The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Selective laser sintering scaffold with hierarchical architecture and gradient composition for osteochondral repair in rabbits
Open accessAbstract
Osteochondral defects cannot be adequately self-repaired due to the presence of the sophisticated hierarchical structure and the lack of blood supply in cartilage. Thus, one of the major challenges remaining in this field is the structural design of a biomimetic scaffold that satisfies the specific requirements for osteochondral repair. To address this hurdle, a bio-inspired multilayer osteochondral scaffold that consisted of the poly(ε-caprolactone) (PCL) and the hydroxyapatite (HA)/PCL microspheres, was constructed via selective laser sintering (SLS) technique. The SLS-derived scaffolds exhibited an excellent biocompatibility to support cell adhesion and proliferation in vitro. The repair effect was evaluated by implanting the acellular multilayer scaffolds into osteochondral defects of a rabbit model. Our findings demonstrated that the multilayer scaffolds were able to induce articular cartilage formation by accelerating the early subchondral bone regeneration, and the newly formed tissues could well integrate with the native tissues. Consequently, the current study not only achieves osteochondral repair, but also suggests a promising strategy for the fabrication of bio-inspired multilayer scaffolds with well-designed architecture and gradient composition via SLS technique.
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1 retracted
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RetractedThe return of a forgotten polymer—Polycaprolactone in the 21st century
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Porous scaffold design for tissue engineering
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Bone tissue engineering using polycaprolactone scaffolds fabricated via selective laser sintering
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Unlike Bone, Cartilage Regeneration Remains Elusive
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Cited by
Arif, Z. U., Khalid, M. Y., Noroozi, R., Sadeghianmaryan, A., Jalalvand, M., & Hossain, M. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.07.140 · Cited by 395
Gao, F., Xu, Z., Liang, Q., Li, H., Peng, L., Wu, M., Zhao, X., Cui, X., Ruan, C., & Liu, W. (2019) · Advanced Science · doi:10.1002/advs.201900867 · Cited by 365
Design, printing, and engineering of regenerative biomaterials for personalized bone healthcare
Jia, Z., Xu, X., Zhu, D., & Zheng, Y. (2023) · Progress in Materials Science · doi:10.1016/j.pmatsci.2023.101072 · Cited by 176
Metadata
- Authors
- Du, Y., Liu, H., Yang, Q., Wang, S., Wang, J., Ma, J., Noh, I., Mikos, A. G., & Zhang, S.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 137
- Pages
- 37-48
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2613275913
- Cited by
- 322
- References
- 44
- FWCI
- 13.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Du, Y., Liu, H., Yang, Q., Wang, S., Wang, J., Ma, J., Noh, I., Mikos, A. G., & Zhang, S. (2017). Selective laser sintering scaffold with hierarchical architecture and gradient composition for osteochondral repair in rabbits. Biomaterials. https://doi.org/10.1016/j.biomaterials.2017.05.021
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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