Recent progress on magnetic iron oxide nanoparticles: synthesis, surface functional strategies and biomedical applications
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applications, the IONPs must have combined properties of high magnetic saturation, stability, biocompatibility, and interactive functions at the surface. Moreover, the surface of IONPs could be modified by organic materials or inorganic materials, such as polymers, biomolecules, silica, metals, etc. The new functionalized strategies, problems and major challenges, along with the current directions for the synthesis, surface functionalization and bioapplication of IONPs, are considered. Finally, some future trends and the prospects in these research areas are also discussed.
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SPION can be produced by chemical, physical and biosynthetic methodologies.
“SPION can be produced in several different ways, encompassing chemical, physical and biosynthetic methodologies [3, 25, 28, 29].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [3]
Physical and biosynthetic synthesis protocols together make up less than 10% of all SPION synthesis methods.
“Together, physical and biosynthetic synthesis protocols make up for less than 10% of all SPION synthesis methods [3].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [3]
Under hydrothermal conditions, it is difficult to control the final size of particles and most of the time polydisperse samples are obtained.
“However, it is difficult to control the final size of particles and most of the times polydisperse samples are obtained under hydrothermal conditions [3, 28, 46].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [3]
Since electrochemical synthesis reactions are usually performed at room temperature, the synthesized products often show some amorphous parts.
“Also, since reactions are usually performed at room temperature, the synthesized products often show some amorphous parts [3, 49].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [3]
Amorphous SPION obtained from sonochemical synthesis need further heat-treatment after synthesis.
“Thus, the obtained amorphous SPION need to be further processed by heat-treatment after they have been synthesized [3, 28, 46–48].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [3]
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- Authors
- Wu, W., Wu, Z., Yu, T., Jiang, C., & Kim, W.-S.
- Affiliations
- Wuhan University (CN)
- Kyung Hee University (KR)
- Corresponding author
- Wu, Wei
- Jiang, Changzhong
- Kim, Woo-Sik
- Venue
- Science and Technology of Advanced Materials
- Publisher
- Informa UK Limited
- Published
- 2015-04-28
- Volume
- 16
- Issue
- 2
- Pages
- 023501
- ISSN
- 1468-6996 (ISSN-L)
- 1878-5514
- PMC
- PMC5036481
- OpenAlex
- W2053720633
- Cited by
- 1,574
- References
- 405
- Citations by year
- 2026: 78 · 2025: 102 · 2024: 118 · 2023: 162 · 2022: 149 · 2021: 179 · 2020: 207 · 2019: 206 · 2018: 156 · 2017: 124 · 2016: 78 · 2015: 13 · 2014: 1
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Science and Technology of Advanced Materials (publishedVersion)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Materials Science › Materials Chemistry › Magnetic Properties and Synthesis of Ferrites
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- magnetic iron oxide nanoparticles, nanoparticle synthesis, surface functionalization, biomedical applications, biocompatibility, magnetic saturation, stability, silica coating, polymer coatings, biomolecule conjugation, metal coatings
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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