The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
TAT-conjugated nanoparticles for the CNS delivery of anti-HIV drugs
Open accessAbstract
We have shown that nanoparticles (NPs) conjugated to trans-activating transcriptor (TAT) peptide bypass the efflux action of P-glycoprotein and increases the transport of the encapsulated ritonavir, a protease inhibitor (PI), across the blood-brain-barrier (BBB) to the central nervous system (CNS). A steady increase in the drug parenchyma/capillary ratio with time without disrupting the BBB integrity suggests that TAT-conjugated NPs are first immobilized in the brain vasculature prior to their transport into parenchyma. Localization of NPs in the brain parenchyma was further confirmed with histological analysis of the brain sections. The brain drug level with conjugated NPs was 800-fold higher than that with drug in solution at two weeks. Drug clearance was seen within four weeks. In conclusion, TAT-conjugated NPs enhance the CNS bioavailability of the encapsulated PI and maintained therapeutic drug level in the brain for a sustained period that could be effective in reducing the viral load in the CNS which acts as a reservoir for replicating HIV-1 virus.
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Sahoo, S. K., & Labhasetwar, V. (2005) · Molecular Pharmaceutics · doi:10.1021/mp050032z · Cited by 340
Self-citationTorchilin, V. P. (2008) · Peptide Science · doi:10.1002/bip.20989 · Cited by 283
Bazile, D. V., Ropert, C., Huve, P., Verrecchia, T., Mariard, M., Frydman, A., Veillard, M., & Spenlehauer, G. (1992) · Biomaterials · doi:10.1016/0142-9612(92)90142-b · Cited by 200
Trans-Activating Transcriptional Activator (TAT) Peptide-Mediated Brain Drug Delivery
Rao, K. S., & Labhasetwar, V. (2006) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2006.036 · Cited by 17
Self-citation
Cited by
Nicolas, J., Mura, S., Brambilla, D., Mackiewicz, N., & Couvreur, P. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35265f · Cited by 1,270
Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases
Furtado, D., Björnmalm, M., Ayton, S., Bush, A. I., Kempe, K., & Caruso, F. (2018) · Advanced Materials · doi:10.1002/adma.201801362 · Cited by 708
Drug delivery to the central nervous system by polymeric nanoparticles: What do we know?
Kreuter, J. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.08.008 · Cited by 554
Development of Polymeric Nanoparticles for Blood–Brain Barrier Transfer—Strategies and Challenges
Zhang, W., Mehta, A., Tong, Z., Esser, L., & Voelcker, N. H. (2021) · Advanced Science · doi:10.1002/advs.202003937 · Cited by 430
Polydopamine-Based Simple and Versatile Surface Modification of Polymeric Nano Drug Carriers
Park, J., Brust, T. F., Lee, H. J., Lee, S. C., Watts, V. J., & Yeo, Y. (2014) · ACS Nano · doi:10.1021/nn405809c · Cited by 407
Metadata
- Authors
- Rao, K. S., Reddy, M. K., Horning, J. L., & Labhasetwar, V.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 29
- Issue
- 33
- Pages
- 4429-4438
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2074754374
- Cited by
- 314
- References
- 4
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- green
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