Nitric oxide-releasing S-nitrosothiol-modified xerogels
Open accessAbstract
The synthesis, material characterization, and in vitro biocompatibility of S-nitrosothiol (RSNO)-modified xerogels are described. Thiol-functionalized xerogel films were formed by hydrolysis and co-condensation of 3-mercaptopropyltrimethoxysilane (MPTMS) and methyltrimethoxysilane (MTMOS) sol-gel precursors at varying concentrations. Subsequent thiol nitrosation via acidified nitrite produced RSNO-modified xerogels capable of generating nitric oxide (NO) for up to 2 weeks under physiological conditions. Xerogels also exhibited NO generation upon irradiation with broad-spectrum light or exposure to copper, with NO fluxes proportional to wattage and concentration, respectively. Xerogels were capable of storing up to approximately 1.31 micromol NO mg(-1), and displayed negligible fragmentation over a 2-week period. Platelet and bacterial adhesion to nitrosated films was reduced compared to non-nitrosated controls, confirming the antithrombotic and antibacterial properties of the NO-releasing materials. Fibroblast cell viability was maintained on the xerogel surfaces illustrating the promise of RSNO-modified xerogels as biomedical device coatings.
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NO reduced bacterial cell coverage on these surfaces by up to 40%.
“NO successfully reduced bacterial cell coverage on these surfaces by up to 40 %.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [216]
The dose of NO required to kill bacteria (e.g., 200 ppm gaseous NO) does not show cytotoxic effects in human dermal fibroblasts when exposed for 48 h.
“Moreover, the dose of NO required to kill bacteria (e.g., 200 ppm of gaseous NO)281,282,285 does not show any cytotoxic effects in human dermal fibroblasts when exposed for 48 h.216,220”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [216]
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Hwang, S., & Meyerhoff, M. E. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.02.004 · Cited by 82 · see citing works
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Polymeric materials with antimicrobial activity
Muñoz-Bonilla, A., & Fernández-García, M. (2012) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2011.08.005 · Cited by 1,221 · see citing works
Nitric oxide release: Part II. Therapeutic applications
Carpenter, A. W., & Schoenfisch, M. H. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15273h · Cited by 964 · see citing works
Self-citationNitric oxide release: Part I. Macromolecular scaffolds
Riccio, D. A., & Schoenfisch, M. H. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15272j · Cited by 475 · see citing works
Self-citationBiocompatible Materials for Continuous Glucose Monitoring Devices
Nichols, S. P., Koh, A., Storm, W. L., Shin, J. H., & Schoenfisch, M. H. (2013) · Chemical Reviews · doi:10.1021/cr300387j · Cited by 347 · see citing works
Self-citationLight-controlled nitric oxide delivering molecular assemblies
Sortino, S. (2010) · Chemical Society Reviews · doi:10.1039/b908663n · Cited by 277 · see citing works
Wo, Y., Brisbois, E. J., Bartlett, R. H., & Meyerhoff, M. E. (2016) · Biomaterials Science · doi:10.1039/c6bm00271d · Cited by 251 · see citing works
Polymer‐Based Nitric Oxide Therapies: Recent Insights for Biomedical Applications
Jen, M. C., Serrano, M. C., van Lith, R., & Ameer, G. A. (2012) · Advanced Functional Materials · doi:10.1002/adfm.201101707 · Cited by 194 · see citing works
Brisbois, E. J., Davis, R. P., Jones, A. M., Major, T. C., Bartlett, R. H., Meyerhoff, M. E., & Handa, H. (2015) · Journal of Materials Chemistry B · doi:10.1039/c4tb01839g · Cited by 101 · see citing works
Peng, Z., Ao, H., Wang, L., Guo, S., & Tang, T. (2015) · RSC Advances · doi:10.1039/c5ra07540h · Cited by 31 · see citing works
- Authors
- Riccio, D. A., Dobmeier, K. P., Hetrick, E. M., Privett, B. J., Paul, H. S., & Schoenfisch, M. H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Schoenfisch, Mark H.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 30
- Issue
- 27
- Pages
- 4494-4502
- ISSN
- 0142-9612 (ISSN-L)
- PMC
- PMC2743564
- OpenAlex
- W2110285736
- Cited by
- 107
- References
- 1
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 4 · 2022: 3 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 2 · 2017: 6 · 2016: 7 · 2015: 8 · 2014: 7 · 2013: 20 · 2012: 12
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Science Foundation
- Pfizer
- National Institutes of Health
- University of North Carolina at Chapel Hill
- National Institute of Biomedical Imaging and Bioengineering (EB 000708, R01EB000708)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- nitric oxide release, S-nitrosothiols, xerogels, 3-mercaptopropyltrimethoxysilane, methyltrimethoxysilane, sol-gel thin films, antithrombotic coatings, antibacterial coatings, platelet adhesion, bacterial adhesion, fibroblast viability, biocompatibility
- MeSH terms
- Animals, Anti-Bacterial Agents, Antithrombins, Bacterial Adhesion, Blood Platelets, Cell Survival, Fibroblasts, Gels, Microbial Sensitivity Tests, Nitric Oxide, Pseudomonas aeruginosa, Silanes, Platelet Activation, Organosilicon Compounds, S-Nitrosothiols, Sus scrofa, Mice
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