Cited by 746Platelet Disorders and TreatmentsNitric Oxide and Endothelin EffectsCell Adhesion Molecules Research

The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium

Radomski, Marek W., Palmer, Richard M.J., Moncada, Salvador·1987·Biochemical and Biophysical Research Communications

Abstract

The inhibition of platelet adhesion by nitric oxide (NO) and prostacyclin and their mechanism of action was studied. Platelet adhesion to collagen fibrils and endothelial cell matrix was inhibited completely by NO but only partially by prostacyclin. Adhesion of platelets to endothelial cell monolayers was inhibited by bradykinin. This effect of bradykinin was unaffected by aspirin, and was accounted for by the amounts of NO released by the endothelial cells. Inhibition of platelet adhesion by NO and prostacyclin was potentiated by selective inhibitors of cGMP phosphodiesterase, but not of cAMP phosphodiesterase, indicating that elevation of cGMP regulates platelet adhesion.

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Registry

Crossref · 10.1016/s0006-291x(87)80299-1

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19 of 19 references verified0 citation errors · 0 not checkable

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  • Sodium nitrite administration resulted in vascular smooth muscle relaxation in pre-contracted rat mesenteric arteries via cGMP production, an effect amplified in the presence of exogenous guanosine triphosphate.

    “Laustiola et al. (103) showed that sodium nitrite administration resulted in vascular smooth muscle relaxation in pre-contracted rat mesenteric arteries via cGMP production, an effect that was amplified in the presence of exogenous guanosine triphosphate.”

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Authors
Radomski, M. W., Palmer, R. M. J., & Moncada, S.
Affiliations
Wellcome Trust (GB)
Venue
Biochemical and Biophysical Research Communications
Publisher
Elsevier BV
Published
1987-11
Volume
148
Issue
3
Pages
1482-1489
ISSN
0006-291X (ISSN-L)
OpenAlex
W1967225427
Cited by
746
References
19
Citations by year
2025: 5 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 10 · 2020: 13 · 2019: 7 · 2018: 20 · 2017: 11 · 2016: 20 · 2015: 13 · 2014: 21 · 2013: 12 · 2012: 15
FWCI
11.49
Type
journal article
Language
en
Open access
closed
Locations
  • Biochemical and Biophysical Research Communications (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
nitric oxide, cyclic GMP, platelet adhesion, vascular endothelium, prostacyclin, bradykinin, collagen fibrils, phosphodiesterase inhibitors, aspirin, cyclic AMP
MeSH terms
Aspirin, Blood Platelets, Collagen, Endothelium, Vascular, Extracellular Matrix, Cyclic GMP, Humans, Nitric Oxide, Phthalazines, Platelet Adhesiveness, Epoprostenol, Purinones, Superoxide Dismutase, Thrombin, 3',5'-Cyclic-GMP Phosphodiesterases, In Vitro Techniques

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