR-11-RSNR-0019-01)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
  • Physical Sciences › Environmental Science › Global and Planetary Change › Radioactive contamination and transfer
Keywords
sodium iodide symporter, potassium iodide, Wolff-Chaikoff effect, iodide uptake, thyroid hormone synthesis, iodide metabolism, gene regulatory networks, path analysis, radioiodine exposure
MeSH terms
Thyroid Epithelial Cells, Sodium-Iodide Symporters, Animals, Biological Transport, Potassium Iodide, Radiation Injuries, Thyroid Gland, Thyroid Hormones, Symporters, Systems Biology, Rats

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