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Engineering adipose-like tissue in vitro and in vivo utilizing human bone marrow and adipose-derived mesenchymal stem cells with silk fibroin 3D scaffolds
Open accessAbstract
Biomaterials derived from silk fibroin prepared by aqueous (AB) and organic (HFIP) solvent-based processes, along with collagen (COL) and poly-lactic acid (PLA)-based scaffolds were studied in vitro and in vivo for their utility in adipose tissue engineering strategies. For in vitro studies, human bone marrow and adipose-derived mesenchymal stem cells (hMSCs and hASCs) were seeded on the various biomaterials and cultured for 21 days in the presence of adipogenic stimulants (AD) or maintained as noninduced controls. Alamar Blue analysis revealed each biomaterial supported initial attachment of hMSCs and hASCs to similar levels for all matrices except COL in which higher levels were observed. hASCs and hMSCs cultured on all biomaterials in the presence of AD showed significant upregulation of adipogenic mRNA transcript levels (LPL, GLUT4, FABP4, PPARgamma, adipsin, ACS) to similar extents when compared to noninduced controls. Similarly Oil-Red O analysis of hASC or hMSC-seeded scaffolds displayed substantial amounts of lipid accumulating adipocytes following cultivation with AD. The data revealed AB and HFIP scaffolds supported similar extents of lipid accumulating cells while PLA and COL scaffolds qualitatively displayed lower and higher extents by comparison, respectively. Following a 4-week implantation period in a rat muscle pouch defect model, both AB and HFIP scaffolds supported in vivo adipogenesis either alone or seeded with hASCs or hMSCs as assessed by Oil-Red O analysis, however the presence of exogenous cell sources substantially increased the extent and frequency of adipogenesis observed. In contrast, COL and PLA scaffolds underwent rapid scaffold degradation and were irretrievable following the implantation period. The results suggest that macroporous 3D AB and HFIP silk fibroin scaffolds offer an important platform for cell-based adipose tissue engineering applications, and in particular, provide longer-term structural integrity to promote the maintenance of soft tissue in vivo.
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“Although the silk protein-based scaffold does not contain any cell-specific signal expression in its primary sequence, it provides a suitable matrix for supporting the proliferation and adhesion of mesenchymal stem cells [31,32].”
From Recent Advances in Silk Fibroin-Based Composites for Bone Repair Applications: A Review (2025) · cites this paper as [32]
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Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Altman, G. H., Diaz, F., Jakuba, C., Calabro, T., Horan, R. L., Chen, J., Lu, H., Richmond, J., & Kaplan, D. L. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00353-8 · Cited by 3,458
Self-citationPPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro
Rosen, E. D., Sarraf, P., Troy, A. E., Bradwin, G., Moore, K. J., Milstone, D. S., Spiegelman, B. M., & Mortensen, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80211-7 · Cited by 2,081
Principles of Tissue Engineering
(2014) · Elsevier eBooks · doi:10.1016/c2011-0-07193-4 · Cited by 1,912
C/EBPα induces adipogenesis through PPARγ: a unified pathwayPreprint
Rosen, E. D., Hsu, C.-H., Wang, X., Sakai, S., Freeman, M. W., Gonzalez, F. J., & Spiegelman, B. M. (2002) · Genes & Development · doi:10.1101/gad.948702 · Cited by 1,497
Control of the peroxisomal β-oxidation pathway by a novel family of nuclear hormone receptors
Dreyer, C., Krey, G. D., Keller, H., Givel, F., Helftenbein, G., & Wahli, W. (1992) · Cell · doi:10.1016/0092-8674(92)90031-7 · Cited by 1,393
PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance
Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Komeda, K., Satoh, S., Nakano, R., Ishii, C., 杉山, 拓., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80210-5 · Cited by 1,351
Schoonjans, K., Staels, B., & Auwerx, J. H. (1996) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(96)00066-5 · Cited by 1,045
Three-dimensional aqueous-derived biomaterial scaffolds from silk fibroin
Kim, U., Park, J. H., Kim, H. J., Wada, M., & Kaplan, D. L. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.07.044 · Cited by 979
Self-citationPorous 3-D Scaffolds from Regenerated Silk Fibroin
Nazarov, R., Jin, H., & Kaplan, D. L. (2004) · Biomacromolecules · doi:10.1021/bm034327e · Cited by 888
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Items 101–200 of 372
Isolation, expansion, and differentiation of goat adipose-derived stem cells
Ren, Y., Wu, H., Zhou, X., Wen, J., Jin, M., Cang, M., Guo, X., Wang, Q., Liu, D., & Ma, Y. (2011) · Research in Veterinary Science · doi:10.1016/j.rvsc.2011.08.014 · Cited by 67
Ghanaati, S., Orth, C., Unger, R. E., Barbeck, M., Webber, M. J., Motta, A., Migliaresi, C., & Kirkpatrick, C. J. (2010) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.257 · Cited by 66
Adipose stem cells for bone tissue repair
Ciuffi, S. (2017) · Clinical cases in mineral and bone metabolism · doi:10.11138/ccmbm/2017.14.1.217 · Cited by 65
Microfabricated Porous Silk Scaffolds for Vascularizing Engineered Tissues
Wray, L. S., Tsioris, K., Gil, E. S., Omenetto, F. G., & Kaplan, D. L. (2013) · Advanced Functional Materials · doi:10.1002/adfm.201202926 · Cited by 65
Self-citationJung, S.-R., Song, N.-J., Yang, D. K., Cho, Y.-J., Kim, B.-J., Hong, J.-W., Yun, U. J., Jo, D.-G., Lee, Y. M., Choi, S. Y., et al. (2013) · Nutrition Research · doi:10.1016/j.nutres.2012.11.006 · Cited by 64
O’Halloran, N., Courtney, D., Kerin, M. J., & Lowery, A. (2017) · Breast Cancer Basic and Clinical Research · doi:10.1177/1178223417726777 · Cited by 69
Chuang, C., Lin, R., Melero‐Martin, J. M., & Chen, Y. (2018) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2018.1499660 · Cited by 63
Adipose-Derived Stem Cells in Functional Bone Tissue Engineering: Lessons from Bone Mechanobiology
Bodle, J. C., Hanson, A. D., & Loboa, E. G. (2011) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2010.0738 · Cited by 63
Biodegradation behavior of silk fibroin membranes in repairing tympanic membrane perforations
Lee, O. J., Lee, J. M., Kim, J. H., Kim, J., Kweon, H., Jo, Y., & Park, C. H. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.33308 · Cited by 62
Kim, J. H., Park, C. H., Lee, O., Lee, J., Kim, J. W., Park, Y. H., & Ki, C. S. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34274 · Cited by 61
Human dental pulp progenitor cell behavior on aqueous and hexafluoroisopropanol based silk scaffolds
Zhang, W., Ahluwalia, I. P., Literman, R., Kaplan, D. L., & Yelick, P. C. (2011) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.33062 · Cited by 61
Self-citationLu, H., Kawazoe, N., Tateishi, T., Chen, G., Jin, X., & Chang, J. (2009) · Journal of Biomaterials Applications · doi:10.1177/0885328209342469 · Cited by 61
Itoi, Y., Takatori, M., Hyakusoku, H., & Mizuno, H. (2009) · Journal of Plastic Reconstructive & Aesthetic Surgery · doi:10.1016/j.bjps.2009.01.069 · Cited by 61
Lee, D. H., Tripathy, N., Shin, J. H., Song, J. E., Geun, J., Min, K. D., Park, C. H., & Khang, G. (2016) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2016.11.002 · Cited by 61
Fabrication and evaluation of poly(epsilon‐caprolactone)/silk fibroin blend nanofibrous scaffold
Lim, J., Ki, C. S., Kim, J. W., Lee, K. G., Kang, S. W., Kweon, H., & Park, Y. H. (2011) · Biopolymers · doi:10.1002/bip.22016 · Cited by 59
Adipogenic differentiation of human adipose-derived stem cells grown as spheroids
Turner, P. A., Gurumurthy, B., Bailey, J. L., Elks, C. M., & Janorkar, A. V. (2017) · Process Biochemistry · doi:10.1016/j.procbio.2017.02.003 · Cited by 59
Bioengineering strategies to generate vascularized soft tissue grafts with sustained shape
Stosich, M. S., Moioli, E. K., Wu, J. K., Lee, C. H., Rohde, C. H., Yousefi, A., Ascherman, J. A., DiRaddo, R. W., Marion, N. W., & Mao, J. J. (2008) · Methods · doi:10.1016/j.ymeth.2008.10.013 · Cited by 59
A digital light processing 3D printed magnetic bioreactor system using silk magnetic bioink
Ajiteru, O., Choi, K. Y., Lim, T. H., Kim, D. Y., Hong, H., Lee, Y. J., Lee, J. S., Lee, H., Suh, Y. J., Sultan, M. T., et al. (2021) · Biofabrication · doi:10.1088/1758-5090/abfaee · Cited by 58
Li, G., Chen, K., You, D., Xia, M., Li, W., Fan, S., Chai, R., Zhang, Y., Li, H., & Sun, S. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00190 · Cited by 58
Nazari, H., Heirani‐Tabasi, A., Hajiabbas, M., Bani, M. S., Nazari, M., Mahabadi, V. P., Rad, I., Kehtari, M., Tafti, S. H. A., & Soleimani, M. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29553 · Cited by 58
Silk protein as a fascinating biomedical polymer: Structural fundamentals and applications
Ki, C. S., Park, Y. H., & Jin, H. (2009) · Macromolecular Research · doi:10.1007/bf03218639 · Cited by 57
Flexible silk fibroin films for wound dressing
Srivastava, C. M., Purwar, R., Kannaujia, R., & Sharma, D. (2015) · Fibers and Polymers · doi:10.1007/s12221-015-1020-y · Cited by 56
Schiller, Z. A., Schiele, N. R., Sims, J. K., Lee, K., & Kuo, C. K. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt230 · Cited by 56
Hydrogels in adipose tissue engineering—Potential application in post‐mastectomy breast regeneration
O’Halloran, N., Dolan, E. B., Kerin, M. J., Lowery, A., & Duffy, G. P. (2018) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2753 · Cited by 55
Ramamoorthy, P., Thomas, S. M., Kaushik, G., Subramaniam, D., Chastain, K. M., Dhar, A., Tawfik, O. W., Kasi, A., Sun, W., Ramalingam, S., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-18-2602 · Cited by 55
Mauney, J. R., Olsen, B. R., & Volloch, V. (2010) · Matrix Biology · doi:10.1016/j.matbio.2010.08.008 · Cited by 54
Self-citationThe effect of lactose-conjugated silk biomaterials on the development of fibrogenic fibroblasts
Acharya, C., Hinz, B., & Kundu, S. C. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.08.033 · Cited by 54
Directing Chondrogenesis of Stem Cells with Specific Blends of Cellulose and Silk
Singh, N., Rahatekar, S. S., Koziol, K. K., Ng, T. S., Patil, A. J., Mann, S., Hollander, A. P., & Kafienah, W. (2013) · Biomacromolecules · doi:10.1021/bm301762p · Cited by 53
Sustained volume retention in vivo with adipocyte and lipoaspirate seeded silk scaffolds
Bellas, E., Panilaitis, B., Glettig, D. L., Kirker‐Head, C. A., Yoo, J. J., Marra, K. G., Rubin, J. P., & Kaplan, D. L. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.058 · Cited by 52
Self-citationWang, L., Pathak, J. L., Liang, D., Zhong, N., Guan, H., Wan, M., Miao, G., Li, Z., & Ge, L. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.09.107 · Cited by 52
Synthesis of Silk Fibroin–Glycopolypeptide Conjugates and Their Recognition with Lectin
Das, S., Pati, D., Tiwari, N., Nisal, A. A., & Gupta, S. S. (2012) · Biomacromolecules · doi:10.1021/bm301170u · Cited by 50
Ratanavaraporn, J., Kanokpanont, S., Tabata, Y., & Damrongsakkul, S. (2009) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2009.07.006 · Cited by 50
Mimicking the functional niche of adipose-derived stem cells for regenerative medicine
Kaewsuwan, S., Song, S. Y., Kim, J. H., & Sung, J.-H. (2012) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2012.721763 · Cited by 49
Li, D.-W., He, J., He, F., Liu, Y., Liu, Y., Ye, Y., Deng, X., & Yin, D. (2018) · Journal of Biomaterials Applications · doi:10.1177/0885328218757767 · Cited by 49
Bioengineered silk scaffolds in 3D tissue modeling with focus on mammary tissues
Maghdouri‐White, Y., Bowlin, G. L., Lemmon, C. A., & Dréau, D. (2015) · Materials Science and Engineering C · doi:10.1016/j.msec.2015.10.007 · Cited by 47
Chemically crosslinked gelatin hydrogels as scaffolding materials for adipose tissue engineering
Negrini, N. C., Tarsini, P., Tanzi, M. C., & Farè, S. (2018) · Journal of Applied Polymer Science · doi:10.1002/app.47104 · Cited by 47
The Role of Pref-1 during Adipogenic Differentiation: An Overview of Suggested Mechanisms
da Silva, C., Durandt, C., Kallmeyer, K., Ambele, M. A., & Pepper, M. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114104 · Cited by 47
Zhu, J., Du, Y. L., Backman, L. J., Chen, J., Ouyang, H., & Zhang, W. (2024) · Small · doi:10.1002/smll.202409739 · Cited by 49
Noninvasive Metabolic Imaging of Engineered 3D Human Adipose Tissue in a Perfusion Bioreactor
Ward, A., Quinn, K. P., Bellas, E., Georgakoudi, I., & Kaplan, D. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055696 · Cited by 44
Self-citationGotoh, Y., Ishizuka, Y., Matsuura, T., & Niimi, S. (2011) · Biomacromolecules · doi:10.1021/bm101495c · Cited by 44
Tissue engineering and regenerative medicine strategies for the female breast
Conci, C., Bennati, L., Bregoli, C., Buccino, F., Danielli, F., Gallan, M., Gjini, E., & Raimondi, M. T. (2019) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.2999 · Cited by 45
Youn, J., Choi, J. H., Lee, S., Lee, S. W., Moon, B. K., Song, J. E., & Khang, G. (2021) · Materials · doi:10.3390/ma14051287 · Cited by 44
Kandhasamy, S., Liang, B., Yang, D., & Zeng, Y. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c01650 · Cited by 44
Perteghella, S., Martella, E., de Girolamo, L., Orfei, C. P., Pierini, M., Fumagalli, V., Pintacuda, D. V., Chlapanidas, T., Viganò, M., Faragò, S., et al. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091829 · Cited by 43
Bioengineered Silk Proteins to Control Cell and Tissue Functions
Preda, R. C., Leisk, G. G., Omenetto, F. G., & Kaplan, D. L. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-354-1_2 · Cited by 43
Self-citationVascularized adipose tissue engineering: moving towards soft tissue reconstruction
Peirsman, A., Nguyen, H. T., Waeyenberge, M. V., Ceballos‐González, C. F., Bolívar‐Monsalve, E. J., Kawakita, S., Vanlauwe, F., Tirpáková, Z., Dorpe, S. V., Damme, L. V., et al. (2023) · Biofabrication · doi:10.1088/1758-5090/acd7a5 · Cited by 48
Chlapanidas, T., Faragò, S., Mingotto, F., Crovato, F., Tosca, M. C., Antonioli, B., Bucco, M., Lucconi, G., Scalise, A., Vigo, D., et al. (2011) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0636 · Cited by 40
Clinical Outcomes of Silk Patch in Acute Tympanic Membrane Perforation
Lee, J. H., Lee, J. S., Kim, D., Park, C. H., & Lee, H. R. (2015) · Clinical and Experimental Otorhinolaryngology · doi:10.3342/ceo.2015.8.2.117 · Cited by 40
Increased Adipogenesis of Human Adipose-Derived Stem Cells on Polycaprolactone Fiber Matrices
Brännmark, C., Paul, A., Ribeiro, D., Magnusson, B., Brolén, G., Enejder, A. M. K., & Forslöw, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113620 · Cited by 40
In vitro tissue-engineered adipose constructs for modeling disease
Murphy, C. S., Liaw, L., & Reagan, M. R. (2019) · BMC Biomedical Engineering · doi:10.1186/s42490-019-0027-7 · Cited by 45
A Novel Mixed‐Type Stem Cell Pellet for Cementum/Periodontal Ligament–Like Complex
Xie, H., & Liu, H. (2011) · Journal of Periodontology · doi:10.1902/jop.2011.110267 · Cited by 39
Dunne, L. W., Iyyanki, T. S., Hubenak, J. R., & Mathur, A. B. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.05.005 · Cited by 39
Adipose regeneration and implications for breast reconstruction: update and the future.
Combellack, E. J., Jessop, Z. M., Naderi, N., Griffin, M., Dobbs, T. D., Ibrahim, A., Evans, S. J., Burnell, S. E. A., Doak, S. H., & Whitaker, I. S. (2016) · PubMed Central · doi:10.3978/j.issn.2227-684x.2016.01.01 · Cited by 40
Han, P., Xu, M., Chang, J., Chakravorty, N., Wu, C., & Xiao, Y. (2014) · Biomaterials Science · doi:10.1039/c4bm00111g · Cited by 39
Florczyk, S. J., Leung, M. C., Jana, S., Li, Z., Bhattarai, N., Huang, J. I., Hopper, R. A., & Zhang, M. (2012) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.34288 · Cited by 38
Electrospun fibrous silk fibroin/poly(L-lactic acid) scaffold for cartilage tissue engineering
Liu, W., Li, Z., Zheng, L., Zhang, X., Liu, P., Yang, T., & Han, B. (2016) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-016-9099-9 · Cited by 37
Louis, F., & Matsusaki, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-102906-0.00008-8 · Cited by 37
Biomaterials for breast reconstruction: Promises, advances, and challenges
Abdul-Al, M., Zaernia, A., & Sefat, F. (2020) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.3121 · Cited by 30
Chang, T., Zimmerley, M., Quinn, K. P., Lamarre, I., Kaplan, D. L., Beaurepaire, E., & Georgakoudi, I. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.07.066 · Cited by 36
Self-citationRecent Advances in Silk Fibroin-Based Composites for Bone Repair Applications: A Review
Zhu, S., Zhang, Q., Xu, X., Liu, Z., Cheng, G., Long, D., Cheng, L., & Dai, F. (2025) · Polymers · doi:10.3390/polym17060772 · Cited by 36
“Although the silk protein-based scaffold does not contain any cell-specific signal expression in its primary sequence, it provides a suitable matrix for supporting the proliferation and adhesion of mesenchymal stem cells [31,32].”
Sharma, C., Dinda, A. K., Potdar, P. D., & Mishra, N. C. (2015) · Journal of Applied Polymer Science · doi:10.1002/app.42743 · Cited by 35
Mauney, J. R., & Volloch, V. (2009) · Matrix Biology · doi:10.1016/j.matbio.2009.04.002 · Cited by 35
Self-citationWang, X., Zhang, X., Sun, L., Subramanian, B., Maffini, M. V., Soto, A. M., Sonnenschein, C., & Kaplan, D. L. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0670 · Cited by 35
Self-citationCha, B. J., Kwak, H. W., Park, A. R., Kim, S. H., Park, S., Kim, H. J., Kim, I. S., Lee, K. H., & Park, Y. H. (2013) · Biopolymers · doi:10.1002/bip.22359 · Cited by 35
Choi, J. H. K., Gimble, J. M., Vunjak‐Novakovic, G., & Kaplan, D. L. (2010) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2009.0760 · Cited by 34
Self-citationLin, S., Huang, S., Lin, Y.-N., Wu, S., Chang, H., Lin, T.-M., Chai, C., & Lai, C. (2011) · Tissue Engineering Part A · doi:10.1089/ten.tea.2010.0688 · Cited by 33
Silk from silkworms and spiders as high-performance fibers
Babu, K. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-08-100550-7.00013-9 · Cited by 33
Bessot, A., Gunter, J. H., Waugh, D. J. J., Clements, J. A., Hutmacher, D. W., McGovern, J., & Bock, N. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202201701 · Cited by 32
Silk Fibroin/Sodium Carboxymethylcellulose Blended Films for Biotechnological Applications
Kundu, J., Mohapatra, R. A. B., & Kundu, S. C. (2010) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/092050610x487864 · Cited by 32
Acrylic acid plasma coatings for enhanced cell migration in PCL 3D additive manufactured scaffolds
Cools, P., Declercq, H., Ghobeira, R., Morent, R., & Geyter, N. D. (2018) · Surface and Coatings Technology · doi:10.1016/j.surfcoat.2018.03.067 · Cited by 31
Goetzke, R., Keijdener, H., Franzen, J., Ostrowska, A., Nüchtern, S., Mela, P., & Wagner, W. (2019) · Scientific Reports · doi:10.1038/s41598-019-51911-5 · Cited by 31
Antimicrobial biocompatible bioscaffolds for orthopaedic implants
Qureshi, A. T., Terrell, L., Monroe, W. T., Dasa, V., Janes, M. E., Gimble, J. M., & Hayes, D. J. (2012) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1532 · Cited by 30
Self-citationMorgan, S. M., Ainsworth, B., Kanczler, J. M., Babister, J. C., Chaudhuri, J. B., & Oreffo, R. O. C. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.033 · Cited by 30
Human adipose-derived stem cells: definition, isolation, tissue-engineering applications.
Nae, S., Bordeianu, I., Stăncioiu, A. T., & Antohi, N. (2013) · PubMed · Cited by 30
Adipose Stroma Induces Branching Morphogenesis of Engineered Epithelial Tubules
Pavlovich, A. L., Manivannan, S., & Nelson, C. M. (2010) · Tissue Engineering Part A · doi:10.1089/ten.tea.2009.0836 · Cited by 30
Sayın, E., Readioff, R., Rodríguez‐Cabello, J. C., Elsheikh, A., Baran, E. T., & Hasırcı, V. (2017) · Bioactive Materials · doi:10.1016/j.bioactmat.2017.04.001 · Cited by 29
Phull, M. K., Eydmann, T., Roxburgh, J., Sharpe, J. R., Lawrence‐Watt, D. J., Phillips, G. J., & Hewings-Martin, Y. (2012) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-012-4806-0 · Cited by 29
Zhang, B.-X., Zhang, Z.-L., Lin, A. L., Wang, H., Pilia, M., Ong, J. L., Dean, D. D., Chen, X., & Yeh, C. (2015) · Tissue Engineering Part A · doi:10.1089/ten.tea.2014.0411 · Cited by 29
Nanoscaffold based stem cell regeneration therapy: recent advancement and future potential
Prakash, S., Khan, A. A., & Paul, A. (2010) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2010.528387 · Cited by 29
Kochhar, D., DeBari, M. K., & Abbott, R. D. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.697981 · Cited by 27
Poh, P. S. P., Hege, C. S., Chhaya, M. P., Balmayor, E. R., Foehr, P., Burgkart, R., Schantz, J., Schiller, S., Schilling, A. F., & Hutmacher, D. W. (2016) · Polymer International · doi:10.1002/pi.5181 · Cited by 28
A prospective cohort study of the silk fibroin patch in chronic tympanic membrane perforation
Lee, J. H., Kim, D., Park, H. S., Jeong, J. Y., Yeon, Y. K., Kumar, V., Bae, S. H., Lee, J. M., Moon, B. M., & Park, C. H. (2016) · The Laryngoscope · doi:10.1002/lary.25980 · Cited by 28
Effects of silk fibroin in murine dry eye
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Metadata
- Authors
- Mauney, J. R., Nguyen, T., Gillen, K., Kirker-Head, C., Gimble, J. M., & Kaplan, D. L.
- Affiliations
- Tufts University (US)
- Pennington Biomedical Research Center (US)
- Corresponding author
- Kaplan, David L.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2007-12
- Volume
- 28
- Issue
- 35
- Pages
- 5280-5290
- ISSN
- 0142-9612 (ISSN-L)
- PMC
- PMC2695965
- OpenAlex
- W2095560028
- Cited by
- 373
- References
- 57
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 9 · 2023: 10 · 2022: 12 · 2021: 22 · 2020: 11 · 2019: 21 · 2018: 16 · 2017: 29 · 2016: 25 · 2015: 25 · 2014: 35 · 2013: 34 · 2012: 30
- FWCI
- 9.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (R01EB003210, P41EB002520)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- adipose tissue engineering, silk fibroin scaffolds, adipose-derived stem cells, bone marrow mesenchymal stem cells, adipogenesis, collagen scaffolds, polylactic acid scaffolds, scaffold degradation, cell seeding, macroporous scaffolds
- MeSH terms
- Adipose Tissue, Adult, Animals, Biocompatible Materials, Bone Marrow Cells, Cell Differentiation, Cells, Cultured, Fibroins, Humans, Male, Rats, Nude, Bombyx, Tissue Engineering, Silk, Rats, Tissue Scaffolds, Mesenchymal Stem Cells
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