Cited by 163Cellular Mechanics and InteractionsTissue Engineering and Regenerative MedicinePluripotent Stem Cells Research

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Guidance of stem cell fate on 2D patterned surfaces

Kolind, Kristian, Leong, Kam W., Besenbacher, Flemming, Foss, Morten·2012·Biomaterials

DOI 10.1016/j.biomaterials.2012.05.070

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Abstract

Stem cells possess unique abilities as they can renew themselves for extended periods of time and have the capacity to differentiate into a variety of lineages. They hold promise for treating a plethora of diseases ranging from musculoskeletal defects to myocardial infarction and to neural disorders. Understanding how to control the fate decision of these cells to self-renew or differentiate is paramount in stem cell tissue engineering. Recently, significant progress has been made in guiding stem cell differentiation in vitro, and we are beginning to understand the complex interplay of factors that control their fate. Here, we highlight the recent approaches for guidance of stem cells through patterning of surfaces at the micro- and nanoscale. Particular attention is given to chemical patterning of substrates with adhesion ligands and physical patterning with a variety of topographical features. These surface-mediated biochemical and mechanical cues have proven influential in altering a wide range of stem cell phenotypes. This approach to guide or ultimately control stem cells by surface patterning has enormous potential implications in cell therapies and regenerative medicine.

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Authors: Kolind, K., Leong, K. W., Besenbacher, F., & Foss, M.
Affiliations: Aarhus University (DK)
Duke University (US)
Corresponding author: Foss, Morten
ORCID: Leong, Kam W.
Besenbacher, Flemming
Foss, Morten
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2012-10
Volume: 33
Issue: 28
Pages: 6626-6633
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2012.05.070
OpenAlex: W1966420048
Cited by: 163
References: 73
Citations by year: 2026: 2 · 2025: 10 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 6 · 2019: 12 · 2018: 12 · 2017: 19 · 2016: 22 · 2015: 18 · 2014: 25 · 2013: 19 · 2012: 1
FWCI: 1.85
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
Funders: Danish Agency for Science Technology and Innovation (2052-01-0006)
NIH (EB015300)
AOSpine Foundation
Danish Research Councils
Carlsberg Foundation
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords: stem cell fate, surface patterning, chemical patterning, topography, mechanical cues, biochemical cues, stem cell differentiation, self-renewal, regenerative medicine, cell therapy
MeSH terms: Cell Adhesion, Cell Communication, Cell Differentiation, Extracellular Matrix, Humans, Stem Cells, Surface Properties, Cell Culture Techniques, Cell Lineage, Tissue Engineering, Mechanotransduction, Cellular, Regenerative Medicine, Guided Tissue Regeneration, Cell Proliferation, Cellular Microenvironment

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Guidance of stem cell fate on 2D patterned surfaces

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