The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Dimensionality and spreading influence MSC YAP/TAZ signaling in hydrogel environments
Open accessAbstract
Improved fundamental understanding of how cells interpret microenvironmental signals is integral to designing better biomaterial therapies. YAP/TAZ are key mediators of mechanosensitive signaling; however, it is not clear how they are regulated by the complex interplay of microenvironmental factors (e.g., stiffness and degradability) and culture dimensionality. Using covalently crosslinked norbornene-functionalized hyaluronic acid (HA) hydrogels with controlled stiffness (via crosslink density) and degradability (via susceptibility of crosslinks to proteolysis), we found that human mesenchymal stem cells (MSCs) displayed increased spreading and YAP/TAZ nuclear localization when cultured atop stiffer hydrogels; however, the opposite trend was observed when MSCs were encapsulated within degradable hydrogels. When stiffness-matched hydrogels of reduced degradability were used, YAP/TAZ nuclear translocation was greater in cells that were able to spread, which was confirmed through pharmacological inhibition of YAP/TAZ and actin polymerization. Together, these data illustrate that YAP/TAZ signaling is responsive to hydrogel stiffness and degradability, but the outcome is dependent on the dimensionality of cell-biomaterial interactions.
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Cited by
Effects of extracellular matrix viscoelasticity on cellular behaviour
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Self-citationFiber density modulates cell spreading in 3D interstitial matrix mimetics
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Metadata
- Authors
- Caliari, S. R., Vega, S. L., Kwon, M., Soulas, E. M., & Burdick, J. A.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 103
- Pages
- 314-323
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2469522634
- Cited by
- 331
- References
- 34
- FWCI
- 12.32
- Type
- journal article
- Language
- en
- Open access
- green
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- Caliari, S. R., Vega, S. L., Kwon, M., Soulas, E. M., & Burdick, J. A. (2016). Dimensionality and spreading influence MSC YAP/TAZ signaling in hydrogel environments. Biomaterials. https://doi.org/10.1016/j.biomaterials.2016.06.061
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