The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Guidance of stem cell fate on 2D patterned surfaces
Abstract
Stem cells possess unique abilities as they can renew themselves for extended periods of time and have the capacity to differentiate into a variety of lineages. They hold promise for treating a plethora of diseases ranging from musculoskeletal defects to myocardial infarction and to neural disorders. Understanding how to control the fate decision of these cells to self-renew or differentiate is paramount in stem cell tissue engineering. Recently, significant progress has been made in guiding stem cell differentiation in vitro, and we are beginning to understand the complex interplay of factors that control their fate. Here, we highlight the recent approaches for guidance of stem cells through patterning of surfaces at the micro- and nanoscale. Particular attention is given to chemical patterning of substrates with adhesion ligands and physical patterning with a variety of topographical features. These surface-mediated biochemical and mechanical cues have proven influential in altering a wide range of stem cell phenotypes. This approach to guide or ultimately control stem cells by surface patterning has enormous potential implications in cell therapies and regenerative medicine.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Engineered 2D surface patterning and modification creates a 2D microenvironment with unique biochemical factors, topography, stiffness, and mechanical load for cell culture (72,81).”
From Modeling physiological events in 2D vs. 3D cell culture (2017) · cites this paper as [72]
Citations
Cites
Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment
McBeath, R., Pirone, D. M., Nelson, C. M., Bhadriraju, K., & Chen, C. S. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00075-9 · Cited by 4,182
Exploring and Engineering the Cell Surface Interface
Stevens, M. M., & George, J. H. (2005) · Science · doi:10.1126/science.1106587 · Cited by 2,607
The control of human mesenchymal cell differentiation using nanoscale symmetry and disorder
Dalby, M. J., Gadegaard, N., Tare, R. S., Andar, A. U., Riehle, M. O., Herzyk, P., Wilkinson, C. D. W., & Oreffo, R. O. C. (2007) · Nature Materials · doi:10.1038/nmat2013 · Cited by 2,420
Control of Stem Cell Fate by Physical Interactions with the Extracellular Matrix
Guilak, F., Cohen, D. M., Estes, B. T., Gimble, J. M., Liedtke, W., & Chen, C. S. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.06.016 · Cited by 1,872
Geometric cues for directing the differentiation of mesenchymal stem cells
Kilian, K. A., Bugarija, B., Lahn, B. T., & Mrksich, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903269107 · Cited by 1,841
Adult Bone Marrow Stromal Cells Differentiate into Neural Cells in Vitro
Sanchez‐Ramos, J., Song, S., Cardozo‐Pelaez, F., Hazzi, C., Stedeford, T. J., Willing, A. E., Freeman, T. B., Saporta, S., Janssen, W. E., Patel, N. A., et al. (2000) · Experimental Neurology · doi:10.1006/exnr.2000.7389 · Cited by 1,568
Unconventional Methods for Fabricating and Patterning Nanostructures
Younan Xia, A., Rogers, J. A., Paul, K. E., & Whitesides, G. M. (1999) · Chemical Reviews · doi:10.1021/cr980002q · Cited by 1,548
Patterning proteins and cells using soft lithography
Kane, R. S. (1999) · Biomaterials · doi:10.1016/s0142-9612(99)00165-9 · Cited by 1,508
Effects of synthetic micro- and nano-structured surfaces on cell behavior
Flemming, R. G., Murphy, C. J., Abrams, G. A., Goodman, S. L., & Nealey, P. F. (1999) · Biomaterials · doi:10.1016/s0142-9612(98)00209-9 · Cited by 1,450
Engineering Substrate Topography at the Micro‐ and Nanoscale to Control Cell Function
Bettinger, C. J., Langer, R., & Borenstein, J. T. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200805179 · Cited by 1,269
Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.
Miyamoto, S., Teramoto, H., Coso, O. A., Gutkind, J. S., Burbelo, P. D., Akiyama, S. K., & Yamada, K. M. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.3.791 · Cited by 1,204
Nanosize and Vitality: TiO 2 Nanotube Diameter Directs Cell Fate
Park, J., Bauer, S., von der Mark, K., & Schmuki, P. (2007) · Nano Letters · doi:10.1021/nl070678d · Cited by 1,195
Stem cell fate dictated solely by altered nanotube dimension
Oh, S., Brammer, K. S., Li, Y. S. J., Teng, D., Engler, A. J., Chien, S., & Jin, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0813200106 · Cited by 1,177
Electron beam lithography: resolution limits and applications
Christophe Vieu, A., Carcenac, F., Pépin, A., Chen, Y., Mejias, M., Lebib, A., Ferlazzo, L., Couraud, L., & Launois, H. (2000) · Applied Surface Science · doi:10.1016/s0169-4332(00)00352-4 · Cited by 1,150
Surface engineering approaches to micropattern surfaces for cell-based assays
Falconnet, D., Csúcs, G., Grandin, H. M., & Textor, M. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2005.12.024 · Cited by 958
The interaction of cells and bacteria with surfaces structured at the nanometre scale
Anselme, K., Davidson, P. M., Popa, A., Giazzon, M., Liley, M., & Ploux, L. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.04.001 · Cited by 828
Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells
Anderson, D. G., Levenberg, S., & Langer, R. (2004) · Nature Biotechnology · doi:10.1038/nbt981 · Cited by 747
Yim, E. K. F., Pang, S. W., & Leong, K. W. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.02.031 · Cited by 735
Self-citationA role for bone morphogenetic proteins in the induction of cardiac myogenesis.Preprint
Schultheiss, T. M., Burch, J. B., & Lassar, A. B. (1997) · Genes & Development · doi:10.1101/gad.11.4.451 · Cited by 687
Visualizing the mechanical activation of Src
Wang, Y., Botvinick, E. L., Zhao, Y., Berns, M. W., Usami, S., Tsien, R. Y., & Chien, S. (2005) · Nature · doi:10.1038/nature03469 · Cited by 674
Patterning: Principles and Some New Developments
Geißler, M., & Younan Xia, A. (2004) · Advanced Materials · doi:10.1002/adma.200400835 · Cited by 640
Influence of nanoscale surface topography on protein adsorption and cellular response
Lord, M. S., Foss, M., & Besenbacher, F. (2010) · Nano Today · doi:10.1016/j.nantod.2010.01.001 · Cited by 605
Self-citationCombinatorial development of biomaterials for clonal growth of human pluripotent stem cells
Mei, Y., Saha, K., Bogatyrev, S. R., Yang, J., Hook, A. L., Kalcioglu, Z. I., Cho, S., Mitalipova, M. M., Pyzocha, N., Rojas, F., et al. (2010) · Nature Materials · doi:10.1038/nmat2812 · Cited by 550
Mechanotransduction at Cell-Matrix and Cell-Cell Contacts
Chen, C. S., Tan, J. L., & Tien, J. (2004) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.6.040803.140040 · Cited by 544
Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis
Pandur, P., Läsche, M., Eisenberg, L. M., & Kühl, M. (2002) · Nature · doi:10.1038/nature00921 · Cited by 536
Nantotechniques and approaches in biotechnology
Curtis, A. S. G., & Wilkinson, C. D. W. (2001) · Trends in biotechnology · doi:10.1016/s0167-7799(00)01536-5 · Cited by 500
Engineering gene expression and protein synthesis by modulation of nuclear shape
Thomas, C. H., Collier, J. H., Sfeir, C. S., & Healy, K. E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032668799 · Cited by 489
Deng, W., Obrocka, M., Fischer, I., & Prockop, D. J. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4570 · Cited by 485
Bauwens, C. L., Peerani, R., Niebruegge, S., Woodhouse, K. A., Kumacheva, E., Husain, M., & Zandstra, P. W. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0183 · Cited by 454
The differentiation of embryonic stem cells seeded on electrospun nanofibers into neural lineages
Xie, J., Willerth, S. M., Li, X., MacEwan, M. R., Rader, A., Sakiyama‐Elbert, S. E., & Younan Xia, A. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.09.046 · Cited by 445
Wislet‐Gendebien, S., Hans, G. A., Leprince, P., Rigo, J., Moonen, G., & Rogister, B. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0149 · Cited by 427
Hwang, Y., Chung, B. G., Ortmann, D., Hattori, N., Moeller, H., & Khademhosseini, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905550106 · Cited by 396
An algorithm-based topographical biomaterials library to instruct cell fate
Unadkat, H. V., Hulsman, M., Cornelissen, K., Papenburg, B. J., Truckenmüller, R. K., Carpenter, A. E., Weßling, M., Post, G. F., Uetz, M., Reinders, M. J. T., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109861108 · Cited by 389
Nanotopographical Control of Stem Cell Differentiation
McNamara, L. E., McMurray, R. J., Biggs, M. J. P., Kantawong, F., Oreffo, R. O. C., & Dalby, M. J. (2010) · Journal of Tissue Engineering · doi:10.4061/2010/120623 · Cited by 371
Controlling size, shape and homogeneity of embryoid bodies using poly(ethylene glycol) microwells
Karp, J. M., Yeh, J., Eng, G. M., Fukuda, J., Blumling, J., Suh, K. Y., Cheng, J., Mahdavi, A., Borenstein, J. T., Langer, R., et al. (2007) · Lab on a Chip · doi:10.1039/b705085m · Cited by 368
Lee, M. R., Kwon, K. W., Jung, H., Kim, H. N., Suh, K. Y., Kim, K., & Kim, K.-S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.02.012 · Cited by 333
Washburn, N. R., Yamada, K. M., Simon, C. G., Kennedy, S. B., & Amis, E. J. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.08.043 · Cited by 308
Cytoskeleton-based forecasting of stem cell lineage fates
Treiser, M. D., Yang, E., Gordonov, S., Cohen, D. M., Androulakis, I. P., Kohn, J., Chen, C. S., & Moghe, P. V. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909597107 · Cited by 296
Control of Cell Behavior: Topological Factors 2
Curtis, A. S. G., & Varde, M. (1964) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/33.1.15 · Cited by 278
Cohen, E. D., Tian, Y., & Morrisey, E. E. (2008) · Development · doi:10.1242/dev.016865 · Cited by 272
Lim, S. H., Liu, X. Y., Song, H., Yarema, K. J., & Mao, H. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.08.021 · Cited by 263
Activated Signal Transducer and Activator of Transcription (STAT) 3
Silver, D. L., Naora, H., Liu, J., Cheng, W., & Montell, D. J. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3959 · Cited by 257
Nix, D. A., & Beckerle, M. C. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.5.1139 · Cited by 254
Recknor, J. B., Sakaguchi, D. S., & Mallapragada, S. K. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.03.029 · Cited by 254
Mohr, J. C., Zhang, J., Azarin, S. M., Soerens, A. G., de Pablo, J. J., Thomson, J. A., Lyons, G. E., Palecek, S. P., & Kamp, T. J. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.11.033 · Cited by 228
Qian, L., & Saltzman, W. M. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.08.013 · Cited by 197
Seo, C. H., Furukawa, K. S., Montagne, K., Jeong, H., & Ushida, T. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.077 · Cited by 195
Spatial and Temporal Regulation of Focal Adhesion Kinase Activity in Living Cells
Cai, X., Lietha, D., Ceccarelli, D. F. J., Karginov, A. V., Rajfur, Z., Jacobson, K., Hahn, K. M., Eck, M. J., & Schaller, M. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01324-07 · Cited by 183
Al-Kofahi, O., Radke, R. J., Goderie, S. K., Shen, Q., Temple, S., & Roysam, B. (2006) · Cell Cycle · doi:10.4161/cc.5.3.2426 · Cited by 172
Tailoring Cell Adhesion Using Surface‐Grafted Polymer Gradient Assemblies
Bhat, R. R., Chaney, B., Rowley, J. A., Liebmann-Vinson, A., & Genzer, J. (2005) · Advanced Materials · doi:10.1002/adma.200500858 · Cited by 171
Substrate topography shapes cell function
Kulangara, K., & Leong, K. W. (2009) · Soft Matter · doi:10.1039/b910132m · Cited by 145
Self-citationSugi, Y., & Lough, J. (1994) · Developmental Dynamics · doi:10.1002/aja.1002000207 · Cited by 144
Continuous concentration of bacteria in a microfluidic flow cell using electrokinetic techniques
Cabrera, C. R., & Yager, P. (2001) · Electrophoresis · doi:10.1002/1522-2683(200101)22:2 · Cited by 139
Biomedical Engineering, Trends in Materials Science
Laskovski, A. N. (2011) · InTech eBooks · doi:10.5772/992 · Cited by 137
Lovmand, J., Justesen, J., Foss, M., Lauridsen, R. H., Lovmand, M., Modin, C., Besenbacher, F., Pedersen, F. S., & Duch, M. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.081 · Cited by 126
Self-citationWnt11 facilitates embryonic stem cell differentiation to Nkx2.5-positive cardiomyocytes
Terami, H., Hidaka, K., Katsumata, T., Iio, A., & Morisaki, T. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.10.103 · Cited by 124
Hydrophobic nanopillars initiate mesenchymal stem cell aggregation and osteo-differentiation
Brammer, K. S., Choi, C., Frandsen, C. J., Oh, S., & Jin, S. (2010) · Acta Biomaterialia · doi:10.1016/j.actbio.2010.09.022 · Cited by 120
Computational prediction of neural progenitor cell fates
Cohen, A. R., Gomes, F. L. A. F., Roysam, B., & Cayouette, M. (2010) · Nature Methods · doi:10.1038/nmeth.1424 · Cited by 109
Shibanuma, M., Kim‐Kaneyama, J., Ishino, K., Sakamoto, N., Hishiki, T., Yamaguchi, K., Mori, K., Mashimo, J., & Nose, K. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.02-06-0099 · Cited by 95
Protein adsorption and surface patterning
Ekblad, T., & Liedberg, B. (2010) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2010.07.008 · Cited by 83
Modulation of Wnt/β-catenin signaling in human embryonic stem cells using a 3-D microwell array
Azarin, S. M., Lian, X. L., Larson, E. A., Popelka, H. M., de Pablo, J. J., & Palecek, S. P. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.11.070 · Cited by 78
Markert, L. D., Lovmand, J., Foss, M., Lauridsen, R. H., Lovmand, M., Füchtbauer, E., Füchtbauer, A. C., Wertz, K., Besenbacher, F., Pedersen, F. S., et al. (2009) · Stem Cells and Development · doi:10.1089/scd.2009.0114 · Cited by 71
Self-citationNanoscale surfacing for regenerative medicine
Yang, Y. S., & Leong, K. W. (2010) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.74 · Cited by 66
Self-citationWnt1 and Wnt5a affect endothelial proliferation and capillary length; Wnt2 does not
Goodwin, A. M., Kitajewski, J., & D'Amore, P. A. (2007) · Growth Factors · doi:10.1080/08977190701272933 · Cited by 64
Kim, S.-J., Lee, J. K., Kim, J. W., Jung, J., Seo, K., Park, S., Roh, K.-H., Lee, S., Hong, Y. H., Kim, S. J., et al. (2008) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-008-3413-6 · Cited by 62
Vertebrate neural stem cell segmentation, tracking and lineaging with validation and editing
Winter, M. R., Wait, E. C., Roysam, B., Goderie, S. K., Ali, R. A. N., Kokovay, E., Temple, S., & Cohen, A. R. (2011) · Nature Protocols · doi:10.1038/nprot.2011.422 · Cited by 58
Gradient substrate assembly for quantifying cellular response to biomaterials
Mei, Y., Elliott, J. T., Smith, J. R., Langenbach, K. J., Wu, T., Xu, C., Beers, K. L., Amis, E. J., & Henderson, L. A. (2006) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30883 · Cited by 52
Cohen, A. R., Bjornsson, C. S., Temple, S., Banker, G. A., & Roysam, B. (2009) · IEEE Transactions on Pattern Analysis and Machine Intelligence · doi:10.1109/tpami.2008.162 · Cited by 44
The development of high-throughput screening approaches for stem cell engineering
Mei, Y., Goldberg, M. S., & Anderson, D. G. (2007) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2007.07.006 · Cited by 42
Neurogenic Cells Inhibit the Differentiation of Cardiogenic Cells
Climent, S., Sarasa, M., Villar, J. M., & Murillo-Ferrol, N. L. (1995) · Developmental Biology · doi:10.1006/dbio.1995.1266 · Cited by 32
Nanopatterned Surfaces for Biomedical Applications
McMurray, R. J., Matthew, J., & Gadegaar, N. (2011) · InTech eBooks · doi:10.5772/13453 · Cited by 16
Mok, S. S., Clippingdale, A. B., Beyreuther, K. T., Masters, C. L., Barrow, C. J., & Small, D. H. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20000815)61:4 · Cited by 10
Microengineering Approach for Directing Embryonic Stem Cell Differentiation
Bae, H., Nichol, J. W., Foudeh, A. M., Zamanian, B., Kwon, C. H., & Khademhosseini, A. (2010) · Studies in mechanobiology, tissue engineering and biomaterials · doi:10.1007/8415_2010_7 · Cited by 5
Flagged first, then by citations
Research works printed but not linked: 1
- Curtis, 1964, Control of cell behaviour: topological factors, J Natl Cancer Inst, 33, 15
Cited by
Sorted by citations
Modeling physiological events in 2D vs. 3D cell culture
Duval, K., Grover, H., Han, L.-H., Mou, Y., Pegoraro, A. F., Fredberg, J., & Chen, Z. (2017) · Physiology · doi:10.1152/physiol.00036.2016 · Cited by 1,849
Qi, Y., Wang, H., Wei, K., Yang, Y. F., Zheng, R., Kim, I. S., & Zhang, K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030237 · Cited by 551
Bone tissue regeneration: the role of scaffold geometry
ZADPOOR, A. A. (2014) · Biomaterials Science · doi:10.1039/c4bm00291a · Cited by 523
Electrically Controlled Drug Delivery from Graphene Oxide Nanocomposite Films
Weaver, C. L., LaRosa, J. M., Luo, X., & Cui, X. T. (2014) · ACS Nano · doi:10.1021/nn406223e · Cited by 424
A review of microfabrication and hydrogel engineering for micro-organs on chips
Verhulsel, M., Vignes, M., Descroix, S., Malaquin, L., Vignjevic, D. M., & Viovy, J. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.021 · Cited by 244
Metadata
- Authors
- Kolind, K., Leong, K. W., Besenbacher, F., & Foss, M.
- Affiliations
- Aarhus University (DK)
- Duke University (US)
- Corresponding author
- Foss, Morten
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 33
- Issue
- 28
- Pages
- 6626-6633
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W1966420048
- Cited by
- 163
- References
- 73
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 6 · 2019: 12 · 2018: 12 · 2017: 19 · 2016: 22 · 2015: 18 · 2014: 25 · 2013: 19 · 2012: 1
- FWCI
- 1.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Danish Agency for Science Technology and Innovation (2052-01-0006)
- NIH (EB015300)
- AOSpine Foundation
- Danish Research Councils
- Carlsberg Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- stem cell fate, surface patterning, chemical patterning, topography, mechanical cues, biochemical cues, stem cell differentiation, self-renewal, regenerative medicine, cell therapy
- MeSH terms
- Cell Adhesion, Cell Communication, Cell Differentiation, Extracellular Matrix, Humans, Stem Cells, Surface Properties, Cell Culture Techniques, Cell Lineage, Tissue Engineering, Mechanotransduction, Cellular, Regenerative Medicine, Guided Tissue Regeneration, Cell Proliferation, Cellular Microenvironment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
