Nano-assemblies of J-aggregates based on a NIR dye as a multifunctional drug carrier for combination cancer therapy
Abstract
The combination of chemotherapy with photothermal therapy, which may lead to improved therapeutic efficacies and reduced side effects of conventional chemotherapy, would require safe drug delivery systems (DDSs) with strong near-infrared (NIR) absorbance, efficient drug loading, and effective tumor homing ability. Herein, we fabricate nano-assemblies containing J-aggregates of a NIR dye, IR825, for drug delivery and combined photothermal & chemotherapy of cancer. It is found that IR825 could be complexed with a low-molecular-weight cationic polymer polyethylenimine (PEI), forming IR825@PEI J-aggregates with greatly enhanced NIR absorbance red-shifted to 915 nm. Those nano-assemblies of J-aggregates are further modified with polyethylene glycol (PEG), obtaining IR825@PEI-PEG nano-complex which exhibits great dispersity in physiological solutions, excellent photostability, and is able to efficiently load chemotherapeutic drug doxorubicin (DOX) via a unique strategy different from drug loading in conventional amphiphilic polymer-based DDSs. In vivo animal experiments uncover that IR825@PEI-PEG/DOX upon intravenous injection into tumor-bearing mice shows rather high tumor uptake as illustrated by photoacoustic imaging. In vivo combined photothermal & chemotherapy is then carried out, demonstrating great synergistic anti-tumor therapeutic effect remarkably superior to those achieved by the respective mono-therapies. Hence, we present a novel type of nanoscale DDSs based on nano-assemblies of small molecules without involving amphiphilic polymers, promising for imaging-guided combination cancer therapy.
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IR825 cyanine dye encapsulated in low-molecular-weight cationic polymer polyethylenimine (PEI) forms IR825@PEI J-aggregates with greatly enhanced and red-shifted NIR absorbance at 915 nm.
“IR825 cyanine dye encapsulated in low-molecular-weight cationic polymer polyethylenimine (PEI) form IR825@PEI J-aggregates with greatly enhanced and red-shifted NIR absorbance at 915 nm (Figure 4a).111”
From The Pursuit of Shortwave Infrared-Emitting Nanoparticles with Bright Fluorescence through Molecular Design and Excited-State Engineering of Molecular Aggregates (2022) · cites this paper as [111]
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- Authors
- Song, X., Zhang, R., Liang, C., Chen, Q., Gong, H., & Liu, Z.
- Affiliations
- Soochow University (CN)
- Corresponding author
- Liu, Zhuang
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2015-07
- Volume
- 57
- Pages
- 84-92
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W1997659581
- Cited by
- 101
- References
- 54
- Citations by year
- 2025: 6 · 2024: 2 · 2023: 6 · 2022: 12 · 2021: 12 · 2020: 11 · 2019: 9 · 2018: 12 · 2017: 12 · 2016: 15 · 2015: 4
- FWCI
- 7.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (51222203, 51132006)
- National 973 Program of China (2011CB911002, 2012CB932601)
- Juangsu Natural Science Fund for Distinguished Young Scholars (BK20130005)
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Keywords
- J-aggregates, near-infrared dyes, polyethyleneimine, PEGylation, doxorubicin, photothermal therapy, combination cancer therapy, drug delivery systems, photoacoustic imaging, tumor targeting, photostability, synergistic antitumor effect
- MeSH terms
- Animals, Antibiotics, Antineoplastic, Benzoates, Breast, Breast Neoplasms, Combined Modality Therapy, Doxorubicin, Drug Carriers, Female, Humans, Hyperthermia, Induced, Indoles, Mice, Inbred BALB C, Photochemotherapy, Polyethylene Glycols, Polyethyleneimine, Cell Line, Tumor, Nanostructures, Mice
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