Cited by 46Microfluidic and Bio-sensing TechnologiesNanoparticle-Based Drug DeliverySilicone and Siloxane Chemistry

Herceptin functionalized polyhedral oligomeric silsesquioxane – conjugated oligomers – silica/iron oxide nanoparticles for tumor cell sorting and detection

Mi, Yu, Li, Kai, Liu, Yutao, Pu, Kan-Yi, Liu, Bin, Feng, Si-Shen·2011·Biomaterials

Abstract

Sorting and detection of circulating tumor cells (CTC) in peripheral blood as an efficient and non-invasive method to diagnose cancer have recently attracted much attention. In this article, we developed a multiply-engineered nanoparticle system for CTC sorting and detection, which consists of (1) conjugated oligomer (CO) as fluorescence signal source, (2) polyhedral oligomeric silsesquioxanes (POSS) scaffold for CO localization for better fluorescent effects, (3) silica nanoparticles (SiNPs) as formulation matrix of the POSS containing CO, (4) iron oxide (IO) layer on the silica nanoparticles (IO-SiNPs) for magnetic collection, and (5) herceptin surface functionalization of the IO-SiNPs to target cancer cells of HER2 overexpression. Such a multiply-engineered structure can be used for either traditional immunomagnetic methods or microfluidic devices for CTC sorting and detection.

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Crossref · 10.1016/j.biomaterials.2011.07.040

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Authors
Mi, Y., Li, K., Liu, Y., Pu, K.-Y., Liu, B., & Feng, S.-S.
Affiliations
National University of Singapore (SG)
Corresponding author
Feng, Si-Shen
Venue
Biomaterials
Publisher
Elsevier BV
Published
2011-11
Volume
32
Issue
32
Pages
8226-8233
ISSN
0142-9612 (ISSN-L)
OpenAlex
W2000332479
Cited by
46
References
35
Citations by year
2025: 2 · 2022: 4 · 2021: 4 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 5
FWCI
3.40
Type
journal article
Language
en
Open access
closed
Locations
  • Biomaterials (publishedVersion)
  • PubMed (publishedVersion)
  • National University of Singapore (submittedVersion)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Bio-sensing Technologies
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Materials Chemistry › Silicone and Siloxane Chemistry
Keywords
circulating tumor cells, CTC detection, polyhedral oligomeric silsesquioxane, conjugated oligomers, silica nanoparticles, iron oxide nanoparticles, magnetic separation, trastuzumab, HER2 overexpression, fluorescent labeling, microfluidics, cancer diagnosis
MeSH terms
Trastuzumab, Animals, Cell Survival, Ferric Compounds, Flow Cytometry, Fluorescence, Humans, Magnetics, Neoplastic Cells, Circulating, Silicon Dioxide, Surface Properties, Cell Death, Organosilicon Compounds, Microscopy, Confocal, NIH 3T3 Cells, Cell Line, Tumor, Mice, Nanoparticles, Antibodies, Monoclonal, Humanized

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