The DOI matches its Crossref record; 130 of the 130 references it cites were found in a registry or an index.
Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants
Open accessAbstract
The two leading causes of failure for joint arthroplasty prostheses are aseptic loosening and periprosthetic joint infection. With the number of primary and revision joint replacement surgeries on the rise, strategies to mitigate these failure modes have become increasingly important. Much of the recent work in this field has focused on the design of coatings either to prevent infection while ignoring bone mineralization or vice versa, to promote osseointegration while ignoring microbial susceptibility. However, both coating functions are required to achieve long-term success of the implant; therefore, these two modalities must be evaluated in parallel during the development of new orthopaedic coating strategies. In this review, we discuss recent progress and future directions for the design of multifunctional orthopaedic coatings that can inhibit microbial cells while still promoting osseointegration.
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“infection is caused by the prevalence of the disease, and death may occur, which is truly overwhelming for the community and patient.(141) Because of these, it is required to make a new path for implants in bone tissue regeneration.”
Background
Metadata
- Authors
- Raphel, J., Holodniy, M., Goodman, S. B., & Heilshorn, S. C.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 84
- Pages
- 301-314
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2265531934
- Cited by
- 674
- References
- 130
- FWCI
- 80.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Raphel, J., Holodniy, M., Goodman, S. B., & Heilshorn, S. C. (2016). Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants. Biomaterials. https://doi.org/10.1016/j.biomaterials.2016.01.016
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