The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Zwitterionic polymer ligands: an ideal surface coating to totally suppress protein-nanoparticle corona formation?
Open accessAbstract
In the last few years, zwitterionic polymers have been developed as antifouling surface coatings. However, their ability to completely suppress protein adsorption at the surface of nanoparticles in complex biological media remains undemonstrated. Here we investigate the formation of hard (irreversible) and soft (reversible) protein corona around model nanoparticles (NPs) coated with sulfobetaine (SB), phosphorylcholine (PC) and carboxybetaine (CB) polymer ligands in model albumin solutions and in whole serum. We show for the first time a complete absence of protein corona around SB-coated NPs, while PC- and CB-coated NPs undergo reversible adsorption or partial aggregation. These dramatic differences cannot be described by naïve hard/soft acid/base electrostatic interactions. Single NP tracking in the cytoplasm of live cells corroborate these in vitro observations. Finally, while modification of SB polymers with additional charged groups lead to consequent protein adsorption, addition of small neutral targeting moieties preserves antifouling and enable efficient intracellular targeting.
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Soo Choi, H., Liu, W., Misra, P., Tanaka, E., Zimmer, J. P., Itty Ipe, B., Bawendi, M. G., & Frangioni, J. V. (2007) · Nature Biotechnology · doi:10.1038/nbt1340 · Cited by 4,476
Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake
Walkey, C. D., Olsen, J. B., Guo, H., Emili, A., & Chan, W. C. W. (2012) · Journal of the American Chemical Society · doi:10.1021/ja2084338 · Cited by 1,926
Bertrand, N., Grenier, P., Mahmoudi, M., Lima, E. M., Appel, E. A., Dormont, F., Lim, J.-M., Karnik, R., Langer, R., & Farokhzad, O. C. (2017) · Nature Communications · doi:10.1038/s41467-017-00600-w · Cited by 708
Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo
Chen, F., Wang, G., Griffin, J. I., Brenneman, B., Banda, N. K., Holers, V. M., Backos, D. S., Wu, L., Moghimi, S. M., & Simberg, D. (2017) · Nature Nanotechnology · doi:10.1038/nnano.2016.269 · Cited by 599
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Polymeric Nanoparticles for Drug Delivery
Beach, M. A., Nayanathara, U., Gao, Y., Zhang, C., Xiong, Y., Wang, Y., & Such, G. K. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00705 · Cited by 1,155
Chemical and Biophysical Signatures of the Protein Corona in Nanomedicine
Ren, J., Andrikopoulos, N., Velonia, K., Tang, H., Cai, R., Ding, F., Ke, P. C., & Chen, C. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c02277 · Cited by 284
The protein corona and its effects on nanoparticle-based drug delivery systems
Li, H., Wang, Y., Tang, Q., Yin, D., Tang, C., He, E., Zou, L., & Peng, Q. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.05.019 · Cited by 265
Nanoparticles toxicity: An overview of its mechanism and plausible mitigation strategies
Sharma, N., Kurmi, B. D., Singh, D., Mehan, S., Khanna, K., Karwasra, R., Kumar, S., Chaudhary, A., Jakhmola, V., Sharma, A., et al. (2024) · Journal of Drug Targeting · doi:10.1080/1061186x.2024.2316785 · Cited by 58
Metadata
- Authors
- Debayle, M., Balloul, E., Dembele, F., Xu, X., Hanafi, M., Ribot, F., Monzel, C., Coppey, M., Fragola, A., Dahan, M., Pons, T., & Lequeux, N.
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 219
- Pages
- 119357
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2962281447
- Cited by
- 196
- References
- 4
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Debayle, M., Balloul, E., Dembele, F., Xu, X., Hanafi, M., Ribot, F., Monzel, C., Coppey, M., Fragola, A., Dahan, M., Pons, T., & Lequeux, N. (2019). Zwitterionic polymer ligands: an ideal surface coating to totally suppress protein-nanoparticle corona formation? Biomaterials. https://doi.org/10.1016/j.biomaterials.2019.119357
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