Herceptin functionalized polyhedral oligomeric silsesquioxane – conjugated oligomers – silica/iron oxide nanoparticles for tumor cell sorting and detection
Abstract
Sorting and detection of circulating tumor cells (CTC) in peripheral blood as an efficient and non-invasive method to diagnose cancer have recently attracted much attention. In this article, we developed a multiply-engineered nanoparticle system for CTC sorting and detection, which consists of (1) conjugated oligomer (CO) as fluorescence signal source, (2) polyhedral oligomeric silsesquioxanes (POSS) scaffold for CO localization for better fluorescent effects, (3) silica nanoparticles (SiNPs) as formulation matrix of the POSS containing CO, (4) iron oxide (IO) layer on the silica nanoparticles (IO-SiNPs) for magnetic collection, and (5) herceptin surface functionalization of the IO-SiNPs to target cancer cells of HER2 overexpression. Such a multiply-engineered structure can be used for either traditional immunomagnetic methods or microfluidic devices for CTC sorting and detection.
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Slamon, D. J., Leyland-Jones, B., Shak, S., Fuchs, H., Paton, V., Bajamonde, A., Fleming, T., Eiermann, W., Wolter, J., Pegram, M., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103153441101 · Cited by 11,500 · see citing works
The distribution of secondary growths in cancer of the breast.
Paget, S. (1889) · The Lancet · doi:10.1016/s0140-6736(00)49915-0 · Cited by 5,277 · see citing works
Ultra-large-scale syntheses of monodisperse nanocrystals
Park, J., An, K., Hwang, Y., Park, J.-G., Noh, H.-J., Kim, J.-Y., Park, J.-H., Hwang, N.-M., & Hyeon, T. (2004) · Nature Materials · doi:10.1038/nmat1251 · Cited by 4,076 · see citing works
Isolation of rare circulating tumour cells in cancer patients by microchip technology
Nagrath, S., Sequist, L. V. D., Maheswaran, S., Bell, D. W., Irimia, D., Ulkus, L., Smith, M. R., Kwak, E. L., Digumarthy, S. R., Muzikansky, A., et al. (2007) · Nature · doi:10.1038/nature06385 · Cited by 3,565 · see citing works
Trastuzumab — Mechanism of Action and Use in Clinical Practice
Hudis, C. A. (2007) · New England Journal of Medicine · doi:10.1056/nejmra043186 · Cited by 2,592 · see citing works
Allard, W. J., Matera, J., Miller, M. C., Repollet, M., Connelly, M. C., Rao, C., Tibbe, A. G. J., Uhr, J. W., & Terstappen, L. W. M. M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0378 · Cited by 2,542 · see citing works
Tumor metastasis: mechanistic insights and clinical challenges
Steeg, P. S. (2006) · Nature Medicine · doi:10.1038/nm1469 · Cited by 2,125 · see citing works
Creating new fluorescent probes for cell biology
Zhang, J., Campbell, R. E., Ting, A. Y., & Tsien, R. Y. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm976 · Cited by 1,984 · see citing works
Baney, R. H., Itoh, M., Sakakibara, A., et al. (1995) · Chemical Reviews · doi:10.1021/cr00037a012 · Cited by 1,522 · see citing works
Monoclonal antibody therapy of cancer
Adams, G. P., & Weiner, L. M. (2005) · Nature Biotechnology · doi:10.1038/nbt1137 · Cited by 1,254 · see citing works
Bioconjugated quantum dots for in vivo molecular and cellular imaging☆
SMITH, A., Duan, H., Mohs, A. M., & Nie, S. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.015 · Cited by 1,196 · see citing works
Circulating Tumor Cells: A Novel Prognostic Factor for Newly Diagnosed Metastatic Breast Cancer
Cristofanilli, M., Hayes, D. F., Budd, G. T., Ellis, M. J., Stopeck, A., Reuben, J. M., Doyle, G. V., Matera, J., Allard, W. J., Miller, M. C., et al. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.08.140 · Cited by 1,134 · see citing works
Lee, J. E., Lee, N., Kim, H., Kim, J., Choi, S. H., Kim, J. H., Kim, T., Song, I. C., Park, S. P., Moon, W. K., et al. (2009) · Journal of the American Chemical Society · doi:10.1021/ja905793q · Cited by 706 · see citing works
Adams, A. A., Okagbare, P. I., Feng, J., Hupert, M. L., Patterson, D., Göttert, J., McCarley, R. L., Nikitopoulos, D. E., Murphy, M. C., & Soper, S. A. (2008) · Journal of the American Chemical Society · doi:10.1021/ja8015022 · Cited by 521 · see citing works
Three‐Dimensional Nanostructured Substrates toward Efficient Capture of Circulating Tumor Cells
Wang, S., Wang, H., Jiao, J., Chen, K., Owens, G. E., Kamei, K., Sun, J., Sherman, D. J., Behrenbruch, C. P., Wu, H., et al. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200901668 · Cited by 512 · see citing works
Yoo, H. S., & Park, T. G. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.08.017 · Cited by 443 · see citing works
Potent antibody drug conjugates for cancer therapy
Senter, P. D. (2009) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.03.023 · Cited by 403 · see citing works
Microfluidic sorting and multimodal typing of cancer cells in self-assembled magnetic arrays
Saliba, A., Saïas, L., Psychari, E., Minc, N., Simon, D., Bidard, F., Mathiot, C., Pierga, J., Fraisier, V., Salamero, J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001515107 · Cited by 338 · see citing works
Zhang, C., Liu, T., Su, Y., Luo, S., Zhu, Y., Tan, X., Fan, S., Zhang, L., Zhou, Y., Cheng, T., et al. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.007 · Cited by 270 · see citing works
Circulating tumour cells in clinical practice: Methods of detection and possible characterization
Alunni‐Fabbroni, M., & Sandri, M. T. (2010) · Methods · doi:10.1016/j.ymeth.2010.01.027 · Cited by 250 · see citing works
Circulating tumor cell clusters in the peripheral blood of colorectal cancer patients.
Molnar, B. A., Ladányi, A., Tanko, L. M., Sreter, L., & Tulassay, Z. (2001) · PubMed · Cited by 241 · see citing works
In Situ Molecular Profiling of Breast Cancer Biomarkers with Multicolor Quantum Dots
Yezhelyev, M. V., Al-Hajj, A., Morris, C., Marcus, A. I., Liu, T., Lewis, M. M., Cohen, C., Zrazhevskiy, P., Simons, J. W., Rogatko, A., et al. (2007) · Advanced Materials · doi:10.1002/adma.200701983 · Cited by 213 · see citing works
Brown, K. C. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790963788 · Cited by 146 · see citing works
Helo, P., Cronin, A. M., Danila, D. C., et al. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.117952 · Cited by 138 · see citing works
Cubic silsesquioxanes for use in solution processable organic light emitting diodes (OLED)
Chan, K. L., Sonar, P. M., & Sellinger, A. (2009) · Journal of Materials Chemistry · doi:10.1039/b909234j · Cited by 136 · see citing works
Uptake and Metabolism of a Dual Fluorochrome Tat-nanoparticle in HeLa Cells
Koch, A., Reynolds, F., Kircher, M. F., Merkle, H. P., Weissleder, R., & Josephson, L. (2003) · Bioconjugate Chemistry · doi:10.1021/bc034123v · Cited by 129 · see citing works
Microsystems for the Capture of Low-Abundance Cells
Dharmasiri, U., Witek, M. A., Adams, A. A., & Soper, S. A. (2010) · Annual Review of Analytical Chemistry · doi:10.1146/annurev.anchem.111808.073610 · Cited by 129 · see citing works
Ahlgren, S., Wållberg, H., Tran, T. A., et al. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.056929 · Cited by 112 · see citing works
Pu, K., Li, K. S., & Liu, B. (2009) · Advanced Materials · doi:10.1002/adma.200902409 · Cited by 103 · see citing works
Self-citationPu, K., Li, K. S., Zhang, X., et al. (2010) · Advanced Materials · doi:10.1002/adma.201001544 · Cited by 101 · see citing works
Self-citationDetection of circulating breast tumor cells by differential expression of marker genes.
Bosma, A. J., Weigelt, B., Lambrechts, A. C., et al. (2002) · PubMed · Cited by 95 · see citing works
Detection and Isolation of Circulating Tumor Cells in Urologic Cancers: A Review
Loberg, R. D., Fridman, Y., Pienta, B. A., et al. (2004) · Neoplasia · doi:10.1593/neo.03484 · Cited by 59 · see citing works
Wiig, H., Gyenge, C. C., & Tenstad, O. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.089615 · Cited by 58 · see citing works
One-round determination of seven leukocyte subsets in Rhesus macaque blood by flow cytometry
Lafont, B. A. P., Gloeckler, L., D'Hautcourt, J. L., Gut, J. P., & Aubertin, A. M. (2000) · Cytometry · doi:10.1002/1097-0320(20001101)41:3 · Cited by 16 · see citing works
Immunological Approaches in the Treatment of Metastasized Breast Cancer
Müller, V., Witzel, I., & Stickeler, E. (2009) · Breast Care · doi:10.1159/000262454 · Cited by 10 · see citing works
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Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works
- Authors
- Mi, Y., Li, K., Liu, Y., Pu, K.-Y., Liu, B., & Feng, S.-S.
- Affiliations
- National University of Singapore (SG)
- Corresponding author
- Feng, Si-Shen
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 32
- Issue
- 32
- Pages
- 8226-8233
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2000332479
- Cited by
- 46
- References
- 35
- Citations by year
- 2025: 2 · 2022: 4 · 2021: 4 · 2019: 2 · 2018: 5 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 5
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Bio-sensing Technologies
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Materials Chemistry › Silicone and Siloxane Chemistry
- Keywords
- circulating tumor cells, CTC detection, polyhedral oligomeric silsesquioxane, conjugated oligomers, silica nanoparticles, iron oxide nanoparticles, magnetic separation, trastuzumab, HER2 overexpression, fluorescent labeling, microfluidics, cancer diagnosis
- MeSH terms
- Trastuzumab, Animals, Cell Survival, Ferric Compounds, Flow Cytometry, Fluorescence, Humans, Magnetics, Neoplastic Cells, Circulating, Silicon Dioxide, Surface Properties, Cell Death, Organosilicon Compounds, Microscopy, Confocal, NIH 3T3 Cells, Cell Line, Tumor, Mice, Nanoparticles, Antibodies, Monoclonal, Humanized
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