Cited by 308Nanoparticle-Based Drug DeliveryCharacterization and Applications of Magnetic NanoparticlesNanoplatforms for cancer theranostics

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Polyethylene glycol modified, cross-linked starch-coated iron oxide nanoparticles for enhanced magnetic tumor targeting

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Cole, Adam J., David, Allan E., Wang, Jianxin, Galbán, Craig J., Hill, Hannah L., Yang, Victor C.·2011·Biomaterials

DOI 10.1016/j.biomaterials.2010.11.040PMC PMC3022959

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Abstract

While successful magnetic tumor targeting of iron oxide nanoparticles has been achieved in a number of models, the rapid blood clearance of magnetically suitable particles by the reticuloendothelial system (RES) limits their availability for targeting. This work aimed to develop a long-circulating magnetic iron oxide nanoparticle (MNP) platform capable of sustained tumor exposure via the circulation and, thus, potentially enhanced magnetic tumor targeting. Aminated, cross-linked starch (DN) and aminosilane (A) coated MNPs were successfully modified with 5 kDa (A5, D5) or 20 kDa (A20, D20) polyethylene glycol (PEG) chains using simple N-Hydroxysuccinimide (NHS) chemistry and characterized. Identical PEG-weight analogues between platforms (A5 & D5, A20 & D20) were similar in size (140-190 nm) and relative PEG labeling (1.5% of surface amines - A5/D5, 0.4% - A20/D20), with all PEG-MNPs possessing magnetization properties suitable for magnetic targeting. Candidate PEG-MNPs were studied in RES simulations in vitro to predict long-circulating character. D5 and D20 performed best showing sustained size stability in cell culture medium at 37 °C and 7 (D20) to 10 (D5) fold less uptake in RAW264.7 macrophages when compared to previously targeted, unmodified starch MNPs (D). Observations in vitro were validated in vivo, with D5 (7.29 h) and D20 (11.75 h) showing much longer half-lives than D (0.12 h). Improved plasma stability enhanced tumor MNP exposure 100 (D5) to 150 (D20) fold as measured by plasma AUC(0-∞). Sustained tumor exposure over 24 h was visually confirmed in a 9L-glioma rat model (12 mg Fe/kg) using magnetic resonance imaging (MRI). Findings indicate that a polyethylene glycol modified, cross-linked starch-coated MNP is a promising platform for enhanced magnetic tumor targeting, warranting further study in tumor models.

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Gupta, A. K., & Gupta, M. S. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2004.10.012 · Cited by 6,906
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Moore, S., & Stein, W. H. (1948) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)51034-6 · Cited by 3,035
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Zhang, Y., Kohler, N., & Zhang, M. (2002) · Biomaterials · doi:10.1016/s0142-9612(01)00267-8 · Cited by 1,266
Tumor-Selective Delivery of Macromolecular Drugs via the EPR Effect: Background and Future Prospects
Maeda, H. (2010) · Bioconjugate Chemistry · doi:10.1021/bc100070g · Cited by 997
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Chertok, B., Moffat, B. A., David, A. E., Yu, F., Bergemann, C., Ross, B. D., & Yang, V. C.-M. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2007.08.050 · Cited by 901
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Dobson, J. (2006) · Drug Development Research · doi:10.1002/ddr.20067 · Cited by 887
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Xie, J., Xu, C., Kohler, N., Hou, Y., & Sun, S. (2007) · Advanced Materials · doi:10.1002/adma.200701975 · Cited by 686
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Dobson, J. (2006) · Gene Therapy · doi:10.1038/sj.gt.3302720 · Cited by 567

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Authors: Cole, A. J., David, A. E., Wang, J., Galbán, C. J., Hill, H. L., & Yang, V. C.
Affiliations: University of Michigan (US)
Fudan University (CN)
Tianjin University (CN)
Corresponding author: Yang, Victor C.
ORCID: David, Allan E.
Wang, Jianxin
Galbán, Craig J.
Yang, Victor C.
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2011-03
Volume: 32
Issue: 8
Pages: 2183-2193
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2010.11.040
PMC: PMC3022959
OpenAlex: W2029871153
Cited by: 308
References: 41
Citations by year: 2026: 4 · 2025: 9 · 2024: 15 · 2023: 15 · 2022: 14 · 2021: 20 · 2020: 19 · 2019: 25 · 2018: 23 · 2017: 18 · 2016: 25 · 2015: 26 · 2014: 24 · 2013: 35 · 2012: 24
FWCI: 9.36
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (NIH) (CA114612, NS066945)
Hartwell Foundation Biomedical Research Award
WCU project (R31-2008-000-10103-01)
NIGMS (GM007767)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords: iron oxide nanoparticles, polyethylene glycol coating, long-circulating nanoparticles, reticuloendothelial system clearance, macrophage uptake, glioma, MRI contrast agents
MeSH terms: Animals, Biocompatible Materials, Cell Line, Cross-Linking Reagents, Electron Spin Resonance Spectroscopy, Ferric Compounds, Macrophages, Magnetic Resonance Imaging, Magnetics, Male, Materials Testing, Neoplasms, Particle Size, Polyethylene Glycols, Rats, Inbred F344, Starch, Molecular Structure, Spectroscopy, Fourier Transform Infrared, Mice, Rats, Metal Nanoparticles

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Polyethylene glycol modified, cross-linked starch-coated iron oxide nanoparticles for enhanced magnetic tumor targeting

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