Electrically Controlled Drug Delivery from Biotin‐Doped Conductive Polypyrrole
Abstract
A platform for controlled drug delivery using a conductive-polymer substrate has been created. Through the incorporation of biotin into the conductive polymer polypyrrole (PPy) and the subsequent attachment of the desired drug molecule (such as nerve growth factor, NGF) via a streptavidin linker, an applied potential can trigger release of the drug from the polymer surface (see figure).
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Common conductive polymers include polypyrrole (PPy), polyaniline along its derivatives poly(3,4-ethylenedioxythiophene) (PEDOT), which are widely used because of their biocompatibility and ability to convert electrical energy into mechanical energy.
“Common conductive polymers include polypyrrole (PPy), polyaniline along its derivatives poly(3,4-ethylenedioxythiophene) (PEDOT), which are widely used because of their biocompatibility and ability to convert electrical energy into mechanical energy.182,183”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [182]
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- Authors
- George, P. M., LaVan, D. A., Burdick, J. A., Chen, C. ‐., Liang, E., & Langer, R.
- Affiliations
- Massachusetts Institute of Technology (US)
- Yale University (US)
- National Tsing Hua University (TW)
- Corresponding author
- Langer, R.
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2006-03-02
- Volume
- 18
- Issue
- 5
- Pages
- 577-581
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W2005299431
- Cited by
- 320
- References
- 31
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 6 · 2023: 22 · 2022: 12 · 2021: 14 · 2020: 18 · 2019: 18 · 2018: 28 · 2017: 21 · 2016: 23 · 2015: 21 · 2014: 15 · 2013: 9 · 2012: 19
- FWCI
- 15.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- polypyrrole, conducting polymers, biotin, nerve growth factor, biotin-streptavidin binding
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