The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Effect of surface properties on liposomal siRNA delivery
Open accessAbstract
Liposomes are one of the most widely investigated carriers for siRNA delivery. The surface properties of liposomal carriers, including the surface charge, PEGylation, and ligand modification can significantly affect the gene silencing efficiency. Three barriers of systemic siRNA delivery (long blood circulation, efficient tumor penetration and efficient cellular uptake/endosomal escape) are analyzed on liposomal carriers with different surface charges, PEGylations and ligand modifications. Cationic formulations dominate siRNA delivery and neutral formulations also have good performance while anionic formulations are generally not proper for siRNA delivery. The PEG dilemma (prolonged blood circulation vs. reduced cellular uptake/endosomal escape) and the side effect of repeated PEGylated formulation (accelerated blood clearance) were discussed. Effects of ligand modification on cationic and neutral formulations were analyzed. Finally, we summarized the achievements in liposomal siRNA delivery, outlined existing problems and provided some future perspectives.
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Cited by
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Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery
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Metadata
- Authors
- Xia, Y., Tian, J., & Chen, X.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 79
- Pages
- 56-68
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2182835963
- Cited by
- 220
- References
- 11
- FWCI
- 6.18
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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