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The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system
Open accessAbstract
Devices implanted into the body become encapsulated due to a foreign body reaction. In the central nervous system (CNS), this can lead to loss of functionality in electrodes used to treat disorders. Around CNS implants, glial cells are activated, undergo gliosis and ultimately encapsulate the electrodes. The primary cause of this reaction is unknown. Here we show that the mechanical mismatch between nervous tissue and electrodes activates glial cells. Both primary rat microglial cells and astrocytes responded to increasing the contact stiffness from physiological values (G' ∼ 100 Pa) to shear moduli G' ≥ 10 kPa by changes in morphology and upregulation of inflammatory genes and proteins. Upon implantation of composite foreign bodies into rat brains, foreign body reactions were significantly enhanced around their stiff portions in vivo. Our results indicate that CNS glial cells respond to mechanical cues, and suggest that adapting the surface stiffness of neural implants to that of nervous tissue could minimize adverse reactions and improve biocompatibility.
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Response of brain tissue to chronically implanted neural electrodes
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A Pericyte Origin of Spinal Cord Scar Tissue
Göritz, C., Dias, D. O., Tomilin, N., Barbacid, M., Shupliakov, O., & Frisén, J. (2011) · Science · doi:10.1126/science.1203165 · Cited by 858
Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis
Georges, P. C., Hui, J.-J., Gombos, Z., McCormick, M. E., Wang, A. Y., Uemura, M., Mick, R., Janmey, P. A., Furth, E. E., & Wells, R. G. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00032.2007 · Cited by 577
Implanted Neural Interfaces: Biochallenges and Engineered Solutions
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Self-citationMechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
Atcha, H., Jairaman, A., Holt, J. R., Meli, V. S., Nagalla, R. R., Veerasubramanian, P. K., Brumm, K. T., Lim, H. E., Othy, S., Cahalan, M. D., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23482-5 · Cited by 644
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Metadata
- Authors
- Moshayedi, P., Ng, G., Kwok, J. C. F., Yeo, G. S. H., Bryant, C. E., Fawcett, J. W., Franze, K., & Guck, J.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 35
- Issue
- 13
- Pages
- 3919-3925
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2001379153
- Cited by
- 394
- References
- 6
- FWCI
- 9.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Moshayedi, P., Ng, G., Kwok, J. C. F., Yeo, G. S. H., Bryant, C. E., Fawcett, J. W., Franze, K., & Guck, J. (2014). The relationship between glial cell mechanosensitivity and foreign body reactions in the central nervous system. Biomaterials. https://doi.org/10.1016/j.biomaterials.2014.01.038
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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