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Cited by 3323D Printing in Biomedical ResearchCancer Cells and MetastasisMathematical Biology Tumor Growth

The DOI matches its Crossref record; 43 of the 44 references it cites were found in a registry or an index.

Vascularized cancer on a chip: The effect of perfusion on growth and drug delivery of tumor spheroid

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Nashimoto, Yuji, Okada, Ryu, Hanada, Sanshiro, Arima, Yuichiro, Nishiyama, Koichi, Miura, Takashi, Yokokawa, Ryuji·2020·Biomaterials
DOI 10.1016/j.biomaterials.2019.119547
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Abstract

Tumor vasculature creates a hostile tumor microenvironment (TME) in vivo and nourishes cancers, resulting in cancer progression and drug resistance. To mimic the biochemical and biomechanical environments of tumors in vitro, several models integrated with a vascular network have been reported. However, the tumor responses to biochemical and biomechanical stimuli were evaluated under static conditions and failed to incorporate the effects of blood flow to tumors. In this study, we present a tumor-on-a-chip platform that enables the evaluation of tumor activities with intraluminal flow in an engineered tumor vascular network. The fibroblasts in the tumor spheroid induced angiogenic sprouts, which constructed a perfusable vascular network in a tumor spheroid. The perfusability of the engineered vascular network was preserved during the culture. Moreover, perfusion for over 24 h significantly increased the proliferation activities of tumor cells and decreased cell death in the spheroid. Drug administration under perfusion condition did not show the dose-dependent effects of anticancer drugs on tumor activities in contrast to the results under static conditions. Our results demonstrate the importance of flow in a vascular network for the evaluation of tumor activities in a drug screening platform.

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Crossref · 10.1016/j.biomaterials.2019.119547

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Metadata

Authors
Nashimoto, Y., Okada, R., Hanada, S., Arima, Y., Nishiyama, K., Miura, T., & Yokokawa, R.
Affiliations
  • Tohoku University (JP)
  • Kyoto University (JP)
  • International Research Center for Medical Sciences, Kumamoto University (JP)
  • Kyushu University (JP)
Corresponding author
Yokokawa, Ryuji
ORCID
Venue
Biomaterials
Publisher
Elsevier BV
Published
2020-01
Volume
229
Pages
119547
ISSN
0142-9612 (ISSN-L)
DOI
10.1016/j.biomaterials.2019.119547
OpenAlex
W2981018318
Cited by
332
References
44
Citations by year
2026: 36 · 2025: 46 · 2024: 66 · 2023: 59 · 2022: 58 · 2021: 39 · 2020: 28
FWCI
10.97
Type
journal article
Language
en
Open access
Licence
Locations
  • Biomaterials (acceptedVersion)
  • PubMed (publishedVersion)
Funders
  • Japan Society for the Promotion of Science
  • Nakatomi Foundation
  • Japan Science and Technology Agency
  • Japan Agency for Medical Research and Development
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
  • Physical Sciences › Mathematics › Modeling and Simulation › Mathematical Biology Tumor Growth
Keywords
tumor-on-a-chip, tumor spheroids, perfusion, tumor vasculature, fibroblasts, tumor microenvironment, tumor cell proliferation, cell death, anticancer drug delivery, drug screening, blood flow
MeSH terms
Pharmaceutical Preparations, Humans, Neoplasms, Perfusion, Lab-On-A-Chip Devices, Tumor Microenvironment

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