Leong, Kam W.

Scaffolding in tissue engineering: general approaches and tissue-specific considerations

Chan, B. P., & Leong, K. W. (2008) · European Spine Journal

Bone Tissue Engineering MaterialsTissue Engineering and Regenerative Medicine

Cited by 1,708

Diverse Applications of Nanomedicine

Pelaz, B., Alexiou, C., Alvarez-Puebla, R. A., Alves, F., Andrews, A. M., Ashraf, S., Balogh, L. P., Ballerini, L., Bestetti, A., Brendel, C., et al. (2017) · ACS Nano

Nanotechnology research and applicationsNanoparticle-Based Drug Delivery

Cited by 1,350

RNA-guided gene activation by CRISPR-Cas9-based transcription factors

Perez-Pinera, P., Kocak, D. D., Vockley, C. M., Adler, A. F., Kabadi, A. M., Polstein, L. R., Thakore, P. I., Glass, K. A., Ousterout, D. G., Leong, K. W., et al. (2013) · Nature Methods

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 1,328

Synthetic nanostructures inducing differentiation of human mesenchymal stem cells into neuronal lineage

Yim, E. K. F., Pang, S. W., & Leong, K. W. (2007) · Experimental Cell Research

Cellular Mechanics and InteractionsBone Tissue Engineering Materials

Cited by 735

Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells

Yim, E. K. F., Darling, E. M., Kulangara, K., Guilak, F., & Leong, K. W. (2010) · Biomaterials

Cellular Mechanics and InteractionsCell Adhesion Molecules Research

Cited by 712

Natural Polymers for Gene Delivery and Tissue Engineering

DANG, J., & LEONG, K. (2006) · Advanced Drug Delivery Reviews

RNA Interference and Gene DeliveryAdvanced Drug Delivery Systems

Cited by 694

Nanopattern-induced changes in morphology and motility of smooth muscle cells

Yim, E. K. F., Reano, R. M., Pang, S. W., Yee, A. F., Chen, C. S., & Leong, K. W. (2005) · Biomaterials

Cellular Mechanics and InteractionsNanofabrication and Lithography Techniques

Cited by 628

CRISPR/Cas9-based genome editing for disease modeling and therapy: challenges and opportunities for nonviral delivery

Wang, H.-X., Li, M., Lee, C. M., Chakraborty, S., Kim, H.-W., Bao, G., & Leong, K. W. (2017) · Chemical Reviews

CRISPR and Genetic EngineeringRNA Interference and Gene Delivery

Cited by 560

Bioerodible polyanhydrides as drug‐carrier matrices. I: Characterization, degradation, and release characteristics

Leong, K. W., Brott, B. C., & Langer, R. (1985) · Journal of Biomedical Materials Research

biodegradable polymer synthesis and propertiesAdvanced Drug Delivery Systems

Cited by 541

Spatial epigenome–transcriptome co-profiling of mammalian tissues

Zhang, D., Deng, Y., Kukanja, P., Agirre, E., Bartosovic, M., Dong, M., Ma, C., Ma, S., Su, G., Bao, S., et al. (2023) · Nature

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 483

Spatial profiling of chromatin accessibility in mouse and human tissues

Deng, Y., Bartosovic, M., Ma, S., Zhang, D., Kukanja, P., Xiao, Y., Su, G., Liu, Y., Qin, X., Rosoklija, G. B., et al. (2022) · Nature

Single-cell and spatial transcriptomicsGenomics and Chromatin Dynamics

Cited by 417

Characterization of topographical effects on macrophage behavior in a foreign body response model

Chen, S., Jones, J. A., Xu, Y., Low, H.-Y., Anderson, J. M., & Leong, K. W. (2010) · Biomaterials

Cellular Mechanics and InteractionsBone Tissue Engineering Materials

Cited by 389

Significance of synthetic nanostructures in dictating cellular response

Yim, E. K. F., & Leong, K. W. (2005) · Nanomedicine: Nanotechnology, Biology and Medicine

Cellular Mechanics and InteractionsNanofabrication and Lithography Techniques

Cited by 281

Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide

Wang, H.-X., Song, Z., Lao, Y.-H., Xu, X., Gong, J., Cheng, D., Chakraborty, S., Park, J. S., Li, M., Huang, D., et al. (2018) · Proceedings of the National Academy of Sciences

RNA Interference and Gene DeliveryCRISPR and Genetic Engineering

Cited by 277

Blood-brain barrier–penetrating single CRISPR-Cas9 nanocapsules for effective and safe glioblastoma gene therapy

Zou, Y., Sun, X., Yang, Q., Zheng, M., Shimoni, O., Ruan, W., Wang, Y., Zhang, D., Yin, J., Huang, X., et al. (2022) · Science Advances

RNA Interference and Gene DeliveryCRISPR and Genetic Engineering

Cited by 227

Challenges and opportunities for the next generation of cardiovascular tissue engineering

Cho, S., Discher, D. E., Leong, K. W., Vunjak-Novakovic, G., & Wu, J. C. (2022) · Nature Methods

Pluripotent Stem Cells ResearchTissue Engineering and Regenerative Medicine

Cited by 176

Guidance of stem cell fate on 2D patterned surfaces

Kolind, K., Leong, K. W., Besenbacher, F., & Foss, M. (2012) · Biomaterials

Cellular Mechanics and InteractionsTissue Engineering and Regenerative Medicine

Cited by 163

Substrate topography shapes cell function

Kulangara, K., & Leong, K. W. (2009) · Soft Matter

Cellular Mechanics and Interactions3D Printing in Biomedical Research

Cited by 145

Ocular Nanoparticle Toxicity and Transfection of the Retina and Retinal Pigment Epithelium

Prow, T. W., Bhutto, I., Kim, S. Y., Grebe, R., Merges, C., McLeod, D. S., Uno, K., Mennon, M., Rodriguez, L., Leong, K., et al. (2008) · Nanomedicine: Nanotechnology, Biology and Medicine

Advanced Drug Delivery SystemsRNA Interference and Gene Delivery

Cited by 111

The effect of substrate topography on direct reprogramming of fibroblasts to induced neurons

Kulangara, K., Adler, A. F., Wang, H., Chellappan, M., Hammett, E., Yasuda, R., & Leong, K. W. (2014) · Biomaterials

Cellular Mechanics and InteractionsPluripotent Stem Cells Research

Cited by 102

Engineering Liver Microtissues for Disease Modeling and Regenerative Medicine

Huang, D. (., Gibeley, S. B., Xu, C., Xiao, Y., Celik, O., Ginsberg, H. N., & Leong, K. W. (2020) · Advanced Functional Materials

3D Printing in Biomedical ResearchTissue Engineering and Regenerative Medicine

Cited by 65

Prevention of excessive scar formation using nanofibrous meshes made of biodegradable elastomer poly(3-hydroxybutyrate- co -3-hydroxyvalerate)

Kim, H. S., Chen, J., Wu, L.-P., Wu, J., Xiang, H., Leong, K. W., & Han, J. (2020) · Journal of Tissue Engineering

Electrospun Nanofibers in Biomedical ApplicationsWound Healing and Treatments

Cited by 42

Squidiff: predicting cellular development and responses to perturbations using a diffusion model

He, S., Zhu, Y., Tavakol, D. N., Ye, H., Lao, Y.-H., Zhu, Z., Xu, C., Chauhan, S., Garty, G., Tomer, R., et al. (2026) · Nature Methods

Single-cell and spatial transcriptomicsGene Regulatory Network Analysis

Cited by 38

Focused ultrasound‐mediated APOE4 knockdown in mouse brain

Zheng, K., Tsitsos, F. N., Batts, A. J., Ji, R., Nuriel, T., Konofagou, E. E., & Leong, K. W. (2025) · Alzheimer's & Dementia

Ultrasound and Hyperthermia ApplicationsAlzheimer's disease research and treatments

Cited by 8