Cited by 443Wound Healing and TreatmentsDiabetic Foot Ulcer Assessment and ManagementElectrospun Nanofibers in Biomedical Applications

The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.

Exosome laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound healing

Shiekh, Parvaiz A., Singh, Anamika, Kumar, Ashok·2020·Biomaterials

DOI 10.1016/j.biomaterials.2020.120020

Open this paper in CoChat — free account

Abstract

Lack of oxygen, reduced vascularization, elevated oxidative stress, and infection are critical clinical hallmarks of non-healing chronic diabetic wounds. Therefore, delivering oxygen, inducing angiogenesis, and management of oxidative stress and infection may provide newer and improved therapeutic avenues for better clinical outcomes in diabetic wound healing. Here, we report the development and evaluation of an exosome laden oxygen releasing antioxidant wound dressing OxOBand to promote wound closure and skin regeneration in diabetic wounds. OxOBand is composed of antioxidant polyurethane (PUAO), as highly porous cryogels with sustained oxygen releasing properties and supplemented with adipose-derived stem cells (ADSCs) exosomes. Exosomes engulfed by the cells enhanced the migration of human keratinocytes and fibroblasts and increased the survival of human neuroblastoma cells under hyperglycemic conditions. OxOBand facilitated faster wound closure, enhanced collagen deposition, faster re-epithelialization, increased neo-vascularization, and decreased oxidative stress within two weeks as compared to untreated diabetic control wounds. The dressing promoted the development of mature epithelial structures with hair follicles and epidermal morphology similar to that of healthy skin. In clinically challenging infected diabetic wounds, these dressings prevented infection and ulceration, improved wound healing with increased collagen deposition, and re-epithelialization. Altogether, OxOBand is a remarkably newer treatment strategy for enhanced diabetic wound healing and may lead to novel therapeutic interventions for the treatment of diabetic ulcers.

Integrity signals

Registry

Crossref · 10.1016/j.biomaterials.2020.120020

Cites

53 of 53 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040
Ogurtsova, K., Fernandes, J. D. D. R., Huang, Y., Linnenkamp, U., Guariguata, L., Cho, N. H., Cavan, D. A., Shaw, J. E., & Makaroff, L. (2017) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2017.03.024 · Cited by 7,138
Oxidative stress and diabetic complications
Giacco, F., & Brownlee, M. (2010) · Circulation Research · doi:10.1161/circresaha.110.223545 · Cited by 5,461
Wound healing and its impairment in the diabetic foot
Falanga, V. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67700-8 · Cited by 2,715
Extracellular Matrix Reorganization During Wound Healing and Its Impact on Abnormal Scarring
Xue, M., & Jackson, C. J. (2015) · Advances in Wound Care · doi:10.1089/wound.2013.0485 · Cited by 1,468
Fibroblasts and myofibroblasts in wound healing
Desmouliere, A., Darby, I. A., Laverdet, B., & Bonté, F. (2014) · Clinical, Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s50046 · Cited by 1,039
Oxidative stress in normal and impaired wound repair
SCHAFER, M., & WERNER, S. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.06.004 · Cited by 902
Topical Vascular Endothelial Growth Factor Accelerates Diabetic Wound Healing through Increased Angiogenesis and by Mobilizing and Recruiting Bone Marrow-Derived Cells
Galiano, R. D., Tepper, O. M., Pelo, C. R., Bhatt, K. A., Callaghan, M. J., Bastidas, N., Bunting, S., Steinmetz, H., & Gurtner, G. C. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63754-6 · Cited by 812
Wound healing essentials: Let there be oxygen
Sen, C. K. (2009) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00436.x · Cited by 738
Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts
Hu, L., Wang, J., Zhou, X., Xiong, Z., Zhao, J., Yu, R., Huang, F., Zhang, H., & Chen, L. (2016) · Scientific Reports · doi:10.1038/srep32993 · Cited by 693
Concise Review: Adipose‐Derived Stem Cells as a Novel Tool for Future Regenerative Medicine
Mizuno, H., Tobita, M., & Uysal, Ç. A. (2012) · Stem Cells · doi:10.1002/stem.1076 · Cited by 668

Show all 53 references

Sorted by citations

Items 101–200 of 443

A polyphenol-modified chitosan hybrid hydrogel with enhanced antimicrobial and antioxidant activities for rapid healing of diabetic wounds
Xu, Z., Liu, G., Zheng, L. X., & Wu, J. (2022) · Nano Research · doi:10.1007/s12274-022-4792-6 · Cited by 65
Chlorella sp.-Ameliorated Undesirable Microenvironment Promotes Diabetic Wound Healing
Wu, H., Yang, P., Li, A., Jin, X., Zhang, Z., & Lv, H. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.06.012 · Cited by 65
Multi-functional carboxymethyl chitosan/sericin protein/halloysite composite sponge with efficient antibacterial and hemostatic properties for accelerating wound healing
Li, S., Jiang, M., Zhang, Y., Xie, X., Li, W., Ming, P., Jiang, X., Yang, B., He, Y., Chen, J., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123357 · Cited by 65
Mitochondrial dysfunction and oxidative stress in diabetic wound
Jiang, G., Jiang, T., Chen, J., Yao, H., Mao, R., Yang, X., Chen, Z., & Li, W. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23407 · Cited by 65
Combination Therapy of Stem Cell-derived Exosomes and Biomaterials in the Wound Healing
Golchin, A., Shams, F., Basiri, A., Ranjbarvan, P., Kiani, S., Sarkhosh‐Inanlou, R., Ardeshirylajimi, A., Aziz, S. G., Sadigh, S., & Rasmi, Y. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10309-5 · Cited by 67
Nanobiotechnology: Applications in Chronic Wound Healing
Jiang, T., Li, Q., Qiu, J., Chen, J., Du, S., Xu, X., Wu, Z., Yang, X., Chen, Z., & Chen, T. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s372211 · Cited by 69
A 3D bioprinted decellularized extracellular matrix/gelatin/quaternized chitosan scaffold assembling with poly(ionic liquid)s for skin tissue engineering
Xu, J., Fang, H., Su, Y., Kang, Y., Xu, D., Cheng, Y. Y., Nie, Y., Wang, H., Liu, T., & Song, K. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.08.149 · Cited by 64
Signaling pathways in cutaneous wound healing
Križanová, O., Penesová, A., Sokol, J., Hokynková, A., Samadian, A., & Babula, P. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1030851 · Cited by 66
Construction of Smart Biomaterials for Promoting Diabetic Wound Healing
Huang, C., Yuan, W., Chen, J., Wu, L., & You, T. (2023) · Molecules · doi:10.3390/molecules28031110 · Cited by 62
Sprayed copper peroxide nanodots for accelerating wound healing in a multidrug-resistant bacteria infected diabetic ulcer
Zhang, R., Jiang, G., Gao, Q., Wang, X., Wang, Y., Xu, X., Yan, W., & Shen, H. (2021) · Nanoscale · doi:10.1039/d1nr04687j · Cited by 61
Oxygen-releasing hydrogels promote burn healing under hypoxic conditions
Bai, Q., Zheng, C., Sun, N., Chen, W., Gao, Q., Liu, J., Hu, F., Zhou, T., Zhang, Y., & Lu, T. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.09.077 · Cited by 64
Nanozyme‐Incorporated Microneedles for the Treatment of Chronic Wounds
Hu, Z., Jie, S., Cui, Y., Cheng, L., Chen, X., & Wang, X. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202400101 · Cited by 62
Electrospun multifunctional nanofibrous mats loaded with bioactive anemoside B4 for accelerated wound healing in diabetic mice
Zhang, H., Zhang, M., Wang, X., Zhang, M., Wang, X., Li, Y., Cui, Z., Chen, X., Han, Y., & Zhao, W. (2022) · Drug Delivery · doi:10.1080/10717544.2021.2021319 · Cited by 59
Rational design of porous structure-based sodium alginate/chitosan sponges loaded with green synthesized hybrid antibacterial agents for infected wound healing
Jiang, M., Li, S., Ming, P., Guo, Y., Yuan, L., Jiang, X., Liu, Y., Chen, J., Xia, D., He, Y., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123944 · Cited by 61
Functional carbohydrate-based hydrogels for diabetic wound therapy
Zhang, Y. X., Zhu, Y., Ma, P., Wu, H., Xiao, D., Zhang, Y., Sui, X., Zhang, L., & Dong, A. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120823 · Cited by 59
Extracellular vesicles from hair follicle-derived mesenchymal stromal cells: isolation, characterization and therapeutic potential for chronic wound healing
Heras, K. L., Royo, F., Garcia‐Vallicrosa, C., Igartúa, M., Santos‐Vizcaíno, E., Falcón‐Pérez, J. M., & Hernández, R. M. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-02824-0 · Cited by 62
Sprayable alginate hydrogel dressings with oxygen production and exosome loading for the treatment of diabetic wounds
Zhang, Y., Fang, M., Xie, W., Zhang, Y., Jiang, C., Li, N., Li, L., Tian, J., & Zhou, C. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125081 · Cited by 57
Multifunctional Biomedical Materials Derived from Biological Membranes
Wang, Y., Xu, X., Chen, X., & Li, J. (2021) · Advanced Materials · doi:10.1002/adma.202107406 · Cited by 56
Rational design of flexible microneedles coupled with CaO 2 @PDA-loaded nanofiber films for skin wound healing on diabetic rats
Zeng, Z., Jiang, G., Sun, Y., Aharodnikau, U. E., Yunusov, K. E., Gao, X., Liu, T., & Solomevich, S. O. (2022) · Biomaterials Science · doi:10.1039/d2bm00861k · Cited by 55
Emerging roles of exosomes in oral diseases progression
Wang, J., Jing, J., Zhou, C., & Fan, Y. (2024) · International Journal of Oral Science · doi:10.1038/s41368-023-00274-9 · Cited by 58
Advanced wound healing with Stimuli-Responsive nanozymes: mechanisms, design and applications
Liu, X., Zhang, H., Chen, L., Zheng, Z., Li, W., Huang, C., Zhou, H. L., Chen, Y.-C., Jiang, Z., Liang, J., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03558-w · Cited by 59
Exosomes based advancements for application in medical aesthetics
Bin, Z., Gong, J., He, L., Khan, A., Xiong, T., Shen, H., & Li, Z. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1083640 · Cited by 55
3D bioprinting of engineered exosomes secreted from M2-polarized macrophages through immunomodulatory biomaterial promotes in vivo wound healing and angiogenesis
Dutta, S. D., An, J. M., Hexiu, J., Randhawa, A., Ganguly, K., Patil, T. V., Thambi, T., Kim, J., Lee, Y.-K., & Lim, K. (2024) · Bioactive Materials · doi:10.1016/j.bioactmat.2024.11.026 · Cited by 57
Mechanisms of microbial infection and wound healing in diabetic foot ulcer: pathogenicity in the inflammatory-proliferative phase, chronicity, and treatment strategies
Wang, Q., Liu, C., An, J., Liu, J., Wang, Y., & Cai, Y. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1657928 · Cited by 69
Self-Homeostasis Immunoregulatory Strategy for Implant-Related Infections through Remodeling Redox Balance
Xu, D., Zhu, W., Ding, C., Mei, J., Zhou, J. Y., Cheng, T., Guo, G., & Zhang, X. (2023) · ACS Nano · doi:10.1021/acsnano.2c10660 · Cited by 55
Corneal regeneration strategies: From stem cell therapy to tissue engineered stem cell scaffolds
Wang, M., Li, Y., Wang, H., Li, M., Wang, X., Liu, R., Zhang, D., & Xu, W. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115206 · Cited by 53
Enhanced burn wound healing by controlled-release 3D ADMSC-derived exosome-loaded hyaluronan hydrogel
Zhu, D., Hu, Y., Kong, X., Luo, Y., Zhang, Y., Wu, Y., Tan, J., Chen, J., Xu, T., & Zhu, L. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae035 · Cited by 55
Intelligent Patches for Wound Management: In Situ Sensing and Treatment
Wang, Y., Guo, M., He, B., & Gao, B. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.0c04956 · Cited by 52
Strategies for improving adipose-derived stem cells for tissue regeneration
Yuan, X., Li, L., Liu, H., Luo, J. C., Zhao, Y., Pan, C., Zhang, X., Chen, Y., & Gou, M. (2022) · Burns & Trauma · doi:10.1093/burnst/tkac028 · Cited by 52
Lonicerin promotes wound healing in diabetic rats by enhancing blood vessel regeneration through Sirt1-mediated autophagy
Lin, Z., Li, L., Chen, L., Chen, J., Li, Y., Yang, L., Li, C.-Z., Qi, C., Gan, Y., Zhang, J.-R., et al. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01193-5 · Cited by 56
Exosomes: Emerging Cell-Free Based Therapeutics in Dermatologic Diseases
Shi, H., Wang, M., Sun, Y., Yang, D., Xu, W., & Qian, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.736022 · Cited by 54
Biopolymeric composite hydrogel loaded with silver NPs and epigallocatechin gallate (EGCG) effectively manages ROS for rapid wound healing in type II diabetic wounds
Kar, A. K., Singh, A., Singh, D. K., Shraogi, N., Verma, R. K., Saji, J., Jagdale, P. R., Ghosh, D., & Patnaik, S. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.06.196 · Cited by 51
Development of in situ bioprinting: A mini review
MacAdam, A. J., Chaudry, E., McTiernan, C. D., Cortes, D., Suuronen, E. J., & Alarcon, E. I. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.940896 · Cited by 53
Stem cell niche-inspired microcarriers with ADSCs encapsulation for diabetic wound treatment
Wu, X., Zhu, H., Che, J., Xu, Y., Tan, Q., & Zhao, Y. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.02.031 · Cited by 51
Advances of hydrogel combined with stem cells in promoting chronic wound healing
Li, Q., Wang, D., Jiang, Z., Li, R., Xue, T., Lin, C., Deng, Y., Jin, Y. H., & Sun, B. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.1038839 · Cited by 50
Oxidative Stimuli‐Responsive “Pollen‐Like” Exosomes from Silver Nanoflowers Remodeling Diabetic Wound Microenvironment for Accelerating Wound Healing
Chen, Y., Younis, M. R., He, G., Zheng, Z., Wang, Y., Xue, K., Sun, J., Liu, K., Huang, P., & Wang, X. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300456 · Cited by 48
Efficacy of topical and systemic transplantation of mesenchymal stem cells in a rat model of diabetic ischemic wounds
Yan, J., Liang, J., Cao, Y., Akkawi, M. M. E., Liao, X., Chen, X., Li, C., Li, K., Xie, G.-H., & Liu, H. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02288-8 · Cited by 49
Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight
Houerbi, N., Kim, J., Overbey, E. G., Batra, R., Schweickart, A., Pătraș, L., Lucotti, S., Ryon, K. A., Najjar, D., Meydan, C., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48841-w · Cited by 48
Photosynthetic Microorganisms for the Oxygenation of Advanced 3D Bioprinted Tissues
Ortega, J. S., Corrales-Orovio, R., Ralph, P., Egaña, J. T., & Gentile, C. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.05.009 · Cited by 47
Mesenchymal Stem Cell Derived Exosomes Therapy in Diabetic Wound Repair
Jing, S., Li, K., & Xu, H. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s411562 · Cited by 49
Antimicrobial and anti-biofilm activities of bio-inspired nanomaterials for wound healing applications
Arshad, R., Razlansari, M., Hosseinikhah, S. M., Pandey, A. T., Ajalli, N., Manicum, A.-L. E., Thorat, N. D., Rahdar, A., Zhu, Y., & Tabish, T. A. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103673 · Cited by 47
Mechanisms and applications of adipose-derived stem cell-extracellular vesicles in the inflammation of wound healing
Jia, Q., Zhao, H., Wang, Y., Cen, Y., & Zhang, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1214757 · Cited by 49
Extracellular vesicle biopotentiated hydrogels for diabetic wound healing: The art of living nanomaterials combined with soft scaffolds
Yan, Z., Zhang, T., Wang, Y., Xiao, S., & Gao, J. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100810 · Cited by 48
Antibacterial hydrogels for bacteria-infected wound treatment
Li, W., Chen, Q., Ma, Y., Su, H., Ren, H., & Wang, H. (2024) · Biomedical Technology · doi:10.1016/j.bmt.2024.11.001 · Cited by 45
Engineered hydrogel platform for diabetic wound healing
Cui, J., Shi, J., Liu, Y., Shi, X., Sun, J. X., He, Z., Luo, C., & Zhang, S. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.160379 · Cited by 45
Antimicrobial cryogel dressings towards effective wound healing
Akın, B., & Ozmen, M. M. (2022) · Progress in Biomaterials · doi:10.1007/s40204-022-00202-w · Cited by 44
GelMA Hydrogel Loaded with Extracellular Vesicles Derived from Umbilical Cord Mesenchymal Stem Cells for Promoting Cutaneous Diabetic Wound Healing
Tang, L., Zhao, C., Liu, Y., Zhou, J., Dong, Y., Huang, J., Yang, T., Xiao, H., Liu, D., Wang, S., et al. (2023) · ACS Omega · doi:10.1021/acsomega.2c07291 · Cited by 44
Antioxidant and Immunomodulatory Polymer Vesicles for Effective Diabetic Wound Treatment through ROS Scavenging and Immune Modulating
Zhang, W., Ge, Z., Xiao, Y., Liu, D., & Du, J. (2024) · Nano Letters · doi:10.1021/acs.nanolett.4c01869 · Cited by 46
Adipose stem cell exosomes promote mitochondrial autophagy through the PI3K/AKT/mTOR pathway to alleviate keloids
Liu, C., Khairullina, L., Qin, Y., Zhang, Y., & Xiao, Z. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03928-5 · Cited by 44
Advances of exosomes in diabetic wound healing
Jin, W., Li, Y., Yu, M., Ren, D., Han, C., & Guo, S. (2024) · Burns & Trauma · doi:10.1093/burnst/tkae078 · Cited by 50
Adipose-derived stem cell exosomes: mechanisms and therapeutic potentials in wound healing
Feng, H., Gong, S., Liu, J., Aghayants, S., Liu, Y., Wu, M., Wu, Y., & Song, J. (2025) · Biomarker Research · doi:10.1186/s40364-025-00801-2 · Cited by 45
Mesenchymal stem cells-derived extracellular vesicles protect against oxidative stress-induced xenogeneic biological root injury via adaptive regulation of the PI3K/Akt/NRF2 pathway
Fu, H., Sen, L., Zhang, F., Liu, S., Wang, M., Mi, H., Liu, M., Li, B., Peng, S., Hu, Z., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02214-5 · Cited by 44
Enhancing diabetic wound healing with a pH/glucose dual-responsive hydrogel for ROS clearance and antibacterial activity
Hao, J., Liu, C., Zhou, L., Wu, N., Sun, M., Kuang, J., Pan, H., Yu, L., Li, J., Dong, Y., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.132935 · Cited by 47
Preparation strategy of hydrogel microsphere and its application in skin repair
Chi, H., Qiu, Y., Ye, X., Shi, J., & Li, Z. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1239183 · Cited by 43
Oxygen releasing patches based on carbohydrate polymer and protein hydrogels for diabetic wound healing: A review
Mamun, A. A., Ullah, A., Chowdhury, M. E. H., Marei, H. E. S., Madappura, A. P., Hassan, M., Rizwan, M., Gomes, V. G., Amirfazli, A., & Hasan, A. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126174 · Cited by 41
Conjugated Polymer Composite Nanoparticles Augmenting Photosynthesis‐Based Light‐Triggered Hydrogel Promotes Chronic Wound Healing
Yuan, Q., Yin, J., Li, L., Bao, B., Zhang, X., Li, M., & Tang, Y. (2023) · Advanced Science · doi:10.1002/advs.202304048 · Cited by 40
Stem Cells-Derived Extracellular Vesicles: Potential Therapeutics for Wound Healing in Chronic Inflammatory Skin Diseases
Manchon, E., Hirt, N., Bouaziz, J., Jabrane‐Ferrat, N., & Al‐Daccak, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22063130 · Cited by 42
Research Advances in the Application of Adipose-Derived Stem Cells Derived Exosomes in Cutaneous Wound Healing
Zeng, W., & Guo, L. (2021) · Annals of Dermatology · doi:10.5021/ad.2021.33.4.309 · Cited by 43
Local delivery to malignant brain tumors: potential biomaterial-based therapeutic/adjuvant strategies
Alghamdi, M. A., Gumbleton, M., & Newland, B. (2021) · Biomaterials Science · doi:10.1039/d1bm00896j · Cited by 45
Congenital microtia patients: the genetically engineered exosomes released from porous gelatin methacryloyl hydrogel for downstream small RNA profiling, functional modulation of microtia chondrocytes and tissue-engineered ear cartilage regeneration
Chen, J., Huang, T., Liu, R., Wang, C., Jiang, H., & Sun, H. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01352-6 · Cited by 42
Multifunctional hydrogel loaded with 4-octyl itaconate exerts antibacterial, antioxidant and angiogenic properties for diabetic wound repair
Ding, Q., Jing, X., Yao, S., Su, W., Ye, B., Qu, Y., Gao, F., Sun, T., & Guo, X. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.212979 · Cited by 40
Advancements and Insights in Exosome-Based Therapies for Wound Healing: A Comprehensive Systematic Review (2018–June 2023)
Sousa, P., Lopes, B., Sousa, A. C., Moreira, A. D. S., Coelho, A. F., Alvites, R., Alves, N. M., Geuna, S., & Maurício, A. C. (2023) · Biomedicines · doi:10.3390/biomedicines11082099 · Cited by 40
Functional drug-delivery hydrogels for oral and maxillofacial wound healing
Hao, M., Wang, D., Duan, M., Kan, S., Li, S., Wu, H., Xiang, J., & Liu, W. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1241660 · Cited by 48
Tailored biomedical materials for wound healing
Liu, W., Zu, L., Wang, S., Li, J., Fei, X., Geng, M., Zhu, C., & Shi, H. (2023) · Burns & Trauma · doi:10.1093/burnst/tkad040 · Cited by 43
Electrospun PCL/gelatin/arbutin nanofiber membranes as potent reactive oxygen species scavengers to accelerate cutaneous wound healing
Du, M., Liu, S., Lan, N., Liang, R., Liang, S., Lan, M., Feng, D., Zheng, L. X., Wei, Q., & Ma, K. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbad114 · Cited by 42
Hydrogels loaded with MSC‐derived small extracellular vesicles: A novel cell‐free tissue engineering system for diabetic wound management
Zhong, W., Meng, H., Ma, L., Wan, X., Chen, S., Ma, K., Lu, L., Su, J., Guo, K., Jiang, Y., et al. (2024) · Open Research (University of Surrey) · doi:10.1002/viw.20230110 · Cited by 42
In situ fused granular hydrogels with ultrastretchability, strong adhesion, and mutli-bioactivities for efficient chronic wound care
Yuan, Z., Wan, Z., Tian, Z., Han, Y., Huang, X., Feng, Y., Xie, W., Duan, X., Huang, S., Liu, X., et al. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.138076 · Cited by 38
Extracellular Vesicle-Based Hydrogels for Wound Healing Applications
Amengual-Tugores, A. M., Ráez-Meseguer, C., Forteza‐Genestra, M. A., Monjo, M., & Ramis, J. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24044104 · Cited by 38
High glucose-induced endothelial STING activation inhibits diabetic wound healing through impairment of angiogenesis
Luo, L., An, Y., Geng, K., Wan, S., Zhang, F., Tan, X., Jiang, Z., & Xu, Y. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.05.081 · Cited by 39
Sodium hyaluronate hydrogel for wound healing and human health monitoring based on deep eutectic solvent
Huang, T., Zhang, Y., Zhao, L., Ren, Y. Y., Wang, K., Zhang, N., Zhang, X., Wang, J., & Tu, Q. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128801 · Cited by 38
The role of adipose-derived stem cells-derived extracellular vesicles in the treatment of diabetic foot ulcer: Trends and prospects
Deng, H., & Chen, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.902130 · Cited by 39
Ameliorating impaired cardiac function in myocardial infarction using exosome-loaded gallic-acid-containing polyurethane scaffolds
Das, A., Nikhil, A., Shiekh, P. A., Yadav, B., Jagavelu, K., & Kumar, A. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.11.009 · Cited by 38
Simultaneous regulation of AGE/RAGE signaling and MMP-9 expression by an immunomodulating hydrogel accelerates healing in diabetic wounds
Banerjee, A., Singh, P., Shiekh, P. A., Kumar, A., Koul, V., & Bhattacharyya, J. (2024) · Biomaterials Advances · doi:10.1016/j.bioadv.2024.213937 · Cited by 37
Multifunctional polymeric wound dressings
Soylu, Z., Oktay, B., Erarslan, A., & Özerol, E. A. (2025) · Polymer Bulletin · doi:10.1007/s00289-025-05753-z · Cited by 37
ZIF-8/Curcumin-Loaded Electrospun Nanofiber Membrane for Wound Healing
Chen, H., Wei, Z., Jieyu, X., Li, M., Ye, Y., Ling, Z., Wang, M., Danyang, C., & Guo, L. (2023) · ACS Applied Nano Materials · doi:10.1021/acsanm.3c02443 · Cited by 36
Opportunities and challenges of engineered exosomes for diabetic wound healing
Shi, L., Song, D., Meng, C., Cheng, Y., Wang, B., & Yang, Z. (2024) · Giant · doi:10.1016/j.giant.2024.100251 · Cited by 36
The Role of Mesenchymal Stromal Cells-Derived Small Extracellular Vesicles in Diabetes and Its Chronic Complications
Li, F., Lin, X., Xu, F., Shan, S., Guo, B., Lei, L.-M., Zheng, M.-H., Wang, Y., Xu, Q.-S., & Yuan, L. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.780974 · Cited by 39
Nucleic Acid-Scavenging Hydrogels Accelerate Diabetic Wound Healing
Zhong, H., Liang, H., Yan, Y., Chen, L., Zhao, T., Liu, L., & Chen, Y. (2022) · Biomacromolecules · doi:10.1021/acs.biomac.2c00526 · Cited by 36
Comprehensive management of diabetic ulceration: strategies and perspectives
Zheng, Z., Juan, Y., Wang, Z., Chu, Z., Wang, W., Qian, H., & Xu, L. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114058 · Cited by 37
Skin cell-derived extracellular vesicles: a promising therapeutic strategy for cutaneous injury
Wang, M., Wu, P., Huang, J. G., Liu, W., Qian, H., Sun, Y., & Shi, H. (2022) · Burns & Trauma · doi:10.1093/burnst/tkac037 · Cited by 34
Bioengineered mesenchymal stem cell-derived exosomes: emerging strategies for diabetic wound healing
Liu, L., & Liu, D. (2024) · Burns & Trauma · doi:10.1093/burnst/tkae030 · Cited by 35
Advances in Skin Wound and Scar Repair by Polymer Scaffolds
Zhou, S., Wang, Q., Huang, A., Fan, H., Yan, S., & Zhang, Q. (2021) · Molecules · doi:10.3390/molecules26206110 · Cited by 34
The Therapeutic Role of ADSC-EVs in Skin Regeneration
Wang, Y., Cheng, L., Zhao, H., Li, Z., Chen, J., Cen, Y., & Zhang, Z. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.858824 · Cited by 34
Effect of composite biodegradable biomaterials on wound healing in diabetes
Ren, S., Guo, S., Yang, L., & Wang, C. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.1060026 · Cited by 34
Exosomes: Potential key players towards novel therapeutic options in diabetic wounds
Feng, J., Yao, Y., Wang, Q., Han, X., Deng, X., Cao, Y., Chen, X., Zhou, M., & Zhao, C. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115297 · Cited by 33
Engineering extracellular vesicles for ROS scavenging and tissue regeneration
Dayem, A. A., Yan, E., Do, M., Kim, Y., Lee, Y. K., Cho, S., & Kim, D. (2024) · Nano Convergence · doi:10.1186/s40580-024-00430-9 · Cited by 34
Emerging Technological Advancement for Chronic Wound Treatment and Their Role in Accelerating Wound Healing
Ghosh, R., Singh, P., Pandit, A. H., Tariq, U., Bhunia, B. K., & Kumar, A. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c01064 · Cited by 34
Squid Suckerin‐Spider Silk Fusion Protein Hydrogel for Delivery of Mesenchymal Stem Cell Secretome to Chronic Wounds
Koh, K., Wang, J. K., Chen, J. X. Y., Hiew, S. H., Cheng, H. S., Gabryelczyk, B., Vos, M. I. G., Yip, Y. S., Chen, L., Sobota, R. M., et al. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201900 · Cited by 34
Exosomes for hair growth and regeneration
Zhou, Y., Seo, J., Tu, S., Nanmo, A., Kageyama, T., & Fukuda, J. (2023) · Journal of Bioscience and Bioengineering · doi:10.1016/j.jbiosc.2023.11.001 · Cited by 43
Multi-functional nanozyme-integrated astragalus polysaccharide hydrogel for targeted phased therapy in diabetic wound healing
Zhang, X., Wen, S., Liu, Q., Cai, W., Ning, K., Liu, H., Liu, E., Huang, Y., & Zeng, F. (2025) · Nano Today · doi:10.1016/j.nantod.2025.102739 · Cited by 34
How to maximize the therapeutic effect of exosomes on skin wounds in diabetes mellitus: Review and discussion
Dong, J., Wu, B., & Tian, W. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1146991 · Cited by 32
Scavenging ROS and inflammation produced during treatment to enhance the wound repair efficacy of photothermal injectable hydrogel
Luo, Y., Zhou, X., Liu, C., Lu, R., Jia, M., Li, P., & Zhang, S. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213096 · Cited by 33
In-situ oxygen-supplying ROS nanopurifier for enhanced healing of MRSA-infected diabetic wounds via microenvironment modulation
Wang, Q., Luo, Z., Li, Z., Hu, H., Lin, Y., Fan, X., Li, Z., & Wu, Y. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.12.044 · Cited by 32
Multifunctional Extracellular Matrix Hydrogel with Self-Healing Properties and Promoting Angiogenesis as an Immunoregulation Platform for Diabetic Wound Healing
Sun, Z., Xiong, H., Lou, T., Liu, W., Xu, Y., Yu, S., Wang, H., Liu, W., Yang, L., Zhou, C., et al. (2023) · Gels · doi:10.3390/gels9050381 · Cited by 29
Establishing the Callus-Based Isolation of Extracellular Vesicles from Cissus quadrangularis and Elucidating Their Role in Osteogenic Differentiation
Gupta, R., Gupta, S. V., Gupta, P., Nussler, A. K., & Kumar, A. (2023) · Journal of Functional Biomaterials · doi:10.3390/jfb14110540 · Cited by 29
Adipose-Derived Stem Cell Exosomes Facilitate Diabetic Wound Healing: Mechanisms and Potential Applications
Wang, K., Yang, Z., Zhang, B., Gong, S., & Wu, Y. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s466034 · Cited by 34
Mesenchymal Stem Cell-Derived Exosome Therapy of Microbial Diseases: From Bench to Bed
Wu, X., Jin, S., Ding, C., Wang, Y., He, D., & Liu, Y. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.804813 · Cited by 29
Oxygen Delivery Biomaterials in Wound Healing Applications
Bayraktar, S., Üstün, C., & Kehr, N. S. (2023) · Macromolecular Bioscience · doi:10.1002/mabi.202300363 · Cited by 28
ROS-scavenging lipid-based liquid crystalline as a favorable stem cell extracellular vesicles delivery vector to promote wound healing
Li, L., Wang, Y., Xu, Y., Xu, J., Zhao, Y., Cheng, Z., Fang, Y., Miao, Y., & Zhang, X. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.05.048 · Cited by 28
Superabsorbent poly(acrylic acid) and antioxidant poly(ester amide) hybrid hydrogel for enhanced wound healing
Zhang, J., Hu, J., Chen, B., Zhao, T., & Gu, Z. (2021) · Regenerative Biomaterials · doi:10.1093/rb/rbaa059 · Cited by 29

Authors: Shiekh, P. A., Singh, A., & Kumar, A.
Affiliations: Indian Institute of Technology Kanpur (IN)
Corresponding author: Kumar, Ashok
ORCID: Shiekh, Parvaiz A.
Singh, Anamika
Kumar, Ashok
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2020-08
Volume: 249
Pages: 120020
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2020.120020
OpenAlex: W3015385912
Cited by: 443
References: 53
Citations by year: 2026: 53 · 2025: 75 · 2024: 82 · 2023: 97 · 2022: 82 · 2021: 40 · 2020: 14
FWCI: 32.28
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
Funders: Ministry of Human Resource Development (2019/P612/SL)
Impacting Research Innovation and Technology (MHRD_6714)
Indian Institute of Technology Kanpur
Department of Science and Technology, Ministry of Science and Technology, India
Department of Biotechnology, Ministry of Science and Technology, India (DST/INT/SWD/P-11/2016, DBT/IN/SWEDEN/08/AK/2017-1, MHRD_IITK_006, SPARC/2018\u20132019/P612/SL)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords: diabetic wound healing, infected diabetic wounds, exosomes, adipose-derived stem cells, angiogenesis, oxidative stress, re-epithelialization, collagen deposition, keratinocyte migration, fibroblast survival, skin regeneration, wound closure
MeSH terms: Anti-Bacterial Agents, Antioxidants, Bandages, Diabetes Mellitus, Humans, Oxygen, Wound Healing, Exosomes, Cryogels

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Exosome laden oxygen releasing antioxidant and antibacterial cryogel wound dressing OxOBand alleviate diabetic and infectious wound healing

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks