Therapeutical strategies for anxiety and anxiety-like disorders using plant-derived natural compounds and plant extracts

Prevalence, Severity, and Comorbidity of 12-Month DSM-IV Disorders in the National Comorbidity Survey Replication

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The Epidemiology of Major Depressive Disorder: Results From the National Comorbidity Survey Replication (NCS-R)

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Anxiety disorders in primary care: prevalence, impairment, comorbidity, and detection

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The Prevalence and Correlates of Adult ADHD in the United States: Results From the National Comorbidity Survey Replication

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The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review.

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Complementary and Alternative Medicine Use Among Adults and Children: United States, 2007

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Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization's World Mental Health Survey Initiative.

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Epidemiology of anxiety disorders in the 21st century

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The mouse light/dark box test

Bourin, M., & Hascoët, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01274-3 · Cited by 1,440 · see citing works

Prevalence and incidence studies of anxiety disorders: A systematic review of the literature

Somers, J. M., Goldner, E. M., Waraich, P., & Hsu, L. (2006) · The Canadian Journal of Psychiatry · doi:10.1177/070674370605100206 · Cited by 1,114 · see citing works

Molecular and neuronal substrate for the selective attenuation of anxiety

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Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients

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Generalized anxiety disorder: prevalence, burden, and cost to society

Wittchen, H.-U. (2002) · Depression and Anxiety · doi:10.1002/da.10065 · Cited by 733 · see citing works

p ‐Coumaric acid and its conjugates: dietary sources, pharmacokinetic properties and biological activities

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The Mouse Forced Swim Test

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Elevated Plus Maze for Mice

Komada, M., Takao, K., & Miyakawa, T. (2008) · Journal of Visualized Experiments · doi:10.3791/1088 · Cited by 551 · see citing works

Therapeutic applications of compounds in the Magnolia family

Lee, Y., Lee, Y. M., Lee, C., Jung, J., Han, S., & Hong, J. T. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.01.010 · Cited by 490 · see citing works

Anxiety disorders and GABA neurotransmission: a disturbance of modulation

Nuss, P. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s58841 · Cited by 482 · see citing works

Animal models of anxiety disorders and stress

Campos, A. C., Fogaça, M. V., de Aguiar, D. C., & Guimarães, F. S. (2013) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2013-1139 · Cited by 473 · see citing works

Depression and Anxiety in the United States: Findings From the 2006 Behavioral Risk Factor Surveillance System

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Disability and Poor Quality of Life Associated With Comorbid Anxiety Disorders and Physical Conditions

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Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders

Zhang, Z. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.04.014 · Cited by 345 · see citing works

Chlorogenic acid, a polyphenol from Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects

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A combined marble burying–locomotor activity test in mice: A practical screening test with sensitivity to different classes of anxiolytics and antidepressants

Nicolas, L. B., Kolb, Y., & Prinssen, E. P. M. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.07.015 · Cited by 234 · see citing works

A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder

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Bioassay‐guided Evaluation of Antioxidant and Antinociceptive Activities of Carvacrol

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Involvement of the opioid system in the anxiolytic-like effects induced by Δ9-tetrahydrocannabinol

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Impact of Comorbid Anxiety Disorders on Outcome in a Cohort of Patients With Bipolar Disorder

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Do benzodiazepines still deserve a major role in the treatment of psychiatric disorders? A critical reappraisal

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Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review

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GABAA receptors as in vivo substrate for the anxiolytic action of valerenic acid, a major constituent of valerian root extracts

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Clinical relevance of comorbidity in anxiety disorders: A report from the Netherlands Study of Depression and Anxiety (NESDA)

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Disorder-specific mental health service use for mood and anxiety disorders: Associations with age, sex, and psychiatric comorbidity

Mackenzie, C. S., Reynolds, K., Cairney, J., Streiner, D. L., & Sareen, J. (2012) · Depression and Anxiety · doi:10.1002/da.20911 · Cited by 169 · see citing works

Animal models for screening anxiolytic-like drugs: a perspective.

Bourin, M. (2015) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2015.17.3/mbourin · Cited by 163 · see citing works

Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial

Mao, J. J., Xie, S. X., Keefe, J. R., Soeller, I., Li, Q. S., & Amsterdam, J. D. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.10.012 · Cited by 161 · see citing works

Clinical practice guidelines. Management of anxiety disorders.

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The Behavioral Profile of the Potent and Selective mGlu5 Receptor Antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in Rodent Models of Anxiety

Busse, C. S., Brodkin, J. D., Tattersall, D., Anderson, J. J., Warren, N., Tehrani, L. R., Bristow, L. J., Varney, M. A., & Cosford, N. D. P. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300540 · Cited by 159 · see citing works

GABA A Receptors and the Diversity in their Structure and Pharmacology

Chua, H. C., & Chebib, M. (2017) · Advances in pharmacology · doi:10.1016/bs.apha.2017.03.003 · Cited by 154 · see citing works

The Vogel conflict test: procedural aspects, γ-aminobutyric acid, glutamate and monoamines

Millan, M. J., & Brocco, M. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01275-5 · Cited by 149 · see citing works

Antidepressant-like effects of fractions, essential oil, carnosol and betulinic acid isolated from Rosmarinus officinalis L.

Machado, D. G., Cunha, M. P., Neis, V. B., Balen, G. O., Colla, A. R. D. S., Bettio, L. E. B., Oliveira‐Giacomelli, Á., Pazini, F. L., Dalmarco, J. B., Simionatto, E. L., et al. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.09.028 · Cited by 146 · see citing works

Pharmacology of acid-sensing ion channels – Physiological and therapeutical perspectives

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Neurobiological Signatures of Anxiety and Depression in Resting-State Functional Magnetic Resonance Imaging

Oathes, D. J., Patenaude, B., Schatzberg, A. F., & Etkin, A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.08.006 · Cited by 144 · see citing works

Community Survey of Bipolar Disorder in Canada: Lifetime Prevalence and Illness Characteristics

Schaffer, A., Cairney, J., Cheung, A., Veldhuizen, S., & Levitt, A. (2006) · The Canadian Journal of Psychiatry · doi:10.1177/070674370605100104 · Cited by 143 · see citing works

The GABAergic system contributes to the anxiolytic-like effect of essential oil from Cymbopogon citratus (lemongrass)

Costa, C. A. R. D. A., Köhn, D., de Lima, V. M., Gargano, A. C., Flório, J. C., & Costa, M. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.07.003 · Cited by 142 · see citing works

Cellular Mechanisms Underlying the Anxiolytic Effect of Low Doses of Peripheral Δ9-Tetrahydrocannabinol in Rats

Rubino, T., Sala, M., Viganò, D., Braida, D., Castiglioni, C., Limonta, V., Guidali, C., Realini, N., & Parolaro, D. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301330 · Cited by 137 · see citing works

A Meta-analytic Review of the Efficacy of Drug Treatment in Generalized Anxiety Disorder

Mitte, K., Noack, P., Steil, R., & Hautzinger, M. (2005) · Journal of Clinical Psychopharmacology · doi:10.1097/01.jcp.0000155821.74832.f9 · Cited by 137 · see citing works

Influence of single and repeated cannabidiol administration on emotional behavior and markers of cell proliferation and neurogenesis in non-stressed mice

Schiavon, A. P., Bonato, J. M., Milani, H., Guimarães, F. S., & Weffort de Oliveira, R. M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.06.017 · Cited by 135 · see citing works

Neurosteroid biosynthesis down‐regulation and changes in GABA_Areceptor subunit composition: a<i>biomarker axis</i>in stress‐induced cognitive and emotional impairment

Locci, A., & Pinna, G. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13843 · Cited by 132 · see citing works

The age-dependent effects of selective serotonin reuptake inhibitors in humans and rodents: a review

Olivier, J. D. A., Blom, T., Arentsen, T., & Homberg, J. R. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.09.013 · Cited by 131 · see citing works

Anxiolytic-like effects of sinapic acid in mice

Yoon, B. H., Jung, J. W., Lee, J.-J., Cho, Y.-W., Jang, C.-G., Jin, C., Oh, T. H., & Ryu, J. H. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.05.007 · Cited by 129 · see citing works

Anxiolytic‐like effect of Carvacrol (5‐isopropyl‐2‐methylphenol) in mice: involvement with GABAergic transmission

Melo, F. H. C., Venâncio, E. T., de Sousa, D. P., Fonteles, M. M. D. F., Vasconcelos, S. M. M., Viana, G. S. D. B., & de Sousa, F. C. F. (2009) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2009.00788.x · Cited by 127 · see citing works

A double-blind, randomized and placebo-controlled trial of Saffron ( Crocus sativus L.) in the treatment of anxiety and depression

Mazidi, M., Shemshian, M., Mousavi, S. H., Norouzy, A., Kermani, T., Moghiman, T., Sadeghi, A., Mokhber, N., Ghayour‐Mobarhan, M., & Ferns, G. A. (2016) · Journal of Complementary and Integrative Medicine · doi:10.1515/jcim-2015-0043 · Cited by 125 · see citing works

Disability, Employment and Work Performance Among People with ICD-10 Anxiety Disorders

Waghorn, G., Chant, D. C., White, P., & Whiteford, H. (2005) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.2005.01510.x · Cited by 113 · see citing works

Anxiolytic-like effects of phytol: Possible involvement of GABAergic transmission

Costa, J. P., de Oliveira, G. A. L., de Almeida, A. A. C., Islam, M. T., de Sousa, D. P., & de Freitas, R. M. (2013) · Brain Research · doi:10.1016/j.brainres.2013.12.003 · Cited by 112 · see citing works

The adverse skeletal effects of selective serotonin reuptake inhibitors

Tsapakis, E.-M., Gamie, Z., Tran, G. T., Adshead, S., Lampard, A. L., Mantalaris, A., & Tsiridis, E. E. (2011) · European Psychiatry · doi:10.1016/j.eurpsy.2010.10.006 · Cited by 112 · see citing works

Patterns in the use of benzodiazepines in British Columbia: Examining the impact of increasing research and guideline cautions against long-term use

Cunningham, C. M., Hanley, G. E., & Morgan, S. (2010) · Health Policy · doi:10.1016/j.healthpol.2010.03.008 · Cited by 111 · see citing works

Opioids and anxiety

Colasanti, A., Rabiner, E. A., Lingford-Hughes, A. R., & Nutt, D. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881110367726 · Cited by 111 · see citing works

Prevalence, incidence, morbidity and treatment patterns in a cohort of patients diagnosed with anxiety in UK primary care

Martin-Merino, E., Ruigomez, A., Wallander, M.-A., Johansson, S., & Garcia-Rodriguez, L. A. (2010) · Family Practice · doi:10.1093/fampra/cmp071 · Cited by 109 · see citing works

Anxiolytic-like effects of mGlu1 and mGlu5 receptor antagonists in rats

Pietraszek, M., Sukhanov, I., Maciejak, P., Szyndler, J., Gravius, A., Wisłowska, A., Płaźnik, A., Bespalov, A., & Danysz, W. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.03.028 · Cited by 108 · see citing works

Effects of selective serotonin reuptake inhibitors on bone health in adults: Time for recommendations about screening, prevention and management?

Haney, E. M., Warden, S. J., & Bliziotes, M. M. (2009) · Bone · doi:10.1016/j.bone.2009.07.083 · Cited by 104 · see citing works

Acute and chronic effects of selective serotonin reuptake inhibitor treatment on fear conditioning: Implications for underlying fear circuits

Burghardt, N. S., & Bauer, E. P. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.05.050 · Cited by 101 · see citing works

GABA and 5-HT systems are implicated in the anxiolytic-like effect of spinosin in mice

Liu, J., Wei-min, Z., Yang, Y., Shi, J., Liu, Q.-T., Guo-lin, L., Fang, N., Li, J., & Guo, J. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.11.003 · Cited by 98 · see citing works

Infrequency of ?pure? GAD: Impact of psychiatric comorbidity on clinical course

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Anxiolytic effect of saponins from Panax quinquefolium in mice

Wei, X., Yang, J., Wang, J., & Wu, C. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.01.009 · Cited by 81 · see citing works

Implication of limonene and linalyl acetate in cytotoxicity induced by bergamot essential oil in human neuroblastoma cells

Russo, R., Ciociaro, A., Berliocchi, L., Cassiano, M. G. V., Rombolà, L., Ragusa, S., Bagetta, G., Blandini, F., & Corasaniti, M. T. (2013) · Fitoterapia · doi:10.1016/j.fitote.2013.05.014 · Cited by 77 · see citing works

Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, exerts antiepileptic effects via the GABA/benzodiazepine receptor complex in mice

Chen, C., Tan, R., Qu, W., Wu, Z., Wang, Y., Urade, Y., & Huang, Z. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01456.x · Cited by 75 · see citing works

Anxiolytic-like effects of acute and chronic treatment with Achillea millefolium L. extract

Baretta, I. P., Felizardo, R. A., Bimbato, V. F., dos Santos, M. G. J., Kassuya, C. A. L., Gasparotto, A., da Silva, C. R., Oliveira, S. M., Ferreira, J., & Andreatini, R. (2011) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2011.11.047 · Cited by 74 · see citing works

Anxiolytic and sedative-hypnotic activities of polygalasaponins fromPolygala tenuifoliain mice

Yao, Y., Jia, M., Wu, J.-G., Zhang, H., Sun, L.-N., Chen, W., & Rahman, K. (2010) · Pharmaceutical Biology · doi:10.3109/13880200903280042 · Cited by 74 · see citing works

Cinnamon Counteracts the Negative Effects of a High Fat/High Fructose Diet on Behavior, Brain Insulin Signaling and Alzheimer-Associated Changes

Anderson, R. A., Qin, B., Canini, F., Poulet, L., & Roussel, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083243 · Cited by 71 · see citing works

Recent Advances in the Design and Development of Novel Negative Allosteric Modulators of mGlu5

Emmitte, K. A. (2011) · ACS Chemical Neuroscience · doi:10.1021/cn2000266 · Cited by 70 · see citing works

Functioning and disability levels in primary care out-patients with one or more anxiety disorders

Sherbourne, C. D., Sullivan, G., Craske, M. G., Roy-Byrne, P., Golinelli, D., Rose, R. D., Chavira, D. A., Bystritsky, A., & Stein, M. B. (2010) · Psychological Medicine · doi:10.1017/s0033291710000176 · Cited by 70 · see citing works

Long-Term Pharmacological Treatments of Anxiety Disorders: An Updated Systematic Review

Perna, G., Alciati, A., Riva, A., Micieli, W., & Caldirola, D. (2016) · Current Psychiatry Reports · doi:10.1007/s11920-016-0668-3 · Cited by 70 · see citing works

Anxiolytic-like effects of ursolic acid in mice

Colla, A. R. D. S., Rosa, J. M., Cunha, M. P., & Rodrigues, A. L. S. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.077 · Cited by 67 · see citing works

Anxiolytic-like effects and mechanism of (−)-myrtenol: A monoterpene alcohol

Moreira, M. R. C., Salvadori, M. G. D. S. S., de Almeida, A. A. C., de Sousa, D. P., Jordán, J., Satyal, P., de Freitas, R. M., & de Almeida, R. N. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.07.007 · Cited by 64 · see citing works

A Systematic Review of Plant-Derived Natural Compounds for Anxiety Disorders

Farzaei, M. H., Bahramsoltani, R., Rahimi, R., Abbasabadi, F., & Abdollahi, M. R. (2016) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026616666160204121039 · Cited by 64 · see citing works

Preoperative use of anxiolytic-sedative agents; are we on the right track?

Bucx, M. J. L., Krijtenburg, P., & Kox, M. (2016) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2016.03.025 · Cited by 63 · see citing works

The effect of Elettaria cardamomum extract on anxiety-like behavior in a rat model of post-traumatic stress disorder

Masoumi‐Ardakani, Y., Mahmoudvand, H., Mirzaei, A., Esmaeilpour, K., Ghazvini, H., Khalifeh, S., & Sepehri, G. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.12.116 · Cited by 62 · see citing works

Differential inhibitory effects of honokiol and magnolol on excitatory amino acid-evoked cation signals and NMDA-induced seizures

LIN, Y., Chen, H., KO, C., & Chan, M. (2005) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.04.009 · Cited by 61 · see citing works

Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain

Lin, Y.-R., Chen, H., Lin, Y., Ko, C.-H., & Chan, M. (2009) · Journal of Biomedical Science · doi:10.1186/1423-0127-16-94 · Cited by 60 · see citing works

Efficacy and safety of silexan, a new, orally administered lavender oil preparation, in subthreshold anxiety disorder – evidence from clinical trials

Kasper, S. F., Gastpar, M., Müller, W. E., Volz, H., Möller, H., Dienel, A., & Schläfke, S. (2010) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-010-0845-7 · Cited by 58 · see citing works

Effect of a proprietary Magnolia and Phellodendronextract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial

Kalman, D., Feldman, S., Feldman, R., Schwartz, H. I., Krieger, D., & Garrison, R. (2008) · Nutrition Journal · doi:10.1186/1475-2891-7-11 · Cited by 58 · see citing works

Synergistic effects of tandospirone and selective serotonin reuptake inhibitors on the contextual conditioned fear stress response in rats

Nishikawa, H., Inoue, T., Izumi, T., & Koyama, T. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.02.010 · Cited by 58 · see citing works

Effects of a hops (Humulus lupulus L.) dry extract supplement on self-reported depression, anxiety and stress levels in apparently healthy young adults: A randomized, placebo-controlled, double-blind, crossover pilot study

Kyrou, I., Christou, A., Panagiotakos, D., Stefanaki, C., Skenderi, K., Katsana, K., & Tsigos, C. (2017) · Hormones · doi:10.14310/horm.2002.1738 · Cited by 58 · see citing works

An orally administered lavandula oil preparation (Silexan) for anxiety disorder and related conditions: an evidence based review

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Modulation of GABAA-Receptors by Honokiol and Derivatives: Subtype Selectivity and Structure–Activity Relationship

Taferner, B., Schuehly, W., Huefner, A., Baburin, I., Wiesner, K., Ecker, G. F., & Hering, S. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200186n · Cited by 57 · see citing works

Antidepressant and anxiolytic activity of Lavandula officinalis aerial parts hydroalcoholic extract in scopolamine-treated rats

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