Cited by 320Conducting polymers and applicationsAdvanced Drug Delivery SystemsPolymer Surface Interaction Studies

Electrically Controlled Drug Delivery from Biotin‐Doped Conductive Polypyrrole

George, P. M., LaVan, D. A., Burdick, J. A., Chen, C.‐Y., Liang, E., Langer, R.·2006·Advanced Materials

Abstract

A platform for controlled drug delivery using a conductive-polymer substrate has been created. Through the incorporation of biotin into the conductive polymer polypyrrole (PPy) and the subsequent attachment of the desired drug molecule (such as nerve growth factor, NGF) via a streptavidin linker, an applied potential can trigger release of the drug from the polymer surface (see figure).

Integrity signals

Registry

Crossref · 10.1002/adma.200501242

Cites

31 of 31 references verified0 citation errors · 0 not checkable

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  • Common conductive polymers include polypyrrole (PPy), polyaniline along its derivatives poly(3,4-ethylenedioxythiophene) (PEDOT), which are widely used because of their biocompatibility and ability to convert electrical energy into mechanical energy.

    “Common conductive polymers include polypyrrole (PPy), polyaniline along its derivatives poly(3,4-ethylenedioxythiophene) (PEDOT), which are widely used because of their biocompatibility and ability to convert electrical energy into mechanical energy.182,183”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [182]

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Authors
George, P. M., LaVan, D. A., Burdick, J. A., Chen, C. ‐., Liang, E., & Langer, R.
Affiliations
  • Massachusetts Institute of Technology (US)
  • Yale University (US)
  • National Tsing Hua University (TW)
Corresponding author
Langer, R.
Venue
Advanced Materials
Publisher
Wiley
Published
2006-03-02
Volume
18
Issue
5
Pages
577-581
ISSN
  • 0935-9648 (ISSN-L)
  • 1521-4095
OpenAlex
W2005299431
Cited by
320
References
31
Citations by year
2026: 5 · 2025: 8 · 2024: 6 · 2023: 22 · 2022: 12 · 2021: 14 · 2020: 18 · 2019: 18 · 2018: 28 · 2017: 21 · 2016: 23 · 2015: 21 · 2014: 15 · 2013: 9 · 2012: 19
FWCI
15.16
Type
journal article
Language
en
Open access
closed
Locations
Advanced Materials (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
Keywords
polypyrrole, conducting polymers, biotin, nerve growth factor, biotin-streptavidin binding

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