The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Guidance of stem cell fate on 2D patterned surfaces
Abstract
Stem cells possess unique abilities as they can renew themselves for extended periods of time and have the capacity to differentiate into a variety of lineages. They hold promise for treating a plethora of diseases ranging from musculoskeletal defects to myocardial infarction and to neural disorders. Understanding how to control the fate decision of these cells to self-renew or differentiate is paramount in stem cell tissue engineering. Recently, significant progress has been made in guiding stem cell differentiation in vitro, and we are beginning to understand the complex interplay of factors that control their fate. Here, we highlight the recent approaches for guidance of stem cells through patterning of surfaces at the micro- and nanoscale. Particular attention is given to chemical patterning of substrates with adhesion ligands and physical patterning with a variety of topographical features. These surface-mediated biochemical and mechanical cues have proven influential in altering a wide range of stem cell phenotypes. This approach to guide or ultimately control stem cells by surface patterning has enormous potential implications in cell therapies and regenerative medicine.
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“Engineered 2D surface patterning and modification creates a 2D microenvironment with unique biochemical factors, topography, stiffness, and mechanical load for cell culture (72,81).”
From Modeling physiological events in 2D vs. 3D cell culture (2017) · cites this paper as [72]
Citations
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Modeling physiological events in 2D vs. 3D cell culture
Duval, K., Grover, H., Han, L.-H., Mou, Y., Pegoraro, A. F., Fredberg, J., & Chen, Z. (2017) · Physiology · doi:10.1152/physiol.00036.2016 · Cited by 1,849
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A review of microfabrication and hydrogel engineering for micro-organs on chips
Verhulsel, M., Vignes, M., Descroix, S., Malaquin, L., Vignjevic, D. M., & Viovy, J. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.021 · Cited by 244
Metadata
- Authors
- Kolind, K., Leong, K. W., Besenbacher, F., & Foss, M.
- Affiliations
- Aarhus University (DK)
- Duke University (US)
- Corresponding author
- Foss, Morten
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 33
- Issue
- 28
- Pages
- 6626-6633
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W1966420048
- Cited by
- 163
- References
- 73
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 6 · 2019: 12 · 2018: 12 · 2017: 19 · 2016: 22 · 2015: 18 · 2014: 25 · 2013: 19 · 2012: 1
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Danish Agency for Science Technology and Innovation (2052-01-0006)
- NIH (EB015300)
- AOSpine Foundation
- Danish Research Councils
- Carlsberg Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- stem cell fate, surface patterning, chemical patterning, topography, mechanical cues, biochemical cues, stem cell differentiation, self-renewal, regenerative medicine, cell therapy
- MeSH terms
- Cell Adhesion, Cell Communication, Cell Differentiation, Extracellular Matrix, Humans, Stem Cells, Surface Properties, Cell Culture Techniques, Cell Lineage, Tissue Engineering, Mechanotransduction, Cellular, Regenerative Medicine, Guided Tissue Regeneration, Cell Proliferation, Cellular Microenvironment
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