Improved hemocompatibility of poly(ethylene terephthalate) modified with various thiol-containing groups
Abstract
Thiol groups were attached to polyethylene terephthalate (PET) to promote the transfer of a known platelet inhibitor, nitric oxide (NO), from nitrosated thiols naturally found in the body to PET, followed by the release of NO from PET to prevent platelet adhesion. In order to immobilize the most thiols on the modified polymer, the processing parameters used to attach the following three thiol containing groups were assessed: L-cysteine, 2-iminothiolane, and a cysteine polypeptide. When comparing the immobilized concentrations of thiol groups from each of the optimized processes the amount of immobilized thiol groups increased in order with the following groups: cysteine polypeptide <2-iminothiolane <L-cysteine. The effect of each optimized polymer on platelet adhesion was studied by in vitro experiments utilizing a parallel plate perfusion chamber. Platelets in the following solutions were tested: Tyrode's buffer, 7 microm nitrosated bovine serum albumin in Tyrode's buffer, 50% plasma in Tyrode's buffer, and 50% whole blood in Tyrode's buffer. All of the polymers demonstrated a significant decrease in platelet adhesion compared to controls when exposed to the BSANO, plasma and whole blood solutions. The most significant decrease was for the L-cysteine modified polymer in the plasma solution with a 65% decrease.
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Catalysis-based NO generating polymers generate NO from endogenous RSNOs or infused RSNO solutions through thiol transnitrosations and subsequent catalytic reactions using immobilized copper or selenium species.
“Instead of incorporating NO donors or NO functionalities into polymers, many efforts have been devoted to generate NO from endogenous RNSOs or infusion of RSNO solutions through thiol transnitrosations,160,253 and subsequent catalytic reactions using immobilized copper or selenium-based species”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [253]
Cites
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064 · see citing works
Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin.
Stamler, J. S., Jaraki, O., Osborne, J., Simon, D. I., Keaney, J., Vita, J., Singel, D., Valeri, C. R., & Loscalzo, J. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7674 · Cited by 1,238 · see citing works
Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1987) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1987.tb11310.x · Cited by 813 · see citing works
The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium
Radomski, M. W., Palmer, R. M. J., & Moncada, S. (1987) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(87)80299-1 · Cited by 746 · see citing works
Endothelium‐dependent inhibition of platelet aggregation
Azuma, H., Ishikawa, M., & Sekizaki, S. (1986) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1986.tb10218.x · Cited by 532 · see citing works
[26] Oxidative reactions of hemoglobin
Winterbourn, C. C. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86118-f · Cited by 411 · see citing works
Scharfstein, J., Keaney, J. F., Slivka, A., Welch, G. N., Vita, J. A., Stamler, J. S., & Loscalzo, J. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117480 · Cited by 288 · see citing works
Biological chemistry and clinical potential of S-nitrosothiols
Hogg, N. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00248-3 · Cited by 272 · see citing works
Biological responses to polyethylene oxide modified polyethylene terephthalate surfaces
Desai, N. P., & Hubbell, J. A. (1991) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820250704 · Cited by 257 · see citing works
Meyer, D. J., Kramer, H., Özer, N., Coles, B., & KETTERER, B. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00429-3 · Cited by 156 · see citing works
Mechanism of S-Nitrosothiol Formation and Degradation Mediated by Copper Ions
Stubauer, G., Giuffrè, A., & Sarti, P. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28128 · Cited by 147 · see citing works
Formation of nanomolar concentrations of S-nitroso-albumin in human plasma by nitric oxide
Marley, R., Patel, R. P., Orie, N. N., CEASER, E. K., Darley-Usmar, V. M., & Moore, K. P. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00627-x · Cited by 104 · see citing works
Role of a copper (I)‐dependent enzyme in the anti‐platelet action of S‐nitrosoglutathione
Gordge, M. P., Hothersall, J. S., Neild, G. H., & Noronha-Dutra, A. A. (1996) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1996.tb15704.x · Cited by 91 · see citing works
S-Nitrosothiols and role of metal ions in decomposition to nitric oxide
Williams, D. L. H. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)68032-x · Cited by 88 · see citing works
Improved haemocompatibility of cysteine-modified polymers via endogenous nitric oxide
Duan, X., & Lewis, R. S. (2002) · Biomaterials · doi:10.1016/s0142-9612(01)00234-4 · Cited by 75 · see citing works
Self-citationEffects of Cyclic Nucleotides and Protein Kinases on Platelet Calcium Homeostasis and Mobilization
Haynes, D. H. (1993) · Platelets · doi:10.3109/09537109309013223 · Cited by 45 · see citing works
Design of a Novel Apparatus to Study Nitric Oxide (NO) Inhibition of Platelet Adhesion
Ramamurthi, A., & Lewis, R. S. (1998) · Annals of Biomedical Engineering · doi:10.1114/1.34 · Cited by 20 · see citing works
Self-citationAnalysis of immobilized L ‐cysteine on polymers
Gappa‐Fahlenkamp, H., Duan, X., & Lewis, R. S. (2004) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30180 · Cited by 10 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Wo, Y., Brisbois, E. J., Bartlett, R. H., & Meyerhoff, M. E. (2016) · Biomaterials Science · doi:10.1039/c6bm00271d · Cited by 251 · see citing works
Nitric Oxide Donors for Cardiovascular Implant Applications
Naghavi, N., de Mel, A., Alavijeh, O. S., Cousins, B. G., & Seifalian, A. M. (2013) · Small · doi:10.1002/smll.201200458 · Cited by 188 · see citing works
A platform for nitric oxide delivery
Kim, J., Saravanakumar, G., Choi, H. W., Park, D., & Kim, W. J. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb21259a · Cited by 167 · see citing works
Control of Blood Coagulation by Hemocompatible Material Surfaces—A Review
Kuchinka, J., Willems, C., Telyshev, D. V., & Groth, T. (2021) · Bioengineering · doi:10.3390/bioengineering8120215 · Cited by 127 · see citing works
Nitric oxide based strategies for applications of biomedical devices
Yang, Y., Qi, P., Yang, Z., & Huang, N. (2015) · Biosurface and Biotribology · doi:10.1016/j.bsbt.2015.08.003 · Cited by 85 · see citing works
Hwang, S., & Meyerhoff, M. E. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.02.004 · Cited by 82 · see citing works
Basic Science Review: Nitric Oxide—Releasing Prosthetic Materials
Varu, V. N., Tsihlis, N. D., & Kibbe, M. R. (2008) · Vascular and Endovascular Surgery · doi:10.1177/1538574408322752 · Cited by 58 · see citing works
Platelet adhesion to human umbilical vein endothelial cells cultured on anionic hydrogel scaffolds
Chen, Y. M., Tanaka, M., Gong, J. P., Yasuda, K., Yamamoto, S., Shimomura, M., & Osada, Y. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.12.005 · Cited by 52 · see citing works
The Use of Antithrombotic Therapies in Reducing Synthetic Small-Diameter Vascular Graft Thrombosis
Tatterton, M., Wilshaw, S., Ingham, E., & Homer‐Vanniasinkam, S. (2012) · Vascular and Endovascular Surgery · doi:10.1177/1538574411433299 · Cited by 50 · see citing works
Pawlak, M., Grygołowicz‐Pawlak, E., Crespo, G. A., Mistlberger, G., & Bakker, E. (2013) · Electroanalysis · doi:10.1002/elan.201300212 · Cited by 45 · see citing works
Coatings for biomaterials to improve hemocompatibility
Fischer, M., Maitz, M. F., & Werner, C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-100497-5.00007-0 · Cited by 45 · see citing works
Effect of thiol functionalization on the hemo‐compatibility of PLGA nanoparticles
Thasneem, Y. M., Sajeesh, S., & Sharma, C. P. (2011) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.33220 · Cited by 42 · see citing works
Liu, Y., Li, C. M., Hu, W., & LU, Z. (2008) · Talanta · doi:10.1016/j.talanta.2008.08.024 · Cited by 38 · see citing works
Liu, Y., Yang, Y., & Wu, F. (2010) · Applied Surface Science · doi:10.1016/j.apsusc.2010.01.060 · Cited by 38 · see citing works
Sastri, V. R. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-3201-2.00007-0 · Cited by 35 · see citing works
Strategies for surface coatings of implantable cardiac medical devices
Coronel-Meneses, D., Sánchez‐Trasviña, C., Ratera, I., & Mayolo‐Deloisa, K. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1173260 · Cited by 32 · see citing works
Analysis of functionalized polyethylene terephthalate with immobilized NTPDase and cysteine
Muthuvijayan, V., Gu, J. J., & Lewis, R. S. (2009) · Acta Biomaterialia · doi:10.1016/j.actbio.2009.05.020 · Cited by 29 · see citing works
Self-citationWan, X., Liu, P., Jin, X., Xin, X., Li, P., Yuan, J., & Shen, J. (2018) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.36521 · Cited by 28 · see citing works
Li, X., Shen, F., Wang, K., Lin, S., Zhou, L., Chen, S., Wang, J., & Huang, N. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb01976b · Cited by 27 · see citing works
Recent Advances in Hemocompatible Polymers for Biomedical Applications
Brisbois, E. J., Handa, H., & Meyerhoff, M. E. (2014) · Springer eBooks · doi:10.1007/978-3-319-12478-0_16 · Cited by 27 · see citing works
Hao, N., Wang, Y., Zhang, S., Shi, S., Nakashima, K., & Gong, Y. (2013) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34967 · Cited by 26 · see citing works
Improved blood compatibility of poly(ethylene terephthalate) films modified with L-arginine
Liu, Y., Chen, J., Yang, Y., & Wu, F. (2008) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856208783719545 · Cited by 26 · see citing works
Impact of RGD micro-patterns on cell adhesion
Chollet, C., Lazare, S., Guillemot, F., & Durrieu, M. (2009) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2009.08.024 · Cited by 26 · see citing works
Wang, Q., Akhavan, B., Jing, F., Cheng, D., Sun, H. L., Xie, D., Leng, Y. X., Bilek, M., & Huang, N. (2018) · Advanced Materials Interfaces · doi:10.1002/admi.201701487 · Cited by 24 · see citing works
Nitric Oxide as a Surgical Adjuvant
Krausz, A. E., & Friedman, A. (2015) · Future Science OA · doi:10.4155/fso.15.56 · Cited by 23 · see citing works
Zhou, Y., Weng, Y., Zhang, L., Jing, F., Huang, N., & Chen, J. (2011) · Applied Surface Science · doi:10.1016/j.apsusc.2011.10.043 · Cited by 20 · see citing works
Thiol-Containing Degradable Poly(thiourethane-urethane)s for Tissue Engineering
Eglin, D., Griffon, S., & Alini, M. (2010) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856209x424404 · Cited by 20 · see citing works
Effect of pH and Metal Ions on the Decomposition Rate of S-nitrosocysteine
Gu, J. J., & Lewis, R. S. (2007) · Annals of Biomedical Engineering · doi:10.1007/s10439-007-9327-5 · Cited by 20 · see citing works
Self-citationNitric Oxide: What a Vascular Surgeon Needs to Know
Popowich, D. A., Varu, V. N., & Kibbe, M. R. (2007) · Vascular · doi:10.2310/6670.2007.00051 · Cited by 19 · see citing works
Liu, Y., Pang, Y., Toh, M. R., & Chiu, G. N. C. (2015) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12457 · Cited by 16 · see citing works
Mendoza‐Novelo, B., & Valerio, J. C. (2011) · InTech eBooks · doi:10.5772/25184 · Cited by 15 · see citing works
Wu, S., Yang, X., Li, W., Du, L., Zeng, R., & Tu, M. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.11.003 · Cited by 15 · see citing works
Sastri, V. R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85126-8.00011-4 · Cited by 16 · see citing works
Salvagnini, C., Gharbi, S., Boxus, T., & Marchand‐Brynaert, J. (2006) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2006.07.010 · Cited by 14 · see citing works
Characterization of thin films for biomedical applications
Murthy, N. S., Damodaran, V. B., Lee, S. H., Hwang, A. S., & Sung, H. (2016) · Elsevier eBooks · doi:10.1016/b978-1-78242-453-6.00005-5 · Cited by 13 · see citing works
Alidadykhah, M., Peyman, H., Roshanfekr, H., Azizi, S., & Mâaza, M. (2022) · ACS Omega · doi:10.1021/acsomega.1c07082 · Cited by 13 · see citing works
Xue, L., Liang, Q., & Lu, Y. (2013) · Journal of Materials Science Materials in Electronics · doi:10.1007/s10854-013-1081-x · Cited by 13 · see citing works
Sorragi, C. D. L., Shishido, S. M., Lemos, M. E., Marcondes, S., Antunes, E., & Krieger, M. H. (2011) · Cell Biochemistry and Function · doi:10.1002/cbf.1738 · Cited by 13 · see citing works
Polycarbonateurethane films containing complex of copper(II) catalyzed generation of nitric oxide
Zhao, H., Feng, Y., & Guo, J. (2011) · Journal of Applied Polymer Science · doi:10.1002/app.34056 · Cited by 11 · see citing works
Yang, Y., Li, Y., Li, X., Qi, P., Tu, Q., Yang, Z., & Huang, N. (2015) · Biointerphases · doi:10.1116/1.4932195 · Cited by 10 · see citing works
Alibeik, S., & Sask, K. N. (2019) · Polymers and polymeric composites · doi:10.1007/978-3-319-95990-0_3 · Cited by 7 · see citing works
Immobilization of L-Cysteine onto Poly(ethylene glycol) Polymerized by Surface-Wave Plasma
Shao, Z., Ogino, A., & Nagatsu, M. (2011) · Japanese Journal of Applied Physics · doi:10.1143/jjap.50.08jf03 · Cited by 5 · see citing works
Shao, Z., Ogino, A., & Nagatsu, M. (2012) · Applied Physics Express · doi:10.1143/apex.5.046201 · Cited by 4 · see citing works
Novel cinnamic acid-based PET derivatives as quorum sensing modulators
Bogojević, S. Š., Perminova, D., Jakšić, J., Milčić, M. K., Medaković, V. B., Milovanović, J., Runic, J. N., & Maslak, V. (2023) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2023.137291 · Cited by 3 · see citing works
Shao, Z., Ogino, A., & Nagatsu, M. (2010) · Journal of Photopolymer Science and Technology · doi:10.2494/photopolymer.23.561 · Cited by 3 · see citing works
Li, W., Shi, G., & Lu, Y. (2014) · International Journal of Materials Research (formerly Zeitschrift fuer Metallkunde) · doi:10.3139/146.111081 · Cited by 3 · see citing works
Wang, K., Cui, W., Wei, Y., Zhu, M., Zhao, Q., & Kong, D. (2016) · Springer eBooks · doi:10.1007/978-981-10-2293-7_11 · Cited by 3 · see citing works
Alibeik, S., & Sask, K. N. (2018) · Polymers and polymeric composites · doi:10.1007/978-3-319-92066-5_3-1 · Cited by 1 · see citing works
Nitric Oxide Generating Polymers (NOGPs).
Hwang, S. (2007) · Deep Blue (University of Michigan)
Swaminathan, N. (2010) · TigerPrints (Clemson University)
Muthuvijayan, V. (2009) · SHAREOK (University of Oklahoma; Oklahoma State University; Central Oklahoma University)
ANALYSIS OF NITRIC OXIDE TRANSFER AND RELEASE RATE FOR A CYSTEINE MODIFIED POLYMER
Gu, J. J. (2009) · SHAREOK (University of Oklahoma; Oklahoma State University; Central Oklahoma University) · doi:10.13140/2.1.5108.8320
Shao, Z., Ogino, A., & Nagatsu, M. (2017) · International Journal of Modern Physics B · doi:10.1142/s0217979217440933
- Authors
- Gappa-Fahlenkamp, H., & Lewis, R. S.
- Affiliations
- Oklahoma State University (US)
- Corresponding author
- Lewis, Randy S.
- ORCID
- Lewis, Randy S.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 26
- Issue
- 17
- Pages
- 3479-3485
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2057764953
- Cited by
- 53
- References
- 18
- Citations by year
- 2023: 2 · 2022: 2 · 2021: 1 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 5 · 2012: 3
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Physical Sciences › Engineering › Building and Construction › Dyeing and Modifying Textile Fibers
- Keywords
- polyethylene terephthalate, hemocompatibility, nitric oxide release, platelet adhesion, cysteine, 2-iminothiolane, surface modification
- MeSH terms
- Blood, Blood Platelets, Cells, Cultured, Cysteine, Humans, Materials Testing, Nitric Oxide, Platelet Adhesiveness, Polyethylene Terephthalates, Sulfhydryl Compounds, Coated Materials, Biocompatible
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