The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip
Open accessAbstract
Engineering cardiac tissues and organ models remains a great challenge due to the hierarchical structure of the native myocardium. The need of integrating blood vessels brings additional complexity, limiting the available approaches that are suitable to produce integrated cardiovascular organoids. In this work we propose a novel hybrid strategy based on 3D bioprinting, to fabricate endothelialized myocardium. Enabled by the use of our composite bioink, endothelial cells directly bioprinted within microfibrous hydrogel scaffolds gradually migrated towards the peripheries of the microfibers to form a layer of confluent endothelium. Together with controlled anisotropy, this 3D endothelial bed was then seeded with cardiomyocytes to generate aligned myocardium capable of spontaneous and synchronous contraction. We further embedded the organoids into a specially designed microfluidic perfusion bioreactor to complete the endothelialized-myocardium-on-a-chip platform for cardiovascular toxicity evaluation. Finally, we demonstrated that such a technique could be translated to human cardiomyocytes derived from induced pluripotent stem cells to construct endothelialized human myocardium. We believe that our method for generation of endothelialized organoids fabricated through an innovative 3D bioprinting technology may find widespread applications in regenerative medicine, drug screening, and potentially disease modeling.
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Self-citationRapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues
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25th Anniversary Article: Engineering Hydrogels for Biofabrication
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Self-citationHydrogel bioprinted microchannel networks for vascularization of tissue engineering constructs
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Self-citationDirect 3D bioprinting of perfusable vascular constructs using a blend bioink
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Advances in engineering hydrogels
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Self-citationHuman organs-on-chips for disease modelling, drug development and personalized medicine
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Progress and potential in organoid research
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Progress in 3D bioprinting technology for tissue/organ regenerative engineering
Matai, I., Kaur, G., Seyedsalehi, A., McClinton, A., & Laurencin, C. T. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2019.119536 · Cited by 1,156
3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts
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Metadata
- Authors
- Zhang, Y. S., Arneri, A., Bersini, S., Shin, S.-R., Zhu, K., Goli-Malekabadi, Z., Aleman, J., Colosi, C., Busignani, F., Dell'Erba, V., Bishop, C., Shupe, T., Demarchi, D., Moretti, M., Rasponi, M., Dokmeci, M. R., Atala, A., & Khademhosseini, A.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 110
- Pages
- 45-59
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2509523536
- Cited by
- 951
- References
- 16
- FWCI
- 32.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhang, Y. S., Arneri, A., Bersini, S., Shin, S.-R., Zhu, K., Goli-Malekabadi, Z., Aleman, J., Colosi, C., Busignani, F., Dell'Erba, V., Bishop, C., Shupe, T., Demarchi, D., Moretti, M., Rasponi, M., Dokmeci, M. R., Atala, A., & Khademhosseini, A. (2016). Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip. Biomaterials. https://doi.org/10.1016/j.biomaterials.2016.09.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
