Cited by 188Nitric Oxide and Endothelin EffectsTissue Engineering and Regenerative MedicinePolymer Surface Interaction Studies

Nitric Oxide Donors for Cardiovascular Implant Applications

Naghavi, Noora, de Mel, Achala, Alavijeh, Omid Sadeghi, Cousins, Brian G., Seifalian, Alexander M.·2013·Small

Abstract

In an era of increased cardiovascular disease burden in the ageing population, there is great demand for devices that come in to contact with the blood such as heart valves, stents, and bypass grafts that offer life saving treatments. Nitric oxide (NO) elution from healthy endothelial tissue that lines the vessels maintains haemostasis throughout the vasculature. Surgical devices that release NO are desirable treatment options and N ‐diazeniumdiolates and S ‐nitrosothiols are recognized as preferred donor molecules. There is a keen interest to investigate newer methods by which NO donors can be retained within biomaterials so that their release and kinetic profiles can be optimized. A range of polymeric scaffolds incorporating microparticles and nanomaterials are presenting solutions to current challenges, and have been investigated in a range of clinical applications. This review outlines the application of NO donors for cardiovascular therapy using biomaterials that release NO locally to prevent thrombosis and intimal hyperplasia (IH) and enhance endothelialization in the fabrication of next generation cardiovascular device technology.

Integrity signals

Registry

Crossref · 10.1002/smll.201200458

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119 of 119 references verified0 citation errors · 0 not checkable

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Authors
Naghavi, N., de Mel, A., Alavijeh, O. S., Cousins, B. G., & Seifalian, A. M.
Affiliations
  • University College London (GB)
  • Royal Free London NHS Foundation Trust (GB)
Corresponding author
Seifalian, Alexander M.
Venue
Small
Publisher
Wiley
Published
2012-11-08
Volume
9
Issue
1
Pages
22-35
ISSN
  • 1613-6810 (ISSN-L)
  • 1613-6829
OpenAlex
W2025725319
Cited by
188
References
120
Citations by year
2026: 7 · 2025: 16 · 2024: 12 · 2023: 14 · 2022: 18 · 2021: 14 · 2020: 19 · 2019: 16 · 2018: 20 · 2017: 11 · 2016: 11 · 2015: 13 · 2014: 10 · 2013: 7
FWCI
1.03
Type
journal article
Language
en
Open access
closed
Locations
  • Small (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
Keywords
nitric oxide donors, cardiovascular implants, N-diazeniumdiolates, S-nitrosothiols, biomaterials, polymer scaffolds, microparticles, nanomaterials, thromboprophylaxis, intimal hyperplasia, endothelialization, drug-eluting devices, heart valves, stents, bypass grafts, NO release kinetics
MeSH terms
Biocompatible Materials, Cardiology, Cardiovascular Diseases, Endothelium, Vascular, Gold, Humans, Kinetics, Nitric Oxide, Platinum, Polymers, Silicon Dioxide, Silver, Stents, Prostheses and Implants, Nitric Oxide Donors, Hydrogels, S-Nitrosothiols, Nanotechnology, Nanostructures, Metal Nanoparticles

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