Vascularized cancer on a chip: The effect of perfusion on growth and drug delivery of tumor spheroid

Organogenesis in a dish: Modeling development and disease using organoid technologies

Lancaster, M. A., & Knoblich, J. A. (2014) · Science · doi:10.1126/science.1247125 · Cited by 2,931

Influence of tumour micro-environment heterogeneity on therapeutic response

Junttila, M. R., & de Sauvage, F. J. (2013) · Nature · doi:10.1038/nature12626 · Cited by 2,694

Cell and environment interactions in tumor microregions: the multicell spheroid model.

Sutherland, R. M. (1988) · Science · doi:10.1126/science.2451290 · Cited by 1,803

Spheroid-based drug screen: Considerations and practical approach

Friedrich, J., Seidel, C., Ebner, R., & Kunz-Schughart, L. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.226 · Cited by 1,742

Role of tumor microenvironment in tumorigenesis

Wang, M., Zhao, J., Zhang, L., Wei, F., Lian, Y., Wu, Y., Gong, Z., Zhang, S., Zhou, J., Cao, K., et al. (2017) · Journal of Cancer · doi:10.7150/jca.17648 · Cited by 1,404

Cell surface mechanics and the control of cell shape, tissue patterns and morphogenesis

Lecuit, T., & Lenne, P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2222 · Cited by 1,326

Biology's new dimension

Abbott, A. (2003) · Nature · doi:10.1038/424870a · Cited by 1,228

Spherical Cancer Models in Tumor Biology

Weiswald, L., Bellet, D. H., & Dangles‐Marie, V. (2015) · Neoplasia · doi:10.1016/j.neo.2014.12.004 · Cited by 1,194

Reconstruction of Tissues by Dissociated Cells

Steinberg, M. S. (1963) · Science · doi:10.1126/science.141.3579.401 · Cited by 1,127

The Role of Mechanical Forces in Tumor Growth and Therapy

Jain, R. K., Martin, J. D., & Stylianopoulos, T. (2014) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071813-105259 · Cited by 1,044

Fabrication of Angiogenic Sprouting Coculture of Cell Clusteroids Using an Aqueous Two-Phase Pickering Emulsion System

Wang, A., Madden, L. A., & Paunov, V. N. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00168 · Cited by 10

Modeling Immune Checkpoint Inhibitor Efficacy in Syngeneic Mouse Tumors in an Ex Vivo Immuno-Oncology Dynamic Environment

Doty, D. T., Schüler, J. B., Mott, V. L., Bryan, C. M., Moore, N. F., Ho, J. C., & Borenstein, J. T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186478 · Cited by 10

Hypoxia-responsive expression of vascular endothelial growth factor for induction of angiogenesis in artificial three-dimensional tissues

Masumoto, S., Ono, A., Itô, A., Kawabe, Y., & Kamihira, M. (2021) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2021.06.010 · Cited by 12

Selective plane illumination microscope dedicated to volumetric imaging in microfluidic chambers

Bissardon, C., Mermet, X., Quintard, C., Sanjuan, F., Fouillet, Y., Bottausci, F., Carrière, M., Rivera, F., & Blandin, P. (2022) · Biomedical Optics Express · doi:10.1364/boe.455377 · Cited by 10

Recent advances and future prospects of functional organ-on-a-chip systems

Moghaddam, A. S., Moghaddam, Z. S., Davachi, S. M., Sarikhani, E., Mahand, S. N., Khonakdar, H. A., Bagher, Z., & Ashammakhi, N. A. (2022) · Materials Chemistry Frontiers · doi:10.1039/d2qm00072e · Cited by 9

Advancing tissue engineering through vascularized cell spheroids: building blocks of the future

Lü, C., Jin, A., Liu, H., Gao, C., Sun, W., Zhang, Y., Dai, Q., & Liu, Y. (2025) · Biomaterials Science · doi:10.1039/d4bm01206b · Cited by 10

Microphysiological Systems in Cancer Research: Advancing Immunotherapy through Tumor Microenvironment‐Integrated Organ‐On‐Chip Models

Moresi, F., Noto, F., Vasudevan, J., Bisteau, X., Adriani, G., & Pavesi, A. (2025) · Advanced Therapeutics · doi:10.1002/adtp.202500098 · Cited by 10

Unlocking the Potential of Spheroids in Personalized Medicine: A Systematic Review of Seeding Methodologies

Lonkwic, K. M., Zajdel, R., & Kaczka, K. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136478 · Cited by 11

Imaging‐Based Efficacy Evaluation of Cancer Immunotherapy in Engineered Tumor Platforms and Tumor Organoids

Kim, S., Yun, S., Doh, J., & Kim, H. N. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400475 · Cited by 10

Magnetically Integrated Tumor–Vascular Interface System to Mimic Pro-angiogenic Endothelial Dysregulations for On-Chip Drug Testing

Surendran, V., Safarulla, S., Griffith, C. M., Ali, R., Madan, A., Polacheck, W. J., & Chandrasekaran, A. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c01766 · Cited by 9

Slicing Spheroids in Microfluidic Devices for Morphological and Immunohistochemical Analysis

Kuriu, S., Kadonosono, T., Kizaka‐Kondoh, S., & Ishida, T. (2020) · Micromachines · doi:10.3390/mi11050480 · Cited by 9

An Overview of Advancements and Technologies in Vascularization Strategies for Tumor‐On‐A‐Chip Models

Parihar, P., Sunildutt, N., Rahim, C. S. A., Samantasinghar, A., Lim, J., & Choi, K. H. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202300410 · Cited by 10

Continuous inline monitoring of glucose in an organ-on-chip using FreeStyle™ libre glucometers

Sánchez-Salazar, M. G., Garza-Garza, R., Oliver, R. C.-L., Jerezano-Flores, V. S., Gallegos-Martínez, S., Ramos-Meizoso, S., Verduzco-Valenzuela, M., Santiago, G. T., & Álvarez, M. M. (2024) · Frontiers in Lab on a Chip Technologies · doi:10.3389/frlct.2024.1289437 · Cited by 8

Advancing tumor microenvironment and lymphoid tissue research through 3D bioprinting and biofabrication

Mazzaglia, C., Huang, Y. Y. S., & Shields, J. D. (2024) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2024.115485 · Cited by 10

Spheroid‐on‐a‐Chip Platforms for Tumor Microenvironment and Drug Development

Uzabakiriho, P. C., Jiajun, F., Nguchu, B. A., Iqbal, S., Manishimwe, C., & Shaw, P. M. (2025) · Advanced Materials Technologies · doi:10.1002/admt.202401821 · Cited by 8

A tumor-microvessel on-a-chip reveals a mechanism for cancer cell cluster intravasation

Ikeda, Y., Kondō, M., Suehiro, J., Oshima, H., Kok, S. Y., Takahashi, K., Pauty, J., Wang, D., Sakurai, H., Watabe, T., et al. (2025) · iScience · doi:10.1016/j.isci.2025.112517 · Cited by 9

Harnessing Next‐Generation 3D Cancer Models to Elucidate Tumor‐Microbiome Crosstalk

Buzhor, M. G., Longobardi, G., Kandli, O., Krinsky, A., Avramoff, O., Katyal, A., Salomon, K., Miari, A., Venkert, D., Barnatan, T. T., et al. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202503198 · Cited by 7

Co-Culture of a Brain Organoid Derived from Human iPSCs and Vasculature on a Chip

Isshiki, Y., Kaneko, T., Tamada, A., Muguruma, K., & Yokokawa, R. (2020) · IEEE International Conference on Micro Electro Mechanical Systems (MEMS) · doi:10.1109/mems46641.2020.9056422 · Cited by 8

Controlling Cell Organization in 3D Coculture Spheroids Using DNA Interactions

Saemundsson, S. A., Ganguly, S., Curry, S. D., Goodwin, A. P., & Cha, J. N. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c00546 · Cited by 7

Artificial tumor matrices and bioengineered tools for tumoroid generation

Liu, Y., Chen, P., Chang, R., Liu, X., Jhang, J.-W., Enkhbat, M., Chen, S., Wang, H., Deng, C., & Wang, P. (2024) · Biofabrication · doi:10.1088/1758-5090/ad2534 · Cited by 8

Engineering approaches to control and design the in vitro environment towards the reconstruction of organs

Hagiwara, M., & Koh, I. (2020) · Development Growth & Differentiation · doi:10.1111/dgd.12647 · Cited by 7

Electrochemical microwell sensor with Fe–N co-doped carbon catalyst to monitor nitric oxide release from endothelial cell spheroids

Hiramoto, K., Iwase, K., Utagawa, Y., Nashimoto, Y., Honma, I., Ino, K., & Shiku, H. (2022) · Analytical Sciences · doi:10.1007/s44211-022-00160-0 · Cited by 7

Engineering vascularized organotypic tissues via module assembly

Zhou, Z., Liu, C., Guo, Y., Pang, Y., & Sun, W. (2023) · International Journal of Extreme Manufacturing · doi:10.1088/2631-7990/acfcf2 · Cited by 8

Plant-based biodegradable and biocompatible polymers for tissue engineering applications

Guduru, A. T., Sankaranarayanan, S., & Bhatia, D. D. (2025) · Carbohydrate Research · doi:10.1016/j.carres.2025.109699 · Cited by 6

Modeling metastasis with tumor organoid-on-a-chip: from mechanistic study to anti-tumor drug discovery

Lu, J., Huang, Y., Hu, S., Xuzhan, L., Huang, Y., Wu, B., Zhao, C., Huang, J., Tan, B., Zhao, B., et al. (2026) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2026.118791 · Cited by 7

Thinking in 3 dimensions: philosophies of the microenvironment in organoids and organs-on-chip

Caianiello, S., Bertolaso, M., & Militello, G. (2023) · History & Philosophy of the Life Sciences · doi:10.1007/s40656-023-00560-z · Cited by 6

Breast tumor-on-chip: from the tumor microenvironment to medical applications

Liu, Y., Liu, R., Liu, H., Lyu, T., Chen, K., Jin, K., & Tian, Y. (2023) · The Analyst · doi:10.1039/d3an01295f · Cited by 6

Engineering microenvironments for manufacturing therapeutic cells

Kwee, B. J., & Sung, K. E. (2021) · Experimental Biology and Medicine · doi:10.1177/15353702211026922 · Cited by 6

The Effect of Dynamic, In Vivo-like Oxaliplatin on HCT116 Spheroids in a Cancer-on-Chip Model Is Representative of the Response in Xenografts

Komen, J., van Neerven, S. M., Bossink, E. G. B. M., de Groot, N. E., Nijman, L. E., van den Berg, A., Vermeulen, L., & van der Meer, A. D. (2022) · Micromachines · doi:10.3390/mi13050739 · Cited by 6

Recapitulation of dynamic nanoparticle transport around tumors using a triangular multi-chamber tumor-on-a-chip

Chen, Y., Xue, Y., Xu, L., Li, W., Chen, Y., Zheng, S., Dai, R., & Liu, J. (2022) · Lab on a Chip · doi:10.1039/d2lc00631f · Cited by 6

Microfluidic Device for the Analysis of Angiogenic Sprouting under Bidirectional Biochemical Gradients

Nishimura, K., Nie, M., Miura, S., & Takeuchi, S. (2020) · Micromachines · doi:10.3390/mi11121049 · Cited by 8

How Qualification of 3D Disease Models Cuts the Gordian Knot in Preclinical Drug Development

Schäfer‐Korting, M., & Zoschke, C. (2020) · Handbook of experimental pharmacology · doi:10.1007/164_2020_374 · Cited by 6

3D Bioprinted perfusable and vascularized breast tumor model for dynamic screening of chemotherapeutics and CAR-T cellsPreprint

Dey, M., Kim, M. H., Nagamine, M., Dogan, M., Kozhaya, L., Unutmaz, D., & Ozbolat, I. T. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.15.484485 · Cited by 6

A human 3D culture-organ-on-chip platform for investigating the tumor microenvironment response to ionizing radiation

Lacombe, J., Dunn, S. E., Layac, M., Soldevila, M., Fakrudin, N. M., Duane, B., Chen, K., Barrett, M. W., Helton, J., Laiakis, E. C., et al. (2025) · iScience · doi:10.1016/j.isci.2025.114236 · Cited by 6

A modular and reconfigurable microfluidic device for culturing spheroids under continuous perfusion

Aljayyousi, H., Sahloul, S., Orozaliev, A., Baban, N. S., Van, D.-A., Nuairi, A. A., John, P., Zam, A., Percipalle, P., & Song, Y. (2025) · APL Bioengineering · doi:10.1063/5.0262536 · Cited by 5

An agarose-alginate microfluidic device for the study of spheroid invasion, ATRA inhibits CAFs-mediated matrix remodeling

Nasiraee, M. R., Shahrivari, S., Sayad, S., Mahdavi, H., Saraygord‐Afshari, N., & Bagheri, Z. (2023) · Cytotechnology · doi:10.1007/s10616-023-00578-y · Cited by 5

Engineering microfluidic devices to mimic signaling cascades in continuous-flow cell culture as multiorgan microphysiological systems

Ortiz-Collazos, S., Sousa-Batista, A. J., & Balbino, T. A. (2024) · Biochemical Engineering Journal · doi:10.1016/j.bej.2024.109475 · Cited by 5

Disposition of E-selectin-targeting liposomes in tumor spheroids with a perfusable vascular network

Chantarasrivong, C., Okada, R., Yamane, Y., Yang, X., Higuchi, Y., Konishi, M., Komura, N., Ando, H., Yokokawa, R., & Yamashita, F. (2022) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2022.100469 · Cited by 5

Long-term effect of sodium selenite on the integrity and permeability of on-chip microvasculature

Shaji, M., Kitada, A., Fujimoto, K., Karsten, S. L., & Yokokawa, R. (2022) · APL Bioengineering · doi:10.1063/5.0122804 · Cited by 5

Tumor spheroid-based and microtumor-based vascularized models for replicating the vascularized tumor microenvironment

Song, J., Ko, J., Choi, N., Jeon, N. L., & Kim, H. N. (2023) · Organoid · doi:10.51335/organoid.2023.3.e6 · Cited by 5

Homogeneously cross-linked in situ hydrogel enclosing high-density human-cancer cells promotes vascularized in vivo tumor modeling for immune cell therapy

Huang, Z., Tsun, Y. M., Liang, C., Wu, Z., Aurich, T., Liu, L., Kan, C., Sugimura, R., & Lee, S. J. (2025) · Advanced Composites and Hybrid Materials · doi:10.1007/s42114-025-01429-4 · Cited by 4

Microfluidic manipulation of the multicellular spheroids and organoids for modeling human diseases

Zhao, L., Xiong, S., Wang, D., & Wang, X. (2025) · Microchemical Journal · doi:10.1016/j.microc.2025.113718 · Cited by 4

Dual role of electrical stimulation and a biomimetic matrix in neural differentiation within a microfluidic platform

Devamoglu, U., Arslan, Y., Takanlou, L. S., Avcı, Ç. B., & Yeşil-Çeliktaş, Ö. (2025) · Biomaterials Science · doi:10.1039/d4bm01702a · Cited by 4

Advances in In Vitro Modeling of Cancer‐Stromal Interactions: From Fundamental Insights to Translational Applications

Wu, Z., Zeng, B., Seah, D. H., Ng, I. Z. R., Ding, R. H., Zhang, T., Kalaichelvan, M., You, R., & Fong, E. L. S. (2025) · Advanced Materials · doi:10.1002/adma.202512252 · Cited by 5

Spatially controlled diffusion range of tumor-associated angiogenic factors to develop a tumor model using a microfluidic resistive circuit

Hsu, Y., Yang, W.-C., Chen, Y.-T., Lin, C.-Y., Yang, C.-F., Liu, W., Shivani, S., & Li, P. (2024) · Lab on a Chip · doi:10.1039/d3lc00891f · Cited by 3

Towards Cellular Ultrastructural Characterization in Organ-on-a-Chip by Transmission Electron Microscopy

Mares, A. G., Feiner‐Gracia, N., Muela, Y., Martínez, G., Delgado, L., Albertazzi, L., & Pujals, S. (2021) · Applied Nano · doi:10.3390/applnano2040021 · Cited by 4

An Integrated Pulsation-Free, Backflow-Free Micropump Using the Analog Waveform-Driven Braille Actuator

Nishikata, K., Nakamura, M., Arai, Y., & Futai, N. (2022) · Micromachines · doi:10.3390/mi13020294 · Cited by 4

Real‐time visualization and quantitation of cell death and cell cycle progression in 2D and 3D cultures utilizing genetically encoded probes

Varadarajan, S. N., Mathew, K. A., Chandrasekharan, A., Lupitha, S. S., Lekshmi, A., Mini, M., Darvin, P., & Santhoshkumar, T. R. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30222 · Cited by 4

Construction of highly vascularized hepatic spheroids of primary hepatocytes via pro-angiogenic strategy in vitro

Huang, Y.-H., Watanabe, M., Yamashita, T., & Sudo, R. (2025) · Biofabrication · doi:10.1088/1758-5090/adc8d4 · Cited by 3

Tumour-on-Chip Models for the Study of Ovarian Cancer: Current Challenges and Future Prospects

Lim, S. Y., Aboelnasr, L. S., & El-Bahrawy, M. A. (2025) · Cancers · doi:10.3390/cancers17193239 · Cited by 3

Deconstructing cancer in 3D: models, mechanisms, and personalized solutions

Huang, Z., Duan, X., Ji, J., Cai, Q., Jin, P., Yu, B., & (48506), J. Z. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02704-8 · Cited by 5

Different Influences of Biotinylation and PEGylation on Cationic and Anionic Proteins for Spheroid Penetration and Intracellular Uptake to Cancer Cells

Jung, W. H., You, G., & Mok, H. (2022) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2207.07058 · Cited by 3

A Novel Ex Vivo Tumor Spheroid-Tissue Model for Investigating Microvascular Remodeling and Lymphatic Blood Vessel Plasticity

Lampejo, A. O., Lightsey, S. E., Gomes, M. C., Nguyen, C. M., Siemann, D. W., Sharma, B., & Murfee, W. L. (2024) · Annals of Biomedical Engineering · doi:10.1007/s10439-024-03535-8 · Cited by 4

The Microenvironment of Solid Tumors: Components and Current Challenges of Tumor-on-a-Chip Models

Souza, I. D. F., Vieira, J. P. D. J., Bonifácio, E., Freitas, B. A. D. A., & Torres, L. A. G. (2024) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2024.0088 · Cited by 3

Physiological hypoxia promotes cancer cell migration and attenuates angiogenesis in co-culture using a microfluidic device

Aratake, S., & Funamoto, K. (2024) · Microfluidics and Nanofluidics · doi:10.1007/s10404-024-02768-2 · Cited by 3

Understanding and measuring mechanical signals in the tumor stroma

Ortiz, F. D. L. J., Cimmino, C., Ventre, M., & Cambi, A. (2024) · FEBS Open Bio · doi:10.1002/2211-5463.13923 · Cited by 5

Developmental Biology-Based 3D Bioprinting: An Off-the-Shelf Strategy to Induce Tissue Regeneration

Chakraborty, J., & Ghosh, S. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c00213 · Cited by 4

Ion Conductance-Based Perfusability Assay of Vascular Vessel Models in Microfluidic Devices

Akasaka, R., Ozawa, M., Nashimoto, Y., Ino, K., & Shiku, H. (2021) · Micromachines · doi:10.3390/mi12121491 · Cited by 3

Recent advances in tumors-on-chips

Dogan, E., Salemizadehparizi, F., Çeçen, B., & Miri, A. K. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85671-3.00006-3 · Cited by 3

Laser-guided programmable construction of cell-laden hydrogel microstructures for in vitro drug evaluation

Dong, J., Zhou, J., Tang, H., Chen, B., & Huang, L. (2023) · Biofabrication · doi:10.1088/1758-5090/ace47d · Cited by 3

In silico investigation of the reliable models of drug delivery from blood vessels to tumor using tumor spheroid-on-chip models

Zarei, F., Besanjideh, M., & Shamloo, A. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106134 · Cited by 3

Leveraging femtosecond laser machining for the fabrication of tubular-based Organ-on-Chip systems: modeling cancer metastasis from invasion to intravasation

Jouybar, M., van der Kallen, S., Moradi, H., Zuo, P., Stassen, O. M. J. A., & den Toonder, J. M. J. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101926 · Cited by 2

Advancing preclinical drug evaluation: Assessing drug-loaded metal-organic frameworks in droplet-based microfluidics for prostate cancer treatment

Naseri, T., Shamloo, A., Tajahmadi, S., Maleki, S., & Alimohamadi, A. (2025) · Materials Today Advances · doi:10.1016/j.mtadv.2025.100618 · Cited by 2

Engineering breast cancer tumor microenvironment: advanced fabrication for 3D in vitro models

Pitton, M., Draghi, L., & Farè, S. (2026) · Biofabrication · doi:10.1088/1758-5090/ae3987 · Cited by 2

Focused ultrasound for cellular mechanoactivation and nanomedicine delivery in cancer

Luo, A. C., Qian, Z., & King, M. R. (2026) · Biomedical Microdevices · doi:10.1007/s10544-026-00817-x · Cited by 2

Emerging organoids and organoids-on-chip platforms for translational development of antibody‒drug conjugates and next-generation bioconjugates

Hu, Z., Liao, Y., Niu, M., Kong, Z., Vankelecom, H. E. J., Cheng, J., Deleidi, M., Li, C., Jiang, Z., Bian, S., et al. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.05.032 · Cited by 2

Engineering heterogeneous tissues and organs via multi-material bioprinting: Advances, challenges, and opportunities

Wu, M., Yeo, M., Derman, İ. D., Zhang, J., Hou, Z., 桑宏勋, Ozbolat, I. T., & Wu, Y. B. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.07.051 · Cited by 2

Recapitulating In Vivo Pharmacokinetics and Size‐Dependent Nanomedicine Delivery in a Microfluidic Platform

Kang, S. J., Yoon, M. S., Lee, J. M., Jo, M. J., Jin, C. E., & Shin, D. H. (2026) · Advanced Science · doi:10.1002/advs.77137 · Cited by 2

Vascularized platforms for investigating cell communication via extracellular vesicles

Kim, J., Ro, J., & Cho, Y. (2024) · Biomicrofluidics · doi:10.1063/5.0220840 · Cited by 2

Engineered model of tumor microenvironment for replicating intratumoral drug delivery

Besanjideh, M., Zarei, F., Rezaeian, M., & Shamloo, A. (2025) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2025.06.023 · Cited by 2

Advances in cell spheroid technology towards complex tissue formation guided by microfabrication and biomaterial innovations

Saleh, R. I., & Cha, C. (2025) · Biofabrication · doi:10.1088/1758-5090/ade7b1 · Cited by 2

Advances in the construction of human organs-on-chips

Yi, Z., & Gu, Z. (2023) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2023-0435 · Cited by 3

Perfusion-based 3D tumor-on-chip devices for anticancer drug testing

Dhiman, N., & Rath, S. N. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818128-7.00016-2 · Cited by 2

Cultures cellulaires en trois dimensions : applications à la biologie des cancers

Jubelin, C., Golias, M., Cochonneau, D., Muñoz-García, J., & Heymann, D. (2025) · Bulletin du Cancer · doi:10.1016/j.bulcan.2025.09.004 · Cited by 1

Multi-Organ-on-Chip approach to exploring breast cancer liver metastases concerning the endothelial barrier and the influence of immune cells

Konopka, J., Roszczyk, J., Jastrzębska, E., & Żuchowska, A. (2025) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2025.102890 · Cited by 1

An Integrated Microfluidic Platform Possessing Uniform Tumor Spheroids for Evaluating Radio-Therapeutic Nanomaterials

Huang, C., Zhao, S., Wu, Z., Zhu, Q., Zhou, K., Wang, M., Li, R., Cai, B., Zou, D., Liu, W., et al. (2026) · Journal of Analysis and Testing · doi:10.1007/s41664-026-00423-z · Cited by 1

Methodological innovations in perfusable vascular networks: Advancing high-density tissue models

Singh, R., Mori, N., & Kida, Y. S. (2026) · Regenerative Therapy · doi:10.1016/j.reth.2026.101109 · Cited by 3

The Tumor Microenvironment: Translating Intravital Insights into Microphysiological Systems

Imparato, G., Mazio, C., Nevola, P., & Netti, P. A. (2026) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-026-00910-4 · Cited by 1

A Vascularized Bone-on-Paper Platform To Study Periosteum-Vascular Crosstalk and Angiogenic Remodeling

Tong, Y.-W., Chen, A. C., Pai, P., & Lei, K. F. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.6c00457 · Cited by 1

Self-assembly of tumor-related vascularized colorectal tumoroid-on-a-chip for precision medicine drug testing

Dai, Z., Fu, G., Du, Y., Xie, Y., ZHU, J., Tao, X., Luo, Q., Chu, X., & Lei, Z. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2026.102873 · Cited by 1

Vascularized tumor organoids as models for interpreting therapeutic response

Huang, S., Han, S., & Wang, K. (2026) · Vascular Pharmacology · doi:10.1016/j.vph.2026.107673 · Cited by 1

Mechanotherapeutic biomaterials: Overcoming physical barriers to enhance intratumoral drug delivery in solid tumours

Singh, F. (2026) · Biomedical Microdevices · doi:10.1007/s10544-026-00832-y · Cited by 2

Development of a Three-Dimensional Cholangiocarcinoma-on-a-Chip for Improved Drug Response Analysis

Fang, Y., Xu, C., Gao, Z., Ji, Y., Bai, X., Liu, X., Bi, Y., Liang, X., Lu, Y., & Zhang, G. (2026) · Journal of Analysis and Testing · doi:10.1007/s41664-026-00444-8 · Cited by 1

Microfluidics and Cancer Treatment: Emerging Concept of Biomedical Engineering

Tawade, P. V., & Tondapurkar, N. (2023) · Biological and medical physics, biomedical engineering · doi:10.1007/978-981-19-9786-0_15 · Cited by 1

[Research progress on vascularization of organoids].

Shen, J., Ouyang, Z., Zhong, J., Long, Y., Sun, Y., & Zeng, Y. (2023) · PubMed Central · doi:10.7507/1001-5515.202211011 · Cited by 1

Polysaccharide-Based Hydrogels for Bioengineering 3D Tumor Models

Magalhães, M. V., Coutinho, I., Barrias, C. C., & Bidarra, S. J. (2023) · Springer eBooks · doi:10.1007/978-3-030-92090-6_22-1 · Cited by 1

Inspiring a convergent engineering approach to measure and model the tissue microenvironment

Iyer, R. R., Applegate, C. C., Arogundade, O. H., Bangru, S., Berg, I. C., Emon, B., Porras-Gómez, M., Hsieh, P.-H., Jeong, Y., Kim, Y., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32546 · Cited by 1

Influence of a tilted external magnetic field on interstitial fluid pressure within the spherical solid tumors

Ghanbari, A., & Khordad, R. (2025) · ZAMM ‐ Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik · doi:10.1002/zamm.202400674 · Cited by 1

Microengineered Breast Cancer Models: Shaping the Future of Personalized Oncology

Popoiu, T.-A., Cîmpean, A. M., Bojin, F. M., Cerbu, S., Gug, M.-C., Pirvu, C.-A., Pantea, Ș., & Neagu, A. (2025) · Cancers · doi:10.3390/cancers17193160 · Cited by 1

The clinical potential of patient-derived microphysiological systems: a narrative review

Lee, T., Min, J., Lee, Y., & Ko, J. (2025) · Journal of Korean Medical Association · doi:10.5124/jkma.25.0082 · Cited by 1

An On-Chip Vascular Network to Investigate Pericyte Migration and Intercellular Signaling

Erickson, S., Ihara, H., Hanada, S., Nishiyama, K., Miura, T., & Yokokawa, R. (2020) · IEEE International Conference on Micro Electro Mechanical Systems (MEMS) · doi:10.1109/mems46641.2020.9056369 · Cited by 1

3D Microfluidic Device for Perfusion Culture of Spheroids

Nishimura, K., Nie, M., & Takeuchi, S. (2020) · IEEE International Conference on Micro Electro Mechanical Systems (MEMS) · doi:10.1109/mems46641.2020.9056442 · Cited by 3

Microphysiological vascularized solid tumor model for drugs and cell therapies screeningPreprint

Reales‐Calderón, J. A., Lam, M. S. Y., Ow, J. R., Aw, J., Tan, D., Adriani, G., & Pavesi, A. (2022) · Research Square · doi:10.21203/rs.3.rs-1853599/v1 · Cited by 1

Tumor-microvessel on-a-chip reveals sequential intravasation cascade of cancer cell clustersPreprint

Ikeda, Y., Suehiro, J., Oshima, H., Kok, S. Y., Takahashi, K., Sakurai, H., Watabe, T., Oshima, M., & Matsunaga, Y. T. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.28.582606 · Cited by 1

Construction of 3D-tumor model for drug screening:Application of microfluidics

Luo, S., Wang, Y., Wang, S., & Chen, A. (2021) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2021-0245

Mimicking and surpassing the cancer xenograft model with dynamic, in vivo-like, drug concentrations on-chip

Komen, J. (2022) · doi:10.3990/1.9789036553971

Application of organoids-on-a-chip based on microfluidic technology in precision medicine of lung cancer

Zeng, X., Ma, Q., Li, X., You, L., Li, J., Fu, X., Ren, Y., & You, F. (2022) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2022-1027

Mimicking Multicellular Features of the Tumor Microenvironment

Curvello, R., & Loessner, D. (2022) · Royal Society of Chemistry eBooks · doi:10.1039/9781839166013-00141

Exploration of Tissue-Engineered Systems for Cancer Research

Panigrahi, A., Mythreyi, R., Basalingappa, K. M., Gopenath, T. S., & Karthikeyan, M. (2023) · Biological and medical physics, biomedical engineering · doi:10.1007/978-981-19-9786-0_3

Development of Tumor Models Using Microphysiological System

Nashimoto, Y. (2024) · The Journal of the Institute of Electrical Engineers of Japan · doi:10.1541/ieejjournal.144.195

Enabling perfusion through multicellular tumor spheroids promoting lumenization in a vascularized cancer model

Park, J., Kim, S., Hong, J., & Jeon, J. S. (2022) · Lab on a Chip · doi:10.1039/d2lc00597b · Cited by 31

Recapitulation and Manipulation of the Tumor Microenvironment through an Integrated Perfusable Vascular Network Utilizing a Microphysiological System

Yuji, N. (2023) · Proceedings for Annual Meeting of The Japanese Pharmacological Society · doi:10.1254/jpssuppl.97.0_2-b-s39-3

Vascularized Tumor‐on‐a‐Chip Model as a Platform for Studying Tumor‐Microenvironment‐Drug Interaction

Kim, H., Cho, S., & Kim, H. N. (2025) · Macromolecular Bioscience · doi:10.1002/mabi.70061 · Cited by 9

New Strategy for Promoting Vascularization in Tumor Spheroids in a Microfluidic Assay

Wan, Z., Floryan, M. A., Coughlin, M. F., Zhang, S., Zhong, A. X., Shelton, S. E., Wang, X., Xu, C., Barbie, D. A., & Kamm, R. D. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202201784 · Cited by 84

Tumor-on-a-chip: Perfusable vascular incorporation brings new approach to tumor metastasis research and drug development

Wang, R., Zhang, C., Li, D., & Yao, Y. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1057913 · Cited by 30