Imiquimod-gemcitabine nanoparticles harness immune cells to suppress breast cancer

Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

Wolchok, J. D., Chiarion-Sileni, V., Gonzalez, R., Rutkowski, P., Grob, J.-J., Cowey, C. L., Lao, C. D., Wagstaff, J., Schadendorf, D., Ferrucci, P. F., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1709684 · Cited by 5,357 · see citing works

Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

Larkin, J., Chiarion-Sileni, V., Gonzalez, R., Grob, J.-J., Rutkowski, P., Lao, C. D., Cowey, C. L., Schadendorf, D., Wagstaff, J., Dummer, R., et al. (2019) · New England Journal of Medicine · doi:10.1056/nejmoa1910836 · Cited by 3,723 · see citing works

Microfluidic organs-on-chips

Bhatia, S. N., & Ingber, D. E. (2014) · Nature Biotechnology · doi:10.1038/nbt.2989 · Cited by 3,305 · see citing works

Breast cancer statistics, 2019

Desantis, C. E., Ma, J., Gaudet, M. M., Newman, L. A., Miller, K. D., Sauer, A. G., Jemal, A., & Siegel, R. L. (2019) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21583 · Cited by 3,126 · see citing works

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

Bianchini, G., Balko, J. M., Mayer, I. A., Sanders, M. E., & Gianni, L. (2016) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2016.66 · Cited by 3,079 · see citing works

Cellular uptake of nanoparticles: Journey inside the cell

Behzadi, S., Serpooshan, V., Tao, W., Hamaly, M. A., Alkawareek, M. Y., Dreaden, E. C., Brown, D., Alkilany, A. M., Farokhzad, O. C., & Mahmoudi, M. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00636a · Cited by 2,859 · see citing works

Combination therapy in combating cancer

Mokhtari, R. B., Homayouni, T. S., Baluch, N., Morgatskaya, E., Kumar, S., Das, B., & Yeger, H. (2017) · Oncotarget · doi:10.18632/oncotarget.16723 · Cited by 2,543 · see citing works

Hyaluronic Acid Hydrogels for Biomedical Applications

Burdick, J. A., & Prestwich, G. D. (2011) · Advanced Materials · doi:10.1002/adma.201003963 · Cited by 2,150 · see citing works

Molecular mechanisms of drug resistance

Longley, D., & Johnston, P. (2005) · The Journal of Pathology · doi:10.1002/path.1706 · Cited by 1,686 · see citing works

Nanoparticle Delivery of Cancer Drugs

Wang, A. Z., Langer, R., & Farokhzad, O. C. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-040210-162544 · Cited by 1,575 · see citing works

Five-Year Overall Survival for Patients With Advanced Non‒Small-Cell Lung Cancer Treated With Pembrolizumab: Results From the Phase I KEYNOTE-001 Study

Garon, E. B., Hellmann, M. D., Rizvi, N. A., Carcereny, E., Leighl, N. B., Ahn, M.-J., Eder, J. P., Balmanoukian, A. S., Aggarwal, C., Horn, L., et al. (2019) · Journal of Clinical Oncology · doi:10.1200/jco.19.00934 · Cited by 1,231 · see citing works

Advances in organ-on-a-chip engineering

Zhang, B., Korolj, A., Lai, B. F. L., & Radisic, M. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0034-7 · Cited by 1,017 · see citing works

Functionalization, preparation and use of cell-laden gelatin methacryloyl–based hydrogels as modular tissue culture platforms

Loessner, D., Meinert, C., Kaemmerer, E., Martine, L. C., Yue, K., Levett, P. A., Klein, T. J., Melchels, F. P. W., Khademhosseini, A., & Hutmacher, D. W. (2016) · Nature Protocols · doi:10.1038/nprot.2016.037 · Cited by 868 · see citing works

Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer

Ino, Y., Yamazaki–Itoh, R., Shimada, K., Iwasaki, M., Kosuge, T., Kanai, Y., & Hiraoka, N. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.32 · Cited by 853 · see citing works

Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair

Klotz, B. J., Gawlitta, D., Rosenberg, A. J. W. P., Malda, J., & Melchels, F. P. W. (2016) · Trends in biotechnology · doi:10.1016/j.tibtech.2016.01.002 · Cited by 851 · see citing works

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

Skardal, A., Murphy, S. V., Devarasetty, M., Mead, I., Kang, H.-W., Seol, Y.-J., Shrike Zhang, Y., Shin, S.-R., Zhao, L., Aleman, J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08879-x · Cited by 623 · see citing works

Hyaluronic acid targeting of CD44 for cancer therapy: from receptor biology to nanomedicine

Mattheolabakis, G., Milane, L., Singh, A., & Amiji, M. M. (2015) · Journal of Drug Targeting · doi:10.3109/1061186x.2015.1052072 · Cited by 597 · see citing works

Cellular Uptake of Nanoparticles versus Small Molecules: A Matter of Size

Mosquera, J., Garcı́a, I., & Liz‐Marzán, L. M. (2018) · Accounts of Chemical Research · doi:10.1021/acs.accounts.8b00292 · Cited by 489 · see citing works

Application of hyaluronic acid as carriers in drug delivery

Huang, G., & Huang, H. (2018) · Drug Delivery · doi:10.1080/10717544.2018.1450910 · Cited by 478 · see citing works

Surface charge of nanoparticles determines their endocytic and transcytotic pathway in polarized MDCK cells

Harush-Frenkel, O., Rozentur, E., Benita, S., & Altschuler, Y. (2008) · Biomacromolecules · doi:10.1021/bm700535p · Cited by 405 · see citing works

Engineering microscale cellular niches for three-dimensional multicellular co-cultures

Huang, C. P., Lu, J., Seon, H., Lee, A. P., Flanagan, L. A., Kim, H.-Y., Putnam, A. J., & Jeon, N. L. (2009) · Lab on a Chip · doi:10.1039/b818401a · Cited by 384 · see citing works

Role of gemcitabine in cancer therapy

Toschi, L., Finocchiaro, G., Bartolini, S., Gioia, V., & Cappuzzo, F. (2005) · Future Oncology · doi:10.1517/14796694.1.1.7 · Cited by 377 · see citing works

Hyaluronic Acid and Controlled Release: A Review

Bayer, I. S. (2020) · Molecules · doi:10.3390/molecules25112649 · Cited by 356 · see citing works

Digitally Tunable Microfluidic Bioprinting of Multilayered Cannular Tissues

Pi, Q., Maharjan, S., Xiang, Y., Liu, X., Singh, B., van Genderen, A. M., Robledo‐Padilla, F., Parra‐Saldívar, R., Hu, N., Jia, W., et al. (2018) · Advanced Materials · doi:10.1002/adma.201706913 · Cited by 307 · see citing works

Hyaluronic acid-shelled acid-activatable paclitaxel prodrug micelles effectively target and treat CD44-overexpressing human breast tumor xenografts in vivo

Zhong, Y., Goltsche, K., Cheng, L., Xie, F., Meng, F., Deng, C., Zhong, Z., & Haag, R. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.049 · Cited by 290 · see citing works

Self-assembled hyaluronic acid nanoparticles as a potential drug carrier for cancer therapy: synthesis, characterization, and in vivo biodistribution

Choi, K. Y., Min, K. H., Na, J. H., Choi, K., Kim, K., Park, J. H., Kwon, I. C., & Jeong, S. Y. (2009) · Journal of Materials Chemistry · doi:10.1039/b900456d · Cited by 272 · see citing works

Immunization of Malignant Melanoma Patients with Full-Length NY-ESO-1 Protein Using TLR7 Agonist Imiquimod as Vaccine Adjuvant

Adams, S., O’Neill, D. W., Nonaka, D., Hardin, E. A., Chiriboga, L. A., Siu, K., Cruz, C. M., Angiulli, A., Angiulli, F., Ritter, E., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.776 · Cited by 247 · see citing works

Complexation-induced resolution enhancement of 3D-printed hydrogel constructs

Gong, J., Schuurmans, C. C. L., van Genderen, A. M., Cao, X., Li, W., Cheng, F., He, J. J., López, A., Huerta, V., Manríquez, J., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14997-4 · Cited by 235 · see citing works

Beyond drug delivery

Ferrari, M. (2008) · Nature Nanotechnology · doi:10.1038/nnano.2008.46 · Cited by 217 · see citing works

Chemotherapy resistance in metastatic breast cancer: the evolving role of ixabepilone

Rivera, E., & Gómez, H. (2010) · Breast Cancer Research · doi:10.1186/bcr2573 · Cited by 216 · see citing works

Three-dimensional bioprinting of gelatin methacryloyl (GelMA)

Ying, G., Jiang, N., Yu, C., & Zhang, Y. S. (2018) · Bio-Design and Manufacturing · doi:10.1007/s42242-018-0028-8 · Cited by 210 · see citing works

Hyaluronic Acid-Based Theranostic Nanomedicines for Targeted Cancer Therapy

Lee, S. Y., Kang, M. S., Jeong, W. Y., Han, D., & Kim, K. S. (2020) · Cancers · doi:10.3390/cancers12040940 · Cited by 149 · see citing works

Development and characterization of a microfluidic model of the tumour microenvironment

Ayuso, J. M., Virumbrales-Muñoz, M., Lacueva, A., Lanuza, P. M., Checa-Chavarria, E., Botella, P., Fernández, E., Doblare, M., Allison, S. J., Phillips, R. M., et al. (2016) · Scientific Reports · doi:10.1038/srep36086 · Cited by 134 · see citing works

Cancer-on-a-chip systems at the frontier of nanomedicine

Zhang, Y. S., Zhang, Y.-N., & Zhang, W. (2017) · Drug Discovery Today · doi:10.1016/j.drudis.2017.03.011 · Cited by 127 · see citing works

Immunization with a Toll-Like Receptor 7 and/or 8 Agonist Vaccine Adjuvant Increases Protective Immunity againstLeishmania majorin BALB/c Mice

Zhang, W., & Matlashewski, G. (2008) · Infection and Immunity · doi:10.1128/iai.01527-07 · Cited by 115 · see citing works

Symbiotic Photosynthetic Oxygenation within 3D-Bioprinted Vascularized Tissues

Maharjan, S., Alva, J., Cámara, C., Rubio, A. G., Hernández, D., Delavaux, C., Corrêa, É., Romo, M. D., Bonilla, D., Santiago, M. L., et al. (2020) · Matter · doi:10.1016/j.matt.2020.10.022 · Cited by 110 · see citing works

Organ-on-a-chip platforms for accelerating the evaluation of nanomedicine

Chen, X., Zhang, Y. S., Zhang, X., & Liu, C. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.09.022 · Cited by 108 · see citing works

Photo-crosslinked hyaluronic acid nanoparticles with improved stability for in vivo tumor-targeted drug delivery

Yoon, H. Y., Koo, H., Choi, K. Y., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.03.050 · Cited by 104 · see citing works

Gemcitabine Combination Nano Therapies for Pancreatic Cancer

Samanta, K., Setua, S., Kumari, S., Jaggi, M., Yallapu, M. M., & Chauhan, S. C. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11110574 · Cited by 103 · see citing works

A hyaluronic acid conjugate engineered to synergistically and sequentially deliver gemcitabine and doxorubicin to treat triple negative breast cancer

Vogus, D. R., Evans, M. A., Pusuluri, A., et al. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.08.016 · Cited by 94 · see citing works

Two may be better than one: PD-1/PD-L1 blockade combination approaches in metastatic breast cancer

Page, D. B., Bear, H. D., Prabhakaran, S., Gatti-Mays, M. E., Thomas, A., Cobain, E. F., McArthur, H. L., Balko, J. M., Gameiro, S. R., Nanda, R., et al. (2019) · npj Breast Cancer · doi:10.1038/s41523-019-0130-x · Cited by 84 · see citing works

Mimicking Human Pathophysiology in Organ‐on‐Chip Devices

Yeşil-Çeliktaş, Ö., Hassan, S., Miri, A. K., Maharjan, S., Al‐kharboosh, R., Quiñones‐Hinojosa, A., & Zhang, Y. S. (2018) · Advanced Biosystems · doi:10.1002/adbi.201800109 · Cited by 72 · see citing works

A hepatocellular carcinoma–bone metastasis-on-a-chip model for studying thymoquinone-loaded anticancer nanoparticles

Sharifi, F., Yeşil-Çeliktaş, Ö., Kazan, A., Maharjan, S., Saghazadeh, S., Firoozbakhsh, K. K., Firoozabadi, B., & Zhang, Y. S. (2020) · Bio-Design and Manufacturing · doi:10.1007/s42242-020-00074-8 · Cited by 70 · see citing works

Randomized phase I pharmacokinetic study of ipilimumab with or without one of two different chemotherapy regimens in patients with untreated advanced melanoma.

Weber, J. S., Hamid, O., Amin, A., O'Day, S. J., Masson, E., Goldberg, S. M., Williams, D., Parker, S. M., Chasalow, S. D., Alaparthy, S., et al. (2013) · Europe PMC (PubMed Central) · Cited by 68 · see citing works

A Foreign Body Response‐on‐a‐Chip Platform

Sharifi, F., Htwe, S. S., Righi, M., Liu, H., Pietralunga, A., Yeşil-Çeliktaş, Ö., Maharjan, S., Cha, B., Shin, S. R., Dokmeci, M. R., et al. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801425 · Cited by 64 · see citing works

Nanovaccine administration route is critical to obtain pertinent iNKt cell help for robust anti-tumor T and B cell responses

Dölen, Y., Valente, M., Tagit, O., et al. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1738813 · Cited by 59 · see citing works

Dosing immunotherapy combinations: Analysis of 3,526 patients for toxicity and response patterns

Nikanjam, M., Patel, H., & Kurzrock, R. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1338997 · Cited by 40 · see citing works

Tumor-infiltrating Immune Cells in H&E-stained Sections of Colorectal Cancer Tissue as a Reasonable Immunological Biomarker

MATSUTANI, S., Shibutani, M., Maeda, K., et al. (2018) · Anticancer Research · doi:10.21873/anticanres.13041 · Cited by 17 · see citing works

Acid-labile polysaccharide prodrug via lapatinib-sensitizing effect substantially prevented metastasis and postoperative recurrence of triple-negative breast cancer

Sui, J., Zhao, M., Yang, Y., Guo, Z., Ma, M., Xu, Z., Liang, J., Sun, Y., Fan, Y., & Zhang, X. (2020) · Nanoscale · doi:10.1039/d0nr03395b · Cited by 14 · see citing works

Imiquimod: The biochemical mechanisms of immunomodulatory and anti-inflammatory activity

Bozrova, S. V., Levitsky, V. A., Nedospasov, S. A., & Drutskaya, M. S. (2013) · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry · doi:10.1134/s1990750813020042 · Cited by 9 · see citing works

Imiquimod: the biochemical mechanisms of immunomodulatory and anti-inflammatory activity

Bozrova, S. V., Levitsky, V. A., Nedospasov, S. A., & Drutskaya, M. S. (2013) · Biomeditsinskaya Khimiya · doi:10.18097/pbmc20135903249 · Cited by 7 · see citing works

Smart nanoparticles for cancer therapy

Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works

Innovative uses of imiquimod.

Vender, R. B., & Goldberg, O. (2005) · PubMed · Cited by 15 · see citing works

New perspective in immunotherapy: local imiquimod treatment

Kemény, L. V., & Nagy, N. (2010) · Orvosi Hetilap · doi:10.1556/oh.2010.28866 · Cited by 7 · see citing works

Melanoma Arising after Imiquimod Use

Paul, S. P. (2014) · Case Reports in Medicine · doi:10.1155/2014/267535 · Cited by 6 · see citing works

Topical Imiquimod

Kemény, L. V. (2009) · Springer eBooks · doi:10.1007/978-3-540-79341-0_15 · Cited by 1 · see citing works

Imiquimod Cream for BCC Treatment

Hruza, G. (2000) · Journal watch · doi:10.1056/jd200002010000003